Cited by 293Stress Responses and CortisolHealth and Well-being StudiesTryptophan and brain disorders

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Chronic stress, daily stressors, and circulating inflammatory markers

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Gouin, Jean-Philippe, Glaser, Ronald, Malarkey, William B., Beversdorf, David, Kiecolt-Glaser, Janice·2012·Health Psychology

DOI 10.1037/a0025536PMC PMC3253267

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Abstract

OBJECTIVES: Acute laboratory stressors elicit elevations in serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Chronic stressors, such as family dementia caregiving, promote a state of chronic low-grade elevation in circulating inflammatory markers. The recurrent daily stressors associated with chronic stress may lead to repeated and sustained activation of the physiological stress systems. The present study evaluated the possibility that greater exposure and reactivity to daily stressors fueled increased levels of circulating inflammatory markers among family dementia caregivers, compared with noncaregiving controls. METHODS: This cross-sectional study included 53 caregivers and 77 noncaregiving controls. A semistructured interview assessed the occurrence of daily stressors in the past 24 h. A blood sample provided data on two inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6). RESULTS: Caregivers were more likely to experience multiple stressors in the past 24 h than noncaregiving controls. The occurrence of multiple daily stressors was associated with greater serum IL-6 and CRP levels. The greater occurrence of daily stressors in the past 24 h partially mediated the relationship between dementia caregiving and CRP levels. CONCLUSION: These results suggest that the cumulative effect of daily stressors promotes elevations in inflammatory markers. Greater exposure to daily stressors may be a psychobiological mechanism leading to elevations in CRP levels among family dementia caregivers.

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Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
SPSS and SAS procedures for estimating indirect effects in simple mediation models
Preacher, K. J., & Hayes, A. F. (2004) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03206553 · Cited by 17,383
The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278
CHAMPS Physical Activity Questionnaire for Older Adults: outcomes for interventions
Stewart, A. L., Mills, K. M., King, A. C., Haskell, W. L., Gillis, D., & Ritter, P. L. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200107000-00010 · Cited by 1,274
The Development, Validity, and Reliability of the Oars Multidimensional Functional Assessment Questionnaire
Fillenbaum, G. G., & Smyer, M. A. (1981) · Journal of Gerontology · doi:10.1093/geronj/36.4.428 · Cited by 1,127
Resilience and Vulnerability to Daily Stressors Assessed via Diary Methods
Almeida, D. M. (2005) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2005.00336.x · Cited by 871
Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810
Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1377 · Cited by 715
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
Maggio, M. G., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.575 · Cited by 696

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Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
2013 Alzheimer's disease facts and figures
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2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461
2018 Alzheimer's disease facts and figures
Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912
A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
Goldsmith, D. R., Rapaport, M. H., & Miller, B. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.3 · Cited by 1,683
2015 Alzheimer's disease facts and figures
Alzheimer's Association (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.02.003 · Cited by 1,684
2017 Alzheimer's disease facts and figures
(, T. D. B. T. A.-R. C. C. A. S. O. A. C. B. S., different, ). J. A. I. A., destroyed, S. A. T. A. S. T. M. E. T. M. C. I. S. I. A. G. W. A. T. R. N. I. T. O. B. T. F. N. T. B. D. A. D. A. U. I. B. R. I. I. F. N. M. A. N. I. O. P. O. T. B. A. D. A., difficulties, I. E. O., agitation, I. N. S. S. A., & delusions., S. A. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.02.001 · Cited by 1,366
More than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077
“This is not just significant to the psychological wellbeing of the caregivers, because such an increase in number of daily stressors may help explain the greater systemic inflammation in caregivers compared to controls (Gouin et al., 2012).”
2014 Alzheimer's disease facts and figures
Alzheimer's Association (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.02.001 · Cited by 1,064
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Roth, D. L., Fredman, L., & Haley, W. E. (2015) · The Gerontologist · doi:10.1093/geront/gnu177 · Cited by 965
Stimulation of systemic low-grade inflammation by psychosocial stress.
Rohleder, N. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000049 · Cited by 497
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Rohleder, N. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.021 · Cited by 439
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Antoni, M. H., & Dhabhar, F. S. (2019) · Cancer · doi:10.1002/cncr.31943 · Cited by 419
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Evans, W. N., & Garthwaite, C. (2014) · American Economic Journal Economic Policy · doi:10.1257/pol.6.2.258 · Cited by 357
Current directions in stress and human immune function
Morey, J. N., Boggero, I. A., Scott, A. B., & Segerstrom, S. C. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.03.007 · Cited by 356
Affective reactivity to daily stressors and long-term risk of reporting a chronic physical health condition
Piazza, J. R., Charles, S. T., Sliwinski, M. J., Mogle, J., & Almeida, D. M. (2013) · Annals of Behavioral Medicine · doi:10.1007/s12160-012-9423-0 · Cited by 305
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A systematic review of the psychobiological burden of informal caregiving for patients with dementia: focus on cognitive and biological markers of chronic stress.
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Physiological and functional consequences of caregiving for relatives with dementia
Fonareva, I., & Oken, B. S. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214000039 · Cited by 249
“For example, DCGs experience more stressors within a 24-hour period than non-DCGs, and this occurrence of multiple daily stressors is linked to increased serum interleukin (IL)-6 and C-reactive protein (CRP) levels (Gouin et al., 2012).”
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Richardson, T. J., Lee, S. J., Berg‐Weger, M., & Grossberg, G. T. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0367-2 · Cited by 219
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Authors: Gouin, J.-P., Glaser, R., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J.
Affiliations: The Ohio State University (US)
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
University of Missouri (US)
Corresponding author: Gouin, Jean-Philippe
ORCID: Gouin, Jean-Philippe
Malarkey, William B.
Beversdorf, David
Venue: Health Psychology
Publisher: American Psychological Association (APA)
Published: 2012-03
Volume: 31
Issue: 2
Pages: 264-268
ISSN: 0278-6133 (ISSN-L)
1930-7810
DOI: 10.1037/a0025536
PMC: PMC3253267
OpenAlex: W2038138146
Cited by: 293
References: 16
Citations by year: 2026: 16 · 2025: 22 · 2024: 18 · 2023: 17 · 2022: 29 · 2021: 30 · 2020: 22 · 2019: 23 · 2018: 18 · 2017: 22 · 2016: 18 · 2015: 13 · 2014: 23 · 2013: 11 · 2012: 9
FWCI: 5.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Health Psychology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AG025732, UL1RR025755)
Ohio State University Comprehensive Cancer Center Core (CA16058)
Fonds de la Recherche en Santé du Québec
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: chronic stress, daily hassles, C-reactive protein, interleukin-6, inflammatory markers, psychoneuroimmunology, caregiver burden
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Male, Middle Aged, Stress, Psychological, Biomarkers, Interleukin-6, Case-Control Studies, Caregivers

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