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Cited by 366

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Systems Toxicology: From Basic Research to Risk Assessment

Open access
Sturla, Shana J., Boobis, Alan R., FitzGerald, Rex E., Hoeng, Julia, Kavlock, Robert J., Schirmer, Kristin, Whelan, Maurice, Wilks, Martin F., Peitsch, Manuel C.·2014·Chemical Research in Toxicology
DOI 10.1021/tx400410s
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Abstract

Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Society demands increasingly close scrutiny of the potential health risks associated with exposure to chemicals present in our everyday life, leading to an increasing need for more predictive and accurate risk-assessment approaches. Developing such approaches requires a detailed mechanistic understanding of the ways in which xenobiotic substances perturb biological systems and lead to adverse outcomes. Thus, Systems Toxicology approaches offer modern strategies for gaining such mechanistic knowledge by combining advanced analytical and computational tools. Furthermore, Systems Toxicology is a means for the identification and application of biomarkers for improved safety assessments. In Systems Toxicology, quantitative systems-wide molecular changes in the context of an exposure are measured, and a causal chain of molecular events linking exposures with adverse outcomes (i.e., functional and apical end points) is deciphered. Mathematical models are then built to describe these processes in a quantitative manner. The integrated data analysis leads to the identification of how biological networks are perturbed by the exposure and enables the development of predictive mathematical models of toxicological processes. This perspective integrates current knowledge regarding bioanalytical approaches, computational analysis, and the potential for improved risk assessment.

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Crossref · 10.1021/tx400410s

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Metadata

Authors
Sturla, S. J., Boobis, A. R., FitzGerald, R. E., Hoeng, J., Kavlock, R. J., Schirmer, K., Whelan, M., Wilks, M. F., & Peitsch, M. C.
Venue
Chemical Research in Toxicology
Publisher
American Chemical Society (ACS)
Published
2014-01-21
Volume
27
Issue
3
Pages
314-329
ISSN
  • 0893-228X (ISSN-L)
  • 1520-5010
DOI
10.1021/tx400410s
OpenAlex
W1976750784
Cited by
366
References
81
FWCI
15.45
Type
journal article
Language
en
Open access
hybrid

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