Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.

Cardinal, Rudolf N.; Parkinson, John A.; Lachenal, Guillaume; Halkerston, Katherine M.; Rudarakanchana, Nung; Hall, Jeremy; Morrison, Caroline H.; Howes, Simon R.; Robbins, Trevor W.; Everitt, Barry J.

doi:10.1037/0735-7044.116.4.553

Cited by 201Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.

Cardinal, Rudolf N., Parkinson, John A., Lachenal, Guillaume, Halkerston, Katherine M., Rudarakanchana, Nung, Hall, Jeremy, Morrison, Caroline H., Howes, Simon R. +2 more·2002·Behavioral Neuroscience

DOI 10.1037/0735-7044.116.4.553

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Abstract

The nucleus accumbens core (AcbC), anterior cingulate cortex (ACC), and central nucleus of the amygdala (CeA) are required for normal acquisition of tasks based on stimulus-reward associations. However, it is not known whether they are involved purely in the learning process or are required for behavioral expression of a learned response. Rats were trained preoperatively on a Pavlovian autoshaping task in which pairing a visual conditioned stimulus (CS+) with food causes subjects to approach the CS+ while not approaching an unpaired stimulus (CS-). Subjects then received lesions of the AcbC, ACC, or CeA before being retested. AcbC lesions severely impaired performance; lesioned subjects approached the CS+ significantly less often than controls, failing to discriminate between the CS+ and CS-. ACC lesions also impaired performance but did not abolish discrimination entirely. CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations.

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Animals that failed to associate the CS+ with reward were excluded from analysis.
“We excluded animals that did not associate the CS+ with reward.45, 46, 47 Thus, animals that failed to approach screen or reward magazine during CS+ in over 70% of trials (in the last 10 sessions before reversal) and/or failed to avoid screen or reward magazine during CS− less than 70% of trials in the same sessions, were excluded from the analysis.”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [46]

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Effects of limbic corticostriatal lesions on autoshaping performance in rats
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Effects of lesions of the amygdala central nucleus on autoshaped lever pressing
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and was conducted within the MRC Co-operative for Brain, Behaviour and
Cardinal, R. N., Parkinson, J. A., Marbini, H. D., Toner, A. J., Bussey, T. J., Robbins, T. W., Everitt, B. J., Cardinal, R. N., Marbini, H. D., Toner, A. J., et al. (2013)
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Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing
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Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: Further evidence for limbic cortical-ventral striatopallidal systems.
Parkinson, J. A., Willoughby, P. J., Robbins, T. W., & Everitt, B. J. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.1.42 · Cited by 309 · see citing works
Self-citation

Authors: Cardinal, R. N., Parkinson, J. A., Lachenal, G., Halkerston, K. M., Rudarakanchana, N., Hall, J., Morrison, C. H., Howes, S. R., Robbins, T. W., & Everitt, B. J.
Affiliations: University of Cambridge (GB)
ORCID: Cardinal, Rudolf N.
Parkinson, John A.
Rudarakanchana, Nung
Robbins, Trevor W.
Everitt, Barry J.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2002
Volume: 116
Issue: 4
Pages: 553-567
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.116.4.553
OpenAlex: W1980915028
Cited by: 201
References: 84
Citations by year: 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 15 · 2018: 3 · 2017: 9 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 16 · 2012: 11
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: nucleus accumbens core, anterior cingulate cortex, central amygdala, excitotoxic lesions, autoshaping, classical conditioning, stimulus-reward associations, approach behavior, discrimination learning, conditioned stimulus, reward learning
MeSH terms: Amygdala, Animals, Cerebral Cortex, Conditioning, Classical, Discrimination Learning, Male, Nucleus Accumbens, Rats

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Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.

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