The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The germless theory of allergic disease: revisiting the hygiene hypothesis
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Family size, infection and atopy: the first decade of the 'hygiene hypothesis'
Strachan, D. (2000) · Thorax · doi:10.1136/thorax.55.suppl_1.s2 · Cited by 1,183
Having lived on a farm and protection against allergic diseases in Australia
Downs, S. H., Marks, G. B., Mitakakis, T. Z., Lëuppi, J. D., Car, N. G., & Peat, J. K. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01070.x · Cited by 170
Cited by
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241
Environmental biodiversity, human microbiota, and allergy are interrelated
Hanski, I., von Hertzen, L., Fyhrquist, N., Koskinen, K., Torppa, K., Laatikainen, T., Karisola, P., Auvinen, P., Paulin, L., Mäkelä, M. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205624109 · Cited by 1,063
The link between fungi and severe asthma: A summary of the evidence
Denning, D. W., O'Driscoll, B. R., Hogaboam, C. M., Bowyer, P., & Niven, R. M. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00074705 · Cited by 824
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747
Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization
Herbst, T., Sichelstiel, A., Schär, C., Yadava, K., Bürki, K., Cahenzli, J., McCoy, K., Marsland, B. J., & Harris, N. L. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1574oc · Cited by 440
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394
Biofilms in the large bowel suggest an apparent function of the human vermiform appendix
Randal Bollinger, R., Barbas, A. S., Bush, E. L., Lin, S. S., & Parker, W. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.08.032 · Cited by 373
Hartl, D., Koller, B., Mehlhorn, A. T., Reinhardt, D., Nicolai, T., Schendel, D. J., Griese, M., & Krauss-Etschmann, S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.02.023 · Cited by 354
Role of Antibiotics and Fungal Microbiota in Driving Pulmonary Allergic Responses
Noverr, M. C., Noggle, R. M., Toews, G. B., & Huffnagle, G. B. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.4996-5003.2004 · Cited by 330
The differential expression of IL-4 and IL-13 and its impact on type-2 immunity
Bao, K., & Reinhardt, R. L. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.008 · Cited by 316
van den Biggelaar, A. H. J., Rodrigues, L. C., van Ree, R., van der Zee, J. S., Hoeksma‐Kruize, Y. C. M., Souverijn, J. H. M., Missinou, M. A., Borrmann, S., Kremsner, P. G., & Yazdanbakhsh, M. (2004) · The Journal of Infectious Diseases · doi:10.1086/381767 · Cited by 276
Strachan, D. P., Aït‐Khaled, N., Foliaki, S., Mallol, J., Odhiambo, J., Pearce, N., Williams, H. C., & the ISAAC Phase Three Study Group (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12349 · Cited by 123
Atopy and current intestinal parasite infection: a systematic review and meta-analysis
Feary, J., Britton, J., & Leonardi‐Bee, J. (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02512.x · Cited by 115
Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
Rodrigues, L. C., Newcombe, P. J., Cunha, S. S., Alcantara‐Neves, N. M., Genser, B., Cruz, A. A., Simoes, S. M., Fiaccone, R., Amorim, L., Cooper, P. J., et al. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03027.x · Cited by 112
Hammer, T., Nielsen, K. R., Munkholm, P., Burisch, J., & Lynge, E. (2016) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjw050 · Cited by 85
Rennert, P. D., Ichimura, T., Sizing, I. D., Bailly, V., Li, Z., Rennard, R., McCoon, P., Pablo, L., Miklasz, S., Tarilonte, L., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4311 · Cited by 67
Air Pollution, Early Life Microbiome, and Development
Vallès, Y., & Francino, M. P. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0215-y · Cited by 65
Rujeni, N., Nausch, N., Bourke, C. D., Midzi, N., Mduluza, T., Taylor, D. W., & Mutapi, F. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000332949 · Cited by 47
Anadón, A., Martínez-Larrañaga, M. R., Ares, I., & Martínez, M. A. (2016) · Nutraceuticals · doi:10.1016/b978-0-12-802147-7.00055-3 · Cited by 24
Wallen-Russell, C., Pearlman, N., Wallen-Russell, S., Cretoiu, D., Thompson, D. C., & Voinea, S. C. (2023) · Microorganisms · doi:10.3390/microorganisms11112784 · Cited by 14
Atopy and Asthma in Migrants: The Function of Parasites
Rottem, M., Geller-Bernstein, C., & Shoenfeld, Y. (2015) · International Archives of Allergy and Immunology · doi:10.1159/000431360 · Cited by 11
Metadata
- Authors
- Wills-Karp, M., Santeliz, J., & Karp, C. L.
- Venue
- Nature Reviews Immunology
- Published
- 2001-10
- Volume
- 1
- Issue
- 1
- Pages
- 69-75
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2018173725
- Cited by
- 788
- References
- 4
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
