Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons

Lakatta, Edward G.

doi:10.1023/a:1013797722156

Cited by 456Cardiovascular Function and Risk FactorsCardiovascular Health and Disease PreventionCardiovascular and exercise physiology

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Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons

Lakatta, Edward G.·2002·Heart Failure Reviews

DOI 10.1023/a:1013797722156

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Abstract

In the United States, cardiovascular disease, e.g., atherosclerosis and hypertension, that lead to heart failure and stroke, is the leading cause of mortality, accounting for over 40 percent of deaths in those aged 65 years and above. Over 80 percent of all cardio-vascular deaths occur in the same age group. Thus, age, per se, is the major risk factor for cardiovascular disease. Clinical manifestations and prognosis of these cardiovascular diseases likely become altered in older persons with advanced age because interactions occur between age-associated cardiovascular changes in health and specific pathophysiologic mechanisms that underlie a disease. A fundamental understanding of age-associated changes in cardiovascular structure and function ranging in scope from humans to molecules is required for effective and efficient prevention and treatment of cardiovascular disease in older persons. A sustained effort over the past two decades has been applied to characterize the multiple effects of aging in health on cardiovascular structure and function in a single study population, the Baltimore Longitudinal Study on Aging. In these studies, community dwelling, volunteer participants are rigorously screened to detect both clinical and occult cardiovascular disease and characterized with respect to lifestyle, e.g. exercise habits, in an attempt to deconvolute interactions among lifestyle, cardiovascular disease and the aging process in health. This review highlights some specific changes in resting cardiovascular structure and function and cardiovascular reserve capacity that occur with advancing age in healthy humans. Observations from relevant experiments in animal models have been integrated with those in humans to provide possible mechanistic insight.

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Aging is the primary risk factor for cardiovascular diseases.
“Aging is the major risk factor for cardiovascular diseases (CVD).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [98]

Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults
O'Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L., & Wolfson, S. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400103 · Cited by 4,685
The natural history of congestive heart failure: the Framingham study
McKee, P. A., Castelli, W. P., McNamara, P. M., & Kannel, W. B. (1971) · New England Journal of Medicine · doi:10.1056/nejm197112232852601 · Cited by 3,448
Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,354
Effects of age and aerobic capacity on arterial stiffness in healthy adults.
Vaitkevicius, P. V., Fleg, J. L., Engel, J.-H., O’Connor, F. C., Wright, J. G., Lakatta, L. E., Yin, F. C. P., & Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.88.4.1456 · Cited by 1,085
Self-citation
Cardiovascular regulatory mechanisms in advanced age.
Lakatta, E. G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.413 · Cited by 791
Self-citation
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
Olivetti, G., Melissari, M., Capasso, J. M., & Anversa, P. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1560 · Cited by 774
Role of muscle loss in the age-associated reduction in VO2 max
Fleg, J. L., & Lakatta, E. G. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.3.1147 · Cited by 640
Self-citation
Stretch-induced programmed myocyte cell death.
Cheng, W. N., Li, B., Kajstura, J., Li, P., Wolin, M. S., Sonnenblick, E. H., Hintze, T. H., Olivetti, G., & Anversa, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118280 · Cited by 639
Echocardiographic assessment of a normal adult aging population.
Gerstenblith, G., Frederiksen, J. W., Yin, F. C. P., Fortuin, N. J., Lakatta, E. G., & Weisfeldt, M. L. (1977) · Circulation · doi:10.1161/01.cir.56.2.273 · Cited by 573
Self-citation
Human 92- and 72-kilodalton type IV collagenases are elastases.
Senior, R. M., Griffin, G. L., Fliszar, C. J., Shapiro, S. D., Goldberg, G. I., & Welgus, H. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89530-1 · Cited by 544
Hemodynamic forces are complex regulators of endothelial gene expression
Resnick, N., & Cimbrone, M. A. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.10.7615157 · Cited by 539
Production of transforming growth factor beta 1 during repair of arterial injury.
Majesky, M. W., Lindner, V., Twardzik, D. R., Schwartz, S. M., & Reidy, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115393 · Cited by 519
Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women
Fleg, J. L., O'Connor, F., Gerstenblith, G., Becker, L. C., Clulow, J., Schulman, S. P., & Lakatta, E. G. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.890 · Cited by 506
Self-citation
Absence of Age-Related Increase in Central Arterial Stiffness in Physically Active Women
Tanaka, H., DeSouza, C. A., & Seals, D. R. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.127 · Cited by 490
Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.
Anversa, P., Palackal, T., Sonnenblick, E. H., Olivetti, G., Meggs, L. G., & Capasso, J. M. (1990) · Circulation Research · doi:10.1161/01.res.67.4.871 · Cited by 403
Long-Term Effects of Hypertension on the Rat Aortic Wall and Their Relation to Concurrent Aging Changes: MORPHOLOGICAL AND CHEMICAL STUDIES
Wolinsky, H. (1972) · Circulation Research · doi:10.1161/01.res.30.3.301 · Cited by 322
Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation.
Pauly, R. R., Passaniti, A., Bilato, C., Monticone, R. E., Cheng, L., Papadopoulos, N., Gluzband, Y. A., Smith, L. T., Weinstein, C., & Lakatta, E. G. (1994) · Circulation Research · doi:10.1161/01.res.75.1.41 · Cited by 312
Self-citation
Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue
Calis, Z. S., Sukhova, G. K., & Libby, P. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.10.7615167 · Cited by 276
Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats
Kajstura, J., Cheng, W. N., Ranganathan, S., Li, P., Li, B., Nitahara, J., Chapnick, S., Krzysztof Reiss, F., Olivetti, G., & Anversa, P. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.3.h1215 · Cited by 272
Increased Carotid Artery Intimal-Medial Thickness in Asymptomatic Older Subjects With Exercise-Induced Myocardial Ischemia
Nagai, Y., Metter, E. J., Earley, C. J., Kemper, M. K., Becker, L. C., Lakatta, E. G., & Fleg, J. L. (1998) · Circulation · doi:10.1161/01.cir.98.15.1504 · Cited by 250
Self-citation
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
Xiao, R. P., Tomhave, E. D., Wang, D. J., Ji, X., Boluyt, M. O., Cheng, H., Lakatta, E. G., & Koch, W. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1335 · Cited by 213
Self-citation
Angiotensin II Activates Programmed Myocyte Cell Deathin Vitro
Cigola, E., Kajstura, J., Li, B., Meggs, L. G., & Anversa, P. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3477 · Cited by 209
Increased Expression of Matrix Metalloproteinase-2 in the Thickened Intima of Aged Rats
Li, Z., Froehlich, J. P., Galis, Z. S., & Lakatta, E. G. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.116 · Cited by 207
Self-citation
Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males
Fleg, J. L., Tzankoff, S. P., & Lakatta, E. G. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.4.1033 · Cited by 206
Self-citation
Studies of sarcoplasmic reticulum function and contraction duration in young adult and aged rat myocardium
Froehlich, J. P. (1978) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(78)90364-4 · Cited by 197
Expression of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in rat heart during ontogenic development and aging.
