Cited by 172Skin Protection and AgingSmoking Behavior and CessationDermatologic Treatments and Research

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Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies

Yin, Lei, Morita, Akimichi, Tsuji, Takuo·2001·Photodermatology, Photoimmunology & Photomedicine

DOI 10.1034/j.1600-0781.2001.170407.x

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Abstract

Background: Tobacco smoking, similar to ultraviolet (UV) A radiation exposure, has previously been identified as an important factor contributing to premature aging of human skin. Objective and design: To investigate the relationship between these two environmental factors, we have conducted a cross‐sectional study of 83 subjects (48 males, 35 females, age range 23–95), in which sun exposure, pack‐years of smoking history and potential confounding variables were assessed by questionnaire. Facial wrinkles were quantified using the Daniell score. In order to study the molecular mechanism by which smoking caused wrinkle formation, in vitro studies were conducted to assess the alteration of matrix metalloproteinase‐1 (MMP‐1) mRNA expression in human fibroblasts stimulated with tobacco smoke extract or/and UVA. Results: Logistic statistic analysis of the data revealed that age [odds ratio (OR)=7.5, 95% confidence interval (CI)=1.87–30.16], pack‐years (OR=5.8, 95% CI=1.72–19.87), and sun exposure (OR=2.65, 95% CI=1.0–7.0) independently contributed to facial wrinkle formation. When excessive sun exposure (>2 h/day) and heavy smoking (35 pack‐years) occurred together, the risk for developing wrinkles was 11.4 times higher than that of non‐smokers and those with less sun exposure (<2 h/day) at the same age. The in vitro studies revealed that MMP‐1 expression was significantly increased in fibroblasts after the stimulation with either tobacco smoke extract or UVA. Maximum induction was observed when cells were treated with tobacco smoke extract plus UVA, indicating that the two factors act in an additive manner. MMP‐1 induction was significantly higher in the low glutathione (GSH) content fibroblast compared to that in the high GSH fibroblast, indicating that the differences in glutathione content define the susceptibility of fibroblasts towards UV‐ or tobacco smoking‐induced MMP‐1 expression. Conclusion: Tobacco smoke and UVA cause wrinkle formation independently of each other. We propose that both factors cause aging of human skin through additive induction of MMP‐1 expression.

