Anxiety- and depressive-like behaviors are associated with altered hippocampal energy and inflammatory status in a mouse model of Crohn's disease

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

The tail suspension test: A new method for screening antidepressants in mice

Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534 · see citing works

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works

Cytokines in inflammatory bowel disease

Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706 · see citing works

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works

The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice

Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674 · see citing works

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression

David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works

The ascent of mouse: advances in modelling human depression and anxiety

Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works

The neurobiology of anhedonia and other reward-related deficits

Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

Strober, W., & Fuss, I. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.016 · Cited by 1,105 · see citing works

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

Wieckowski, M. R., Giorgi, C., Lebiedzinska, M., Duszynski, J., & Pinton, P. (2009) · Nature Protocols · doi:10.1038/nprot.2009.151 · Cited by 979 · see citing works

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock · doi:10.1097/01.shk.0000225404.51320.82 · Cited by 832 · see citing works

HMGB1: Endogenous Danger Signaling

Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762 · see citing works

Role of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

Papadakis, K. A., & Targan, S. R. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.289 · Cited by 714 · see citing works

Depressive disorders and immunity: 20 years of progress and discovery

Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676 · see citing works

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

Bercik, P., Verdu, E. F., Foster, J. A., Macri, J., Potter, M., Huang, X., Malinowski, P., Jackson, W., Blennerhassett, P., Neufeld, K. A., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.063 · Cited by 674 · see citing works

Brain–Gut Interactions in Inflammatory Bowel Disease

Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667 · see citing works

Neuronal plasticity and survival in mood disorders

Duman, R. S., Malberg, J., Nakagawa, S., & D’Sa, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00935-5 · Cited by 652 · see citing works

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · cited 1× · see citing works

Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation

Chassaing, B., Srinivasan, G., Delgado, M. A., Young, A. N., Gewirtz, A. T., & Vijay–Kumar, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044328 · Cited by 555 · see citing works

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works

Brain gut microbiome interactions and functional bowel disorders

Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496 · see citing works

Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway

Lucas, K., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8425-7 · Cited by 466 · see citing works

Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice

Takeda, H., Tsuji, M., & Matsumiya, T. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00223-4 · Cited by 461 · see citing works

Immune mechanisms linked to depression via oxidative stress and neuroprogression

Bakunina, N., Pariante, C. M., & Zunszain, P. A. (2015) · Immunology · doi:10.1111/imm.12443 · Cited by 444 · see citing works

Mitochondrial Dysfunction and Psychiatric Disorders

Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9865-8 · Cited by 443 · see citing works

Immune–neural connections: how the immune system’s response to infectious agents influences behavior

McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429 · see citing works

Mechanism of IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability

Al–Sadi, R., Ye, D., Dokładny, K., & Ma, T. Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5653 · Cited by 419 · see citing works

Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation

Riazi, K., Galic, M. A., Kuzmiski, J. B., Ho, W., Sharkey, K. A., & Pittman, Q. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806682105 · Cited by 400 · see citing works

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

Patki, G., Solanki, N., Atrooz, F., Allam, F., & Salim, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.033 · Cited by 380 · see citing works

The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders

Barksby, H. E., Lea, S., Preshaw, P. M., & Taylor, J. J. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03441.x · Cited by 372 · see citing works

Oxidative stress in anxiety and comorbid disorders

Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365 · see citing works

Inflammasomes in neuroinflammation and changes in brain function: a focused review

Singhal, G., Jaehne, E. J., Corrigan, F., Toben, C. G., & Baune, B. T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00315 · Cited by 365 · see citing works

Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease

Mikocka-Walus, A., Pittet, V., Rossel, J.-B., von Känel, R., Anderegg, C., Bauerfeind, P., Beglinger, C., Begré, S., Belli, D., Bengoa, J. M., et al. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.12.045 · Cited by 348 · see citing works

Depression and anxiety in people with inflammatory bowel disease

Kurina, L. M., Goldacre, M. J., Yeates, D., & Gill, L. E. (2001) · Journal of Epidemiology & Community Health · doi:10.1136/jech.55.10.716 · Cited by 347 · see citing works

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works

Irritable bowel syndrome: A microbiome-gut-brain axis disorder?

Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works

Untitled work

(2008) · PubMed · Cited by 325 · see citing works

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function

Walker, F. R., Nilsson, M., & Jones, K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990208 · Cited by 324 · see citing works

Interferon-gamma (IFN-γ)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice

Obermeier, F., Kojouharoff, G., Hans, W., Schölmerich, J., GROSS, V., & Falk, W. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00878.x · Cited by 317 · see citing works

Altered brain-gut axis in autism: comorbidity or causative mechanisms

Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works

Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways.

Maes, M. H. J., Kubera, M., Obuchowiczwa, E., Goehler, L. E., & Brzeszcz, J. (2011) · PubMed · Cited by 303 · see citing works

Bacterial manipulation of innate immunity to promote infection

Diacovich, L., & Gorvel, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2295 · Cited by 303 · see citing works

Contributions of the microbial hydrogen economy to colonic homeostasis

Carbonero, F. G., Benefiel, A. C., & Gaskins, H. R. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.85 · Cited by 291 · see citing works

Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders

Mancuso, C. (2006) · Frontiers in bioscience · doi:10.2741/2130 · Cited by 290 · see citing works

Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Ohland, C. L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., & Madsen, K. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.008 · Cited by 273 · see citing works

Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats

Xu, Y., Ku, B., Yao, H.-Y., Lin, Y., Ma, X., Zhang, Y., & Li, X.-J. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.08.009 · Cited by 266 · see citing works

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity

Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263 · see citing works

Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling

Severance, E. G., Yolken, R. H., & Eaton, W. W. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.027 · Cited by 256 · see citing works

Inflammatory Bowel Disease: A Study of the Association between Anxiety and Depression, Physical Morbidity, and Nutritional Status

Addolorato, G., Capristo, E., Stefanini, G. F., & Gasbarrini, A. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011218 · Cited by 243 · see citing works

Assessment of mouse anxiety-like behavior in the light–dark box and open-field arena: Role of equipment and procedure

Kulesskaya, N., & Võikar, V. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.006 · Cited by 237 · see citing works

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

Weber, M. D., Frank, M. G., Tracey, K. J., Watkins, L. R., & Maier, S. F. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3561-14.2015 · Cited by 215 · see citing works

Relationship between Vagal Tone, Cortisol, TNF-Alpha, Epinephrine and Negative Affects in Crohn’s Disease and Irritable Bowel Syndrome

Pellissier, S., Dantzer, C., Mondillon, L., Trocme, C., Gauchez, A.-S., Ducros, V., Mathieu, N., Toussaint, B., Fournier, A., Canini, F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105328 · Cited by 212 · see citing works

Review of the Literature on Major Mental Disorders in Adult Patients With Mitochondrial Diseases

Fattal, O., Budur, K., Vaughan, A. J., & Franco, K. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.1.1 · Cited by 209 · see citing works

Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut–brain pathways

Martín-Subero, M., Anderson, G., Kanchanatawan, B., Berk, M., & Maes, M. H. J. (2015) · CNS Spectrums · doi:10.1017/s1092852915000449 · Cited by 196 · see citing works

Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

Waldner, M. J., & Neurath, M. F. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2013.12.003 · Cited by 193 · see citing works

TNBS-Colitis

Neurath, M. F., Fuss, I. J., & Strober, W. (2000) · International Reviews of Immunology · doi:10.3109/08830180009048389 · Cited by 192 · see citing works

Molecular Hydrogen Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice Through Reducing Inflammation and Apoptosis

Xie, K., Yu, Y., Huang, Y., Zheng, L., Li, J., Chen, H., Han, H.-Z., Hou, L., Gong, G., & Wang, G. (2012) · Shock · doi:10.1097/shk.0b013e31824ddc81 · Cited by 191 · see citing works

Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (−)-epigallocatechin-3-gallate, a polyphenol component of green tea

Youn, H. S., Lee, J. Y., Saitoh, S. I., Miyake, K., Kang, K. W., Choi, Y. J., & Hwang, D. H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.021 · Cited by 189 · see citing works

Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats

Zhao, Z., Wang, W., Guo, H., & Zhou, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.030 · Cited by 187 · see citing works

PSA‐NCAM modulates BDNF‐dependent survival and differentiation of cortical neurons

Vutskits, L., Djebbara‐Hannas, Z., Zhang, H., Paccaud, J. P., Durbec, P. L., Rougon, G. N., Müller, D., & Kiss, J. Z. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01516.x · Cited by 186 · see citing works

Pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation

Leppkes, M., Roulis, M., Neurath, M. F., Kollias, G. A., & Becker, C. (2014) · International Immunology · doi:10.1093/intimm/dxu051 · Cited by 183 · see citing works

Reactivation of inflammatory bowel disease in a mouse model of depression.

