Cited by 1,921Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Amyloid β-peptide is produced by cultured cells during normal metabolism

Haass, Christian, Schlossmacher, Michael G., Hung, Albert Y., Vigo-Pelfrey, Carmen, Mellon, Angela, Ostaszewski, Beth L., Lieberburg, Ivan, Koo, Edward H., Schenk, Dale, Teplow, David B., Selkoe, Dennis J.·1992·Nature

DOI 10.1038/359322a0

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Abstract

Alzheimer's disease is characterized by the extracellular deposition in the brain and its blood vessels of insoluble aggregates of the amyloid beta-peptide (A beta), a fragment, of about 40 amino acids in length, of the integral membrane protein beta-amyloid precursor protein (beta-APP). The mechanism of extracellular accumulation of A beta in brain is unknown and no simple in vitro or in vivo model systems that produce extracellular A beta have been described. We report here the unexpected identification of the 4K (M(r) 4,000) A beta and a truncated form of A beta (approximately 3K) in media from cultures of primary cells and untransfected and beta-APP-transfected cell lines grown under normal conditions. These peptides were immunoprecipitated readily from culture medium by A beta-specific antibodies and their identities confirmed by sequencing. The concept that pathological processes are responsible for the production of A beta must not be reassessed in light of the observation that A beta is produced in soluble form in vitro and in vivo during normal cellular metabolism. Further, these findings provide the basis for using simple cell culture systems to identify drugs that block the formation or release of A beta, the primary protein constituent of the senile plaques of Alzheimer's disease.

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Authors: Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., & Selkoe, D. J.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
ORCID: Haass, Christian
Schlossmacher, Michael G.
Hung, Albert Y.
Koo, Edward H.
Teplow, David B.
Selkoe, Dennis J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1992-09
Volume: 359
Issue: 6393
Pages: 322-325
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/359322a0
OpenAlex: W1979543098
Cited by: 1,921
References: 17
Citations by year: 2026: 12 · 2025: 14 · 2024: 22 · 2023: 15 · 2022: 19 · 2021: 28 · 2020: 31 · 2019: 25 · 2018: 29 · 2017: 35 · 2016: 43 · 2015: 46 · 2014: 51 · 2013: 43 · 2012: 67
FWCI: 80.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, Alzheimer's disease, amyloid precursor protein, amyloid plaques, cell culture model, drug screening
MeSH terms: Antibodies, Epitopes, Cell Line, DNA, Humans, Kidney, Methionine, Molecular Weight, Recombinant Proteins, Transfection, Amyloid beta-Peptides, Amyloid beta-Protein Precursor

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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