Lompré, A., Lambert, F., Lakatta, E. G., & Schwartz, K. (1991) · Circulation Research · doi:10.1161/01.res.69.5.1380 · Cited by 197
Self-citation
Age-related decline in left ventricular filling at rest and exercise
Schulman, S. P., Lakatta, E. G., Fleg, J. L., Lakatta, L. E., Becker, L. C., & Gerstenblith, G. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.6.h1932 · Cited by 181
Self-citation
Effect of chronic ANG I-converting enzyme inhibition on aging processes. II. Large arteries
Michel, J., Heudes, D., Michel, O., Poitevin, P., Philippe, M., Scalbert, E., Corman, B., & Levy, B. I. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.1.r124 · Cited by 179
Aging effects on human sympathetic neuronal function
Esler, M., Turner, A., Kaye, D. M., Thompson, J. M., Kingwell, B. A., Morris, M. J., Lambert, G. W., Jennings, G., Cox, H. S., & Seals, D. R. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.1.r278 · Cited by 173
Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans.
Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.87.2.631 · Cited by 160
Self-citation
Estrogen Supplementation Decreases Norepinephrine-Induced Vasoconstriction and Total Body Norepinephrine Spillover in Perimenopausal Women
Sudhir, K., Esler, M., Jennings, G., & Komesaroff, P. A. (1997) · Hypertension · doi:10.1161/01.hyp.30.6.1538 · Cited by 152
Age-Related Changes of Sympathetic Outflow to Muscles in Humans
Iwase, S., Mano, T., Watanabe, T., Saito, M., & Kobayashi, F. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.1.m1 · Cited by 152
Arterial alpha-adrenergic responsiveness is decreased and SNS activity is increased in older humans
Hogikyan, R. V., & Supiano, M. A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.5.e717 · Cited by 147
Intracellular calcium transients and developed tension in rat heart muscle. A mechanism for the negative interval-strength relationship.
Orchard, C. H., & Lakatta, E. G. (1985) · The Journal of General Physiology · doi:10.1085/jgp.86.5.637 · Cited by 142
Self-citation
Effects of age on mechanical and electrical performance of rat myocardium
Capasso, J. M., Malhotra, A., Remily, R. M., Scheuer, J., & Sonnenblick, E. H. (1983) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1983.245.1.h72 · Cited by 140
Excitation-contraction in rat myocardium: alterations with adult aging
Wei, J. Y., Spurgeon, H. A., & Lakatta, E. G. (1984) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1984.246.6.h784 · Cited by 135
Self-citation
Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
Fraticelli, A., Josephson, R., Danziger, R. S., Lakatta, E. G., & Spurgeon, H. A. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.1.h259 · Cited by 134
Self-citation
Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment
Kang, J., Richards, E. M., Posner, P., & Sumners, C. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.1.c278 · Cited by 133
Age associated changes in membrane currents in rat ventricular myocytes
Walker, K. E., Lakatta, E. G., & Houser, S. R. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.11.1968 · Cited by 128
Self-citation
Age-Associated Changes in Blood Pressure in a Longitudinal Study of Healthy Men and Women
Pearson, J. D., Morrell, C. H., Brant, L. J., Landis, P. K., & Fleg, J. L. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.3.m177 · Cited by 126
Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
Xiao, R. P., Spurgeon, H. A., O'Connor, F., & Lakatta, E. G. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117559 · Cited by 119
Self-citation
Vascular smooth muscle cell growth kinetics in vivo in aged rats.
Stemerman, M. B., Weinstein, R. S., Rowe, J., Maciag, T., Fuhro, R. L., & Gardner, R. T. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.12.3863 · Cited by 115
Which Arterial and Cardiac Parameters Best Predict Left Ventricular Mass?
Chen, C.-H., Ting, C.-T., Lin, S., Hsu, T., Ho, S.-J., Chou, P., Chang, M.-S., O'Connor, F., Spurgeon, H. A., Lakatta, E. G., et al. (1998) · Circulation · doi:10.1161/01.cir.98.5.422 · Cited by 112
Self-citation
Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals
Chen, C.-H., Nakayama, M., Talbot, M. W., Nevo, E., Fetics, B. J., Gerstenblith, G., Becker, L. C., & Kass, D. A. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00052-2 · Cited by 107
Aging and arteriosclerosis. The increased proliferation of arterial smooth muscle cells isolated from old rats is associated with increased platelet-derived growth factor-like activity.
McCaffrey, T. A., NICHOLSON, A. C., Szabó, P. E., Weksler, M. E., & Weksler, B. B. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.1.163 · Cited by 106
Continuum of Cardiovascular Performance Across a Broad Range of Fitness Levels in Healthy Older Men
Schulman, S. P., Fleg, J. L., Goldberg, A. P., Busby‐Whitehead, J., Hagberg, J. M., O’Connor, F. C., Gerstenblith, G., Becker, L. C., Katzel, L. I., Lakatta, L. E., et al. (1996) · Circulation · doi:10.1161/01.cir.94.3.359 · Cited by 104
Self-citation
Enhanced calcium uptake of cardiac sarcoplasmic reticulum in exercise-trained old rats
Tate, C. A., Taffet, G. E., Hudson, E. K., Blaylock, S. L., McBride, R., & Michael, L. H. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.2.h431 · Cited by 103
Expressional analysis of the cardiac Na–Ca exchanger in rat development and senescence
Koban, M. U. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00276-9 · Cited by 99
Aortic endothelial and subendothelial cells in experimental hypertension and aging.
Haudenschild, C. C., PRESCOTT, M. F., & Chobanian, A. V. (1981) · Hypertension · doi:10.1161/01.hyp.3.3_pt_2.i148 · Cited by 98