Ghia, J., Blennerhassett, P., Deng, Y., Verdú, E., Khan, W., & Collins, S. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.069 · Cited by 171 · see citing works

Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

Ohno, K., Ito, M., Ichihara, M., & Ito, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/353152 · Cited by 169 · see citing works

Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

Morris, G., & Maes, M. H. J. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9435-x · Cited by 164 · see citing works

Mitochondrial dysfunction, oxidative stress, and major depressive disorder

Tobe, E. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s44282 · Cited by 156 · see citing works

Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

Amini-Khoei, H., Mohammadi-Asl, A., Amiri, S., Hosseini, M.-J., Momeny, M., Hassanipour, M., Rastegar, M., Haj-Mirzaian, A., Mirzaian, A. H., Sanjarimoghaddam, H., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.022 · Cited by 153 · see citing works

Inhibition of RICK/Nuclear Factor-κB and p38 Signaling Attenuates the Inflammatory Response in a Murine Model of Crohn Disease

Hollenbach, E., Vieth, M. W., Roessner, A., Neumann, M., Malfertheiner, P., & Naumann, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500966200 · Cited by 149 · see citing works

Toxicity of Copper on Isolated Liver Mitochondria: Impairment at Complexes I, II, and IV Leads to Increased ROS Production

Hosseini, M., Shaki, F., Ghazi‐Khansari, M., & Pourahmad, J. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-9922-7 · Cited by 149 · see citing works

Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice

Ducottet, C., & Belzung, C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.018 · Cited by 143 · see citing works

The role of Toll-like receptor proteins (TLR) 2 and 4 in mediating inflammation in proximal tubules

Mudaliar, H., Pollock, C. A., Komala, M. G., Chadban, S. J., Wu, H., & Panchapakesan, U. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00398.2012 · Cited by 141 · see citing works

BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis

Harrisberger, F., Smieskova, R., Schmidt, A., Lenz, C., Walter, A., Wittfeld, K., Grabe, H. J., Lang, U. E., Fusar-Poli, P., & Borgwardt, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.017 · Cited by 138 · see citing works

Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: Further support for the involvement of mitochondrial function in anxiety disorders

Einat, H., YUAN, P., & Manji, H. K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.012 · Cited by 131 · see citing works

Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system

Amiri, S., Haj‐Mirzaian, A., Rahimi-Balaei, M., Razmi, A., Kordjazy, N., Shirzadian, A., Mehr, S. E., Sianati, H., & Dehpour, A. R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.032 · Cited by 128 · see citing works

Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome

Fleshner, M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.012 · Cited by 126 · see citing works

Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: Role of reactive oxygen species, GSH and Nrf2 in radiosensitivity

Jayakumar, S., Kunwar, A., Sandur, S. K., Pandey, B. N., & Chaubey, R. C. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.006 · Cited by 124 · see citing works

Beneficial Effects of N-Acetylcysteine on Acetic Acid-Induced Colitis in Rats

Çetinkaya, A., Bülbüloğlu, E., Kurutaş, E. B., Çıralık, H., Kantarçeken, B., & Büyükbeşe, M. A. (2005) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.206.131 · Cited by 119 · see citing works

A systematic review of disease-related stigmatization in patients living with inflammatory bowel disease

Keefer, L., & Taft, T. (2016) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s83533 · Cited by 119 · see citing works

N-acetylcysteine for major depressive episodes in bipolar disorder

Magalhães, P. V. D. S., Dean, O. M., Bush, A. I., Copolov, D., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000400011 · Cited by 113 · see citing works

HMGB1 modulates inflammatory responses in LPS-activated macrophages

Gazzar, M. E. (2007) · Inflammation Research · doi:10.1007/s00011-006-6112-0 · Cited by 106 · see citing works

The Effects of Antidepressant Treatment in Prenatally Stressed Rats Support the Glutamatergic Hypothesis of Stress-Related Disorders

Marrocco, J., Reynaert, M., Gatta, E., Gabriel, C., Mocaër, E., Prisco, S. D., Merega, E., Pittaluga, A., Nicoletti, F., Maccari, S., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4131-13.2014 · Cited by 103 · see citing works

