Cited by 73Cardiac Health and Mental HealthMental Health Treatment and AccessHealth disparities and outcomes

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Comparing anxiety and depression to obesity and smoking as predictors of major medical illnesses and somatic symptoms.

Open access
Niles, Andrea N., O'Donovan, Aoife·2019·Health Psychology

Abstract

OBJECTIVE: Anxiety and depression predict poor physical health longitudinally, but are neglected in primary care settings compared to other risk factors such as obesity and smoking. Further, anxiety has been less commonly studied than depression, and whether anxiety has unique predictive effects for physical health is unknown. We compared anxiety and depression to obesity and smoking as predictors of physical health indices and examined unique predictive effects of anxiety and depression. METHOD: Using data from the Health and Retirement study, a US population-based cohort study of older adults, we tested longitudinal associations of anxiety and depression symptoms with onset of self-reported physical health indices (N = 15,418; M age = 68). Medical illnesses (heart disease, stroke, arthritis, high blood pressure, diabetes, and cancer) and somatic symptoms (stomach problems, shortness of breath, dizziness, back pain, headache, pain, and eyesight difficulties) were assessed on two occasions over four years. Anxiety and depression were measured at the initial time point and tested as predictors of medical illness and somatic symptom onset. RESULTS: Anxiety and depression symptoms predicted greater incidence of nearly all medical illnesses and somatic symptoms. Effects were as strong as or stronger than those of obesity and smoking, and anxiety and depression independently increased risk for most physical health indices assessed. CONCLUSIONS: Findings suggest that anxiety and depression are as strongly predictive of poor future physical health as obesity and smoking and that anxiety is independently linked to poor physical health. Greater attention should be paid towards these conditions in primary care. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1037/hea0000707

