Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

Inositol trisphosphate and calcium signalling

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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The versatility and universality of calcium signalling

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Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

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The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

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Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

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Molecular mechanisms underlying the activation of eNOS

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Role of the α‐chemokine stromal cell‐derived factor (SDF‐1) in the developing and mature central nervous system

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In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice

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Acetylcholine stimulates cortical precursor cell proliferation in vitro via muscarinic receptor activation and MAP kinase phosphorylation

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Transient increases in intracellular calcium result in prolonged site-selective increases in tau phosphorylation through a glycogen synthase kinase 3β-dependent pathway

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Glycogen synthase kinase 3β is tyrosine phosphorylated by PYK2

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GSK-3 Is Activated by the Tyrosine Kinase Pyk2 during LPA1-mediated Neurite Retraction

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Ras-dependent ERK Activation by the Human Gs-coupled Serotonin Receptors 5-HT4(b) and 5-HT7(a)

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Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

Giralt, A., Brito, V., Chevy, Q., Simonnet, C., Otsu, Y., Cifuentes-Díaz, C., de Pins, B., Coura, R., Alberch, J., Ginés, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15592 · Cited by 102

Inhibition of Endothelial Nitric Oxide Synthase Activity by Proline-Rich Tyrosine Kinase 2 in Response to Fluid Shear Stress and Insulin

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Endocytosis as a Mechanism for Tyrosine Kinase-dependent Suppression of a Voltage-gated Potassium Channel

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Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels

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PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease

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Allicin inhibits SDF-1α-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression

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Tau, where are we now?

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Muscarinic Potentiation of GABAAReceptor Currents Is Gated by Insulin Signaling in the Prefrontal Cortex

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Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia

Fähling, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01894.x · Cited by 57

Proline-Rich Tyrosine Kinase 2 Regulates Hippocampal Long-Term Depression

Hsin, H., Kim, M. J., Wang, C.-F., & Sheng, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1029-10.2010 · Cited by 55

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease

Beck, T. N., Nicolas, E., Kopp, M. C., & Golemis, E. A. (2014) · Oncoscience · doi:10.18632/oncoscience.64 · Cited by 50

Central Role of Calcium-Dependent Tyrosine Kinase PYK2 in Endothelial Nitric Oxide Synthase–Mediated Angiogenic Response and Vascular Function

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Dual Roles for RHOA/RHO-Kinase In the Regulated Trafficking of a Voltage-sensitive Potassium Channel

Stirling, L., Williams, M. R., & Morielli, A. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1074 · Cited by 45

The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

Canobbio, I., Cipolla, L., Guidetti, G. F., Manganaro, D., Visconte, C., Kim, S., Okigaki, M., Falasca, M., Kunapuli, S. P., & Torti, M. (2015) · Biochemical Journal · doi:10.1042/bj20150048 · Cited by 40

Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target

Crossley, C. A., Rajani, V., & Yuan, Q. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.11.049 · Cited by 28

Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB.

Cramer, T., Jüttner, S., Plath, T., Mergler, S., Seufferlein, T., Wang, T. C., Merchant, J., & Höcker, M. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.08.016 · Cited by 27

Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation

Palhano Zanela, T. M., Woudenberg, A., Romero Bello, K. G., & Underbakke, E. S. (2023) · Structure · doi:10.1016/j.str.2023.02.003 · Cited by 12

Molecularly imprinted nanoparticles reveal regulatory scaffolding features in Pyk2 tyrosine kinase

Zanela, T. M. P., Zangiabadi, M., Zhao, Y., & Underbakke, E. S. (2024) · RSC Chemical Biology · doi:10.1039/d3cb00228d · Cited by 3