Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

MeCP2 modulates gene expression pathways in astrocytes

Yasui, D. H., Xu, H., Dunaway, K. W., LaSalle, J. M., Jin, L.-W., & Maezawa, I. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-3 · Cited by 90

DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?

Luo, G.-Z., & He, C. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3412 · Cited by 87

Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression

Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., & Oikawa, T. (2003) · Oncogene · doi:10.1038/sj.onc.1207182 · Cited by 87

Human neuronal maturation comes of age: cellular mechanisms and species differences

Wallace, J. L., & Pollen, A. A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00760-3 · Cited by 82

MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy

Rastegar, M., Hotta, A., Pasceri, P., Makarem, M., Cheung, A. Y. L., Elliott, S., Park, K. J., Adachi, M., Jones, F. S., Clarke, I. D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006810 · Cited by 79

Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications

Szyf, M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.009 · Cited by 76

Misregulation of alternative splicing in a mouse model of Rett syndrome

Li, R., Dong, Q., Yuan, X., Zeng, X., Gao, Y., Chiao, C., Li, H., Zhao, X., Keles, S., Wang, Z., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006129 · Cited by 67

Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis

van Kaam, K. J. A. F., Delvoux, B., Romano, A., D’Hooghe, T., Dunselman, G. A. J., & Groothuis, P. G. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.031 · Cited by 64

Epigenetic Modification of the Norepinephrine Transporter Gene in Postural Tachycardia Syndrome

Bayles, R., KN, H., Lambert, E., Baker, E. K., Agrotis, A., Guo, L., Jowett, J. B. M., Esler, M., Lambert, G., & El-Osta, A. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.244343 · Cited by 56

Histone modifications as a pathogenic mechanism of colorectal tumorigenesis

Gargalionis, A. N., Piperi, C., Adamopoulos, C., & Papavassiliou, A. G. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.002 · Cited by 53

Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex

Piazza, R., Magistroni, V., Mogavero, A., Andreoni, F., Ambrogio, C., Chiarle, R., Mologni, L., Bachmann, P. S., Lock, R. B., Collini, P., et al. (2013) · Neoplasia · doi:10.1593/neo.121784 · Cited by 51

Rett syndrome and the urge of novel approaches to study MeCP2 functions and mechanisms of action

Bedogni, F., Rossi, R. L., Galli, F., Cobolli Gigli, C., Gandaglia, A., Kilstrup-Nielsen, C., & Landsberger, N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.011 · Cited by 51

Retinoblastoma tumor suppressor and genome stability

(2002) · Advances in Cancer Research · doi:10.1016/s0065-230x(02)85002-3 · Cited by 48

Role of MeCP2, DNA methylation, and HDACs in regulating synapse function

Kavalali, E. T., Nelson, E. D., & Monteggia, L. M. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9078-3 · Cited by 46

MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders

Frasca, A., Spiombi, E., Palmieri, M., Albizzati, E., Valente, M. M., Bergo, A., Leva, B., Kilstrup‐Nielsen, C., Bianchi, F., Di Carlo, V., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201910270 · Cited by 46

Activation of a Methylated Promoter Mediated by a Sequence-specific DNA-binding Protein, RFX

Niesen, M. I., Osborne, A. R., Yang, H., Rastogi, S., Chellappan, S., Cheng, J. Q., Boss, J. M., & Blanck, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504633200 · Cited by 42

MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors

Mahgoub, M., Adachi, M., Suzuki, K., Liu, X., Kavalali, E. T., Chahrour, M. H., & Monteggia, L. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4395 · Cited by 40

Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower doses of bisphenol A in embryonic hypothalamic cells

Warita, K., Mitsuhashi, T., Ohta, K.-I., Suzuki, S., Hoshi, N., Miki, T., & Takeuchi, Y. (2013) · The Journal of Toxicological Sciences · doi:10.2131/jts.38.285 · Cited by 41

Subchronic Administration of Phencyclidine Produces Hypermethylation in the Parvalbumin Gene Promoter in Rat Brain

Fachim, H. A., Srisawat, U., Dalton, C. F., Harte, M. K., Marsh, S., Neill, J. C., & Reynolds, G. P. (2016) · Epigenomics · doi:10.2217/epi-2016-0050 · Cited by 22

Characterization of DNA methylation and its association with other biological systems in lymphoblastoid cell lines

Zhang, Z., Liu, J., Kaur, M., & Krantz, I. D. (2012) · Genomics · doi:10.1016/j.ygeno.2012.01.002 · Cited by 18

Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory

Scott, H., Smith, A. E., Barker, G. R., Uney, J. B., & Warburton, E. C. (2017) · Neuroepigenetics · doi:10.1016/j.nepig.2017.02.001 · Cited by 18

Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation

D'Annessa, I., Gandaglia, A., Brivio, E., Stefanelli, G., Frasca, A., Landsberger, N., & Di Marino, D. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.02.005 · Cited by 18

TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation

Liu, Y., He, T., Li, Z., Sun, Z., Wang, S., Shen, H., Hou, L., Li, S., Wei, Y., Zhuo, B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108312 · Cited by 15

Analog epigenetic memory revealed by targeted chromatin editing

Palacios, S., Bruno, S., Weiss, R., Salibi, E., Kane, A., Ilia, K., & Del Vecchio, D. (2024) · doi:10.1101/2024.02.13.580200 · Cited by 13

Analog epigenetic memory revealed by targeted chromatin editing

(2025) · doi:10.1016/j.xgen.2025.100985 · Cited by 13

Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms

Ignatieva, E. V., & Matrosova, E. A. (2021) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj21.003 · Cited by 12

Identification of Region-Specific Cytoskeletal and Molecular Alterations in Astrocytes of Mecp2 Deficient Animals

Albizzati, E., Florio, E., Miramondi, F., Sormonta, I., Landsberger, N., & Frasca, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.823060 · Cited by 12

Transcription factors that define the epigenome structures and transcriptomes in microglia

Saeki, K., & Ozato, K. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104814 · Cited by 11

Pathological Synaptic Plasticity in Neurological Disorders

Jin, C., & Karlstedt, K. (2025) · Synaptic Plasticity - Neurobiology, Neuroanatomy, and Clinical Neuroscience · doi:10.5772/intechopen.1007753 · Cited by 1