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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
Abstract
The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases.
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Cites
Progress in the Chemistry of Organic Natural Products 109
(2019) · Progress in the Chemistry of Organic Natural Products · doi:10.1007/978-3-030-12858-6 · Cited by 2,052
The influence of natural products upon drug discovery (Antiquity to late 1999)
Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293
Self-citationChemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
Scott, J. D., & Williams, R. M. (2002) · Chemical Reviews · doi:10.1021/cr010212u · Cited by 1,149
Staats, P. S., Yearwood, T., Charapata, S. G., Presley, R. W., Wallace, M. S., Byas-Smith, M., Fisher, R., Bryce, D. A., Mangieri, E. A., Luther, R. R., et al. (2004) · JAMA · doi:10.1001/jama.291.1.63 · Cited by 654
Piel, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222481399 · Cited by 609
Halichondrins-antitumor polyether macrolides from a marine sponge
Hirata, Y., & Uemura, D. (1986) · Pure and Applied Chemistry · doi:10.1351/pac198658050701 · Cited by 519
Rinehart, K. L., Holt, T. G., Fregeau, N. L., Stroh, J. G., Keifer, P. A., Sun, F., Li, L. H., & Martin, D. G. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00302a007 · Cited by 492
Marine natural products and their potential applications as anti-infective agents
Donia, M., & Hamann, M. T. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00655-8 · Cited by 425
Total synthesis of halichondrin B and norhalichondrin B
Aicher, T. D., Buszek, K. R., Fang, F. G., Forsyth, C. J., Jung, S. H., Kishi, Y., Matelich, M. C., Scola, P. M., Spero, D. M., & Yoon, S. K. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00034a086 · Cited by 400
Natori, T., Morita, M., Akimoto, K., & Koezuka, Y. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)86991-x · Cited by 397
Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00085a006 · Cited by 365
Takebayashi, Y., Pourquier, P., Zimonjic, D. B., Nakayama, K., Emmert, S., Ueda, T., Urasaki, Y., Kanzaki, A., Akiyama, S.-I., Popescu, N., et al. (2001) · Nature Medicine · doi:10.1038/91008 · Cited by 348
Lindquist, N., Fenical, W., Duyne, G. D. V., & Clardy, J. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00006a060 · Cited by 343
Trimurtulu, G., Ohtani, I., Patterson, G. M. L., Moore, R. E., Corbett, T. H., Valeriote, F. A., & Demchik, L. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00090a020 · Cited by 303
Gowan, S. M., Harrison, J. R., Patterson, L., Valenti, M., Read, M. A., Neidle, S., & Kelland, L. R. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12212-2 · Cited by 303
Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules
Lindel, T., Jensen, P. R., Fenical, W., Long, B. H., Casazza, A. M., Carboni, J., & Fairchild, C. R. (1997) · Journal of the American Chemical Society · doi:10.1021/ja9717828 · Cited by 293
Norhalichondrin A: an antitumor polyether macrolide from a marine sponge
Uemura, D., Takahashi, K., Yamamoto, T., Katayama, C., Tanaka, J., Okumura, Y., & Hirata, Y. (1985) · Journal of the American Chemical Society · doi:10.1021/ja00302a042 · Cited by 289
Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 from Cyanosafracin B
Cuevas, C., Pérez, M., Martín, M. J., Chicharro, J. L., Fernández-Rivas, C., Flores, M., Francesch, A., Gallego, P., Zarzuelo, M., de la Calle, F., et al. (2000) · Organic Letters · doi:10.1021/ol0062502 · Cited by 282
Manoalide, an antibiotic sesterterpenoid from the marine sponge (polejaeff)
de Silva, E. D., & Scheuer, P. J. (1980) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)77766-5 · Cited by 277
Davidson, S. K., Allen, S. W., Lim, G. E., Anderson, C. M., & Haygood, M. G. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.10.4531-4537.2001 · Cited by 275
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
Wright, A. E., Forleo, D. A., Gunawardana, G. P., Gunasekera, S. P., Koehn, F. E., & McConnell, O. J. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00302a006 · Cited by 268
Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp.
