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Cited by 398

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

Open access
Kim, Han-Soo, Choi, Do-Young, Yun, So Jeong, Choi, Seong-Mi, Kang, Jeong Won, Jung, Jin Woo, Hwang, Daehee, Kim, Kwang Pyo, Kim, Dong-Wook·2012·Journal of Proteome Research
DOI 10.1021/pr200682z
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Abstract

Mesenchymal stem cells (MSCs) have emerged as a promising means for treating degenerative or incurable diseases. Recent studies have shown that microvesicles (MVs) from MSCs (MSC-MVs) contribute to recovery of damaged tissues in animal disease models. Here, we profiled the MSC-MV proteome to investigate their therapeutic effects. LC-MS/MS analysis of MSC-MVs identified 730 MV proteins. The MSC-MV proteome included five positive and two variable known markers of MSCs, but no negative marker, as well as 43 surface receptors and signaling molecules controlling self-renewal and differentiation of MSCs. Functional enrichment analysis showed that cellular processes represented by the MSC-MV proteins include cell proliferation, adhesion, migration, and morphogenesis. Integration of MSC's self-renewal and differentiation-related genes and the proteome of MSC-conditioned media (MSC-CM) with the MSC-MV proteome revealed potential MV protein candidates that can be associated with the therapeutic effects of MSC-MVs: (1) surface receptors (PDGFRB, EGFR, and PLAUR); (2) signaling molecules (RRAS/NRAS, MAPK1, GNA13/GNG12, CDC42, and VAV2); (3) cell adhesion (FN1, EZR, IQGAP1, CD47, integrins, and LGALS1/LGALS3); and (4) MSC-associated antigens (CD9, CD63, CD81, CD109, CD151, CD248, and CD276). Therefore, the MSC-MV proteome provides a comprehensive basis for understanding the potential of MSC-MVs to affect tissue repair and regeneration.

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Citations

Cites

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Cited by

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Metadata

Authors
Kim, H.-S., Choi, D.-Y., Yun, S. J., Choi, S.-M., Kang, J. W., Jung, J. W., Hwang, D., Kim, K. P., & Kim, D.-W.
Venue
Journal of Proteome Research
Publisher
American Chemical Society (ACS)
Published
2011-12-28
Volume
11
Issue
2
Pages
839-849
ISSN
  • 1535-3893 (ISSN-L)
  • 1535-3907
DOI
10.1021/pr200682z
OpenAlex
W2043263890
Cited by
398
References
59
FWCI
6.00
Type
journal article
Language
en
Open access
green

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