Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory
Open accessAbstract
Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood. Here we investigated the roles of two epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition memory. Infusion of DNA methyltransferase inhibitors into PRh impaired performance in novel object recognition and object-in-place tasks while infusions into HPC or mPFC impaired object-in-place performance only. In contrast, inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition memory. These results support the emerging role of epigenetic processes in learning and memory.
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Medial prefrontal cortical DNA methylation, but not histone deacetylation, is involved in OiP memory.
“In addition, medial prefrontal cortical DNA methylation, but not histone deacetylation, is involved in OiP memory (Scott et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Scott et al., 2017
Post-sample infusions of the DNMT inhibitor RG108 or 5-aza-2'-deoxycytidine into the hippocampus impaired memory in the OiP, but not NOP, test, suggesting that hippocampal DNA methylation engages in the processing of object-place information.
“Post-sample infusions of the DNMT inhibitor RG108 or 5-aza-2’-deoxycytidine into the hippocampus impaired memory in the OiP, but not NOP, test, suggesting that hippocampal DNA methylation engages in the processing of object-place information (Scott et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Scott et al., 2017
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Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
- Authors
- Scott, H., Smith, A. E., Barker, G. R., Uney, J. B., & Warburton, E. C.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Scott, Hannah
- Venue
- Neuroepigenetics
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 9
- Pages
- 1-9
- ISSN
- 2214-7845 (ISSN-L)
- PMC
- PMC5364272
- OpenAlex
- W2592498240
- Cited by
- 18
- References
- 73
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuroepigenetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Explore Bristol Research (submittedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion, cc-by)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/I00310X/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- recognition memory, hypomethylating agents, histone deacetylase inhibitors, DNA methylation, histone deacetylation, perirhinal cortex, hippocampus, medial prefrontal cortex, novel object recognition, spatial memory, memory consolidation
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