Nanotechnology-Inspired Extracellular Vesicles Theranostics for Diagnosis and Therapy of Central Nervous System Diseases

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

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Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

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The blood-brain barrier: Bottleneck in brain drug development

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Extracellular vesicles as a next-generation drug delivery platform

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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New Technologies for Analysis of Extracellular Vesicles

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Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

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Challenges and directions in studying cell–cell communication by extracellular vesicles

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

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Endothelial progenitor cell–derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA

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Isolation of exosomes from whole blood by integrating acoustics and microfluidics

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Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 894 · see citing works

Exosomes as mediators of intercellular crosstalk in metabolism

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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

Shao, H., Chung, J., Balaj, L., Charest, A., Bigner, D. D., Carter, B. S., Hochberg, F. H., Breakefield, X. O., Weissleder, R., & Lee, H. (2012) · Nature Medicine · doi:10.1038/nm.2994 · Cited by 757 · see citing works

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

Jia, G., Han, Y., An, Y., Ding, Y., He, C., Wang, X., & Tang, Q. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.029 · Cited by 753 · see citing works

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Kojima, R., Bojar, D., Rizzi, G., Hamri, G. C.-E., El-Baba, M. D., Saxena, P., Ausländer, S., Tan, K. R., & Fussenegger, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03733-8 · Cited by 748 · see citing works

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0485-1 · Cited by 744 · see citing works

Multifunctional Gold Nanoparticles for Diagnosis and Therapy of Disease

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Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

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Macrophage‐dependent clearance of systemically administered B16BL6‐derived exosomes from the blood circulation in mice

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Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

Wunsch, B. H., Smith, J. T., Gifford, S. M., Wang, C., Brink, M., Bruce, R. L., Austin, R. H., Stolovitzky, G. A., & Astier, Y. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.134 · Cited by 582 · see citing works

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

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Microfluidic isolation and transcriptome analysis of serum microvesicles

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Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

Morad, G., Carman, C. V., Hagedorn, E. J., Perlin, J. R., Zon, L. I., Mustafaoğlu, N., Park, T., Ingber, D. E., Daisy, C. C., & Moses, M. A. (2019) · ACS Nano · doi:10.1021/acsnano.9b04397 · Cited by 561 · see citing works

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 549 · see citing works

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

Chen, C. C., Liu, L., Ma, F., Wong, C. W., Guo, X. E., Chacko, J. V., Farhoodi, H. P., Zhang, S. X., Zimak, J., Ségaliny, A., et al. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0458-3 · Cited by 537 · see citing works

Acoustic Purification of Extracellular Microvesicles

Lee, K., Shao, H., Weissleder, R., & Lee, H. (2015) · ACS Nano · doi:10.1021/nn506538f · Cited by 535 · see citing works

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

Guo, S., Tao, S., Yin, W., Qi, X., Yuan, T., & Zhang, C. (2016) · Theranostics · doi:10.7150/thno.16803 · Cited by 519 · see citing works

Biodistribution of extracellular vesicles following administration into animals: A systematic review

Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 498 · see citing works

Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows

Liu, C., Guo, J., Tian, F., Yang, N., Yan, F., Ding, Y., Wei, J., Hu, G., Nie, G., & Sun, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b02277 · Cited by 477 · see citing works

Integrated Magneto–Electrochemical Sensor for Exosome Analysis

Jeong, S., Park, J., Pathania, D., Castro, C. M., Weissleder, R., & Lee, H. (2016) · ACS Nano · doi:10.1021/acsnano.5b07584 · Cited by 468 · see citing works

Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration

Liu, X., Yang, Y., Li, Y., Niu, X., Zhao, B., Wang, Y., Bao, C., Xie, Z., Lin, Q., & Zhu, L. (2017) · Nanoscale · doi:10.1039/c7nr00352h · Cited by 466 · see citing works

Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration

Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 459 · see citing works

Biomimetic proteolipid vesicles for targeting inflamed tissues

Molinaro, R., Corbo, C., Martinez, J. O., Taraballi, F., Evangelopoulos, M., Minardi, S., Yazdi, I. K., Zhao, P., Rosa, E. D., Sherman, M. B., et al. (2016) · Nature Materials · doi:10.1038/nmat4644 · Cited by 453 · see citing works

Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges

Laurent, S., Saei, A. A., Behzadi, S., Panahifar, A., & Mahmoudi, M. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.924501 · Cited by 445 · see citing works

Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

Zhang, J., Liu, X., Li, H., Chen, C., Hu, B., Niu, X., Li, Q., Zhao, B., Xie, Z., & Wang, Y. (2016) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-016-0391-3 · Cited by 431 · see citing works

In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles

Betzer, O., Perets, N., Angel, A., Motiei, M., Sadan, T., Yadid, G., Offen, D., & Popovtzer, R. (2017) · ACS Nano · doi:10.1021/acsnano.7b04495 · Cited by 404 · see citing works

Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment

Zhang, K., Zhao, X., Chen, X., Wei, Y., Du, W., Wang, Y., Liu, L., Zhao, W., Han, Z., Kong, D., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08449 · Cited by 394 · see citing works

Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model

Tao, S., Guo, S., Li, M., Ke, Q., Guo, Y., & Zhang, C. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0275 · Cited by 392 · see citing works

Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma

Ibsen, S. D., Wright, J., Lewis, J. M., Kim, S., Ko, S.-Y., Ong, J., Manouchehri, S., Vyas, A. D., Akers, J. C., Chen, C. C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00549 · Cited by 383 · see citing works

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders

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Identification of Therapeutic Covariant MicroRNA Clusters in Hypoxia-Treated Cardiac Progenitor Cell Exosomes Using Systems Biology

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A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Niu, W., Xiao, Q., Wang, X., Zhu, J., Li, J., Liang, X., Peng, Y., Wu, C., Lu, R., Pan, Y., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04753 · Cited by 374 · see citing works

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

Liu, B., Lee, B. W., Nakanishi, K., Villasante, A., Williamson, R., Metz, J. B., Kim, J.-H., Kanai, M., Bi, L., Brown, K. R., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0229-7 · Cited by 373 · see citing works

Exodisc for Rapid, Size-Selective, and Efficient Isolation and Analysis of Nanoscale Extracellular Vesicles from Biological Samples

Woo, H., Sunkara, V., Park, J., Kim, T.-H., Han, J.-R., Kim, C., Choi, H.-I., Kim, Y., & Cho, Y. (2017) · ACS Nano · doi:10.1021/acsnano.6b06131 · Cited by 371 · see citing works

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

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Multiplexed Profiling of Single Extracellular Vesicles

Lee, K., Fraser, K. B., Ghaddar, B., Yang, K. S., Kim, E., Balaj, L., Chiocca, E. A., Breakefield, X. O., Lee, H., & Weissleder, R. (2017) · ACS Nano · doi:10.1021/acsnano.7b07060 · Cited by 362 · see citing works

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

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PKH26 labeling of extracellular vesicles: Characterization and cellular internalization of contaminating PKH26 nanoparticles

Dominkuš, P. P., Stenovec, M., Sitar, S., Lasič, E., Zorec, R., Plemenitaš, A., Žagar, E., Kreft, M., & Lenassi, M. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.03.013 · Cited by 358 · see citing works

Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

Lin, S., Yu, Z., Chen, D., Wang, Z., Miao, J., Li, Q., Zhang, D., Song, J., & Cui, D. (2019) · Small · doi:10.1002/smll.201903916 · Cited by 355 · see citing works

Ti3C2 MXenes nanosheets catalyzed highly efficient electrogenerated chemiluminescence biosensor for the detection of exosomes

Zhang, H., Wang, Z., Zhang, Q., Wang, F., & Liu, Y. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.10.016 · Cited by 333 · see citing works

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles

Reátegui, E., van der Vos, K. E., Lai, C. P., Zeinali, M., Atai, N. A., Aldikacti, B., Floyd, F. P., Khankhel, A. H., Thapar, V., Hochberg, F. H., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02261-1 · Cited by 330 · see citing works

The power of imaging to understand extracellular vesicle biology in vivo

Verweij, F. J., Balaj, L., Boulanger, C. M., Carter, D. R. F., Compeer, E. B., D’Angelo, G., Andaloussi, S. E., Goetz, J. G., Gross, J. C., Hyenne, V., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01206-3 · Cited by 327 · see citing works

