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Cited by 92Bariatric Surgery and OutcomesGastrointestinal motility and disordersDiabetes Management and Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Postprandial GLP-1, Norepinephrine, and Reactive Hypoglycemia in Dumping Syndrome

Gebhard, B., Holst, J.J., Biegelmayer, C., Miholic, J.·2001·Digestive Diseases and Sciences
DOI 10.1023/a:1010635131228
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Abstract

Rapid gastric emptying and exaggerated plasma concentrations of the insulinotropic hormone GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients. We suspected that the plasma volume drop associated with rapid gastric emptying (early dumping) would be accompanied by elevated plasma concentrations of norepinephrine. In order to study any relationship between postprandial norepinephrine, the enteroinsular axis, and plasma glucose, twelve patients with dumping syndrome and nine controls were studied. The plasma concentrations of norepinephrine, GLP-1, GIP, glucagon, insulin, and glucose were measured following a 1.5 g/kg lean body mass glucose meal. The early (0-30 min) integrated norepinephrine concentration was significantly higher in dumpers (22.1 +/- 3.8 nmol/ml/min) compared to controls (14.7 +/- 3.1 nmol/ml/min; P < 0.001) and correlated closely with the postprandial hematocrit increment (r = 0.71; P < 0.05). Early immunoreactivities of GLP-1, GIP, and glucagon peaked 30 min after glucose ingestion and were significantly higher in dumpers. Insulin peaked after 60 min and correlated with early GLP-1. In 11 of the patients glucose fell below baseline after a median interval of 120 min. Glucose at 120 min, when most of the nadirs occurred was lowest in patients with high early GLP-1 concentrations (r = 0.78; P < 0.001). Gel filtration chromatography of the dumpers' plasma revealed that pancreatic glucagon was detectable at time 0 and after 20 min, but…

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1010635131228

Cites

27 of 27 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In alimentary RH, rapid gastric emptying and increased plasma GLP-1 levels precede RH after oral glucose loading in gastrectomy patients.

    “In alimentary RH, rapid gastric emptying and increased plasma GLP-1 levels precede RH after oral glucose loading in gastrectomy patients,[4]”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [4]

Citations

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Research works printed but not linked: 1

  1. Cherrington AD, Liljenquist JE: Role of glucagon in regulating glucose production in vivo. In Glucagon. Physiology, Pathophysiology and Morpology of the Pancreatic A-Cells. RH Unger, L Orci (eds). Amsterdam, Elsevier, 1981, pp 221–254

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Metadata

Authors
Gebhard, B., Holst, J. J., Biegelmayer, C., & Miholic, J.
Affiliations
  • University of Vienna (AT)
  • University of Copenhagen (DK)
ORCID
Holst, J.J.
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2001-09
Volume
46
Issue
9
Pages
1915-1923
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/a:1010635131228
OpenAlex
W1565673342
Cited by
92
References
27
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 6
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
dumping syndrome, reactive hypoglycemia, glucagon-like peptide-1, norepinephrine, rapid gastric emptying, gastrectomy, glucagon, insulin, postprandial blood glucose, enteroinsular axis, catecholamines, hematocrit
MeSH terms
Chromatography, Gel, Dumping Syndrome, Glucagon, Hematocrit, Humans, Hypoglycemia, Middle Aged, Norepinephrine, Peptide Fragments, Protein Precursors, Postprandial Period, Glucagon-Like Peptide 1

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