Erickson, K. L., Beutler, J. A., Cardellina, J. H., & Boyd, M. R. (1997) · The Journal of Organic Chemistry · doi:10.1021/jo971556g · Cited by 255
Agelasphins, novel α-galactosylceramides from the marine sponge Agelas mauritianus
Natori, T., Koezuka, Y., & Higa, T. (1993) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)73889-5 · Cited by 253
Hamann, M. T., Otto, C. S., Scheuer, P. J., & Dunbar, D. C. (1996) · The Journal of Organic Chemistry · doi:10.1021/jo960877+ · Cited by 240
Hamann, M. T., & Scheuer, P. J. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00066a061 · Cited by 237
Krohn, A., Redshaw, S., Ritchie, J. C., Graves, B. J., & Hatada, M. H. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00115a028 · Cited by 233
Kageyama, M., Tamura, T., Nantz, M. H., Roberts, J. C., Somfai, P., Whritenour, D. C., & Masamune, S. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00176a058 · Cited by 230
ROMERO, F., ESPLIEGO, F., BAZ, J. P., QUESADA, T. G. D., GRÁVALOS, D., CALLE, F. D. L., & FERNÁNDEZ-PUENTES, J. L. (1997) · The Journal of Antibiotics · doi:10.7164/antibiotics.50.734 · Cited by 225
Catley, L., Weisberg, E., Tai, Y.-T., Atadja, P., Remiszewski, S., Hideshima, T., Mitsiades, N., Shringarpure, R., LeBlanc, R., Chauhan, D., et al. (2003) · Blood · doi:10.1182/blood-2003-01-0233 · Cited by 216
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.
Wender, P. A., Cribbs, C. M., Koehler, K. F., Sharkey, N. A., Herald, C. L., Kamano, Y., Pettit, G. R., & Blumberg, P. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7197 · Cited by 201
Pettit, G. R., Herald, C. L., Boyd, M. R., Leet, J. E., Dufresne, C., Doubek, D. L., Schmidt, J. M., Cerny, R. L., Hooper, J. N. A., & Rutzler, K. C. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00115a027 · Cited by 191
Golakoti, T., Ogino, J., Heltzel, C. E., Le Husebo, T., Jensen, C. M., Larsen, L. K., Patterson, G. M. L., Moore, R. E., Mooberry, S. L., Corbett, T. H., et al. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00154a002 · Cited by 186
Hamel, E. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90028-x · Cited by 186
Chemistry and clinical biology of the bryostatins
Mutter, R., & Wills, M. (2000) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(00)00150-4 · Cited by 178
Alkaloids from the antarctic sponge Kirkpatrickia varialosa.
Perry, N. B., Ettouati, L., Litaudon, M., Blunt, J. W., Munro, M. H. G., Parkin, S., & Hope, H. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)89673-3 · Cited by 176
Total Synthesis of Bryostatin 3
Ohmori, K., Ogawa, Y., Obitsu, T., Ishikawa, Y., Nishiyama, S., & Yamamura, S. (2000) · Angewandte Chemie International Edition · Cited by 168
A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast
Gachet, Y., Tournier, S., Millar, J. B. A., & Hyams, J. S. (2001) · Nature · doi:10.1038/35085604 · Cited by 161
Natural Products and Derivatives as Leads to Cell Cycle Pathway Targets in Cancer Chemotherapy
Newman, D., Cragg, G., Holbeck, S., & Sausville, E. (2002) · Current Cancer Drug Targets · doi:10.2174/1568009023333791 · Cited by 160
Self-citationα-Galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis
Hayakawa, Y., Rovero, S., Forni, G., & Smyth, M. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630663100 · Cited by 158
Cytotoxic peptides from the marine sponge Cymbastela sp.
Coleman, J. E., de Silva, E. D., Kong, F., et al. (1995) · Tetrahedron · doi:10.1016/0040-4020(95)00646-p · Cited by 157
Wender, P. A., Koehler, K. F., Sharkey, N. A., et al. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4214 · Cited by 157
Cuadrado, A., García‐Fernández, L., González, L., Suárez, Y., Losada, A., Alcaide, V., Martı́nez, T., Fernández-Sousa, J. M., Sánchez-Puelles, J.-M., & Múñoz, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201010200 · Cited by 157
Arenastatin A, a potent cytotoxic depsipeptide from the Okinawan marine sponge Dysidea arenaria
Kobayashi, M., Aoki, S., Ohyabu, N., Kurosu, M., Wang, W., & Kitagawa, I. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)78398-5 · Cited by 155
Progress in the Chemistry of Organic Natural Products.
