Cited by 447Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCognitive Abilities and Testing

Apolipoprotein E and Cognitive Performance: A Meta-Analysis.

Small, Brent J., Rosnick, Christopher B., Fratiglioni, Laura, Bäckman, Lars·2004·Psychology and Aging

Abstract

The epsilon4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's disease and may also affect cognitive performance in normal aging. Evidence of the presence and magnitude of epsilon4-related cognitive deficits was examined with a meta-analysis of the available literature. Thirty-eight studies were included, and cognitive performance was collapsed into 8 domains. Results indicated significant APOE-epsilon4 group differences for global cognitive functioning, episodic memory, and executive functioning, in favor of non-epsilon4 carriers. In addition, older age and APOE-epsilon4 heterozygosity was associated with smaller epsilon4-related impairments. The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance.

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Crossref · 10.1037/0882-7974.19.4.592

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Authors
Small, B. J., Rosnick, C. B., Fratiglioni, L., & Bäckman, L.
Affiliations
  • University of South Florida (US)
  • Karolinska Institutet (SE)
  • Max Planck Society (DE)
Venue
Psychology and Aging
Published
2004
Volume
19
Issue
4
Pages
592-600
ISSN
  • 0882-7974 (ISSN-L)
  • 1939-1498
OpenAlex
W2054798938
Cited by
447
References
83
Citations by year
2026: 6 · 2025: 8 · 2024: 13 · 2023: 7 · 2022: 9 · 2021: 26 · 2020: 15 · 2019: 27 · 2018: 15 · 2017: 20 · 2016: 25 · 2015: 24 · 2014: 27 · 2013: 37 · 2012: 26
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Locations
  • Psychology and Aging (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
apolipoprotein E, APOE ε4, cognitive performance, healthy aging, Alzheimer's disease risk, episodic memory, executive function, age effects, genetic risk factors
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Alleles, Alzheimer Disease, Apolipoproteins E, Cognition, Female, Genotype, Genetic Carrier Screening, Humans, Male, Middle Aged, Neuropsychological Tests, Reaction Time, Apolipoprotein E4

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