Cited by 593Statistical Methods in Clinical TrialsStatistical Methods and Bayesian InferenceMeta-analysis and systematic reviews

Statistical power and optimal design for multisite randomized trials.

Raudenbush, Stephen W., Liu, Xiaofeng·2000·Psychological Methods

Abstract

The multisite trial, widely used in mental health research and education, enables experimenters to assess the average impact of a treatment across sites, the variance of treatment impact across sites, and the moderating effect of site characteristics on treatment efficacy. Key design decisions include the sample size per site and the number of sites. To consider power implications, this article proposes a standardized hierarchical linear model and uses rules of thumb similar to those proposed by J. Cohen (1988) for small, medium, and large effect sizes and for small, medium, and large treatment-by-site variance. Optimal allocation of resources within and between sites as a function of variance components and costs at each level are also considered. The approach generalizes to quasiexperiments with a similar structure. These ideas are illustrated with newly developed software.

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Crossref · 10.1037/1082-989x.5.2.199

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  • A power analysis indicated that 67 total participants were needed for 80% power to detect a between-group effect size of .70 at 12-month follow-up, and 126 were needed for an effect size of .50.

    “Power analyses, conducted in Optimal Design (see Raudenbush & Liu, 2000), indicated that to reach 80% power, a cross sectional between-group difference (e.g., at 12mFU) with an effect size of .70 required 67 total Ps, whereas a between-group effect size of .50 required 126 total Ps.”

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Authors
Raudenbush, S. W., & Liu, X.
Affiliations
University of Michigan (US)
Venue
Psychological Methods
Published
2000
Volume
5
Issue
2
Pages
199-213
ISSN
  • 1082-989X (ISSN-L)
  • 1939-1463
OpenAlex
W1983489591
Cited by
593
References
3
Citations by year
2026: 9 · 2025: 13 · 2024: 18 · 2023: 22 · 2022: 28 · 2021: 29 · 2020: 30 · 2019: 28 · 2018: 24 · 2017: 28 · 2016: 28 · 2015: 34 · 2014: 29 · 2013: 48 · 2012: 34
FWCI
6.66
Type
journal article
Language
en
Open access
closed
Locations
  • Psychological Methods (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Bayesian Inference
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Keywords
statistical power, sample size determination, optimal design, multilevel analysis, effect size, site effects, resource allocation, quasi-experimental design, mental health research
MeSH terms
Humans, Mathematical Computing, Software, Health Care Rationing, Multicenter Studies as Topic, Linear Models, Randomized Controlled Trials as Topic

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