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Cited by 153Hormonal and reproductive studiesSperm and Testicular FunctionHypothalamic control of reproductive hormones

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Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men

Allen, Naomi E., Appleby, Paul N., Davey, Gwyneth K., Key, Timothy J.·2002·Cancer Causes & Control
DOI 10.1023/a:1015238102830
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Abstract

Objective To investigate the lifestyle and nutritional determinants of serum bioavailable androgens and their related hormones in men. Methods This study is based on a sample of 696 men with a wide range of nutrient intakes, whose diet and lifestyle characteristics were assessed with a questionnaire and serum sex hormones measured using immunoassays. Results Men aged 70 years or older had 12% lower testosterone and 40% lower free-testosterone (FT) and androstanediol glucuronide (A-diol-g) concentrations than men who were 20-29 years of age. Conversely, sex hormone-binding globulin (SHBG) and luteinizing hormone (LH) concentrations were 90% and 49% higher in the oldest age group compared with the lowest, respectively. Men who had a body mass index (BMI) of 30+ kg/m2 had 30% lower testosterone, 45% lower SHBG, 22% lower LH and 5% lower FT concentrations compared with men with a BMI of Conclusions Age is the strongest determinant of serum bioavailable androgens. BMI and some lifestyle and dietary factors influence SHBG and testosterone concentrations, but have no strong association with FT, suggesting that homeostasis is effective. A-diol-g shows broadly similar associations to FT, with the exception of the effect of BMI and alcohol.

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Metadata

Authors
Allen, N. E., Appleby, P. N., Davey, G. K., & Key, T. J.
Affiliations
Cancer Research UK (GB)
Corresponding author
Allen, Naomi E.
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
2002-05
Volume
13
Issue
4
Pages
353-363
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1015238102830
OpenAlex
W1491680646
Cited by
153
References
8
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 10
FWCI
2.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
testosterone, free testosterone, sex hormone-binding globulin, luteinizing hormone, androstanediol glucuronide, aging, body mass index, waist circumference, smoking, physical activity, alcohol consumption, saturated fat intake, dietary factors, men's health, British men, obesity
MeSH terms
Adult, Age Factors, Biological Availability, Diet, England, Humans, Luteinizing Hormone, Life Style, Male, Middle Aged, Nutritional Status, Smoking, Testosterone, Body Mass Index

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