The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat
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Recent findings reveal qualitative developmental differences in extinction of learned fear. The present study explored potential developmental differences in the role of NMDA in acquisition and extinction. Rats were injected with MK-801 prior to fear conditioning or extinction training. Acquisition was found to be NMDA dependent in both age groups, whereas extinction was found to be NMDA dependent in 23-day-old rats, but NMDA independent in 16-day-old rats. These results illustrate another fundamental developmental difference in extinction as well as a dissociation in the role of NMDA in the acquisition and extinction of fear early in development.
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NMDA is involved in extinction in postweaning and adult rats.
“but is in postweaning and adult rats (Baker and Azorlosa, 1996;Langton et al, 2007;Langton and Richardson, 2008).”
From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Langton et al, 2007
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- Authors
- Langton, J. M., Kim, J. H., Nicholas, J., & Richardson, R.
- Affiliations
- UNSW Sydney (AU)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-09-25
- Volume
- 14
- Issue
- 10
- Pages
- 665-668
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W2137852374
- Cited by
- 80
- References
- 29
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 3 · 2012: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Australian Research Council (DP0666953)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- MK-801, NMDA receptor antagonists, learned fear, fear conditioning, fear extinction, developmental differences, synaptic plasticity, early postnatal development
- MeSH terms
- Age Factors, Animals, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Fear, Valine, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Excitatory Amino Acid Antagonists, Freezing Reaction, Cataleptic, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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