Apolipoprotein E and Cognitive Performance: A Meta-Analysis.
Abstract
The epsilon4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's disease and may also affect cognitive performance in normal aging. Evidence of the presence and magnitude of epsilon4-related cognitive deficits was examined with a meta-analysis of the available literature. Thirty-eight studies were included, and cognitive performance was collapsed into 8 domains. Results indicated significant APOE-epsilon4 group differences for global cognitive functioning, episodic memory, and executive functioning, in favor of non-epsilon4 carriers. In addition, older age and APOE-epsilon4 heterozygosity was associated with smaller epsilon4-related impairments. The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AβPs and NFTs are present well over a decade before death.
“The interval between initial ADD clinical diagnosis and death is approximately 8 years (129), but AβPs and NFTs are present well over a decade before death (130-138).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [131]
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,347 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works
The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
Reitan, R. M., & Wolfson, D. E. (1993) · Medical Entomology and Zoology · Cited by 3,413 · see citing works
Neuropsychological assessment.
Lisa Cipolotti, A., & Warrington, E. K. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.6.655 · Cited by 3,234 · see citing works
(1995) · Cited by 2,809 · see citing works
Statistical Methods for Meta-Analysis
(1985) · Elsevier eBooks · doi:10.1016/c2009-0-03396-0 · Cited by 2,549 · see citing works
A Compendium of Neuropsychological Tests
Selnes, O. A. (1991) · Neurology · doi:10.1212/wnl.41.11.1856-a · Cited by 2,268 · see citing works
Patterns of Brain Activation in People at Risk for Alzheimer's Disease
Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430701 · Cited by 1,328 · see citing works
Squire, L. R. (1986) · Science · doi:10.1126/science.3086978 · Cited by 1,278 · see citing works
The Journal of Neuropsychiatry and Clinical Neurosciences
Bowden, V. M. (1992) · JAMA · doi:10.1001/jama.1992.03490110111047 · Cited by 1,236 · see citing works
ROGERS, F. B. (1965) · Nature · doi:10.1038/205236a0 · Cited by 565 · see citing works
Haan, M. N. (1999) · JAMA · doi:10.1001/jama.282.1.40 · Cited by 457 · see citing works
Breitner, J. C. S., Wyse, B. W., Anthony, J. C., Welsh-Bohmer, K. A., Steffens, D. C., Norton, M. C., Tschanz, J. T., Plassman, B. L., Meyer, M. R., Skoog, I., et al. (1999) · Neurology · doi:10.1212/wnl.53.2.321 · Cited by 397 · see citing works
A Compendium of Neuropsychological Tests, 2nd ed
(2000) · Archives of Neurology · doi:10.1001/archneur.57.2.278 · Cited by 379 · see citing works
Anstey, K., & Christensen, H. (2000) · Gerontology · doi:10.1159/000022153 · Cited by 377 · see citing works
Ahles, T. A., Saykin, A. J., Noll, W. W., Furstenberg, C. T., Guerin, S. J., Cole, B. F., & Mott, L. A. (2003) · Psycho-Oncology · doi:10.1002/pon.742 · Cited by 357 · see citing works
Activation of medial temporal structures during episodic memory retrieval
Nyberg, L. H., McLntosh, A. R., Houle, S., Nilsson, L.-G., & Tulving, E. (1996) · Nature · doi:10.1038/380715a0 · Cited by 350 · see citing works
Apolipoprotein E polymorphism and coronary artery disease.