Age-associated changes in left ventricular diastolic performance during isometric exercise in normal subjects
Swine, C., Shapiro, E. P., Lima, S. D., & Fleg, J. L. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90518-4 · Cited by 97
Experimental models that mimic the differentiation and dedifferentiation of vascular cells.
Rr, P., Passaniti, A., Crow, M. T., Jl, K., Papadopoulos, N. M., Monticone, R. E., Lakatta, E. G., & Gr, M. (1992) · PubMed · Cited by 95
Self-citation
Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury.
HARIRI, R. J., Alonso, D. R., Hajjar, D. P., Coletti, D., & Weksler, M. E. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.4.1171 · Cited by 95
Changes in myosin isoenzymes, ATPase activity, and contraction duration in rat cardiac muscle with aging can be modulated by thyroxine.
Effron, M. B., Bhatnagar, G. M., Spurgeon, H. A., Ruaño-Arroyo, G., & Lakatta, E. G. (1987) · Circulation Research · doi:10.1161/01.res.60.2.238 · Cited by 94
Self-citation
Role of the extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations.
Fornieri, C., Quaglino, D., & Mori, G. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.9.1008 · Cited by 92
Age-related alterations in the phosphorylation of sarcoplasmic reticulum and myofibrillar proteins and diminished contractile response to isoproterenol in intact rat ventricle.
Jiang, M. T., Moffat, M. P., & Narayanan, N. (1993) · Circulation Research · doi:10.1161/01.res.72.1.102 · Cited by 87
Age-induced decreases in the messenger RNA coding for the sarcoplasmic reticulum Ca2(+)-ATPase of the rat heart.
Maciel, L. M. Z., Polikar, R., Rohrer, D. K., Popovich, B. K., & DILLMANN, W. H. (1990) · Circulation Research · doi:10.1161/01.res.67.1.230 · Cited by 82
Effects of tetrodotoxin-induced neural inactivation on single muscle fiber metabolic enzymes
Michel, R. N., Cowper, G., Chi, M. M., Manchester, J. K., Falter, H., & Lowry, O. H. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.1.c55 · Cited by 79
Age-associated decrease in ventricular response to haemodynamic stress during beta-adrenergic blockade.
Yin, F. C. P., Raizes, G. S., Guarnieri, T., Spurgeon, H. A., Lakatta, E. G., Fortuin, N. J., & Weisfeldt, M. L. (1978) · Heart · doi:10.1136/hrt.40.12.1349 · Cited by 66
Self-citation
ATPase activity and force production in myofibrils and twitch characteristics in intact muscle from neonatal, adult, and senescent rat myocardium
Bhatnagar, G. M., Walford, G. D., Beard, E. S., Humphreys, S., & Lakatta, E. G. (1984) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(84)80587-8 · Cited by 63
Self-citation
ASC system activity is altered by development of cell polarity in trophoblast from human placenta
Furesz, T. C., Smith, C. H., & Moe, A. J. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.1.c212 · Cited by 62
Hemodynamic effects of unloading the old heart
Nussbacher, A., Gerstenblith, G., O’Connor, F. C., Becker, L. C., Kass, D. A., Schulman, S. P., Fleg, J. L., & Lakatta, E. G. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.5.h1863 · Cited by 61
Self-citation
Aging, Cardiac Proenkephalin mRNA and Enkephalin Peptides in the Fisher 344 Rat
Caffrey, J. L., Boluyt, M. O., Younès, A., Barron, B. A., O’Neill, L., Crow, M. T., & Lakatta, E. G. (1994) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1994.1085 · Cited by 59
Self-citation
Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart.
Sarzani, R., Arnaldi, G., Takasaki, I., Brecher, P. I., & Chobanian, A. V. (1991) · Hypertension · doi:10.1161/01.hyp.18.5_suppl.iii93 · Cited by 56
Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes.
O'Neill, L., Nj, H., Fargnoli, J., & Lakatta, E. G. (1991) · PubMed · Cited by 54
Self-citation
Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes
Sakai, M. (1989) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(89)90678-0 · Cited by 48
Comparison of aortic intima and inner media in young adult versus aging rats. Stereology in a polarized system.
Guyton, J. R., Kl, L., & Dao, D. T. (1983) · PubMed Central · Cited by 47
Forskolin activation of adenylate cyclase in rat myocardium with age: Effects of guanine nucleotide analogs
Scarpace, P. J. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90122-v · Cited by 47
Reduced threshold for myocardial cell calcium intolerance in the rat heart with aging
Hano, O., Bogdanov, K. Y., Sakai, M., Danziger, R. G., Spurgeon, H. A., & Lakatta, E. G. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.5.h1607 · Cited by 45
Self-citation
Age-associated increase in rat cardiac opioid production
Boluyt, M. O., Younes, A. B., Caffrey, J. L., O'Neill, L., Barron, B. A., Crow, M. T., & Lakatta, E. G. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.1.h212 · Cited by 43
Self-citation
Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy
Younes, A., Boluyt, M. O., O'Neill, L., Meredith, A. L., Crow, M. T., & Lakatta, E. G. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.3.h1003 · Cited by 39
Self-citation
Chaotic Behavior of Myocardial Cells: Possible Implications Regarding the Pathophysiology of Heart Failure
Lakatta, E. G. (1989) · Perspectives in biology and medicine · doi:10.1353/pbm.1989.0044 · Cited by 27
Self-citation
Additive effects of age and silent myocardial ischemia on the left ventricular response to upright cycle exercise
Fleg, J. L., Schulman, S. P., Gerstenblith, G., Becker, L. C., O’Connor, F. C., & Lakatta, E. G. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.2.499 · Cited by 26
Self-citation