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 53

  1. Aguilar-Gaxiola S, Loera G, Geraghty EM, Ton H, Lim CC, de Jonge P, … Scott KM (2016). Associations between DSM-IV mental disorders and subsequent onset of arthritis. Journal of Psychosomatic Research, 82, 11– 16. http://dx.doi.org/10.10167j.jpsychores.2016.01.006 26944393 PMC4884652
  2. Allgöwer A, Wardle J, & Steptoe A (2001). Depressive symptoms, social support, and personal health behaviors in young men and women. Health Psychology, 20, 223– 227. 10.1037/0278-6133.20.3.223 11403220 · DOI · Paper page
  3. Andersson NW, Gustafsson LN, Okkels N, Taha F, Cole SW, Munk-Jorgensen P, & Goodwin RD (2015). Depression and the risk of autoimmune disease: A nationally representative, prospective longitudinal study. Psychological Medicine, 45, 3559– 3569. 10.1017/S0033291715001488 26271451 · DOI
  4. Archer G, Pikhart H, & Head J (2015). Do depressive symptoms predict cancer incidence?: 17-year follow-up of the Whitehall II study. Journal of Psychosomatic Research, 79, 595– 603. 10.1016/j.jpsychores.2015.07.011 26299450 · DOI
  5. Beck AT, Epstein N, Brown G, & Steer RA (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893– 897. 10.1037/0022-006X.56.6.893 3204199 · DOI · Paper page
  6. Bruce EC, & Musselman DL (2005). Depression, alterations in platelet function, and ischemic heart disease. Psychosomatic Medicine, 67, S34– S36. 10.1097/01.psy.0000164227.63647.d9 15953798 · DOI
  7. Eaker ED, Pinsky J, & Castelli WP (1992). Myocardial infarction and coronary death among women: Psychosocial predictors from a 20-year follow-up of women in the Framingham Study. American Journal of Epidemiology, 135, 854– 864. 10.1093/oxfordjournals.aje.a116381 1585898 · DOI · Paper page
  8. Eaker ED, Sullivan LM, Kelly-Hayes M, D’Agostino RB Sr., & Benjamin EJ (2005). Tension and anxiety and the prediction of the 10-year incidence of coronary heart disease, atrial fibrillation, and total mortality: The Framingham Offspring Study. Psychosomatic Medicine, 67, 692– 696. 10.1097/01.psy.0000174050.87193.96 16204425 · DOI
  9. El-Gabalawy R, Mackenzie CS, Pietrzak RH, & Sareen J (2014). A longitudinal examination of anxiety disorders and physical health conditions in a nationally representative sample of U.S. older adults. Experimental Gerontology, 60, 46– 56. http://dx.doi.org/10.1016Zj.exger.2014.09.012 25245888
  10. Eriksen HR, Svendsrod R, Ursin G, & Ursin H (1998). Prevalence of subjective health complaints in the Nordic European countries in 1993. European Journal of Public Health, 8, 294– 298. 10.1093/eurpub/8.4.294 · DOI
  11. Euesden J, Danese A, Lewis CM, & Maughan B (2017). A bidirectional relationship between depression and the autoimmune disorders - New perspectives from the National Child Development Study. PLoS ONE, 12, e0173015 10.1371/journal.pone.0173015 28264010 PMC5338810 · DOI
  12. Farvid MS, Qi L, Hu FB, Kawachi I, Okereke OI, Kubzansky LD, & Willett WC (2014). Phobic anxiety symptom scores and incidence of type 2 diabetes in U.S. men and women. Brain, Behavior, and Immunity, 36, 176– 182. http://dx.doi.org/10.1016Zj.bbi.2013.10.025 PMC3947213 24184473
  13. Fluegge KR (2016). Comorbidities among persons with incident psychiatric condition. Gerontology & Geriatric Medicine, 2, 233372141663500 10.1177/2333721416635001 PMC5172455 28008416 · DOI
  14. Goldberg EL, Comstock GW, & Graves CG (1980). Psychosocial factors and blood pressure. Psychological Medicine, 10, 243– 255. 10.1017/S0033291700044007 7384327 · DOI
  15. Haug TT, Mykletun A, & Dahl AA (2004). The association between anxiety, depression, and somatic symptoms in a large population: The HUNT-II study. Psychosomatic Medicine, 66, 845– 851. 10.1097/01.psy.0000145823.85658.0c 15564348 · DOI
  16. Heeringa SG, & Conner J (1995). Technical description of the Health and Retirement Study sample design. Ann Arbor, MI: Institute for Social Research, University of Michigan 10.7826/ISR-UM.06.585031.001.05.0001.1995 · DOI
  17. Huang T, Poole EM, Okereke OI, Kubzansky LD, Eliassen AH, Sood AK, … Tworoger SS (2015). Depression and risk of epithelial ovarian cancer: Results from two large prospective cohort studies. Gynecologic Oncology, 139, 481– 486. 10.1016/j.ygyno.2015.10.004 26449316 PMC4679423 · DOI
  18. Janszky I, Ahnve S, Lundberg I, & Hemmingsson T (2010). Early-onset depression, anxiety, and risk of subsequent coronary heart disease: 37-year follow-up of 49,321 young Swedish men. Journal of the American College of Cardiology, 56, 31– 37. 10.1016/jjacc.2010.03.033 20620714 · DOI
  19. Jonas BS, Franks P, & Ingram DD (1997). Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Archives of Family Medicine, 6, 43– 49. 10.1001/archfami.6.1.43 9003169 · DOI
  20. Jonas BS, & Mussolino ME (2000). Symptoms of depression as a prospective risk factor for stroke. Psychosomatic Medicine, 62, 463– 471. 10.1097/00006842-200007000-00001 10949089 · DOI
