CoChat
Sign Up
Cited by 219Neurotransmitter Receptor Influence on BehaviorAnimal Behavior and ReproductionStress Responses and Cortisol

The DOI matches its Crossref record; 89 of the 91 references it cites were found in a registry or an index.

Individual Variation in Aggression of Feral Rodent Strains: A Standard for the Genetics of Aggression and Violence?

de Boer, Sietse F., van der Vegt, Bea J., Koolhaas, Jaap M.·2003·Behavior Genetics
DOI 10.1023/a:1025766415159
Open this paper in CoChat — free account

Abstract

This article summarizes the broad individual differences in aggressiveness and its relationship with several other behavioral, physiological, and neurobiological characteristics that exist in an outbred laboratory strain of male feral rats. Based on the observations that the individual level of offensive aggressive behavior (i.e., the tendency to defend the home territory) is strongly related to the way they react to various other environmental challenges, it is argued that the individual's level of offensiveness is an important indicator and component of a more traitlike behavioral physiological response pattern (coping strategy) to environmental demands. The coping style of aggressive animals is principally aimed at a (pro)active prevention or manipulation of a stressor, whereas the nonaggressive individuals tend to passively accept or react to it. The (pro)active and reactive/passive behavioral coping styles are clearly associated with distinct patterns of autonomic/endocrine (re)activity and underlying neurobiological correlates and determinants. Consequently, these individual differences in aggression/coping style may not only determine the individual vulnerability to stress-related disease, and hence be an important factor in the population dynamics of the species, but may also determine responsivity to pharmacotherapeutic treatments. From an animal modeling point of view, it is argued that the aggressive extremes of this variation may, under the proper testing conditions, have an enhanced propensity to develop pathological forms of aggression and/or coping, for example, antisocial traits, violence, or impulsivity disorders. Finally, it is proposed that the use of these feral animals as base "material" for genetic association (i.e., QTL search, mRNA differential expression, nucleic acid microarray analysis) and manipulation (i.e., gene silencing or amplification by antisense ODN, siRNA, and/or viral gene-transfer methodologies) studies would most likely be the best option for dissecting successfully the genetic basis of both normal and pathological forms of aggression and/or coping.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1025766415159

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 12

  1. Barnett, S. A. (1975). The rat: A study of behavior. Chicago: The University of Chicago Press.
  2. Coccaro, E. F., and Kavoussi, R. J. (1996). Neurotransmitter correlates of aggression. In D. M. Stoff and R. B. Cairns (Eds.). The neurobiology of clinical aggression (pp. 67-85). Mahwah, NJ: Lawrence J. Erlbaum Associates Inc.
  3. de Boer, S. F., van der Vegt, B. J., and Koolhaas, J. M. (2001). Hypersensitivity of 5-HT1A and 5-HT1B autoreceptors as a causal neuromechanism underlying high trait aggressiveness. Soc. Neurosci. Abstr. 89:7.
  4. Koolhaas, J. M., Moor, E., Hiemstra, Y., and Bohus, B. (1991). The testosterone dependent vasopressinergic neurons in the medial amygdala and lateral septum: Involvement in social behavior of male rats. In S. Jard and R. Jamison (Ed.), Vasopressin (pp. 213-219). Paris-London: Inserm/John Libbey Eurotexty Ltd.
  5. Menard, J. L., and Meaney, M. J. (2001). Maternal care in early life influences patterns of defensive responding and associated fos expression in adulthood. Soc. Neurosci. Abstr. 541:4.
  6. Olivier, B., Mos, J., Raghoebar, M., de Koning, P., and Mak, M. (1994). Serenics. In E. Jucker (Eds.), Progress in drug research (Vol. 42, pp. 167-308). Basel: Birkhauser Verlag.
  7. Scott, J. P. (1958). Aggression. Chicago: The University of Chicago Press.
  8. Smit, J., van Oosten, R. V., Palm, I. F., Doze, P., Koolhaas, J. M., and Zaagsma, J. (1998). Prejunctional modulation of noradrenergic neurotransmission in wild type rats: A possible relationship with coping styles. Am. J. Physiol. 7:111-122.
  9. Timmermans, P. J. A. (1978). Social behavior in the rat. PhD thesis. University of Nijmegen.
  10. van Hooff, J. A. R. A. M. (1977). The adaptive meaning of aggressive behavior. In P. R. Wiepkema and J. A. R. A. M. van Hooff (Eds.), Aggressive behavior: Causes and functions. Utrecht: Bohn, Scheltema and Holkema.
  11. van Oortmerssen, G. A., and Busser, J. (1989). Disruptive selection on aggression as a possible force in evolution. In P. F. Brain, D. Mainardi, and S. Parmigiani (Eds.), House mouse aggression: A model for understanding the evolution of social behavior (pp. 87-116). Chur: Harwood Academic.
  12. Wilson, E. A. (1975). Sociobiology. Cambridge: Belknap Press, Harvard University Press.

Cited by

Sorted by citations

See all 219

Related

See all

Metadata

Authors
de Boer, S. F., van der Vegt, B. J., & Koolhaas, J. M.
Venue
Behavior Genetics
Publisher
Springer Science and Business Media LLC
Published
2003-09
Volume
33
Issue
5
Pages
485-501
ISSN
  • 0001-8244 (ISSN-L)
  • 1573-3297
DOI
10.1023/a:1025766415159
OpenAlex
W2151519006
Cited by
219
References
91
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 15 · 2016: 16 · 2015: 6 · 2014: 19 · 2013: 12 · 2012: 7
FWCI
3.23
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Behavior Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
aggression, individual differences, coping styles, proactive coping, reactive coping, stress response, neurobiology of aggression, antisocial behavior, impulse control disorders, genetic association, quantitative trait loci, gene silencing, antisense oligonucleotides, viral gene delivery
MeSH terms
Aggression, Animals, Animals, Wild, Catecholamines, Corticosterone, Female, Housing, Animal, Male, Reaction Time, Genetic Variation, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review