Harbörne, J. B. (1976) · Phytochemistry · doi:10.1016/s0031-9422(00)84429-5 · Cited by 154
Natural products as probes of cell biology: 20 years of didemnin research
Vera, M. D., & Joullié, M. M. (2002) · Medicinal Research Reviews · doi:10.1002/med.10003 · Cited by 153
Isolation and structure of the cytostatic linear depsipeptide dolastatin 15
Pettit, G. R., Kamano, Y., Dufresne, C., Cerny, R. L., Herald, C. L., & Schmidt, J. M. (1989) · The Journal of Organic Chemistry · doi:10.1021/jo00287a003 · Cited by 151
Broggini, M., Marchini, S., Galliera, E., Borsotti, P., Taraboletti, G., Erba, E., Sironi, M., Jimeno, J. M., Faircloth, G. T., Giavazzi, R., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2402788 · Cited by 151
Structure−Activity Relationships of the Didemnins
Sakai, R., Rinehart, K. L., Kishore, V., Kundu, B. K., Faircloth, G. T., Gloer, J. B., Carney, J. R., Namikoshi, M., Sun, F.-R., Hughes, R. G., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm960048g · Cited by 150
Progress in the development and acquisition of anticancer agents from marine sources
Amador, M. L., Jimeno, J. M., Paz-Ares, L. G., Cortés-Funes, H., & Hidalgo, M. M. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg443 · Cited by 150
Cuadros, R., de Garcini, E. M., Wandosell, F. G., Faircloth, G. T., Fernández-Sousa, J. M., & Ávila, J. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00428-0 · Cited by 147
Total synthesis of the immunosuppressive agent (-)-discodermolide
Nerenberg, J. B., Hung, D. T., Somers, P. K., & Schreiber, S. L. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00079a066 · Cited by 145
Warabi, K., Matsunaga, S., van Soest, R. W. M., & Fusetani, N. (2003) · The Journal of Organic Chemistry · doi:10.1021/jo0267910 · Cited by 143
Urdiales, J. L., Morata, P., de Castro, I. N., & Sánchez‐Jiménez, F. (1996) · Cancer Letters · doi:10.1016/0304-3835(96)04151-1 · Cited by 142
Synthesis and Structure Determination of Kahalalide F1,2
López-Macià, À., Jiménez, J. C., Royo, M., et al. (2001) · Journal of the American Chemical Society · doi:10.1021/ja0116728 · Cited by 141
A New Antitumor Isoquinoline Alkaloid from the Marine Nudibranch Jorunna funebris
Fontana, A., Cavaliere, P., Wahidulla, S., Naik, C. G., & Cimino, G. (2000) · Tetrahedron · doi:10.1016/s0040-4020(00)00629-3 · Cited by 141
GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.