  21. Kang HJ, Bae KY, Kim SW, Shin HY, Shin IS, Yoon JS, & Kim JM (2017). Impact of anxiety and depression on physical health condition and disability in an elderly Korean population. Psychiatry Investigation, 14, 240– 248. 10.4306/pi.2017.14.3.240 28539942 PMC5440426 · DOI
  22. Karakus MC, & Patton LC (2011). Depression and the onset of chronic illness in older adults: A 12-year prospective study. The Journal of Behavioral Health Services & Research, 38, 373– 382. 10.1007/s11414-011-9234-2 21293976 · DOI
  23. Kessler RC, Chiu WT, Demler O, Merikangas KR, & Walters EE (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 617– 627. 10.1001/archpsyc.62.6.617 15939839 PMC2847357 · DOI · Paper page
  24. Knol MJ, Twisk JWR, Beekman ATF, Heine RJ, Snoek FJ, & Pouwer F (2006). Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia, 49, 837– 845. 10.1007/s00125-006-0159-x 16520921 · DOI · Paper page
  25. Kroenke K, Spitzer RL, Williams JB, Linzer M, Hahn SR, deGruy FV III, & Brody D (1994). Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment. Archives of Family Medicine, 3, 774– 779. 10.1001/archfami.3.9.774 7987511 · DOI
  26. Lu MC, Guo HR, Lin MC, Livneh H, Lai NS, & Tsai TY (2016). Bidirectional associations between rheumatoid arthritis and depression: A nationwide longitudinal study. Scientific Reports, 6, 20647 10.1038/srep20647 26857028 PMC4746638 · DOI
  27. Maes M, Lin A, Bonaccorso S, van Hunsel F, Van Gastel A, Delmeire L, … Scharpé S (1998). Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiat-rica Scandinavica, 98, 328– 335. http://dx.doi.org/10.1111Zj.1600-0447.1998.tb10092.x 9821456
  28. Markovitz JH, Matthews KA, Kannel WB, Cobb JL, & D’Agostino RB (1993). Psychological predictors of hypertension in the Framingham Study: Is there tension in hypertension? Journal of the American Medical Association, 270, 2439– 2443. 10.1001/jama.1993.03510200045030 8230620 · DOI
  29. Martin EJ, & Nemeroff CB (2010). Diagnostic issues in depression and generalized anxiety disorder: Refining the research agenda for the DSM-V In Goldberg D, Kendler KS, & Sirovatka PJ (Eds.), Diagnostic issues in depression and generalized anxiety disorder: Refining the research agenda for DSM-V (pp. 45– 70). Arlington, VA: American Psychiatric Association.
  30. Maryam ML, & Shervin A (2016). Baseline depressive symptoms predict subsequent heart disease, a 20-year cohort study. International Cardiovascular Research Journal, 10, 29– 34. 10.17795/icrj-10(1)29 · DOI
  31. Mathews A, & MacLeod C (2005). Cognitive vulnerability to emotional disorders. Annual Review of Clinical Psychology, 1, 167– 195. 10.1146/annurev.clinpsy.1.102803.143916 17716086 · DOI · Paper page
  32. Meng L, Chen D, Yang Y, Zheng Y, & Hui R (2012). Depression increases the risk of hypertension incidence: A meta-analysis of prospective cohort studies. Journal of Hypertension, 30, 842– 851. 10.1097/HJH.0b013e32835080b7 22343537 · DOI · Paper page
  33. Menon V, Rajan TM, Kuppili PP, & Sarkar S (2017). Cognitive behavior therapy for medically unexplained symptoms: A systematic review and meta-analysis of published controlled trials. Indian Journal of Psychological Medicine, 39, 399– 406. 10.4103/IJPSYM.IJPSYM_17_17 28852229 PMC5559983 · DOI
  34. Niles AN, Dour HJ, Stanton AL, Roy-Byrne PP, Stein MB, Sullivan G, … Craske MG (2015). Anxiety and depressive symptoms and medical illness among adults with anxiety disorders. Journal of Psychosomatic Research, 78, 109– 115. 10.1016/j.jpsychores.2014.11.018 25510186 PMC4297513 · DOI
  35. O’Donovan A, Ahmadian AJ, Neylan TC, Pacult MA, Edmondson D, & Cohen BE (2017). Current posttraumatic stress disorder and exaggerated threat sensitivity associated with elevated inflammation in the Mind Your Heart Study. Brain, Behavior, and Immunity, 60, 198– 205. 10.1016/j.bbi.2016.10.014 PMC5279867 27765647 · DOI
  36. Okura Y, Urban LH, Mahoney DW, Jacobsen SJ, & Rodeheffer RJ (2004). Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure. Journal of Clinical Epidemiology, 57, 1096– 1103. 10.1016/j.jclinepi.2004.04.005 15528061 · DOI
  37. Poole EM, Kubzansky LD, Sood AK, Okereke OI, & Tworoger SS (2016). A prospective study of phobic anxiety, risk of ovarian cancer, and survival among patients. Cancer Causes & Control, 27, 661– 668. 10.1007/s10552-016-0739-0 27023470 PMC4840033 · DOI
  38. Radloff LS (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385– 401. 10.1177/014662167700100306 · DOI · Paper page
  39. Reeves KW, Okereke OI, Qian J, Tamimi RM, Eliassen AH, & Hankinson SE (2018). Depression, antidepressant use, and breast cancer risk in pre-and postmenopausal women: A prospective cohort study. Cancer Epidemiology, Biomarkers & Prevention, 27, 306– 314. 10.1158/1055-9965.EPI-17-0707 PMC5835185 29263188 · DOI