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

Kim, H. Y., Kim, T. J., Kang, L., Kim, Y. J., Kang, M. K., Kim, J., Ryu, J. H., Hyeon, T., Yoon, B., Ko, S., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119942 · Cited by 322 · see citing works

Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

Sancho‐Albero, M., Rubio‐Ruíz, B., Pérez‐López, A. M., Sebastián, V., Martín-Duque, P., Arruebo, M., Santamarı́a, J., & Unciti‐Broceta, A. (2019) · Nature Catalysis · doi:10.1038/s41929-019-0333-4 · Cited by 315 · see citing works

Recent Progress in NIR-II Contrast Agent for Biological Imaging

Cao, J., Zhu, B., Zheng, K., He, S., Liang, M., Song, J., & Yang, H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00487 · Cited by 314 · see citing works

Universal Ti3C2 MXenes Based Self-Standard Ratiometric Fluorescence Resonance Energy Transfer Platform for Highly Sensitive Detection of Exosomes

Zhang, Q., Wang, F., Zhang, H., Zhang, Y., Liu, M., & Liu, Y. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03083 · Cited by 310 · see citing works

Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration

Khongkow, M., Yata, T., Boonrungsiman, S., Ruktanonchai, U., Graham, D., & Namdee, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-44569-6 · Cited by 305 · see citing works

Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes

Xu, H., Liao, C., Zuo, P., Liu, Z., & Ye, B. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03272 · Cited by 289 · see citing works

An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer

Liang, L.-G., Kong, M., Zhou, S. X., Sheng, Y.-F., Wang, P., Yu, T., İnci, F., Kuo, W. P., Li, L., Demirci, U., et al. (2017) · Scientific Reports · doi:10.1038/srep46224 · Cited by 286 · see citing works

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

Morishita, M., Takahashi, Y., Nishikawa, M., Sano, K., Kato, K., Yamashita, T., Imai, T., Saji, H., & Takakura, Y. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24251 · Cited by 285 · see citing works

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

Lázaro‐Ibáñez, E., Faruqu, F. N., Saleh, A. F. A., da Silva, A. M., Wang, J. T.-W., Rak, J. W., Al‐Jamal, K. T., & Dekker, N. (2021) · ACS Nano · doi:10.1021/acsnano.0c09873 · Cited by 273 · see citing works

Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: a new tool for bone defect repair

Diomede, F., Gugliandolo, A., Cardelli, P., Merciaro, I., Ettorre, V., Traini, T., Bedini, R., Scionti, D., Bramanti, A., Nanci, A., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0850-0 · Cited by 269 · see citing works

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Xie, S., Zhang, Q., & Jiang, L. (2022) · Membranes · doi:10.3390/membranes12050498 · Cited by 262 · see citing works

Towards microfluidic-based exosome isolation and detection for tumor therapy

Wang, J., Ma, P., Kim, D. H., Liu, B., & Demirci, U. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101066 · Cited by 245 · see citing works

Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

Alifu, N., Zebibula, A., Qi, J., Zhang, H., Sun, C., Yu, X., Xue, D., Lam, J. W. Y., Li, G., Qian, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b05937 · Cited by 237 · see citing works

Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics

Santhosh, P. B., & Ulrih, N. P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.04.032 · Cited by 236 · see citing works

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

Hwang, D. W., Choi, H., Jang, S. C., Yoo, M. Y., Park, J. Y., Choi, N. E., Oh, H. J., Ha, S., Lee, Y., Jeong, J. M., et al. (2015) · Scientific Reports · doi:10.1038/srep15636 · Cited by 234 · see citing works

Molecular Detection and Analysis of Exosomes Using Surface-Enhanced Raman Scattering Gold Nanorods and a Miniaturized Device

Kwizera, E. A., O’Connor, R., Vinduska, V., Williams, M., Butch, E. R., Snyder, S. E., Chen, X. '., & Huang, X. (2018) · Theranostics · doi:10.7150/thno.21358 · Cited by 234 · see citing works

Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification

Wang, Q., Zou, L., Yang, X., Liu, X., Nie, W., Zheng, Y., Cheng, Q. J., & Wang, K. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.04.013 · Cited by 231 · see citing works

Exosome Classification by Pattern Analysis of Surface-Enhanced Raman Spectroscopy Data for Lung Cancer Diagnosis.