Crews, C. M., Collins, J. L., Lane, W. S., Snapper, M. L., & Schreiber, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40692-2 · Cited by 140
Brominated tyrosine metabolites from an unidentified sponge
Arabshahi, L., & Schmitz, F. J. (1987) · The Journal of Organic Chemistry · doi:10.1021/jo00392a016 · Cited by 130
Remiszewski, S., Sambucetti, L. C., Bair, K. W., Bontempo, J., Cesarz, D., Chandramouli, N., Chen, R., Cheung, M., Cornell-Kennon, S., Dean, K., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030235w · Cited by 130
Mendola, D. (2003) · Biomolecular Engineering · doi:10.1016/s1389-0344(03)00075-3 · Cited by 130
Trimurtulu, G., Faulkner, D. J., Perry, N. B., et al. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)89674-5 · Cited by 122
Molecular pharmacology of manoalide
Glaser, K. B., & Jacobs, R. S. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90218-2 · Cited by 117
Some pharmacological observations on marine natural products
Jacobs, R. S., Culver, P., Langdon, R. B., O'Brien, T., & White, S. (1985) · Tetrahedron · doi:10.1016/s0040-4020(01)96465-8 · Cited by 117
Cruz‐Monserrate, Z., Vervoort, H. C., Bai, R., Newman, D. J., Howell, S. B., Los, G., Mullaney, J. T., Williams, M. D., Pettit, G. R., Fenical, W., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1273 · Cited by 117
Self-citationWender, P. A., Brabander, J. K. D., Harran, P. G., Jimenez, J., Koehler, M. F. T., Lippa, B., Park, C., Siedenbiedel, C., & Pettit, G. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6624 · Cited by 111
The antitumoral compound Kahalalide F acts on cell lysosomes
Garcı́a-Rocha, M., Bonay, P., & Ávila, J. (1996) · Cancer Letters · doi:10.1016/0304-3835(95)04036-6 · Cited by 103
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges
Gamble, W. R., Durso, N. A., Fuller, R. W., Westergaard, C. K., Johnson, T. R., Sackett, D. L., Hamel, E., Cardellina, J. H., & Boyd, M. R. (1999) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(99)00089-9 · Cited by 98
Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma
Laverdière, C., Kolb, E. A., Supko, J. G., Gorlick, R. G., Meyers, P. A., Maki, R. G., Wexler, L. H., Demetri, G. D., Healey, J. H., Huvos, A. G., et al. (2003) · Cancer · doi:10.1002/cncr.11563 · Cited by 98
Marine-derived anticancer agents in clinical trials
Schwartsmann, G., da Rocha, A. B., Mattei, J., & Lopes, R. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.8.1367 · Cited by 95
Wipf, P., Reeves, J. T., Balachandran, R., Giuliano, K. A., Hamel, E., & Day, B. W. (2000) · Journal of the American Chemical Society · doi:10.1021/ja002213u · Cited by 92
Edler, M., Fernandez, A. M., Lassota, P., Ireland, C. M., & Barrows, L. R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00898-x · Cited by 92
Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases
Calzada, A., Sacristán, M. P., Sánchez, E., et al. (2001) · Nature · doi:10.1038/35085610 · Cited by 90
The combination of yondelis and cisplatin is synergistic against human tumor xenografts
D’Incalci, M., Colombo, T., Ubezio, P., Nicoletti, I., Giavazzi, R., Erba, E., Ferrarese, L., Meco, D., Riccardi, R., Sessa, C., et al. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00490-8 · Cited by 90
The Discovery of NVP-LAQ824: From Concept to Clinic
Remiszewski, S. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456675 · Cited by 88
Yondelis® (trabectedin, ET-743): the development of an anticancer agent of marine origin
van Kesteren, C., de Vooght, M. M. M., Lázaro, L. L., Mathôt, R. A. A., Schellens, J. H. M., Jimeno, J. M., & Beijnen, J. H. (2003) · Anti-Cancer Drugs · doi:10.1097/00001813-200308000-00001 · Cited by 88
The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog
Mooberry, S. L., Leal, R. M., Tinley, T. L., Luesch, H., Moore, R. E., & Corbett, T. H. (2003) · International Journal of Cancer · doi:10.1002/ijc.10982 · Cited by 87
Twelves, C. J., Hoekman, K., Bowman, A., Vermorken, J. B., Anthoney, A., Smyth, J., van Kesteren, C., Beijnen, J. H., Uiters, J., Wanders, J., et al. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00458-1 · Cited by 84
