Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy
Abstract
Glial cells actively participate in synaptic transmission. They clear molecules from the synaptic cleft, receive signals from neurons and, in turn, release molecules that can modulate signaling between neuronal elements. Whether glial-derived transmitters can contribute to enduring changes in postsynaptic efficacy, however, remains to be established. In rat hypothalamic paraventricular nucleus, we demonstrate an increase in the amplitude of miniature excitatory postsynaptic currents in response to norepinephrine that requires the release of ATP from glial cells. The increase in quantal efficacy, which likely results from an insertion of AMPA receptors, is secondary to the activation of P2X(7) receptors, an increase in postsynaptic calcium and the activation of phosphatidylinositol 3-kinase. The gliotransmitter ATP, therefore, contributes directly to the regulation of postsynaptic efficacy at glutamatergic synapses in the CNS.
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NA may trigger ATP release from glial cells activating P2X7R, subsequently enhancing the efficacy of glutamatergic neurotransmission by postsynaptically facilitating AMPA receptor insertion.
“Interestingly, NA may trigger ATP release from glial cells activating P2X7R, subsequently enhancing the efficacy of glutamatergic neurotransmission, by postsynaptically facilitating α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor insertion [97].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [97]
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- Authors
- Gordon, G. R. J., Baimoukhametova, D. V., Hewitt, S. A., Rajapaksha, W. R. A. K. J. S., Fisher, T. E., & Bains, J. S.
- Affiliations
- University of Calgary (CA)
- University of Saskatchewan (CA)
- Corresponding author
- Bains, Jaideep S
- Venue
- Nature Neuroscience
- Published
- 2005-07-03
- Volume
- 8
- Issue
- 8
- Pages
- 1078-1086
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1994440562
- Cited by
- 374
- References
- 50
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 12 · 2023: 17 · 2022: 7 · 2021: 12 · 2020: 20 · 2019: 18 · 2018: 9 · 2017: 21 · 2016: 21 · 2015: 17 · 2014: 27 · 2013: 22 · 2012: 24
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- norepinephrine, gliotransmission, miniature excitatory postsynaptic currents, P2X7 receptor, postsynaptic calcium, phosphatidylinositol 3-kinase, hypothalamic paraventricular nucleus, glutamatergic synapses, glial cells
- MeSH terms
- Adenosine Triphosphate, Animals, Calcium, Enzyme Activation, Male, Neuroglia, Norepinephrine, Paraventricular Hypothalamic Nucleus, Synapses, Tissue Distribution, Biomarkers, Rats, Sprague-Dawley, Receptors, Purinergic P2, Receptors, AMPA, Receptors, Adrenergic, alpha-1, Excitatory Postsynaptic Potentials, Phosphatidylinositol 3-Kinases, Rats, Long-Evans, Rats, Receptors, Purinergic P2X7, In Vitro Techniques
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