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Research works printed but not linked: 6

Guyton JR, Lindsay KL, Dao DT. Comparison of aortic intima and inner media in young adult versus aging rats. Am J Pathol 1983;111:234-246.
Jenkins GM, Crow MT, Bilato C, Li Z, Ryu W-S, Nater C, Froehlich J, Lakatta EG, Cheng L. The role of MMP-2 in neointima formation following balloon injury in the rat. Circulation 1997 (in press).
McCaffrey TA, Nicholson AC, Szabo PE, Weksler ME, Weksler BB. Aging and atherosclerosis: the increased proliferation of arterial smooth muscle cells isolated from old rats is associated with increased platelet derived growth factor-like activity. J Exp Med 1988;167:163-174. · DOI
Gerstenblith G, Fredricksen J, Yin FCP, et al. Echocardiographic assessment of a normal adult aging population. Circ 1977;56:273. · DOI
National Center for Health Statistics Vital statistics of the United States, 1988, Vol. II Mortality, Part A, Tables 1-27, 1-129. National Center for Health Statistics, Rockville, MD, 1991.
Lakatta EG, Weisfeldt ML, Gerstenblith G. The aging heart: Structure, function, and disease. In: E. Braunwald ed. Heart Disease. A Textbook of Cardiovascular Medicine, 5th edition. WB Saunders, NY. Chapter 50, p 1687, 1996.

