Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents

Wahlstrom, Dustin; White, Tonya; Hooper, Catalina J.; Vrshek-Schallhorn, Suzanne; Oetting, William S.; Brott, Marcia J.; Luciana, Monica

doi:10.1016/j.biopsych.2006.05.045

Cited by 66Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesCognitive Abilities and Testing

Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents

Wahlstrom, Dustin, White, Tonya, Hooper, Catalina J., Vrshek-Schallhorn, Suzanne, Oetting, William S., Brott, Marcia J., Luciana, Monica·2007·Biological Psychiatry

DOI 10.1016/j.biopsych.2006.05.045

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Abstract

Background The catechol-O-methyltransferase (COMT) gene codes for an enzyme that degrades prefrontal cortex (PFC) synaptic dopamine. Of two identified alleles (Met and Val), the Met allele results in COMT activity that is up to 4 times less pronounced than that conferred by the Val allele, resulting in greater PFC dopamine concentrations. Met-Met homozygotes perform better than individuals who possess the Val allele on PFC-mediated cognitive tasks. These genotypic variations and their associations with executive functions have been described in adults and prepubescent children, but there is a paucity of research assessing these relations in adolescent samples.Methods In this study, 70 children aged 9-17 were genotyped for COMT and completed measures of working memory, attention, fine motor coordination, and motor speed.Results COMT genotype modulated all but the motor speed measures. The Val-Met genotype was optimal for performance in this adolescent sample.Conclusions Results are discussed within the context of developmental changes in the dopaminergic system during adolescence.

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These results overall suggest a decrease in dopamine levels from puberty to adulthood.
“These results overall suggests a decrease in dopamine levels from puberty to adulthood (23).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [23]
Behavioral findings on COMT genotype in children and adolescents are mixed.
“Behavioral findings are mixed (21-23).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [23]

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Authors: Wahlstrom, D., White, T., Hooper, C. J., Vrshek-Schallhorn, S., Oetting, W. S., Brott, M. J., & Luciana, M.
Affiliations: University of Minnesota (US)
Corresponding author: Wahlstrom, Dustin
ORCID: Wahlstrom, Dustin
White, Tonya
Oetting, William S.
Luciana, Monica
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2007-03
Volume: 61
Issue: 5
Pages: 626-632
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2006.05.045
OpenAlex: W2168115083
Cited by: 66
References: 62
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 9 · 2012: 7
FWCI: 1.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) (submittedVersion)
Funders: National Center for Research Resources (M01RR000400)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords: catechol-O-methyltransferase, COMT gene polymorphism, COMT Val158Met polymorphism, prefrontal cortex, dopamine, executive function, working memory, attention, fine motor coordination, motor speed, adolescents, genotype-phenotype correlation
MeSH terms: Adolescent, Analysis of Variance, Attention, Catechol O-Methyltransferase, Child, Female, Genotype, Humans, Male, Memory, Short-Term, Mental Processes, Methionine, Motor Activity, Neuropsychological Tests, Polymorphism, Genetic, Psychomotor Performance, Reaction Time, Valine, Prefrontal Cortex

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Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents

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