Park, J., Hwang, M., Choi, B., Jeong, H., Jung, J.-H., Kim, H., Hong, S.-H., Park, J.-H., & Choi, Y. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00911 · Cited by 220 · see citing works

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219 · see citing works

Quantitative and Specific Detection of Exosomal miRNAs for Accurate Diagnosis of Breast Cancer Using a Surface‐Enhanced Raman Scattering Sensor Based on Plasmonic Head‐Flocked Gold Nanopillars

Lee, J. U., Kim, W. H., Lee, H. S., Park, K. H., & Sim, S. J. (2019) · Small · doi:10.1002/smll.201804968 · Cited by 217 · see citing works

Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

Gangadaran, P., Rajendran, R. L., Lee, H., Kalimuthu, S., Hong, C. M., Jeong, S. Y., Lee, S., Lee, J., & Ahn, B. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.022 · Cited by 210 · see citing works

An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma

Park, J., Park, J. S., Huang, C.-H., Jo, A., Cook, K. A., Wang, R., Lin, H.-Y., Deun, J. V., Li, H., Min, J., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00752-7 · Cited by 210 · see citing works

Inertio-elastic focusing of bioparticles in microchannels at high throughput

Lim, E. J., Ober, T. J., Jon, F., Desai, S. P., Neal, D. R., Bong, K. W., Doyle, P. S., McKinley, G. H., & Toner, M. (2014) · Nature Communications · doi:10.1038/ncomms5120 · Cited by 210 · see citing works

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

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Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain

Pauwels, M. J., Vandendriessche, C., & Vandenbroucke, R. E. (2021) · Biomedicines · doi:10.3390/biomedicines9111734 · Cited by 37 · see citing works

Rapid Enrichment and Detection of Extracellular Vesicles Enabled by CuS-Enclosed Microgels

Jiang, Q., Liu, Y., Wang, L., Adkins, G. B., & Zhong, W. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04485 · Cited by 35 · see citing works

Current Perspectives on Clinical Use of Exosomes as a Personalized Contrast Media and Theranostics

Lorenc, T., Chrzanowski, J., & Olejarz, W. (2020) · Cancers · doi:10.3390/cancers12113386 · Cited by 33 · see citing works

Neodymium (3+)‐Coordinated Black Phosphorus Quantum Dots with Retrievable NIR/X‐Ray Optoelectronic Switching Effect for Anti‐Glioblastoma

Li, Z., Zhao, C., Fu, Q., Ye, J., Su, L., Ge, X., Chen, L., Song, J., & Yang, H. (2021) · Small · doi:10.1002/smll.202105160 · Cited by 33 · see citing works

Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles

Kiliç, T., Cho, Y. K., Jeong, N. B., Shin, I., Carter, B. S., Balaj, L., Weissleder, R., & Lee, H. (2022) · ACS Central Science · doi:10.1021/acscentsci.1c01193 · Cited by 33 · see citing works

The role of extracellular vesicles in traumatic brain injury-induced acute lung injury

Zhang, C., Li, F., Zhao, Z., & Zhang, J.-N. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00023.2021 · Cited by 32 · see citing works

Electrically driven microfluidic platforms for exosome manipulation and characterization

Díaz-Armas, G. G., Cervantes‐Gonzalez, A. P., Martínez‐Duarte, R., & Pérez‐González, V. H. (2021) · Electrophoresis · doi:10.1002/elps.202100202 · Cited by 32 · see citing works

Gadolinium Deposition Safety: Seeking the Patient’s Perspective

Mallio, C. A., Quattrocchi, C. C., Rovira, À., & Parizel, P. M. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6586 · Cited by 31 · see citing works

Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin

Mattera, V. S., Gerber, P. P., Glisoni, R. J., Ostrowski, M., Verstraeten, S. V., Pasquini, J. M., & Correale, J. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15019 · Cited by 27 · see citing works

Progress in Nanomaterials-Based Optical and Electrochemical Methods for the Assays of Exosomes

Ma, X., Hao, Y., & Liu, L. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s333969 · Cited by 27 · see citing works

Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles

Zaborowski, M. P., Cheah, P.-S., Zhang, X., Bushko, I., Lee, K., Sammarco, A., Zappulli, V., Maas, S. L. N., Allen, R. M., Rumde, P. H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53554-y · Cited by 24 · see citing works