The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies
Martello, L. A., LaMarche, M. J., He, L., Beauchamp, T. J., Smith, A. B., & Horwitz, S. B. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00055-2 · Cited by 83
Bengamides Revisited: New Structures and Antitumor Studies
Thale, Z. I., Kinder, F. R. J., Bair, K. W., Bontempo, J., Czuchta, A. M., Versace, R. W., Phillips, P. E., Sanders, M. L., Wattanasin, S., & Crews, P. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo001380+ · Cited by 83
Margolin, K. A., Longmate, J., Synold, T. W., Gandara, D. R., Weber, J. S., Gonzalez, R. C., Johansen, M. J., Newman, R. A., Baratta, T., & Doroshow, J. H. (2001) · Investigational New Drugs · doi:10.1023/a:1010626230081 · Cited by 82
The clinical development of the bryostatins
Clamp, A. R., & Jayson, G. C. (2002) · Anti-Cancer Drugs · doi:10.1097/00001813-200208000-00001 · Cited by 82
Nogle, L. M., & Gerwick, W. H. (2001) · Journal of Natural Products · doi:10.1021/np010348n · Cited by 79
Zewail‐Foote, M., LI, V. ‐., Kohn, H., Bearss, D. J., Guzman, M., & Hurley, L. H. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00071-0 · Cited by 79
Burgoyne, D. L., Andersen, R. J., & Allen, T. M. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00028a024 · Cited by 75
Cryptophycins: A Novel Class of Potent Antimitotic Antitumor Depsipeptides
Shih, C., & Teicher, B. A. (2001) · Current Pharmaceutical Design · doi:10.2174/1381612013397474 · Cited by 74
Pharmaceutical development of anticancer agents derived from marine sources
Nuijen, B., Bouma, M., Manada, C., Jimeno, J. M., Schellens, J. H. M., Bult, A., & Beijnen, J. H. (2000) · Anti-Cancer Drugs · doi:10.1097/00001813-200011000-00003 · Cited by 71
DISCODERMOLIDE—A NEW, MARINE-DERIVED IMMUNOSUPPRESSIVE COMPOUND
Longley, R. E., CADDIGAN, D., Harmody, D. K., Gunasekera, M., & Gunasekera, S. P. (1991) · Transplantation · doi:10.1097/00007890-199110000-00015 · Cited by 71
Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin
Ludueña, R. F., Roach, M. C., Prasad, V., & Pettit, G. R. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90079-c · Cited by 70
Kernan, M. R., Faulkner, D. J., & Jacobs, R. S. (1987) · The Journal of Organic Chemistry · doi:10.1021/jo00390a021 · Cited by 68
Fulfilling the promise of biotechnology
Colwell, R. R. (2002) · Biotechnology Advances · doi:10.1016/s0734-9750(02)00011-3 · Cited by 64
de Freitas, J. C., Blankemeier, L. A., & Jacobs, R. S. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01951998 · Cited by 63
Phase-trafficking reagents and phase-switching strategies for parallel synthesis
Flynn, D. L. (1999) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199909)19:5<388::aid-med6>3.0.co;2-h · Cited by 61
Marine Natural Products as Lead Anti-HIV Agents
Gochfeld, D. J., Sayed, K. A. E., Yousaf, M., Hu, J., Bartyzel, P., Dunbar, D. C., Wilkins, S. P., Zjawiony, J. K., Schinazi, R. F., & Wirtz, S. S. (2003) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557033487962 · Cited by 59
Neovastat—a novel antiangiogenic drug for cancer therapy
Gingras, D., Boivin, D., Deckers, C., Gendron, S. P., Barthomeuf, C., & Béliveau, R. (2003) · Anti-Cancer Drugs · doi:10.1097/00001813-200302000-00001 · Cited by 57
Inactivation of bee venom phospholipase A2 by manoalide
Glaser, K. B., & Jacobs, R. S. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90134-1 · Cited by 56
Peptides with anticancer use or potential
Janin, Y. L. (2003) · Amino Acids · doi:10.1007/s00726-002-0349-x · Cited by 56
Immunosuppression by Discodermolide
Longley, R. E., Gunasekera, S. P., Faherty, D. A., McLane, J. A., & Dumont, F. J. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb17145.x · Cited by 54
Phase II study of LU 103793 (dolastatin analogue) in patients with metastatic breast cancer
Kerbrat, P., Dieras, V. C., Pavlidis, N. A., Ravaud, A., Wanders, J., & Fumoleau, P. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00531-2 · Cited by 53
Stereochemistry of Kahalalide F