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Sunlight Exposure May Be a Risk Factor of Hearing Impairment: A Community-Based Study in Japanese Older Men and Women
Michikawa, T., Nishiwaki, Y., Asakura, K., Hillebrand, G. G., Miyamoto, K., Ono, M., Kinjo, Y., Akiba, S., & Takebayashi, T. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls114 · Cited by 17
Tabakabh�ngigkeit und die Folgen auf die Haut
Krug, M., W�nsche, A., & Blum, A. (2004) · Der Hautarzt · doi:10.1007/s00105-003-0674-3 · Cited by 16
The combination of cigarette smoke and solar rays causes effects similar to skin aging in a bilayer skin model
Grenier, A., Morissette, M. C., Rochette, P. J., & Pouliot, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-44868-z · Cited by 17
Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells
Kim, H., Park, W. S., BAEK, J.-I., et al. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.2030 · Cited by 14
“Studies have demonstrated that skin aging induced by UV exposure is mediated by the upregulation of MMP1 expression (6,24).”
Background
Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
Tsuchida, K., & Kobayashi, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-78884-0 · Cited by 14
Lipid Peroxidation as the Mechanism Underlying Polycyclic Aromatic Hydrocarbons and Sunlight Synergistic Toxicity in Dermal Fibroblasts
Larnac, E., Montoni, A., Haydont, V., Marrot, L., & Rochette, P. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031905 · Cited by 13
Use microfluidic chips to study the effects of ultraviolet lights on human fibroblasts
Huang, C.-H., Hou, H.-S., Lo, K., et al. (2017) · Microfluidics and Nanofluidics · doi:10.1007/s10404-017-1922-7 · Cited by 13
Skin Protective Activity of Consciousness Energy Healing Treatment Based Herbomineral Formulation
Smith, D. M. (2017) · Journal of Food and Nutrition Sciences · doi:10.11648/j.jfns.20170503.15 · Cited by 13
“The intrinsic aged skin is due to dryness and lack of elastin than youthful skin [39].”
Background
Vitamin C prevents epidermal damage induced by PM‐associated pollutants and UVA1 combined exposure
Dimitrov, A., Zanini, M., Zucchi, H., Boudah, S., Lima, J., Sœur, J., & Marrot, L. (2021) · Experimental Dermatology · doi:10.1111/exd.14315 · Cited by 13
Epidemiology and determinants of facial telangiectasia: a cross‐sectional study
Mekić, S., Hamer, M. A., Wigmann, C., Gunn, D. A., Kayser, M., Jacobs, L. C., Schikowski, T., Nijsten, T. E. C., & Pardo, L. M. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15996 · Cited by 15
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Donato, L., Cecchi, R., Dagoli, S., Treglia, M., Pallocci, M., Zanovello, C., Ubelaker, D. H. V., & Marsella, L. T. (2023) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2023.102614 · Cited by 12
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“187 miological studies tobacco smoking has been identified as an important factor in premature skin aging [6-8].”
Background
A Dermatologist's Ammunition in the War Against Smoking: A Photoaging App
Brinker, T. J., Enk, A. H., Gatzka, M., Nakamura, Y., Sondermann, W., Omlor, A., Petri, M. P., Karoglan, A., Seeger, W., Klode, J., et al. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.8743 · Cited by 11
“Skin damage due to smoking that is culturally associated with a decrease in attractiveness (ie, wrinkles, early hair loss, declined capillary perfusion, pale or grayish skin [7-9]) predominantly affects the self-concept of young people with low education [1], who are at significantly greater risk for tobacco addiction…”
Background
Telangiectasia of the face: risk factors for reappearance in patients treated with dye laser
Guida, S., Galimberti, M., Bencini, M., Pellacani, G., & Bencini, P. L. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14088 · Cited by 12
In contrast to lung fibroblasts – no signs of senescence in skin fibroblasts of patients with emphysema
Müller, K.-C., Paasch, K., Feindt, B., Welker, L., Watz, H., Weise, M., Schmid, R. A., Nakashima, M., Branscheid, D., MAGNUSSEN, H., et al. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.011 · Cited by 10
“The effect is enhanced by sunlight (Yin et al., 2001), but alterations of elastic tissue properties also occur in sun-protected areas (Frances et al., 1991; Helfrich et al., 2007).”
Background
Acquired Disorders of Dermal Connective Tissue
Lovell, C. R. (2016) · doi:10.1002/9781118441213.rtd0097 · Cited by 10
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“MMP-1 has been reported to impact skin aging significantly, and its expression is primarily increased by UV exposure [29,30].”
Cigarette Smoking and Facial Wrinkles: A Review of the Literature
Seitz, C. M., Strack, R. W., & Wyrick, D. L. (2012) · The Journal of Smoking Cessation · doi:10.1017/jsc.2012.8 · Cited by 9
“Yin et al., 2001 N = 83; 23–95 years old; Asian Cross-sectional study from a convenience sample of patients.”
Background
Determinants in the Rate of Skin Aging: Ethnicity, Gender, and Lifestyle Influences
Farage, M. A., Miller, K. W., & Maïbach, H. I. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_92 · Cited by 9
Inhibitory Effects of Coenzyme Q10 on Skin Aging
Ashida, Y. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-2029-0.50017-x · Cited by 8

Authors: Yin, L., Morita, A., & Tsuji, T.
Affiliations: Nagoya City University (JP)
ORCID: Yin, Lei
Morita, Akimichi
Venue: Photodermatology, Photoimmunology & Photomedicine
Publisher: Wiley
Published: 2001-08
Volume: 17
Issue: 4
Pages: 178-183
ISSN: 0905-4383 (ISSN-L)
1600-0781
DOI: 10.1034/j.1600-0781.2001.170407.x
OpenAlex: W2082474879
Cited by: 172
References: 0
Citations by year: 2026: 5 · 2025: 3 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 3 · 2017: 12 · 2016: 11 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 3
FWCI: 6.23
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 142 d)
Locations: Photodermatology Photoimmunology & Photomedicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: skin aging, ultraviolet A radiation, smoking, facial wrinkles, MMP-1, fibroblasts, glutathione, sun exposure, additive effects
MeSH terms: Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Fibroblasts, Glutathione, Humans, Male, Middle Aged, Surveys and Questionnaires, Smoking, Ultraviolet Rays, Skin Aging, Confidence Intervals, Logistic Models, Odds Ratio, Matrix Metalloproteinase 1

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Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies

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