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

Ito, M., Ibi, T., Sahashi, K., et al. (2011) · Medical Gas Research · doi:10.1186/2045-9912-1-24 · Cited by 80 · see citing works

Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice

Ding, J., Li, Q., Wang, X., Sun, C., Lu, C., & Xiao, B. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06876.x · Cited by 79 · see citing works

High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon

Tirosh, O., Levy, E., & Reifen, R. M. (2007) · Nutrition · doi:10.1016/j.nut.2007.08.019 · Cited by 77 · see citing works

Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice

Reichmann, F., Hassan, A. M., Farzi, A., Jain, P., Schuligoi, R., & Holzer, P. D. (2015) · Scientific Reports · doi:10.1038/srep09970 · Cited by 76 · see citing works

Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy

Hasanvand, A., Amini-Khoei, H., Hadian, M. R., Abdollahi, A., Tavangar, S. M., Dehpour, A. R., Semiei, E., & Mehr, S. E. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0275-2 · Cited by 75 · see citing works

Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse

Amiri, S., Amini-Khoei, H., Mohammadi‐Asl, A., Alijanpour, S., Haj‐Mirzaian, A., Rahimi-Balaei, M., Razmi, A., Olson, C. O., Rastegar, M., Mehdizadeh, M., et al. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.052 · Cited by 72 · see citing works

Oral Administration of Curcumin Emulsified in Carboxymethyl Cellulose Has a Potent Anti-inflammatory Effect in the IL-10 Gene-Deficient Mouse Model of IBD

Ung, V., Foshaug, R. R., MacFarlane, S. M., et al. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0843-z · Cited by 71 · see citing works

Elevated level of nitric oxide mediates the anti-depressant effect of rubidium chloride in mice

Kordjazy, N., Haj‐Mirzaian, A., Amiri, S., Ostadhadi, S., Kordjazy, M., Sharifzadeh, M. S., & Dehpour, A. R. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.030 · Cited by 69 · see citing works

The effects of psychiatric treatment on depression, anxiety, quality of life, and sexual dysfunction in patients with inflammatory bowel disease

Yanartas, Ö., Kani, H. T., Bicakci, E., Kilic, I., Banzragch, M., Acikel, C., Atug, O., Kuscu, K., Imeryuz, N., & Akin, H. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106039 · Cited by 69 · see citing works

High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior

Wu, T., Liu, L., Zhang, W., Zhang, Y., Liu, Y., Shen, X.-L., Gong, H., Yang, Y., Bi, X., Jiang, C., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.016 · Cited by 68 · see citing works

Blockade of NMDA receptors reverses the depressant, but not anxiogenic effect of adolescence social isolation in mice

Haj‐Mirzaian, A., Amiri, S., Kordjazy, N., Rahimi-Balaei, M., Haj‐Mirzaian, A., Marzban, H., Aminzadeh, A., Dehpour, A. R., & Mehr, S. E. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.01.006 · Cited by 67 · see citing works

Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice

Hassan, A. M., Jain, P., Reichmann, F., Mayerhofer, R., Farzi, A., Schuligoi, R., & Holzer, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00386 · Cited by 59 · see citing works

Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine

Sonei, N., Amiri, S., Jafarian, I., Anoush, M., Rahimi-Balaei, M., Bergen, H., Haj‐Mirzaian, A., & Hosseini, M. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2016.1149218 · Cited by 59 · see citing works

Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice

Amiri, S., Haj-Mirzaian, A., Momeny, M., Amini-Khoei, H., Rahimi-Balaei, M., Poursaman, S., Rastegar, M., Nikoui, V., Mokhtari, T., Ghazi-Khansari, M., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.003 · Cited by 58 · see citing works

Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function

Amiri, S., Amini-Khoei, H., Haj‐Mirzaian, A., Rahimi-Balaei, M., Naserzadeh, P., Dehpour, A. R., Mehr, S. E., & Hosseini, M. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.09.009 · Cited by 53 · see citing works

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines

Li, J., Dong, Y., Chen, H., et al. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.031 · Cited by 53 · see citing works

Glutathione mediated reductive activation and mitochondrial dysfunction play key roles in lithium induced oxidative stress and cytotoxicity in liver

Eskandari, M. R., Fard, J. K., Hosseini, M., & Pourahmad, J. (2012) · BioMetals · doi:10.1007/s10534-012-9552-8 · Cited by 53 · see citing works