Menzel, H. J., Kladetzky, R. G., & Assmann, G. (1983) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.3.4.310 · Cited by 344 · see citing works
Cognitive change and the APOE ɛ4 allele
Deary, I. J., Whiteman, M. C., Pattie, A., Starr, J. M., Hayward, C., Wright, A. F., Carothers, A. D., & Whalley, L. J. (2002) · Nature · doi:10.1038/418932a · Cited by 296 · see citing works
The role of APOE -ε4 in longitudinal cognitive decline
Bretsky, P., Guralnik, J. M., Launer, L. J., Albert, M., & Seeman, T. E. (2003) · Neurology · doi:10.1212/01.wnl.0000055875.26908.24 · Cited by 257 · see citing works
Preliminary Report of a Genetic Basis for Cognitive Decline After Cardiac Operations
Tardiff, B. E., Newman, M. F., Saunders, A. M., Strittmatter, W. J., Blumenthal, J. A., White, W. D., Croughwell, N. D., Davis, R. D., Roses, A. D., & Reves, J. G. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(97)00757-1 · Cited by 256 · see citing works
Episodic memory changes are associated with the APOE- epsilon 4 allele in nondemented older adults
Bondi, M. W., Salmon, D. P., Monsch, A. U., Galasko, D., Butters, N., Klauber, M. R., Thal, L. J., & Saitoh, T. (1995) · Neurology · doi:10.1212/wnl.45.12.2203 · Cited by 236 · see citing works
Bondi, M. W., Salmon, D. P., Galasko, D., Thomas, R. G., & Thal, L. J. (1999) · Psychology and Aging · doi:10.1037//0882-7974.14.2.295 · Cited by 235 · see citing works
Gerdes, L. U., Jeune, B., Andersen‐Ranberg, K., Nybo, H., & Vaupel, J. W. (2000) · Genetic Epidemiology · doi:10.1002/1098-2272(200010)19:3 · Cited by 204 · see citing works
The Apolipoprotein E ϵ4 Allele and Decline in Different Cognitive Systems During a 6-Year Period
Wilson, R. S., Schneider, J. A., Barnes, L. L., Beckett, L. A., Aggarwal, N. T., Cochran, E. J., Berry‐Kravis, E., Bach, J., Fox, J. H., Evans, D. A., et al. (2002) · Archives of Neurology · doi:10.1001/archneur.59.7.1154 · Cited by 192 · see citing works
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Waring, S. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., Thibodeau, S. N., & Kokmen, E. (1998) · Annals of Neurology · doi:10.1002/ana.410430307 · Cited by 187 · see citing works
A gender difference in the association between APOE genotype and age-related cognitive decline
Mortensen, E. L., & Høgh, P. (2001) · Neurology · doi:10.1212/wnl.57.1.89 · Cited by 172 · see citing works
Lehtovirta, M., Laakso, M. P., Soininen, H. S., Helisalmi, S., Mannermaa, A., Helkala, E.-L., Partanen, K. P. L., Ryynänen, M., Vainio, P. A., Hartikainen, P. H., et al. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00014-a · Cited by 172 · see citing works
Bondi, M. W., Salmon, D. P., Galasko, D. R., et al. (1999) · Psychology and Aging · doi:10.1037/0882-7974.14.2.295 · Cited by 170 · see citing works
Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
den Heijer, T., Oudkerk, M., Launer, L. J., van Duijn, C. M., Albert Hofman, D., & Breteler, M. M. B. (2002) · Neurology · doi:10.1212/wnl.59.5.746 · Cited by 169 · see citing works
Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype
Moffat, S. D., Szekely, C. A., Zonderman, A. B., Kabani, N. J., & Resnick, S. M. (2000) · Neurology · doi:10.1212/wnl.55.1.134 · Cited by 169 · see citing works
Horsburgh, K. J., McCarron, M. O., White, F., & Nicoll, J. A. R. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00097-x · Cited by 169 · see citing works
Smith, G. E., Bohac, D. L., Waring, S. C., Kokmen, E., Tangalos, E. G., Ivnik, R. J., & Petersen, R. C. (1998) · Neurology · doi:10.1212/wnl.50.2.355 · Cited by 167 · see citing works
Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
Cohen, R. M., Small, C., Lalonde, F. M., Friz, J., & Sunderland, T. (2001) · Neurology · doi:10.1212/wnl.57.12.2223 · Cited by 161 · see citing works
The apolipoprotein E varepsilon2 allele and decline in episodic memory
Wilson, R. S. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.6.672 · Cited by 161 · see citing works
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease
Lehtovirta, M., Soininen, H. S., Helisalmi, S., Mannermaa, A., Helkala, E.-L., Hartikainen, P. H., Hänninen, T., Ryynänen, M., & Riekkinen, P. J. (1996) · Neurology · doi:10.1212/wnl.46.2.413 · Cited by 154 · see citing works
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease
Growdon, J. H., Locascio, J. J., Corkin, S., Gómez‐Isla, T., & Hyman, B. T. (1996) · Neurology · doi:10.1212/wnl.47.2.444 · Cited by 153 · see citing works
Apolipoprotein E ϵ4 allele and hippocampal volume in twins with normal cognition
Plassman, B. L., Welsh-Bohmer, K. A., Bigler, E. D., Johnson, S. C., Anderson, C. V., Helms, M. J., Saunders, A. M., & Breitner, J. C. S. (1997) · Neurology · doi:10.1212/wnl.48.4.985 · Cited by 145 · see citing works
Apolipoprotein E Phenotype and Cognitive Decline in a Prospective Study of Elderly Community Women
Yaffe, K. S., Cauley, J. A., Sands, L. P., & Browner, W. S. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550210044011 · Cited by 143 · see citing works
Apolipoprotein E ε4 and the pattern of regional brain atrophy in Alzheimer’s disease
Hashimoto, M., Yasuda, M., Tanimukai, S., Matsui, M., Hirono, N., Kazui, H., & Mori, E. (2001) · Neurology · doi:10.1212/wnl.57.8.1461 · Cited by 143 · see citing works
Apolipoproteins and aging: emerging mechanisms
Smith, J. D. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00005-3 · Cited by 131 · see citing works
O'Hara, R. M., Yesavage, J. A., KRAEMER, H. C., Mauricio, M., Friedman, L., & Murphy, G. M. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01532.x · Cited by 130 · see citing works
Juottonen, K., Lehtovirta, M., Helisalmi, S., R., P. J., & Soininen, H. S. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.3.322 · Cited by 130 · see citing works
Working memory and apolipoprotein E: What's the connection?