Bonnard, I., Manzanares, I., & RINEHART, K. L. J. (2003) · Journal of Natural Products · doi:10.1021/np030334c · Cited by 53
Marshall, K. M., Matsumoto, S. S., Holden, J. A., Concepción, G. P., Taşdemir, D., Ireland, C. M., & Barrows, L. R. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00209-0 · Cited by 52
Takei, M., Burgoyne, D. L., & Andersen, R. J. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830909 · Cited by 50
Cytoskeleton in the cell cycle
Nakaseko, Y., & Yanagida, M. (2001) · Nature · doi:10.1038/35085684 · Cited by 49
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel–Dreyer chromatography
Cruz‐Monserrate, Z., Mullaney, J. T., Harran, P. G., Pettit, G. R., & Hamel, E. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03776.x · Cited by 49
Unique Features of the Mode of Action of ET-743
D’Incalci, M., Erba, E., Damia, G. L. M., Galliera, E., Carrassa, L., Marchini, S., Mantovani, R., Tognon, G., Fruscio, R., Jimeno, J. M., et al. (2002) · The Oncologist · doi:10.1634/theoncologist.7-3-210 · Cited by 46
Interactions of antimitotic peptides and depsipeptides with tubulin
Hamel, E. (2002) · Biopolymers · doi:10.1002/bip.10255 · Cited by 45
A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer
Winegarden, J. A. (2003) · Lung Cancer · doi:10.1016/s0169-5002(02)00447-6 · Cited by 42
Effects of arenastatin A and its synthetic analogs on microtubule assembly
Koiso, Y., Morita, K., Kobayashi, M., Wang, W., Ohyabu, N., & Iwasaki, S. (1996) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(96)03743-x · Cited by 41
Pharmacokinetics and urinary excretion of DMXBA (GTS-21), a compound enhancing cognition
Mahnir, V. M., Lin, B., Prókai-Tátrai, K., & Kem, W. R. (1998) · Biopharmaceutics & Drug Disposition · Cited by 40
AE-941, a multifunctional antiangiogenic compound: trials in renal cell carcinoma
Bukowski, R. M. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.8.1403 · Cited by 36
Activity of the dolastatin analogue, LU103793, in malignant melanoma
Smyth, J., Bonneterre, M.-E., Schellens, J. H. M., Calvert, H., Greim, G., Wanders, J., & Hanauske, A. (2001) · Annals of Oncology · doi:10.1023/a:1011194910571 · Cited by 36
Bramley, A. M., Langlands, J. M., Jones, A. K., et al. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16634.x · Cited by 35
Gómez, S. G., Bueren, J. A., Faircloth, G. T., Jimeno, J. M., & Albella, B. (2003) · Experimental Hematology · doi:10.1016/j.exphem.2003.07.004 · Cited by 35
Population pharmacokinetics of the novel anticancer agent KRN7000
Crul, M., Mathôt, R. A. A., Giaccone, G., Punt, C. J. A., Rosing, H., Hillebrand, M. J. X., Ando, Y., Nishi, N., Tanaka, H., Schellens, J. H. M., et al. (2002) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-001-0413-3 · Cited by 31
Cell-Based Screen for Identification of Inhibitors of Tubulin Polymerization
Kokoshka, J. M., Ireland, C. M., & Barrows, L. R. (1996) · Journal of Natural Products · doi:10.1021/np960144k · Cited by 15
Denhardt, D. T. (2003) · PubMed · Cited by 1
Rinehart (2000) · doi:10.1002/(sici)1098-1128(200001)20:1<1::aid-med1>3.0.co;2-a
Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
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Coll, M., Piroddi, C., Steenbeek, J., Kaschner, K., Ben Rais Lasram, F., Aguzzi, J., Ballesteros, E., Bianchi, C. N., Corbera, J., Dailianis, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011842 · Cited by 2,155
Developing a new resource for drug discovery: marine actinomycete bacteria
Fenical, W., & Jensen, P. R. (2006) · Nature Chemical Biology · doi:10.1038/nchembio841 · Cited by 786
Marine natural products as anticancer drugs
Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.333.4.2 · Cited by 597
Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567
Metadata
- Authors
- Newman, D. J., & Cragg, G. M.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-06-11
- Volume
- 67
- Issue
- 8
- Pages
- 1216-1238
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2052767109
- Cited by
- 759
- References
- 115
- FWCI
- 25.94
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.