Comparing CESD-10, PHQ-9, and PROMIS depression instruments in individuals with multiple sclerosis.
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PURPOSE: This study evaluated psychometric properties of the Patient Health Questionnaire-9 (PHQ-9), the Center for Epidemiological Studies Depression Scale-10 (CESD-10), and the 8-item PROMIS Depression Short Form (PROMIS-D-8; 8b short form) in a sample of individuals living with multiple sclerosis (MS). RESEARCH METHOD: Data were collected by a self-reported mailed survey of a community sample of people living with MS (n = 455). Factor structure, interitem reliability, convergent/discriminant validity and assignment to categories of depression severity were examined. RESULTS: A 1-factor, confirmatory factor analytic model had adequate fit for all instruments. Scores on the depression scales were more highly correlated with one another than with scores on measures of pain, sleep disturbance, and fatigue. The CESD-10 categorized about 37% of participants as having significant depressive symptoms. At least moderate depression was indicated for 24% of participants by PHQ-9. PROMIS-D-8 identified 19% of participants as having at least moderate depressive symptoms and about 7% having at least moderately severe depression. None of the examined scales had ceiling effects, but the PROMIS-D-8 had a floor effect. CONCLUSIONS: Overall, scores on all 3 scales demonstrated essential unidimensionality and had acceptable interitem reliability and convergent/discriminant validity. Researchers and clinicians can choose any of these scales to measure depressive symptoms in individuals living with MS. The PHQ-9 offers validated cutoff scores for diagnosing clinical depression. The PROMIS-D-8 measure minimizes the impact of somatic features on the assessment of depression and allows for flexible administration, including Computerize Adaptive Testing (CAT). The CESD-10 measures 2 aspects of depression, depressed mood and lack of positive affect, while still providing an interpretable total score.
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Daily Depressed Mood was assessed with the PROMIS 8-item short-form, which has been validated in MS.
“Daily Depressed Mood was assessed with the PROMIS 8-item short-form, which has been validated in MS46.”
From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [46]
The PHQ-9 has been validated in MS.
“The PHQ-9 has been validated in MS46,47 and provides clinical cut-points.”
From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [46]
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- Authors
- Amtmann, D., Kim, J., Chung, H., Bamer, A. M., Askew, R. L., Wu, S., Cook, K. F., & Johnson, K. L.
- Affiliations
- University of Washington (US)
- Chungnam National University (KR)
- Northwestern University (US)
- ORCID
- Venue
- Rehabilitation Psychology
- Published
- 2014-05
- Volume
- 59
- Issue
- 2
- Pages
- 220-229
- ISSN
- 0090-5550 (ISSN-L)
- 1939-1544
- PMC
- PMC4059037
- OpenAlex
- W2039921321
- Cited by
- 259
- References
- 12
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 17 · 2023: 16 · 2022: 20 · 2021: 35 · 2020: 26 · 2019: 29 · 2018: 22 · 2017: 20 · 2016: 25 · 2015: 12 · 2014: 3
- FWCI
- 25.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Rehabilitation Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Department of Education
- National Institute on Disability and Rehabilitation Research (H133B080025; H133P120002)
- National Institutes of Health (U01AR052171)
- Topics
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- multiple sclerosis, depression, depressive symptoms, CESD-10, PHQ-9, psychometric properties, factor structure, convergent and discriminant validity, depression severity, floor effect, computerized adaptive testing, patient-reported outcomes
- MeSH terms
- Depressive Disorder, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Psychometrics, Surveys and Questionnaires, Reproducibility of Results
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