Rosen, V. M. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00132-x · Cited by 128 · see citing works
Is APOE -ε4 a risk factor for cognitive impairment in normal aging?
Small, B. J., Graves, A. B., McEvoy, C. L., Crawford, F., MULLAN, M. J., & Mortimer, J. A. (2000) · Neurology · doi:10.1212/wnl.54.11.2082 · Cited by 128 · see citing works
Self-citationThe apolipoprotein E gene, attention, and brain function.
Parasuraman, R., Greenwood, P. M., & Sunderland, T. (2002) · Neuropsychology · doi:10.1037//0894-4105.16.2.254 · Cited by 127 · see citing works
APOE-ε4 is associated with memory decline in cognitively impaired elderly
Dik, M. G., Jonker, C., Bouter, L. M., Geerlings, M. I., van Kamp, G. J., & Deeg, D. J. H. (2000) · Neurology · doi:10.1212/wnl.54.7.1492 · Cited by 126 · see citing works
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
Corder, E. H., Lannfelt, L., Viitanen, M. H., Corder, L. S., Manton, K., Winblad, B. G., & Basun, H. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550050048022 · Cited by 120 · see citing works
Preclinical memory decline in cognitively normal apolipoprotein E–ε4 homozygotes
Caselli, R. J., Graff‐Radford, N. R., Reiman, E. M., Weaver, A., Osborne, D., Lucas, J. A., Uecker, A., & Thibodeau, S. N. (1999) · Neurology · doi:10.1212/wnl.53.1.201 · Cited by 120 · see citing works
Tohgi, H., Takahashi, S., Kato, E., Homma, A., Niina, R., Sasaki, K., Yonezawa, H., & Sasaki, M. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00743-x · Cited by 102 · see citing works
Apolipoprotein E4allele in the normal elderly: neuropsychologic and brain MRI correlates
Schmidt, H., Schmidt, R., Fazekas, F., Semmler, J., Kapeller, P., Reinhart, B., & Kostner, G. M. (1996) · Clinical Genetics · doi:10.1111/j.1399-0004.1996.tb02377.x · Cited by 102 · see citing works
The apolipoprotein E gene, attention, and brain function.
Parasuraman, R., Greenwood, P. M., & Sunderland, T. (2002) · Neuropsychology · doi:10.1037/0894-4105.16.2.254 · Cited by 98 · see citing works
Helkala, E.-L., Koivisto, K. J., Hänninen, T., Vanhanen, M., Kervinen, K., Kuusisto, J., Mykkänen, L. M., Kesäniemi, Y. A., Laakso, M., & Riekkinen, P. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12348-x · Cited by 92 · see citing works
The association of apolipoprotein E polymorphism with memory: a population based study
Helkala, E., Koivisto, K. J., Hänninen, T., Vanhanen, M., Kervinen, K., Kuusisto, J., Mykkänen, L. M., Kesäniemi, Y. A., Laakso, M., & Riekkinen, P. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11575-h · Cited by 89 · see citing works
Small, B. J., Basun, H., & Bäckman, L. (1998) · Psychology and Aging · doi:10.1037//0882-7974.13.1.80 · Cited by 81 · see citing works
Self-citationWinnock, M. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.794 · Cited by 81 · see citing works
Deary, I. J., Whiteman, M. C., Pattie, A., Starr, J. M., Hayward, C., Wright, A. F., Visscher, P. M., Tynan, M. C., & Whalley, L. J. (2004) · Psychology and Aging · doi:10.1037/0882-7974.19.2.367 · Cited by 76 · see citing works
No association between apolipoprotein E polymorphisms and general cognitive ability in children
Turic, D., Fisher, P. J., Plomin, R. J., et al. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01789-4 · Cited by 68 · see citing works
Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta, M., Kuikka, J. T., Helisalmi, S., et al. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.6.742 · Cited by 68 · see citing works
Change in cognitive functioning associated with ApoE genotype in a community sample of older adults.