  40. Russek LG, King SH, Russek SJ, & Russek HI (1990). The Harvard Mastery of Stress Study 35-year follow-up: Prognostic significance of patterns of psychophysiological arousal and adaptation. Psychosomatic Medicine, 52, 271– 285. 10.1097/00006842-199005000-00002 2367619 · DOI
  41. Simon GE, & VonKorff M (1991). Somatization and psychiatric disorder in the NIMH Epidemiologic Catchment Area study. The American Journal of Psychiatry, 148, 1494– 1500. 10.1176/ajp.148.11.1494 1928462 · DOI
  42. Simon GE, VonKorff M, Piccinelli M, Fullerton C, & Ormel J (1999). An international study of the relation between somatic symptoms and depression. The New England Journal of Medicine, 341, 1329– 1335. 10.1056/NEJM199910283411801 10536124 · DOI · Paper page
  43. Smith B, Chu LK, Smith TC, Amoroso PJ, Boyko EJ, Hooper TI, … Millennium Cohort Study Team. (2008). Challenges of self-reported medical conditions and electronic medical records among members of a large military cohort. BMC Medical Research Methodology, 8, 37 10.1186/1471-2288-8-37 18644098 PMC2447848 · DOI
  44. St Clair P, Gaudette E, Zhao H, Tysinger B, Seyedin R, & Goldman DP (2017). Using self-reports or claims to assess disease prevalence: It’s complicated. Medical Care, 55, 782– 788. 10.1097/MLR.0000000000000753 28617703 PMC5507726 · DOI
  45. Stein MB, Roy-Byrne PP, Craske MG, Campbell-Sills L, Lang AJ, Golinelli D, … Sherbourne CD (2011). Quality of and patient satisfaction with primary health care for anxiety disorders. The Journal of Clinical Psychiatry, 72, 970– 976. 10.4088/JCP.09m05626blu 21367351 PMC3111814 · DOI · Paper page
  46. Strik JJMH, Denollet J, Lousberg R, & Honig A (2003). Comparing symptoms of depression and anxiety as predictors of cardiac events and increased health care consumption after myocardial infarction. Journal of the American College of Cardiology, 42, 1801– 1807. 10.1016/j.jacc.2003.07.007 14642691 · DOI
  47. Strine TW, Chapman DP, Kobau R, & Balluz L (2005). Associations of self-reported anxiety symptoms with health-related quality of life and health behaviors. Social Psychiatry and Psychiatric Epidemiology, 40, 432– 438. 10.1007/s00127-005-0914-1 16003592 · DOI
  48. Sumner JA, Kubzansky LD, Kabrhel C, Roberts AL, Chen Q, Winning A,... Koenen KC (2016). Associations of trauma exposure and posttraumatic stress symptoms with venous thromboembolism over 22 years in women. Journal of the American Heart Association, 5(5), e003197 10.1161/JAHA.116.003197 27172912 PMC4889189 · DOI
  49. Tellnes G, Svendsen K-OB, Bruusgaard D, & Bjerkedal T (1989). Incidence of sickness certification. Proposal for use as a health status indicator. Scandinavian Journal of Primary Health Care, 7, 111– 117. 10.3109/02813438909088657 2587857 · DOI
  50. Thayer JF (2006). On the importance of inhibition: Central and peripheral manifestations of nonlinear inhibitory processes in neural systems. Dose-Response, 4, 2– 21. 10.2203/dose-response.004.01.002.Thayer 18648636 PMC2477656 · DOI
  51. Vimalananda VG, Palmer JR, Gerlovin H, Wise LA, Rosenzweig JL, Rosenberg L, & Ruiz-Narvaez EA (2014). Depressive symptoms, antidepressant use, and the incidence of diabetes in the Black Women’s Health Study. Diabetes Care, 37, 2211– 2217. 10.2337/dc13-2642 24784829 PMC4113175 · DOI
  52. Williams JW Jr., Rost K, Dietrich AJ, Ciotti MC, Zyzanski SJ, & Cornell J (1999). Primary care physicians’ approach to depressive disorders. Effects of physician specialty and practice structure. Archives of Family Medicine, 8, 58– 67. 10.1001/archfami.8.1.58 9932074 · DOI
  53. Xiang X, & An R (2015). Depression and onset of cardiovascular disease in the U.S. middle-aged and older adults. Aging & Mental Health, 19, 1084– 1092. 10.1080/13607863.2014.1003281 25616725 · DOI

Cited by

Sorted by citations

Metadata

Authors
Niles, A. N., & O'Donovan, A.
Affiliations
San Francisco VA Medical Center (US)
Venue
Health Psychology
Published
2019-02
Volume
38
Issue
2
Pages
172-181
ISSN
  • 0278-6133 (ISSN-L)
  • 1930-7810
OpenAlex
W2904137001
Cited by
73
References
8
Citations by year
2026: 3 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 13 · 2019: 6
FWCI
5.67
Type
journal article
Language
en
Open access
Locations
  • Health Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
U.S. Department of Veteran’s Affairs
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
  • Social Sciences › Health › Health disparities and outcomes
Keywords
anxiety, depression, obesity, smoking, physical health, somatic symptoms, older adults, primary care, health risk factors, Health and Retirement Study
MeSH terms
Medically Unexplained Symptoms, Tobacco Smoking, Aged, Anxiety, Depression, Disease, Female, Humans, Male, Obesity, Risk Factors, Self Report

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review