Attenuation of oxidative and nitrosative stress in cortical area associates with antidepressant-like effects of tropisetron in male mice following social isolation stress

Haj‐Mirzaian, A., Amiri, S., Amini-Khoei, H., Rahimi-Balaei, M., Kordjazy, N., Olson, C. O., Rastegar, M., Naserzadeh, P., Marzban, H., Dehpour, A. R., et al. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.018 · Cited by 52 · see citing works

Psychological factors and stress in inflammatory bowel disease

Triantafillidis, J. K., Merikas, E., & Gikas, A. (2013) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.13.4 · Cited by 50 · see citing works

Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway

Heydarpour, P., Rahimian, R., Fakhfouri, G., Khoshkish, S., Fakhraei, N., Salehi-Sadaghiani, M., Wang, H., Abbasi, A., Dehpour, A. R., & Ghia, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.004 · Cited by 49 · see citing works

On the benefit of Teucrium in murine colitis through improvement of toxic inflammatory mediators

Abdolghaffari, A. H., Baghaei, A., Moayer, F., et al. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110361754 · Cited by 49 · see citing works

Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance

Sun, Y., Cai, T., Shen, Y., Zhou, X., Chen, T., & Xu, Q. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.08.017 · Cited by 48 · see citing works

Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder

Petit, A., Quesseveur, G., Gressier, F., Colle, R., David, D. J. P., Gardier, A. M., Ferreri, F., Lépine, J., Falissard, B., Verstuyft, C., et al. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.04.013 · Cited by 46 · see citing works

TBK1-Targeted Suppression of TRIF-Dependent Signaling Pathway of Toll-Like Receptors by 6-Shogaol, an Active Component of Ginger

Park, S., Lee, M., Son, B., et al. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80738 · Cited by 45 · see citing works

Effectiveness of disease-specific cognitive–behavioural therapy on depression, anxiety, quality of life and the clinical course of disease in adolescents with inflammatory bowel disease: study protocol of a multicentre randomised controlled trial (HAPPY-IBD)

van den Brink, G., Stapersma, L., Marroun, H. E., Henrichs, J., Szigethy, E., Utens, E. M. W. J., & Escher, J. C. (2016) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2015-000071 · Cited by 34 · see citing works

Psychiatric Diagnoses in Ulcerative Colitis

Magni, G., Bernasconi, G. F., Mauro, P., D’Odorico, A., Sturniolo, G. C., Canton, G., & Martin, A. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.3.413 · Cited by 33 · see citing works

Evidence for the role of the brain–gut axis in inflammatory bowel disease: depression as cause and effect?

Taché, Y., & Bernstein, C. N. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.032 · Cited by 32 · see citing works

Tropisetron suppresses colitis-associated cancer in a mouse model in the remission stage

Amini-Khoei, H., Momeny, M., Abdollahi, A., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.014 · Cited by 31 · see citing works

Depression and anxiety: Role of mitochondria

Burroughs, S. L., & French, D. (2007) · Current Anaesthesia and Critical Care · doi:10.1016/j.cacc.2007.01.007 · Cited by 29 · see citing works

Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

Ghanizadeh, A. J., & Berk, M. (2013) · Medical Gas Research · doi:10.1186/2045-9912-3-11 · Cited by 28 · see citing works

Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort

Senhaji, N., Serrano, A., Badre, W., et al. (2015) · Genes and Immunity · doi:10.1038/gene.2015.52 · Cited by 28 · see citing works

Studies on Psychiatric Disorders

Dietrich‐Muszalska, A., Chauhan, V. P. S., & Grignon, S. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2 · Cited by 28 · see citing works

Psychoneuroimmunologic factors in inflammatory bowel disease

Mackner, L. M., Clough-Paabo, E., PAJER, K. A., Lourie, A., & Crandall, W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21430 · Cited by 25 · see citing works

On the benefit of galls of Quercus brantii Lindl. in murine colitis: the role of free gallic acid

Khanavi, M., Sabbagh-Bani-Azad, M., Abdolghaffari, A. H., Vazirian, M., Isazadeh, I., Rezvanfar, M. A., Baeeri, M., Mohammadirad, A., Rahimi, R., Shams‐Ardekani, M. R., et al. (2014) · Archives of Medical Science · doi:10.5114/aoms.2014.47831 · Cited by 24 · see citing works

Neuroinflammation and Immunity: A New Pharmacological Target in Depression

Crupi, R., & Cuzzocrea, S. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160321105339 · Cited by 20 · see citing works