The Potential of Liquid Biopsy of the Brain Using Blood Extracellular Vesicles: The First Step Toward Effective Neuroprotection Against Neurodegenerative Diseases

Abdel–Haq, H. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00493-4 · Cited by 21 · see citing works

Imaging Advances for Central Nervous System Tumors

Huang, R. Y., & Pope, W. B. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2021.08.002 · Cited by 8 · see citing works

Imaging immune responses in neuroinflammatory diseases

Amor, S., Nutma, E., & Owen, D. R. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13670 · Cited by 5 · see citing works

Small but Fierce: Tracking the Role of Extracellular Vesicles in Glioblastoma Progression and Therapeutic Resistance

Schweiger, M. W., & Tannous, B. A. (2020) · Advanced Biosystems · doi:10.1002/adbi.202000035 · Cited by 4 · see citing works

The role of exosomes in immunopathology and potential therapeutic implications

Wang, W., Qiao, S.-Y., Kong, X., Zhang, G., & Cai, Z. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01323-5 · Cited by 86 · see citing works

Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications

Jiang, H., Kumarasamy, R. V., Pei, J., Raju, K., Kanniappan, G. V., Palanisamy, C. P., & Mironescu, I. D. (2025) · Frontiers in Nanotechnology · doi:10.3389/fnano.2024.1513683 · Cited by 39 · see citing works

Proteomics profiling of extracellular vesicle for identification of potential biomarkers in Alzheimer's disease: A comprehensive review

Pei, J., Palanisamy, C. P., Jayaraman, S., Natarajan, P. M., Umapathy, V. R., Roy, J. R., Thalamati, D., Ahalliya, R. M., Gopalakrishnan, V. K., & Mironescu, M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102359 · Cited by 31 · see citing works

Artificial intelligence-powered nanomedicine

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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works

Tissue Engineering in Neuroscience: Applications and Perspectives

Zhang, X., Liu, F., & Gu, Z. (2022) · BME Frontiers · doi:10.34133/bmef.0007 · Cited by 22 · see citing works

Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy

Meng, L., Ren, N., Dong, M., Zhang, S., Wang, A., Zhuang, Z., Wang, J., Sun, C., & Liu, H. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202309974 · Cited by 22 · see citing works

Nanomaterials-Based Exosomes for the Diagnostics and Drug Deliveries of Central Nervous System Diseases

Haizan, I., Park, D. H., Choi, M. Y., Lee, H.-R., & Choi, J. (2023) · BioChip Journal · doi:10.1007/s13206-023-00112-4 · Cited by 21 · see citing works

Application and Development of Nanotechnology in Traditional Chinese Acupuncture in Recent 20 Years: A Comprehensive Review

Liu, L., Hu, X., Su, Y., Lin, C., & Wang, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c22627 · Cited by 13 · see citing works

Smart Vesicle Therapeutics: Engineering Precision at the Nanoscale

Benedini, L. A., & Messina, P. V. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17121588 · Cited by 12 · see citing works

Nano-Brush Structure for Rapid Label-Free Differentiation of Alzheimer’s Disease Stages and Direct Capture of Neuron-Derived Exosomes from Human Blood Plasma

Lin, S.-P., Lee, W.-J., Sun, M.-C., Yang, Y.-H., Vinzons, L. U., Lin, Y.-M., & Wei, Y.-T. (2023) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.3c12766 · Cited by 11 · see citing works

Aquasomes: novel crystalline nanocarriers ensuring conformational integrity and high surface exposure for enhanced drug encapsulation and delivery

Makavana, A., & Dudhat, K. R. (2025) · Journal of Nanoparticle Research · doi:10.1007/s11051-025-06336-9 · Cited by 9 · see citing works

Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification

Tang, L., Wang, Y., Mao, S., Zhou, Y., Chen, Y., Xu, X., Cai, W., Lai, K., Yang, G., & Huang, T. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03431-w · Cited by 8 · see citing works

012 facets modulated LDH composite for neurotoxicity risk assessment through direct electrochemical profiling of dopamine

Daniel, M., Mathew, G., De, M., & Neppolian, B. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140177 · Cited by 8 · see citing works

