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Cited by 445

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The Proteomes of Human Parotid and Submandibular/Sublingual Gland Salivas Collected as the Ductal Secretions

Open access
Denny, Paul, Hagen, Fred K., Hardt, Markus, Liao, Lujian, Yan, Weihong, Arellanno, Martha, Bassilian, Sara, Bedi, Gurrinder S., Boontheung, Pinmannee, Cociorva, Daniel, Delahunty, Claire M., Denny, Trish, Dunsmore, Jason, Faull, Kym F., Gilligan, Joyce, Gonzalez-Begne, Mireya, Halgand, Frédéric, Hall, Steven C., Han, Xuemei, Henson, Bradley, Hewel, Johannes, Hu, Shen, Jeffrey, Sherry, Jiang, Jiang, Loo, Joseph A., Ogorzalek Loo, Rachel R., Malamud, Daniel, Melvin, James E., Miroshnychenko, Olga, Navazesh, Mahvash, Niles, Richard, Park, Sung Kyu, Prakobphol, Akraporn, Ramachandran, Prasanna, Richert, Megan, Robinson, Sarah, Sondej, Melissa, Souda, Puneet, Sullivan, Mark A., Takashima, Jona, Than, Shawn, Wang, Jianghua, Whitelegge, Julian P., Witkowska, H. Ewa, Wolinsky, Lawrence, Xie, Yongming, Xu, Tao, Yu, Weixia, Ytterberg, Jimmy, Wong, David T., Yates, John R., Fisher, Susan J.·2008·Journal of Proteome Research
DOI 10.1021/pr700764j
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Abstract

Saliva is a body fluid with important functions in oral and general health. A consortium of three research groups catalogued the proteins in human saliva collected as the ductal secretions: 1166 identifications--914 in parotid and 917 in submandibular/sublingual saliva--were made. The results showed that a high proportion of proteins that are found in plasma and/or tears are also present in saliva along with unique components. The proteins identified are involved in numerous molecular processes ranging from structural functions to enzymatic/catalytic activities. As expected, the majority mapped to the extracellular and secretory compartments. An immunoblot approach was used to validate the presence in saliva of a subset of the proteins identified by mass spectrometric approaches. These experiments focused on novel constituents and proteins for which the peptide evidence was relatively weak. Ultimately, information derived from the work reported here and related published studies can be used to translate blood-based clinical laboratory tests into a format that utilizes saliva. Additionally, a catalogue of the salivary proteome of healthy individuals allows future analyses of salivary samples from individuals with oral and systemic diseases, with the goal of identifying biomarkers with diagnostic and/or prognostic value for these conditions; another possibility is the discovery of therapeutic targets.

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Authors
Denny, P., Hagen, F. K., Hardt, M., Liao, L., Yan, W., Arellanno, M., Bassilian, S., Bedi, G. S., Boontheung, P., Cociorva, D., Delahunty, C. M., Denny, T., Dunsmore, J., Faull, K. F., Gilligan, J., Gonzalez-Begne, M., Halgand, F., Hall, S. C., Han, X., Henson, B., Hewel, J., Hu, S., Jeffrey, S., Jiang, J., Loo, J. A., Ogorzalek Loo, R. R., Malamud, D., Melvin, J. E., Miroshnychenko, O., Navazesh, M., Niles, R., Park, S. K., Prakobphol, A., Ramachandran, P., Richert, M., Robinson, S., Sondej, M., Souda, P., Sullivan, M. A., Takashima, J., Than, S., Wang, J., Whitelegge, J. P., Witkowska, H. E., Wolinsky, L., Xie, Y., Xu, T., Yu, W., Ytterberg, J., Wong, D. T., Yates, J. R., & Fisher, S. J.
Venue
Journal of Proteome Research
Publisher
American Chemical Society (ACS)
Published
2008-03-25
Volume
7
Issue
5
Pages
1994-2006
ISSN
  • 1535-3893 (ISSN-L)
  • 1535-3907
DOI
10.1021/pr700764j
OpenAlex
W2027872382
Cited by
445
References
4
FWCI
23.12
Type
journal article
Language
en
Open access
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