Hofer, S. M., Christensen, H. M., Mackinnon, A. J., Korten, A. E., Jorm, A. F., Henderson, A. S., & Easteal, S. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.2.194 · Cited by 67 · see citing works
Yip, A. G., Brayne, C., Easton, D., & Rubinsztein, D. C. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.9.639 · Cited by 65 · see citing works
Cognitive Function and Apolipoprotein E in Very Old Adults: Findings From the Nun Study
Riley, K. P., Snowdon, D. A., Saunders, A. M., Roses, A. D., Mortimer, J. A., & Nanayakkara, N. (2000) · The Journals of Gerontology Series B · doi:10.1093/geronb/55.2.s69 · Cited by 62 · see citing works
Small, B. J., Basun, H., & Bäckman, L. (1998) · Psychology and Aging · doi:10.1037/0882-7974.13.1.80 · Cited by 62 · see citing works
Self-citationCaselli, R. J., Osborne, D., Reiman, E. M., Hentz, J. G., Barbieri, C. J., Saunders, A. M., Hardy, J., Graff‐Radford, N. R., Hall, G. R., & Alexander, G. E. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00577-9 · Cited by 61 · see citing works
Berr, C., Dufouil, C., Brousseau, T., Richard, F., Amouyel, P., Marceteau, E., & Alpérovitch, A. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13059-7 · Cited by 57 · see citing works
Levy, J. A., Bergeson, J., Putnam, K. T., Rosen, V. M., Cohen, R. M., Lalonde, F. M., MIRZA, N., Linker, G., & Sunderland, T. (2004) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617704103044 · Cited by 50 · see citing works
Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults
Pendleton, N., Payton, A., van den Boogerd, E. H., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00135-0 · Cited by 42 · see citing works
Caselli, R. J., Reiman, E. M., Hentz, J. G., Osborne, D., Alexander, G. E., & Boeve, B. F. (2002) · SLEEP · doi:10.1093/sleep/25.4.437 · Cited by 37 · see citing works
Kim, K. W., Youn, J. C., Jhoo, J. H., et al. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.664 · Cited by 36 · see citing works
Deary, I. J., Whalley, L. J., Clair, D. S., Breen, G. D., Leaper, S., Lemmon, H. A., Hayward, C., & Starr, J. M. (2002) · Intelligence · doi:10.1016/s0160-2896(02)00114-9 · Cited by 32 · see citing works
Does Apolipoprotein E Influence Learning and Memory in the Nondemented Oldest Old?
Salo, A., Ylikoski, R., Verkkoniemi, A., Juva, K., Rastas, S., Polvikoski, T. M., Kontula, K., Kainulainen, K., Niinistö, L., Notkola, I.-L. K., et al. (2001) · International Psychogeriatrics · doi:10.1017/s1041610201007864 · Cited by 31 · see citing works
Apolipoprotein E, Cognitive Function, and Dementia in a General Population Aged 85 Years and Over
Juva, K., Verkkoniemi, A., Viramo, P., Polvikoski, T. M., Kainulainen, K., Kontula, K., & Sulkava, R. O. (2000) · International Psychogeriatrics · doi:10.1017/s1041610200006487 · Cited by 23 · see citing works
Learning and Recall in Subjects at Genetic Risk for Alzheimer's Disease
Chen, J. G., Edwards, C. L., Vidyarthi, S., et al. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.1.58 · Cited by 22 · see citing works
Klages, J. D., Fisk, J. D., & Rockwood, K. J. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000066670 · Cited by 19 · see citing works
Helkala, E.-L., Lakka, T. A., Vanhanen, M., et al. (2001) · Diabetic Medicine · doi:10.1046/j.0742-3071.2001.00588.x · Cited by 13 · see citing works
Nilsson, N., & Crozier, A. (2004) · Comma · doi:10.3828/comma.2004.1.21 · Cited by 6 · see citing works
Talkativeness in Cognitively Normal Women at Genetic Risk for Alzheimer’s Disease
Newman, M. C., Holland, A. L., Caselli, R. J., et al. (2000) · Aging Neuropsychology and Cognition · doi:10.1076/anec.7.4.217.797 · Cited by 3 · see citing works
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6
Flagged first, then by citations
Cited by
Sorted by citations
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Age-associated cognitive decline
Deary, I. J., Corley, J., Gow, A. J., Harris, S. E., Houlihan, L. M., Marioni, R. E., Penke, L., Rafnsson, S. B., & Starr, J. M. (2009) · British Medical Bulletin · doi:10.1093/bmb/ldp033 · Cited by 1,295 · see citing works
