Cited by 145Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and AccessMental Health Research Topics

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Clinical significance and comorbidity of subthreshold depression and anxiety in the community

Preisig, M., Merikangas, K. R., Angst, J.·2001·Acta Psychiatrica Scandinavica

DOI 10.1034/j.1600-0447.2001.00284.x

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Abstract

OBJECTIVE: This report examines: 1) the magnitude of co-occurrence of threshold and subthreshold-level depression and anxiety in the community, and 2) the relationship between comorbidity and the diagnostic level of depression and anxiety and their clinical correlates. METHOD: A community sample of 591 subjects was interviewed prospectively five times across 15 years from the ages of 20-35. The diagnostic interview allowed the assignment of diagnoses according to DSM-III criteria and operational definitions of subthreshold syndromes. RESULTS: 1) Comorbidity between depression and anxiety was more frequent when one syndrome reached threshold level; 2) comorbidity at both the threshold and subthreshold diagnostic levels was associated with symptom severity, disability and treatment, whereas the diagnostic level was associated with disability and suicidal attempts. CONCLUSION: The systematic association between comorbidity across diagnostic threshold levels of anxiety and depression with clinical correlates suggests the importance of a more dimensional approach to their classification.

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Authors: Preisig, M., Merikangas, K. R., & Angst, J.
Affiliations: University of Lausanne (CH)
Yale University (US)
Psychiatrische Universitätsklinik Zürich (CH)
ORCID: Preisig, M.
Merikangas, K. R.
Angst, J.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2001-08
Volume: 104
Issue: 2
Pages: 96-103
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1034/j.1600-0447.2001.00284.x
OpenAlex: W2094870250
Cited by: 145
References: 33
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 8 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 6
FWCI: 8.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 817 d)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: Systematics Association
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
U.S. Public Health Service (KO2-0499)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: subthreshold depression, subthreshold anxiety, comorbid depression and anxiety, dimensional classification, symptom severity, disability, suicide attempts, community mental health, young adults
MeSH terms: Adult, Anxiety Disorders, Depressive Disorder, Diagnosis, Differential, Female, Humans, Longitudinal Studies, Male, Comorbidity, Incidence

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Clinical significance and comorbidity of subthreshold depression and anxiety in the community

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