Neural circuit changes mediating lasting brain and behavioral response to predator stress

Adamec, Robert E.; Blundell, Jacqueline; Burton, Paul

doi:10.1016/j.neubiorev.2005.05.007

Cited by 121Memory and Neural MechanismsStress Responses and CortisolNeuroscience and Neuropharmacology Research

Neural circuit changes mediating lasting brain and behavioral response to predator stress

Adamec, Robert E., Blundell, Jacqueline, Burton, Paul·2005·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2005.05.007

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Abstract

This paper reviews recent work which points to critical neural circuitry involved in lasting changes in anxiety like behavior following unprotected exposure of rats to cats (predator stress). Predator stress may increase anxiety like behavior in a variety of behavioral tests including: elevated plus maze, light dark box, acoustic startle, and social interaction. Studies of neural transmission in two limbic pathways, combined with path and covariance analysis relating physiology to behavior, suggest long term potentiation like changes in one or both of these pathways in the right hemisphere accounts for stress induced changes in all behaviors changed by predator stress except light dark box and social interaction. Findings will be discussed within the context of what is known about neural substrates activated by predator odor.

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Stress-induced amygdala morphology and volume changes seem to persist.
“In contrast, stress-induced amygdala morphology and volume changes seem to persist (Vyas et al., 2002, Adamec et al., 2005, Tottenham et al., 2010).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Adamec et al., 2005

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Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors
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The journal of developmental processes
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“In contrast, stress-induced amygdala morphology and volume changes seem to persist (Vyas et al., 2002; Adamec et al., 2005; Tottenham et al., 2010).”
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Low Dose Prenatal Ethanol Exposure Induces Anxiety-Like Behaviour and Alters Dendritic Morphology in the Basolateral Amygdala of Rat Offspring
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The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulus
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Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response
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The aftermath of 9/11: Effect of intensity and recency of trauma on outcome.
Ganzel, B., Casey, B. J., Glover, G., Voss, H. U., & Temple, E. (2007) · Emotion · doi:10.1037/1528-3542.7.2.227 · Cited by 72 · see citing works
CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD
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Role of NMDA receptors in the lateralized potentiation of amygdala afferent and efferent neural transmission produced by predator stress
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Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stress
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Animal models of post-traumatic stress disorder and novel treatment targets
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Manipulation of host behaviour by Toxoplasma gondii: what is the minimum a proposed proximate mechanism should explain?
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Stress and the healthy adolescent brain: Evidence for the neural embedding of life events
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Stress as a one-armed bandit: Differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala
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Environmental Enrichment Reduces Anxiety by Differentially Activating Serotonergic and Neuropeptide Y (NPY)-Ergic System in Indian Field Mouse (Mus booduga): An Animal Model of Post-Traumatic Stress Disorder
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A distinct pattern of intracellular glucocorticoid-related responses is associated with extreme behavioral response to stress in an animal model of post-traumatic stress disorder
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Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone
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Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience
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Modulation of Aversive Memory by Adult Hippocampal Neurogenesis
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Glucocorticoids are required for extinction of predator stress-induced hyperarousal
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The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle
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Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions
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Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models
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Transitional and translational studies of risk for anxiety
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Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
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Supplementation with macular carotenoids reduces psychological stress, serum cortisol, and sub-optimal symptoms of physical and emotional health in young adults
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Cat odor causes long-lasting contextual fear conditioning and increased pituitary-adrenal activation, without modifying anxiety
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The NMDA receptor antagonist CPP blocks the effects of predator stress on pCREB in brain regions involved in fearful and anxious behavior
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Conditioned place aversion organized in the dorsal periaqueductal gray recruits the laterodorsal nucleus of the thalamus and the basolateral amygdala
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Oxidant/antioxidant effects of chronic exposure to predator odor in prefrontal cortex, amygdala, and hypothalamus
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Long-lasting FosB/ΔFosB immunoreactivity in the rat brain after repeated cat odor exposure
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The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice
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Genetic predisposition to anxiety-related behavior predicts predator odor response
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Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder
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Late glucocorticoid receptor antagonism changes the outcome of adult life stress
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Corticosterone mitigates the stress response in an animal model of PTSD
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Previous stress exposure enhances both anxiety-like behaviour and p35 levels in the basolateral amygdala complex: Modulation by midazolam
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Evidence for hemispheric specialization in the marmoset (Callithrix penicillata) based on lateralization of behavioral/neurochemical correlations
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Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress
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Activation patterns of cells in selected brain stem nuclei of more and less stress responsive rats in two animal models of PTSD – Predator exposure and submersion stress
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The amygdala to periaqueductal gray pathway: Plastic changes induced by audiogenic kindling and reversal by gabapentin
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Behavioural characteristics of dogs removed from hoarding situations
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Prolonged stress will induce Alzheimer’s disease in elderly people by increased release of homocysteic acid
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Knowledge of lateralized brain function can contribute to animal welfare
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Elevated pCREB in the PAG after exposure to the elevated plus maze in rats previously exposed to a cat
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Mitigation of adverse behavioral impact from predator exposure by the nociceptin/orphanin FQ peptide antagonist J-113397 in rats
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Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation
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Long lasting effects of predator stress on pCREB expression in brain regions involved in fearful and anxious behavior
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Adaptation or pathology? The role of prenatal stressor type and intensity in the developmental programing of adult phenotype
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Noradrenergic and dopaminergic involvement in novelty modulation of aversive memory generalization of adult rats
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Authors: Adamec, R. E., Blundell, J., & Burton, P.
Affiliations: Memorial University of Newfoundland (CA)
Corresponding author: Adamec, Robert E.
ORCID: Burton, Paul
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2005
Volume: 29
Issue: 8
Pages: 1225-1241
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2005.05.007
OpenAlex: W2042734298
Cited by: 121
References: 100
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 9
FWCI: 5.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: predator stress, anxiety-like behavior, neural circuits, long-term potentiation, right hemisphere, predator odor, acoustic startle response, social interaction, elevated plus maze, light-dark box, rats
MeSH terms: Action Potentials, Amygdala, Analysis of Variance, Animals, Behavior, Animal, Brain, Cats, Electric Stimulation, Exploratory Behavior, Functional Laterality, Male, Nerve Net, Neuronal Plasticity, Periaqueductal Gray, Random Allocation, Reaction Time, Reflex, Startle, Stress, Psychological, Maze Learning, Rats, Long-Evans, Rats

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Neural circuit changes mediating lasting brain and behavioral response to predator stress

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