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Frequency of fixation of adaptive mutations is higher in evolving diploid than haploid yeast populations
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“Hence, adaptive laboratory evolution was already performed about a hundred years ago by William Dallinger [22] and during the middle of the last century [24,25];”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [25]
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“This assumption has been evaluated on several occasions and in different High-Precision Fitness Measures 183 organisms (Richmond et al. 1975; Goodman 1979; Paquin and Adams 1983; De Visser and Lenski 2002; Bell 2008).”
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BackgroundToward a General Theory of Adaptive Radiation
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“…work from microbial systems largely supports this view: experiments in bacteria (Elena et al. 2006; Lenski et al. 1991) and yeast (Zeyl 2005; Paquin & Adams 1983) have inferred that between three and six mutations were involved in adaptation over the course of between a few hundred and…”
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“A number of selection experiments have reported results that are consistent with this paradigm (Novick & Szilard 1950; Atwood et al. 1951; Paquin & Adams 1983; Lenski & Travisano 1994).”
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“Early theoretical models assume that beneficial mutations are rare, such that once a beneficial 39 mutation escapes drift, it will fix (3-5).”
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Immler, S., & Otto, S. P. (2018) · The American Naturalist · doi:10.1086/698483 · Cited by 68
Zhou, N., Bottagisi, S., Katz, M., Schacherer, J., Friedrich, A., Gojkovic, Z., Swamy, K. B. S., Knecht, W., Compagno, C., & Piškur, J. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox060 · Cited by 67
Couceiro, L., Gac, M. L., Hunsperger, H. M., Mauger, S., Destombe, C., Cock, J. M., Ahmed, S., Coelho, S. M., Valéro, M., & Peters, A. F. (2015) · Evolution · doi:10.1111/evo.12702 · Cited by 70
“…hypotheses, based on the genetic advantages of having two sets of homologous chromosomes, were thus advanced to explain the evolution of an extended diploid phase: the masking hypothesis (Crow and Kimura 1965) and the hypothesis of the higher rate of beneficial mutations (Paquin and Adams 1983).”
BackgroundWyatt, R., Odrzykoski, I. J., & Stoneburner, A. (1992) · Systematic Botany · doi:10.2307/2419725 · Cited by 66
Somatic mutation favors the evolution of diploidy.
Orr, H. A. (1995) · Genetics · doi:10.1093/genetics/139.3.1441 · Cited by 65
Weikert, C., Sauer, U., & Bailey, J. E. (1997) · Microbiology · doi:10.1099/00221287-143-5-1567 · Cited by 63
Boisselier‐Dubayle, M., Jubier, M.-F., Lejeune, B., & Bischler, H. (1995) · Taxon · doi:10.2307/1223406 · Cited by 63
Evolution of the life cycle in land plants
Qiu, Y., TAYLOR, A. B., & McManus, H. A. (2012) · Journal of Systematics and Evolution · doi:10.1111/j.1759-6831.2012.00188.x · Cited by 62
“For this reason, beneficial mutations may be fixed faster in diploids, a conjecture that has received some experimental support (Paquin & Adams, 1983).”
BackgroundGenome evolution mediated by Ty elements in Saccharomyces
Garfinkel, D. J. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084939 · Cited by 62
“Paquin and Adams (1983) have shown that S. cerevisiae cultures evolve genetically when limited for glucose.”
BackgroundPeruzzi, B., Araten, D. J., Notaro, R., & Luzzatto, L. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.12.004 · Cited by 61
“Compared to bacteria and yeasts [10], the study of somatic mutations in animals and in animal cells is more complicated for various reasons, including the fact that animal cells are diploid.”
BackgroundFrenkel, E. M., Good, B. H., & Desai, M. M. (2014) · Genetics · doi:10.1534/genetics.113.160069 · Cited by 61
“…Oeller, 1986; Atwood et al., 1951; Barrett et al., 2006; Barrick et al., 2010; de Visser and Rozen, 2006; Hegreness et al., 2006; Helling et al., 1981; Imhof and Schlötterer, 2001; Kao and Sherlock, 2008; Lang et al., 2011; Novick and Szilard, 1950; Paquin and Adams, 1983; Perfeito et al., 2007).”
