The touchscreen cognitive testing method for rodents: How to get the best out of your rat
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The touchscreen testing method for rodents is a computer-automated behavioral testing method that allows computer graphic stimuli to be presented to rodents and the rodents to respond to the computer screen via a nose-poke directly to the stimulus. The advantages of this method are numerous; however, a systematic study of the parameters that affect learning has not yet been conducted. We therefore sought to optimize stimuli and task parameters in this method. We found that when parameters were optimized, Lister Hooded rats could learn rapidly using this method, solving a discrimination of two-dimensional stimuli to a level of 80% within five to six sessions lasting ∼30 min each. In a final experiment we tested both male and female rats of the albino Sprague-Dawley strain, which are often assumed to have visual abilities far too poor to be useful for studies of visual cognition. The performance of female Sprague-Dawley rats was indistinguishable from that of their male counterparts. Furthermore, performance of male Sprague-Dawley rats was indistinguishable from that of their Lister Hooded counterparts. Finally, Experiment 5 examined the ability of Lister Hooded rats to learn a discrimination between photographic stimuli. Under conditions in which parameters were optimized, rats were remarkably adept at this discrimination. Taken together, these experiments served to optimize the touchscreen method and have demonstrated its usefulness as a high-throughput method for the cognitive testing of rodents.
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Available mouse operant touchscreen paradigms seem to have face validity relative to human cognitive touchscreen tasks, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome.
“available mouse operant touchscreen paradigms seem to have face validity63,89,101–104 relative to human cognitive touchscreen tasks97, although there is concern that the cognitive profile of Fmr1-KO mice may not emulate the cognitive deficits in the human syndrome63.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [104]
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- Authors
- Bussey, T. J., Padain, T. L., Skillings, E. A., Winters, B. D., Morton, A. J., & Saksida, L. M.
- Affiliations
- University of Cambridge (GB)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-07
- Volume
- 15
- Issue
- 7
- Pages
- 516-523
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC2505319
- OpenAlex
- W2052032617
- Cited by
- 255
- References
- 29
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 15 · 2023: 16 · 2022: 18 · 2021: 17 · 2020: 17 · 2019: 15 · 2018: 23 · 2017: 21 · 2016: 14 · 2015: 21 · 2014: 11 · 2013: 14 · 2012: 13
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- visual discrimination learning, Lister hooded rats, Sprague-Dawley rats, sex differences in learning, visual cognition
- MeSH terms
- Animals, Cognition, Discrimination Learning, Female, Learning, Male, Psychological Tests, Touch, Visual Perception, Rats, Sprague-Dawley, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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