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Aronow, W. S., Fleg, J. L., Pepine, C. J., Artinian, N. T., Bakris, G. L., Brown, A. S., Ferdinand, K. C., Forciea, M. A., Frishman, W. H., Jaigobin, C. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31821daaf6 · Cited by 627
Effect of Aging and Physical Activity on Left Ventricular Compliance
Arbab-Zadeh, A., Dijk, E., Prasad, A., Fu, Q., Torres, P., Zhang, R., Thomas, J. D., Palmer, D., & Levine, B. D. (2004) · Circulation · doi:10.1161/01.cir.0000142863.71285.74 · Cited by 535
ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly
Aronow, W. S., Fleg, J. L., Pepine, C. J., Artinian, N. T., Bakris, G. L., Brown, A. S., Ferdinand, K. C., Forciea, M. A., Frishman, W. H., Jaigobin, C. S., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.008 · Cited by 518
Aging and Cardiac Fibrosis.
Biernacka, A., & Frangogiannis, N. G. (2011) · Europe PMC (PubMed Central) · Cited by 455
Multimorbidity Patterns in the Elderly: A New Approach of Disease Clustering Identifies Complex Interrelations between Chronic Conditions
Schäfer, I., von Leitner, E.-C., Schön, G., Koller, D., Hansen, H., Kolonko, T., Kaduszkiewicz, H., Wegscheider, K., Glaeske, G., & van den Bussche, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015941 · Cited by 405
MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
Boon, R. A., Seeger, T., Heydt, S., Fischer, A., Hergenreider, E., Horrevoets, A. J. G., Vinciguerra, M., Rosenthal, N. A., Sciacca, S., Pilato, M., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.255737 · Cited by 372
25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults
Jablonski, K., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160929 · Cited by 364
Myocyte Turnover in the Aging Human Heart
Kajstura, J., Gurusamy, N., Ogórek, B., Goichberg, P., Clavo-Rondon, C., Hosoda, T., D'Amario, D., Bardelli, S., Beltrami, A. P., Cesselli, D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.231498 · Cited by 287
Retracted
Modeling arterial pulse waves in healthy aging: a database for in silico evaluation of hemodynamics and pulse wave indexes
Charlton, P. H., Harana, J. M., Vennin, S., Li, Y., Chowienczyk, P., & Alastruey, J. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00218.2019 · Cited by 269
Consensus statement on best practice management regarding the use of intravesical immunotherapy with BCG for bladder cancer
Kamat, A. M., Flaig, T. W., Grossman, H. B., Konety, B. R., Lamm, D. L., O’Donnell, M. A., Uchio, E., Efstathiou, J. A., & Taylor, J. A. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.58 · Cited by 255
Procedural results and acute complications in stenting native and recurrent coarctation of the aorta in patients over 4 years of age: A multi‐institutional study
Forbes, T. J., Garekar, S., Amin, Z., Zahn, E. M., Nykanen, D., Moore, P., Qureshi, S. A., Cheatham, J. P., Ebeid, M. R., Hijazi, Z. M., et al. (2007) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.21164 · Cited by 252
Vital Signs in Older Patients: Age-Related Changes
Chester, J. G., & Rudolph, J. L. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.009 · Cited by 250
MEDICAL MAGNETIC RESONANCE (MR) PROCEDURES: PROTECTION OF PATIENTS
The International Commission on Non-Ionizing Radiation Protection (2004) · Health Physics · doi:10.1097/00004032-200408000-00008 · Cited by 246
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging
Ocorr, K. A., Reeves, N., Wessells, R. J., Fink, M., Chen, H.-S. V., Akasaka, T., Yasuda, S., Metzger, J. M., Giles, W. R., Posakony, J. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609278104 · Cited by 239
Cardiac Care for Older Adults
Forman, D. E., Rich, M. W., Alexander, K. P., Zieman, S., Maurer, M. S., Najjar, S. S., Cleveland, J. C., Krumholz, H. M., & Wenger, N. K. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.014 · Cited by 228
Secondary Prevention of Atherosclerotic Cardiovascular Disease in Older Adults
Fleg, J. L., Forman, D. E., Berra, K. A., Bittner, V., Blumenthal, J. A., Chen, M. A., Cheng, S. C., Kitzman, D. W., Maurer, M. S., Rich, M. W., et al. (2013) · Circulation · doi:10.1161/01.cir.0000436752.99896.22 · Cited by 225
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging
Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218
The Aging Heart: Figure 1.Preprint
Chiao, Y. A., & Rabinovitch, P. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025148 · Cited by 204
Management of the critically ill geriatric patient
Marik, P. E. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000232624.14883.9a · Cited by 195
Physical activity and cardiovascular aging: Physiological and molecular insights
Jakovljević, D. G. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.05.016 · Cited by 186
A patient-specific computational model of fluid–structure interaction in abdominal aortic aneurysms
Wolters, B. J. B. M., Rutten, M. C. M., Schurink, G. W. H., Kose, U., de Hart, J., & van de Vosse, F. N. (2005) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2005.06.008 · Cited by 184
Ageing and activity: their effects on the functional reserve capacities of the heart and vascular smooth and skeletal muscles
Goldspink, D. F. (2005) · Ergonomics · doi:10.1080/00140130500101247 · Cited by 177
Perioperative Drug Therapy in Elderly Patients
Rivera, R., Antognini, J. F., & Riou, B. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181a10207 · Cited by 177
The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases
Izzo, C., Vitillo, P., Pietro, P. D., Visco, V., Strianese, A., Virtuoso, N., Ciccarelli, M., Galasso, G., Carrizzo, A., & Vecchione, C. (2021) · Life · doi:10.3390/life11010060 · Cited by 176
Heart failure with preserved ejection fraction in the elderly: scope of the problem
Upadhya, B., Taffet, G. E., Cheng, C. P., & Kitzman, D. W. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.02.025 · Cited by 160
Syndromes of orthostatic intolerance: a hidden danger
Fedorowski, A., & Melander, O. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12021 · Cited by 151
ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly
Aronow, W. S., Fleg, J. L., Pepine, C. J., Artinian, N. T., Bakris, G. L., Brown, A. S., Ferdinand, K. C., Forciea, M. A., Frishman, W. H., Jaigobin, C. S., et al. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.06.001 · Cited by 151
Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries
Parker, B. A., Ridout, S. J., & Proctor, D. N. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00190.2006 · Cited by 150
The role of inflammatory and fibrogenic pathways in heart failure associated with aging
Chen, W., & Frangogiannis, N. G. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9161-y · Cited by 147
NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
Sahoo, S., Meijles, D. N., & Pagano, P. J. (2016) · Clinical Science · doi:10.1042/cs20150087 · Cited by 147
Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors
Voghel, G., Thorin‐Trescases, N., Farhat, N., Nguyen, A. Q., Villeneuve, L. R., Mamarbachi, A. M., Fortier, A., Perrault, L. P., Carrier, M., & Thorin, É. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.09.006 · Cited by 145