NPRA-mediated suppression of AngII-induced ROS production contribute to the antiproliferative effects of B-type natriuretic peptide in VSMC

Gao, P., Qian, D., Li, W., & Huang, L. J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9995-y · Cited by 19 · see citing works

Amelioration of Severe TNBS Induced Colitis by Novel AP-1 and NF-κB Inhibitors in Rats

El‐Salhy, M., Umezawa, K., Gilja, O. H., Hatlebakk, J. G., Gundersen, D., & Hausken, T. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/813804 · Cited by 18 · see citing works

Compromised neuroimmune status in rats with experimental colitis

Boisse, L., Sickle, M. D. V., Sharkey, K. A., & Pittman, Q. J. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00929.x · Cited by 11 · see citing works

Compromised neuroimmune status in rats with experimental colitis

Lomax, L. B., Sickle, M. D. V., Sharkey, K. A., & Pittman, Q. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034546 · Cited by 9 · see citing works

Mitochondrial Dysfunction in Psychiatric Disorders

Rossignol, D. A., & Frye, R. E. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_12 · Cited by 5 · see citing works

P-079 YI The Association Between Anxiety and Depression and Health Related Quality of Life in Patients with Inflammatory Bowel Disease (IBD)

Chauhan, U., Farbod, Y., Marshall, J. K., Halder, S. L. S., Armstrong, D., Tse, F., Popov, J., Kaasalainen, S., & Moayyedi, P. (2016) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000480173.43285.d1 · Cited by 3 · see citing works

Behavioral Comorbidities in Dextran Sulphate Sodium (DSS) Colitis, an animal model of Inflammatory Bowel Diseases

Nyuyki‐Dufe, K., Cluny, N. L., Sharkey, K. A., et al. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.lb637 · Cited by 3 · see citing works

Novel targets identified in gene expression profiles from patients with inflammatory bowel disease

Alex, P., Frank, M. A., Dozmorov, I. M., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200705001-00012 · Cited by 1 · see citing works

Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

Bisgaard, T. H., Allin, K. H., Keefer, L., Ananthakrishnan, A. N., & Jess, T. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00634-6 · Cited by 572 · see citing works

Inflammation from peripheral organs to the brain: how does systemic inflammation cause Neuroinflammation?

Sun, Y., Koyama, Y., & Shimada, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903455 · Cited by 304 · see citing works

Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications

Ge, L., Liu, S., Li, S., Yang, J., Hu, G., Xu, C., & Song, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016578 · Cited by 187 · see citing works

Stress triggers flare of inflammatory bowel disease in children and adults

Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works

Schizophrenia and risk of new-onset inflammatory bowel disease: A nationwide longitudinal study

Sung, K., Zhang, B., Wang, H. E., Bai, Y., Tsai, S., Su, T., Chen, T., Hou, M., Lu, C., Wang, Y., et al. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16856 · Cited by 38 · see citing works

Involvement of <scp>l</scp>‐arginine‐nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice

Ben‐Azu, B., Aderibigbe, A. O., Ajayi, A. M., Umukoro, S., & Iwalewa, E. O. (2019) · Drug Development Research · doi:10.1002/ddr.21588 · Cited by 21 · see citing works

Causal associations between inflammatory bowel disease and anxiety: A bidirectional Mendelian randomization study

He, Y., Chen, C.-L., He, J., & Liu, S.-D. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i44.5872 · Cited by 10 · see citing works

The fifth dimension of innate immunity

Schmidt, C., Schneble, N., & Wetzker, R. (2014) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-014-0246-6 · Cited by 14 · see citing works

Innate Immunity in Allergic Disease

Sabroe, I. (2008) · Allergy and Allergic Diseases · doi:10.1002/9781444300918.ch9 · Cited by 1 · see citing works

The Innate Immunity

Sun, H., Sun, C., & Tian, Z. (2016) · Springer eBooks · doi:10.1007/978-94-024-0902-4_2

The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

Silva, M. J. D., Vilegas, W., da Silva, M. A., et al. (2017) · Drug Research · doi:10.1055/s-0043-119750 · Cited by 8 · see citing works

LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection

Bernheiden, M., Heinrich, J., Minigo, G., et al. (2001) · Journal of Endotoxin Research · doi:10.1177/09680519010070060901 · Cited by 73 · see citing works