CoChat
Sign Up
Cited by 88Posttraumatic Stress Disorder ResearchMigration, Health and TraumaChild Abuse and Trauma

Co‐twin control study of relationships among combat exposure, combat‐related PTSD, and other mental disorders

Koenen, Karestan C., Lyons, Michael J., Goldberg, Jack, Simpson, John, Williams, Wesley M., Toomey, Rosemary, Eisen, Seth A., True, William +1 more·2003·Journal of Traumatic Stress
DOI 10.1023/a:1025786925483
Open this paper in CoChat — free account

Abstract

The well-documented association between combat-related PTSD (C-PTSD) and other mental disorders may be an artifact of shared familial vulnerability. This study uses a co-twin control design to examine whether the association between C-PTSD and other mental disorders persists after adjusting for shared familial vulnerability. Data were from male monozygotic twin pairs in the Vietnam Era Twin Registry. Logistic regression analyses demonstrated that combat exposure, adjusted for C-PTSD, was significantly associated with increased risk for alcohol and cannabis dependence and that C-PTSD mediated the association between combat exposure and both major depression and tobacco dependence. We conclude C-PTSD comorbidity persists after controlling for shared vulnerability. Combat exposure is directly and indirectly, through C-PTSD, associated with increased risk for other mental disorders.

Integrity signals

Registry

Crossref · 10.1023/a:1025786925483

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The current study's null findings for other traumatic SLEs are not in accordance with previous genetically informative studies that found increased depression risk associated with combat exposure and somatic illness/injury.

    “This is not in accordance with results from previous genetically informative studies, which have found increased depression risk associated with combat exposure (Koenen et al., 2003) and somatic illness and injury (Kendler et al., 1999a).”

    From Stressful life events increase the risk of major depressive episodes: A population-based twin study (2023) · cites this paper as Koenen et al., 2003

  • Previous genetically informative studies have found increased depression risk associated with combat exposure and somatic illness/injury.

    “previous genetically informative studies, which have found increased depression risk associated with combat exposure (Koenen et al., 2003) and somatic illness and injury (Kendler et al., 1999a).”

    From Stressful life events increase the risk of major depressive episodes: A population-based twin study (2023) · cites this paper as Koenen et al., 2003

Cited by

Sorted by citations

Authors
Koenen, K. C., Lyons, M. J., Goldberg, J., Simpson, J., Williams, W. M., Toomey, R., Eisen, S. A., True, W., & Tsuang, M. T.
Affiliations
  • Boston University (US)
  • University of Washington (US)
  • Harvard University (US)
  • Washington University in St. Louis (US)
  • St. Louis VA Medical Center (US)
Corresponding author
Koenen, Karestan C.
ORCID
Venue
Journal of Traumatic Stress
Publisher
Wiley
Published
2003-10
Volume
16
Issue
5
Pages
433-438
ISSN
  • 0894-9867 (ISSN-L)
  • 1573-6598
DOI
10.1023/a:1025786925483
OpenAlex
W2100365790
Cited by
88
References
0
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 2
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 638 d)
Locations
  • Journal of Traumatic Stress (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01aa010339-03)
  • Centers for Disease Control and Prevention
  • National Institute on Alcohol Abuse and Alcoholism (R01AA010586, AA-10339, AA10586)
  • National Institute of Mental Health (MH11954-01, F31MH011954)
  • National Institute on Drug Abuse (R01DA004604, DA-04604)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
combat-related PTSD, combat exposure, alcoholism, cannabis use disorder, major depressive disorder, tobacco dependence, Vietnam Era Twin Registry, monozygotic twins, mediation
MeSH terms
Adult, Alcohol Drinking, Mental Disorders, Marijuana Abuse, Humans, Male, Middle Aged, Military Personnel, Risk Factors, Stress Disorders, Post-Traumatic, Warfare, Comorbidity, Odds Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review