Left ventricular structure and diastolic function with human ageing Relation to habitual exercise and arterial stiffness
Gates, P. E. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.09.026 · Cited by 144
Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies – A Review
Adamski, Z., Bufo, S. A., Chowański, S., Falabella, P., Lubawy, J., Marciniak, P., Pacholska‐Bogalska, J., Salvia, R., Scrano, L., Słocińska, M., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00319 · Cited by 142
Increased Nitration of Sarcoplasmic Reticulum Ca 2+ -ATPase in Human Heart Failure
Lokuta, A. J., Maertz, N. A., Meethal, S. V., Potter, K. T., Kamp, T. J., Valdivia, H. H., & Haworth, R. A. (2005) · Circulation · doi:10.1161/01.cir.0000156461.81529.d7 · Cited by 142
Vascular Hyperpermeability and Aging
Oakley, R. P. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500114 · Cited by 138
FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries
Bural, G. G., Torigian, D. A., Chamroonrat, W., Houseni, M., Chen, W., Basu, S. K., Kumar, R., & Alavi, A. A. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0528-9 · Cited by 138
Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants
Park, S., Kim, K., Page, G. P., Allison, D. B., Weindruch, R., & Prolla, T. A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00496.x · Cited by 134
The Impact of Aging on Cardio and Cerebrovascular Diseases
Izzo, C., Carrizzo, A., Alfano, A., Virtuoso, N., Capunzo, M., Calabrese, M., Simone, E. D., Sciarretta, S., Frati, G., Oliveti, M., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020481 · Cited by 134
Change of Serum Albumin and Risk of Cardiovascular Disease and All-Cause Mortality
Schalk, B. W. M., Visser, M., Bremmer, M. A., Penninx, B. W. J. H., Bouter, L. M., & Deeg, D. J. H. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj312 · Cited by 128
The role of melatonin, a multitasking molecule, in retarding the processes of ageing
Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 126
Atrial strain rate is a sensitive measure of alterations in atrial phasic function in healthy ageing
Boyd, A. C., Richards, D. A. B., Marwick, T. H., & Thomas, L. (2011) · Heart · doi:10.1136/heartjnl-2011-300134 · Cited by 126
Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: A theoretical review
Salminen, L. E., & Paul, R. H. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0046 · Cited by 113
Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology
Merino, J. L., Tamargo, J. L., Blomström‐Lundqvist, C., Boriani, G., Crijns, H. J. G. M., Dobrev, D., Goette, A., Hohnloser, S. H., Naccarelli, G. V., Reiffel, J. A., et al. (2025) · EP Europace · doi:10.1093/europace/euaf076 · Cited by 112
Habitual Exercise and the Age-Associated Decline in Large Artery Compliance
Seals, D. R. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200304000-00003 · Cited by 106
Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00879.2003 · Cited by 106
Protein glycation during aging and in cardiovascular disease
Simm, A. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.05.012 · Cited by 105
Myocardial Aging and Senescence: Where Have the Stem Cells Gone?
Sussman, M. A., & Anversa, P. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.140723 · Cited by 105
Pharmacodynamics in the elderly
Vuyk, J. (2003) · Best practice & research. Clinical anaesthesiology · doi:10.1016/s1521-6896(03)00008-9 · Cited by 103
Serum Vitamin D Deficiency as a Predictor of Incident Non-Alzheimer Dementias: A 7-Year Longitudinal Study
Annweiler, C., Rolland, Y., Schott, A., Blain, H., Vellas, B. J., & Beauchet, O. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000334944 · Cited by 99
Obesity increases cerebrocortical reactive oxygen species and impairs brainfunction
Freeman, L. R., Zhang, L., Nair, A. R., Dasuri, K., Francis, J., Fernandez-Kim, S.-O., Bruce‐Keller, A. J., & Keller, J. N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.577 · Cited by 95
Urgent needs of caregiving in ageing populations with Alzheimer’s disease and other chronic conditions: Support our loved ones
Culberson, J. W., Kopel, J. J., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102001 · Cited by 94
The Incidence of Coronary Heart Disease and the Population Attributable Fraction of Its Risk Factors in Tehran: A 10-Year Population-Based Cohort Study
Khalili, D., Sheikholeslami, F. H., Bakhtiyari, M., Azizi, F., Momenan, A. A., & Hadaegh, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105804 · Cited by 94
Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging
Zhu, Y., Qiu, H., Trzeciakowski, J. P., Sun, Z., Li, Z., Hong, Z., Hill, M. A., Hunter, W. C., Vatner, D. E., Vatner, S. F., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00840.x · Cited by 92
Healthcare Stereotype Threat in Older Adults in the Health and Retirement Study
Abdou, C. M., Fingerhut, A. W., Jackson, J. S., & Wheaton, F. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.07.034 · Cited by 88
New horizons in frailty: ageing and the deficit-scaling problem
Howlett, S. E., & Rockwood, K. J. (2013) · Age and Ageing · doi:10.1093/ageing/aft059 · Cited by 88
Multimorbidity in the community-dwelling elderly in urban China
Gu, J., Chao, J., Chen, W., Xu, H., Wu, Z., Chen, H., He, T., Deng, L., & Zhang, R. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.09.001 · Cited by 88
Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products
Fleenor, B. S., Sindler, A. L., Eng, J. S., Nair, D. P., Dodson, R. B., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.05.004 · Cited by 85
Effect of combined aerobic and resistance training versus aerobic training on arterial stiffness
Montero, D., Vinet, A., & Roberts, C. K. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.10.147 · Cited by 85
Heart Rate Variability following Combined Aerobic and Resistance Training in Sedentary Hypertensive Women: A Randomised Control Trial
Masroor, S., Bhati, P., Verma, S., Khan, M., & Hussain, M. E. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.03.005 · Cited by 83
Emerging Roles for MicroRNAs in Perioperative Medicine
Neudecker, V., Brodsky, K. S., Kreth, S., Ginde, A. A., & Eltzschig, H. K. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000969 · Cited by 83
Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients
Voghel, G., Thorin‐Trescases, N., Farhat, N., Mamarbachi, A. M., Villeneuve, L. R., Fortier, A., Perrault, L. P., Carrier, M., & Thorin, É. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.01.004 · Cited by 83
Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular Senescence
Xiong, S., Salazar, G., Patrushev, N. A., Ma, M., Forouzandeh, F., Hilenski, L. L., & Alexander, R. W. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301019 · Cited by 80
Augmentation Index and Systolic Load Are Lower in Competitive Endurance Athletes
Edwards, D. G., & LANG, J. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.028 · Cited by 79
Effects of leg resistance training on arterial function in older men
