Moderating effects of a craving intervention on the relation between negative mood and heavy drinking following treatment for alcohol dependence.
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OBJECTIVE: Negative affect is a significant predictor of alcohol relapse, and the relation between negative affect and drinking has been shown to be strongly mediated by alcohol craving. Thus, targeting craving during treatment could potentially attenuate the relation between negative affect and drinking. METHOD: The current study is a secondary analysis of data from the COMBINE study, a randomized clinical trial that combined pharmacotherapy with behavioral intervention in the treatment of alcohol dependence. Our goal in the current study was to examine whether a treatment module that targeted craving would predict changes in negative mood during the 16-week combined behavioral intervention (n = 776) and the relation among changes in mood, craving, and changes in heavy drinking during treatment and 1 year posttreatment. RESULTS: Changes in negative mood were significantly associated with changes in heavy drinking during treatment (f² = 0.78). Participants (n = 432) who received the craving module had significantly fewer heavy drinking days during treatment (d = 0.31), and receiving the module moderated the relation between negative mood and heavy drinking during treatment (f² = 0.92) and 1 year posttreatment (f² = 0.03). Moderating effects of the craving module were mediated by changes in craving during treatment. Within-subject analyses indicated significant pre- to postmodule reductions in negative mood. Additionally, postmodule craving significantly mediated the association between negative mood and heavy drinking during treatment and at posttreatment. CONCLUSIONS: The craving module of the combined behavioral intervention may weaken the relation between negative affect and heavy drinking by fostering greater decreases in craving during treatment.
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Individuals who received a skills training module focused on coping with craving and urges had significantly better drinking outcomes via decreases in negative mood and craving that occurred after receiving the module.
“In another study examining the behavioral intervention arm of the COMBINE study [128], individuals who received a skills training module focused on coping with craving and urges had significantly better drinking outcomes via decreases in negative mood and craving that occurred after receiving the module.”
From Relapse prevention for addictive behaviors (2011) · cites this paper as [128]
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- Authors
- Witkiewitz, K., Bowen, S., & Donovan, D. M.
- Affiliations
- Washington State University Vancouver (US)
- University of Washington (US)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2011-02
- Volume
- 79
- Issue
- 1
- Pages
- 54-63
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- PMC
- PMC3157314
- OpenAlex
- W2050211235
- Cited by
- 94
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 8
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA017137)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcohol craving, negative mood, heavy drinking, alcoholism, COMBINE study, alcohol relapse, moderation, mediation
- MeSH terms
- Acamprosate, Adult, Affect, Alcohol Deterrents, Alcohol Drinking, Alcoholism, Behavior Therapy, Combined Modality Therapy, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Naltrexone, Narcotic Antagonists, Taurine, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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