Depp, C. A., & Jeste, D. V. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000192501.03069.bc · Cited by 1,292 · see citing works
Brewin, C. R., Kleiner, J. S., Vasterling, J. J., & Field, A. P. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.3.448 · Cited by 290 · see citing works
Head (2012) · doi:10.1001/archneurol.2011.845 · Cited by 267 · see citing works
Fusar‐Poli, P., Cappucciati, M., Rutigliano, G., Schultze‐Lutter, F., Bonoldi, I., Borgwardt, S., Riecher‐Rössler, A., Addington, J., Perkins, D., Woods, S. W., et al. (2015) · World Psychiatry · doi:10.1002/wps.20250 · Cited by 234 · see citing works
Martínez-Morillo, E., Hansson, O., Atagi, Y., Bu, G., Minthon, L., Diamandis, E. P., & Nielsen, H. M. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1266-2 · Cited by 168 · see citing works
Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade
Honjo, K., Black, S. E., & Verhoeff, N. P. L. G. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100015547 · Cited by 152 · see citing works
Dore, G. A., Elias, M. F., Robbins, M. A., Elias, P. K., & Nagy, Z. (2009) · Diabetologia · doi:10.1007/s00125-009-1497-2 · Cited by 81 · see citing works
Homocysteine and cognitive performance: Modification by the ApoE genotype
Elias, M. F., Robbins, M. A., Budge, M. M., Elias, P. K., Dore, G. A., Brennan, S. L., Johnston, C., & Nagy, Z. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.10.021 · Cited by 45 · see citing works
Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging
Papenberg, G., Salami, A., Persson, J., Lindenberger, U., & Bäckman, L. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9279-8 · Cited by 39 · see citing works
Self-citationChang, Y., Fennema‐Notestine, C., Holland, D., McEvoy, L. K., Stricker, N. H., Salmon, D. P., Dale, A. M., Bondi, M. W., & Initiative, A. D. N. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.05.1763 · Cited by 39 · see citing works
Aguilar, C., Muehlboeck, J.-S., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., Lovestone, S., Wahlund, L.-O., Simmons, A., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00145 · Cited by 34 · see citing works
Apolipoprotein E ε4-related thickening of the cerebral cortex modulates selective attention
Espeseth, T., Westlye, L. T., Walhovd, K. B., Fjell, A. M., Endestad, T., Rootwelt, H., & Reinvang, I. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.12.027 · Cited by 32 · see citing works
Ready, R. E., Baran, B., Chaudhry, M., Schatz, K., Gordon, J., & Spencer, R. M. C. (2011) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317511421921 · Cited by 21 · see citing works
Supasitthumrong, T., Tunvirachaisakul, C., Aniwattanapong, D., Tangwongchai, S., Chuchuen, P., Tawankanjanachot, I., Snabboon, T., Hemrungrojn, S., Carvalho, A. F., & Maes, M. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190114 · Cited by 13 · see citing works
- Authors
- Small, B. J., Rosnick, C. B., Fratiglioni, L., & Bäckman, L.
- Affiliations
- University of South Florida (US)
- Karolinska Institutet (SE)
- Max Planck Society (DE)
- Venue
- Psychology and Aging
- Published
- 2004
- Volume
- 19
- Issue
- 4
- Pages
- 592-600
- ISSN
- 0882-7974 (ISSN-L)
- 1939-1498
- OpenAlex
- W2054798938
- Cited by
- 447
- References
- 83
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 13 · 2023: 7 · 2022: 9 · 2021: 26 · 2020: 15 · 2019: 27 · 2018: 15 · 2017: 20 · 2016: 25 · 2015: 24 · 2014: 27 · 2013: 37 · 2012: 26
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychology and Aging (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- apolipoprotein E, APOE ε4, cognitive performance, healthy aging, Alzheimer's disease risk, episodic memory, executive function, age effects, genetic risk factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Alleles, Alzheimer Disease, Apolipoproteins E, Cognition, Female, Genotype, Genetic Carrier Screening, Humans, Male, Middle Aged, Neuropsychological Tests, Reaction Time, Apolipoprotein E4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review