Maeda, S., Otsuki, T., Iemitsu, M., Kamioka, M., Sugawara, J., Kuno, S., Ajisaka, R., & Tanaka, H. (2006) · British Journal of Sports Medicine · doi:10.1136/bjsm.2006.029538 · Cited by 79
Microvascular NADPH oxidase in health and disease
Li, Y., & Pagano, P. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.049 · Cited by 79
Motor plasticity in a juggling task in older adults—a developmental study
Voelcker‐Rehage, C., & Willimczik, K. (2006) · Age and Ageing · doi:10.1093/ageing/afl025 · Cited by 78
Hypertensive disorders of pregnancy and long-term risk of maternal stroke—a systematic review and meta-analysis
Brohan, M. P., Daly, F. P., Kelly, L., McCarthy, F. P., Khashan, A. S., Kublickiene, K. R., & Barrett, P. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.03.034 · Cited by 77
Aging, telomeres and heart failure
Wong, L. S. M., van der Harst, P., de Boer, R. A., Huzen, J., van Gilst, W. H., & van Veldhuisen, D. J. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9173-7 · Cited by 77
Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats
LeBlanc, A. J., Reyes, R., Kang, L. S., Dailey, R. A., Stallone, J. N., Moningka, N. C., & Muller‐Delp, J. M. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00178.2009 · Cited by 76
Blood Flow Restricted Exercise and Vascular Function
Horiuchi, M., & Okita, K. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/543218 · Cited by 75
Aging is associated with increased matrix metalloproteinase-2 activity in the human aorta
McNulty, M., Spiers, P., MCGOVERN, E., & Feely, J. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.011 · Cited by 75
Cardiovascular disease-related miRNAs expression: potential role as biomarkers and effects of training exercise
Ultimo, S., Zauli, G., Martelli, A. M., Vitale, M., McCubrey, J. A., Capitani, S., & Neri, L. M. (2018) · Oncotarget · doi:10.18632/oncotarget.24428 · Cited by 72
MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure
Zhang, B., Mao, S., Liu, X., Li, S., Zhou, H., Gu, Y., Liu, W., Fu, L., Liao, C., & Wang, P. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00328-w · Cited by 71
Chronic aerobic exercise training attenuates aortic stiffening and endothelial dysfunction through preserving aortic mitochondrial function in aged rats
Gu, Q., Wang, B., Zhang, X.-F., Ma, Y.-P., Liu, J., & Wang, X. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.014 · Cited by 71
Estrogen, Aging and the Cardiovascular System
Stice, J. P., Lee, J. S., Pechenino, A. S., & Knowlton, A. A. (2008) · Future Cardiology · doi:10.2217/14796678.5.1.93 · Cited by 70
Exercise-Induced Changes in Cardiovascular Function after Stroke: A Randomized Controlled Trial
Tang, A., Eng, J. J., Krassioukov, A. V., Madden, K. M., Mohammadi, A., Tsang, M. Y. C., & Tsang, T. S. M. (2014) · International Journal of Stroke · doi:10.1111/ijs.12156 · Cited by 69
Apolipoprotein E, an important player in longevity and age-related diseases
Ang, L. S., Cruz, R. P., Hendel, A., & Granville, D. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.010 · Cited by 69
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68
Influence of cardiac‐specific overexpression of insulin‐like growth factor 1 on lifespan and aging‐associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression
Li, Q., & Ren, J. T. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00343.x · Cited by 68
And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat
Grimes, K. M., Reddy, A. K., Lindsey, M. L., & Buffenstein, R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00305.2014 · Cited by 67
Uterine blood flow and perfusion in mares with uterine cysts: effect of the size of the cystic area and age
Ferreira, J. C., Gastal, E. L., & Ginther, O. J. (2008) · Reproduction · doi:10.1530/rep-07-0447 · Cited by 65
Reconciling Successful Aging with HIV
Vance, D. E., & Robinson, F. P. (2004) · Journal of HIV/AIDS & Social Services · doi:10.1300/j187v03n01_06 · Cited by 63
Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study
Beker, N., Sikkes, S. A. M., Hulsman, M., Tesi, N., van der Lee, S. J., Scheltens, P., & Holstege, H. H. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.0094 · Cited by 62
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
Pillai, V. B., Samant, S. A., Hund, S., Gupta, M., & Gupta, M. P. (2021) · Aging · doi:10.18632/aging.203027 · Cited by 62
Heart failure – a challenge to our current concepts of excitation–contraction coupling
Sjaastad, I., Wasserstrom, J. A., & Sejersted, O. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034728 · Cited by 61
Analysis of the Effect of Ageing on Rising Edge Characteristics of the Photoplethysmogram using a Modified Windkessel Model
Zahedi, E., Chellappan, K., Ali, M. A. M., & Singh, H. (2007) · Cardiovascular Engineering An International Journal · doi:10.1007/s10558-007-9037-5 · Cited by 60
Repositioning the Old Fungicide Ciclopirox for New Medical Uses
Shen, T., & Huang, S. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160530151209 · Cited by 60
Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging
Vatner, S. F., Park, M., Yan, L., Lee, G. J., Lai, L., Iwatsubo, K., Ishikawa, Y., Pessin, J. E., & Vatner, D. E. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00080.2013 · Cited by 60
Cardioprotective actions of relaxin
Martin, B., Romero, G. G., & Salama, G. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.016 · Cited by 59
Effects of Age and Gender on Right Ventricular Systolic and Diastolic Function Using Two-Dimensional Speckle-Tracking Strain
Chia, E.-M., Hsieh, C. H. C., Boyd, A. C., Pham, P., Vidaic, J., Leung, D. Y., & Thomas, L. (2014) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.06.007 · Cited by 59
Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes
Büchner, N., Ale‐Agha, N., Jakob, S., Sydlik, U., Kunze, K., Unfried, K., Altschmied, J., & Haendeler, J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.03.017 · Cited by 57
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Authors: Lakatta, E. G.
Affiliations: National Institutes of Health (US)
Corresponding author: Lakatta, Edward G.
ORCID: Lakatta, Edward G.
Venue: Heart Failure Reviews
Publisher: Springer Science and Business Media LLC
Published: 2002-01
Volume: 7
Issue: 1
Pages: 29-49
ISSN: 1382-4147 (ISSN-L)
1573-7322
DOI: 10.1023/a:1013797722156
OpenAlex: W1577665082
Cited by: 445
References: 72
Citations by year: 2026: 13 · 2025: 23 · 2024: 21 · 2023: 14 · 2022: 13 · 2021: 29 · 2020: 21 · 2019: 12 · 2018: 12 · 2017: 17 · 2016: 14 · 2015: 18 · 2014: 38 · 2013: 31 · 2012: 25
FWCI: 6.76
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Heart Failure Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: cardiovascular aging, cardiovascular disease in older adults, atherosclerosis, hypertension, heart failure, stroke, exercise habits, cardiovascular structure and function, animal models of aging
MeSH terms: Aged, Aging, Cardiovascular Diseases, Cardiovascular System, Hemodynamics, Humans, Risk Factors

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Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons

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