Electrokinetic Enhancement of Membrane Techniques for Efficient Nanoparticle Separation and Preconcentration

Park, J. H., Yoo, Y., Yoon, J. S., Kang, D. H., Kim, J. H., Han, H. N., & Kim, K. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04124 · Cited by 7 · see citing works

Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling

Berle, B. F., Juliussen, S., Castilho, Á., Solel, E., Saed, H. S., Vanderpoorten, O., Lunavat, T. R., Thorsen, F. A., & Rigg, E. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s520791 · Cited by 7 · see citing works

Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles

Xie, Z., Cao, H.-W., Wang, Q., Lu, H. J., & Du, W. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00716-9 · Cited by 5 · see citing works

Advances in nanotechnology-based platforms for liquid biopsy: Unlocking precision molecular classification in ovarian cancer

Tan, Q., Zhao, Y., Wu, Z., Kong, W., Xu, L., & Qu, F. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118558 · Cited by 4 · see citing works

Nano-Biomaterial-Assisted Targeted Therapy of Central Nervous System Disorders

Phatale, V., Kolipaka, T., Khairnar, P., Pandey, G., Negi, M., Saraf, S., & Srivastava, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-3925-7_11 · Cited by 3 · see citing works

Therapeutic application of engineered extracellular vesicles via pulmonary delivery for inflammatory lung disorders

Jha, A., Patole, V., Bhardwaj, N., Gupta, U., Sharma, M., Gupta, A., & Kumar, M. (2026) · Discover Nano · doi:10.1186/s11671-026-04552-3 · Cited by 2 · see citing works

The simultaneous use of nanovesicles and magnetic nanoparticles for cancer targeting and imaging

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Macrophage‐Derived Extracellular Vesicles Deliver Progranulin to Alleviate Skin Wound Fibrosis

Huang, X., Chen, C., Liu, X. A., Zhao, C., Li, Z., Dong, G., & Li, S. (2026) · The FASEB Journal · doi:10.1096/fj.202602086r · Cited by 1 · see citing works

Nanoparticle-facilitated traditional Chinese medicine in precision therapy for ischemic stroke

Pang, W., Ikwuagwu, P. A., Chen, A., Li, X., Xu, C., & Wu, A. (2025) · Precision medicine and engineering. · doi:10.1016/j.preme.2025.100039 · Cited by 1 · see citing works

Exploring Carbon Dot Nanoparticles for Imaging and Cellular Interaction in Triple-Negative Breast Cancer

Bahadorani, M., Wu, K., Wei, J., & Zadegan, R. M. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s544373

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Dahanayake, M. H., Hossain, M. S. A., Liu, C., Salomón, C., Yamauchi, Y., & Masud, M. K. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71611

Extracellular vesicle-integrated brain organoid-on-a-chip systems for neuroimmune communication and precision therapy in viral encephalitis

Azim, M. M. N. (2026) · Frontiers in Lab on a Chip Technologies · doi:10.3389/frlct.2026.1915723

Carbon Dots in Breast Cancer Theranostics: Structure–Property Relationships, Mechanisms, and Translational Insights

Sur, S., & Varamini, P. (2026) · MedComm – Oncology · doi:10.1002/mog2.70095

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works

Emerging prospects of extracellular vesicles for brain disease theranostics

Wang, R., Wang, X., Zhang, Y., Zhao, H., Cui, J., Li, J., & Di, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.024 · Cited by 48 · see citing works

Current progression in application of extracellular vesicles in central nervous system diseases

Zhang, X., Huang, J., Ni, X.-Y., Zhu, H.-R., Huang, Z., Ding, S., Yang, X., Tan, Y.-D., Chen, J., & Cai, J. (2024) · European journal of medical research · doi:10.1186/s40001-023-01606-5 · Cited by 16 · see citing works

Extracellular vesicles for the treatment of central nervous system diseases

Gratpain, V., Mwema, A., Labrak, Y., Muccioli, G. G., Pesch, V. V., & Rieux, A. D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.006 · Cited by 78 · see citing works

Extracellular vesicles in the central nervous system: Pathogenic mechanisms, diagnostic biomarkers, and therapeutic applications

Premchandani, T., Qutub, M., Pandey, A., Tatode, A., Taksande, J., Umekar, M. J., & Khan, R. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108611