BackgroundMutational effects depend on ploidy level: all else is not equal
Gerstein, A. C. (2012) · Biology Letters · doi:10.1098/rsbl.2012.0614 · Cited by 59
Synthetic Gene Recruitment Reveals Adaptive Reprogramming of Gene Regulation in Yeast
Stolovicki, E., Dror, T. W., Brenner, N., & Braun, E. (2006) · Genetics · doi:10.1534/genetics.106.055442 · Cited by 57
“Microorganisms grown in continuous cultures (chemostats) are an ideal prototype system for such studies (Novick and Szilard 1950; Paquin and Adams 1983; Saldanha et al. 2004).”
BackgroundEvolution of haploid selection in predominantly diploid organisms
Otto, S. P., Scott, M. F., & Immler, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512004112 · Cited by 57
“These models have shown that purging of deleterious mutations favors expansion of the haploid phase when recombination is infrequent, but that diploids are favored because they better mask mutations from selection when recombination is common (33, 34).”
BackgroundThe Impact of Yeast Genetics and Recombinant DNA Technology on the Wine Industry - A Review
Pretorius, L., & van der Westhuizen, T. J. (1991) · South African Journal of Enology and Viticulture · doi:10.21548/12-1-2220 · Cited by 56
Experimental microbial evolution: history and conceptual underpinnings
Adams, J., & Rosenzweig, F. (2014) · Genomics · doi:10.1016/j.ygeno.2014.10.004 · Cited by 57
“For example, microbial systems were exploited to address questions addressing the predominance of the diploid phase [27], and the neutral theory of evolutionary change [28,29].”
BackgroundSelf-citationThe Influence of Polyploidy on the Evolution of Yeast Grown in a Sub-Optimal Carbon Source
Scott, A. L., Richmond, P. A., Dowell, R. D., & Selmecki, A. M. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx205 · Cited by 52
“Some of these theories have been confirmed experimentally, yet studies have focused almost exclusively on haploid and diploid yeast (Paquin and Adams 1983; Anderson et al. 2004; Zeyl 2004; Gerstein and Otto 2009).”
BackgroundThe population biology and evolutionary significance of Ty elements in Saccharomyces cerevisiae
Wilke, C. M., Maimer, E., & Adams, J. (1992) · Genetica · doi:10.1007/bf00133718 · Cited by 54
“Paquin & Adams, 1983; Kondrashov & Crow, 1991; Perrot, Richerd & Valrro, 1991).”
Self-citationFunctional genomics and the study of development, variation and evolution
White, K. P. (2001) · Nature Reviews Genetics · doi:10.1038/35080565 · Cited by 53
Using Parthenogenetic Lineages to Identify Advantages of Sex
Neiman, M., & Schwander, T. (2011) · Evolutionary Biology · doi:10.1007/s11692-011-9113-z · Cited by 52
“…of higher ploidy levels among old parthenogenetic lineages could instead be a consequence of harboring more targets ‘‘capable’’ of beneficial mutation (Paquin and Adams 1983; Otto and Whitton 2000) or genetic variance that may be beneficial in the face of environmental change (Bell 1982).”
BackgroundExperimental evolution with yeast
Zeyl, C. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00061.x · Cited by 52
Experimental Studies of Evolutionary Dynamics in Microbes
Cvijović, I., Ba, A. N. N., & Desai, M. M. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.06.004 · Cited by 51
“For example, one can construct yeast strains in which loss-of-function mutations in the gene CAN1 lead to resistance to the drug canavanine; the frequency of these mutations can then be precisely tracked by plating on media containing this drug [31].”
Metadata
- Authors
- Paquin, C., & Adams, J.
- Affiliations
- University of Michigan (US)
- Venue
- Nature
- Published
- 1983-04
- Volume
- 302
- Issue
- 5908
- Pages
- 495-500
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2057017576
- Cited by
- 239
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 25 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 9 · 2012: 8
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007544)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- adaptive mutation, fixation frequency, diploidy, haploid populations, Saccharomyces cerevisiae, yeast evolution, population genetics
- MeSH terms
- Adaptation, Biological, Diploidy, Biological Evolution, Gene Frequency, Haploidy, Mutation, Saccharomyces cerevisiae
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