The DOI matches its Crossref record.
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210
BrafV600E cooperates with Pten loss to induce metastatic melanoma
Dankort, D., Curley, D. P., Cartlidge, R. A., Nelson, B., Karnezis, A. N., Damsky Jr, W. E., You, M. J., DePinho, R. A., McMahon, M., & Bosenberg, M. (2009) · Nature Genetics · doi:10.1038/ng.356 · Cited by 1,189
Chakarov, S., Lim, H. Y., Tan, L., Lim, S. Y., See, P., Lum, J., Zhang, X.-M., Foo, S., Nakamizo, S., Duan, K., et al. (2019) · Science · doi:10.1126/science.aau0964 · Cited by 1,114
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019
Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A. (2011) · Science · doi:10.1126/science.1213214 · Cited by 742
Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674
Bentzinger, C. F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.002 · Cited by 640
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646
Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, M., Vlantis, K., Kumari, S., Polykratis, A., Kim, C., Wachsmuth, L., Eftychi, C., Lin, J., Corona, T., Hermance, N., et al. (2014) · Nature · doi:10.1038/nature13608 · Cited by 534
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524
Rothwell, P. E., Fuccillo, M. V., Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K., Fowler, S. C., Malenka, R. C., & Südhof, T. C. (2014) · Cell · doi:10.1016/j.cell.2014.04.045 · Cited by 477
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl
Busslinger, G. A., Stocsits, R. R., van der Lelij, P., Axelsson, E., Tedeschi, A., Galjart, N., & Peters, J.-M. (2017) · Nature · doi:10.1038/nature22063 · Cited by 468
Koch, U., Fiorini, E., Benedito, R., Besseyrias, V., Schuster-Gossler, K., Pierres, M., Manley, N. R., Duarte, A., MacDonald, H. R., & Radtke, F. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080829 · Cited by 464
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
Hoogaars, W. M. H., Engel, A., Brons, J. F., Verkerk, A. O., de Lange, F. J., Wong, L. Y. E., Bakker, M. L., Clout, D. E., Wakker, V., Barnett, P., et al. (2007) · Genes & Development · doi:10.1101/gad.416007 · Cited by 409
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.021 · Cited by 396
The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity
Damgaard, R. B., Walker, J. A., Marco-Casanova, P., Morgan, N. V., Titheradge, H. L., Elliott, P. R., McHale, D., Maher, E. R., McKenzie, A. N. J., & Komander, D. (2016) · Cell · doi:10.1016/j.cell.2016.07.019 · Cited by 348
Wapl is an essential regulator of chromatin structure and chromosome segregation
Tedeschi, A., Wutz, G., Huet, S., Jaritz, M., Wuensche, A., Schirghuber, E., Davidson, I. F., Tang, W., Cisneros, D. A., Bhaskara, V., et al. (2013) · Nature · doi:10.1038/nature12471 · Cited by 359
Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
Melzer, S., Michael, M., Caputi, A., Eliava, M., Fuchs, E. C., Whittington, M. A., & Monyer, H. (2012) · Science · doi:10.1126/science.1217139 · Cited by 333
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
Takahashi, N., Vereecke, L., Bertrand, M. J. M., Duprez, L., Berger, S. B., Divert, T., Gonçalves, A., Sze, M., Gilbert, B., Kourula, S., et al. (2014) · Nature · doi:10.1038/nature13706 · Cited by 318
Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex
Schaefer, A., Sampath, S. C., Intrator, A., Min, A., Gertler, T. S., Surmeier, D. J., Tarakhovsky, A., & Greengard, P. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.019 · Cited by 317
PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory
Volk, L. J., Bachman, J. L., Johnson, R., Yu, Y., & Huganir, R. L. (2013) · Nature · doi:10.1038/nature11802 · Cited by 310
A conditional knockout mouse line of the oxytocin receptor
Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1710 · Cited by 269
Identification of spinal circuits involved in touch-evoked dynamic mechanical pain
Cheng, L., Duan, B., Huang, T., Zhang, Y., Chen, Y., Britz, O., Garcia-Campmany, L., Ren, X., Vong, L., Lowell, B. B., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4549 · Cited by 240
Pirinen, E., Cantó, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.002 · Cited by 254
Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1679 · Cited by 237
Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
Hiller, B., Achleitner, M., Glage, S., Naumann, R., Behrendt, R., & Roers, A. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120876 · Cited by 245
Wunderlich, F. T., Ströhle, P., Könner, A. C., Gruber, S., Tovar, S., Brönneke, H. S., Juntti-Berggren, L., Li, L.-S., van Rooijen, N., Libert, C., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.011 · Cited by 229
Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation
Migliarini, S., Pacini, G., Pelosi, B., Lunardi, G., & Pasqualetti, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.128 · Cited by 225
Roberti, M. P., Yonekura, S., Duong, C. P. M., Picard, M., Ferrere, G., Tidjani Alou, M., Rauber, C., Iebba, V., Lehmann, C. H. K., Amon, L., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0882-8 · Cited by 208
The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy
Soleimanpour, S. A., Gupta, A., Bakay, M., Ferrari, A. M., Groff, D. N., Fadista, J., Spruce, L. A., Kushner, J. A., Groop, L., Seeholzer, S. H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.016 · Cited by 211
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197
IAPs limit activation of RIP kinases by TNF receptor 1 during development
Moulin, M., Anderton, H., Voss, A. K., Thomas, T., Wong, W. W., Bankovacki, A., Feltham, R., Chau, D., Cook, W. D., Silke, J., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.18 · Cited by 193
Inhibition of MTOR Disrupts Autophagic Flux in Podocytes
Cinà, D. P., Onay, T., Paltoo, A., Li, C., Maezawa, Y., De Arteaga, J., Jurisicova, A., & Quaggin, S. E. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011070690 · Cited by 172
Cre‐lox P‐Mediated Recombination: General Principles and Experimental Considerations
McLellan, M. A., Rosenthal, N. A., & Pinto, A. R. (2017) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.22 · Cited by 172
Nakamura, Y., Inloes, J. B., Katagiri, T., & Kobayashi, T. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05178-11 · Cited by 170
An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase
Kranz, A., Fu, J., Duerschke, K., Weidlich, S., Naumann, R., Stewart, A. F., & Anastassiadis, K. (2010) · genesis · doi:10.1002/dvg.20641 · Cited by 153
Current issues in mouse genome engineering
Glaser, S., Anastassiadis, K., & Stewart, A. F. (2005) · Nature Genetics · doi:10.1038/ng1668 · Cited by 160
Self-citationMouton‐Liger, F., Rosazza, T., Sepulveda‐Diaz, J., Ieang, A., Hassoun, S., Claire, E., Mangone, G., Brice, A., Michel, P. P., Corvol, J., et al. (2018) · Glia · doi:10.1002/glia.23337 · Cited by 160
Origin of the Precerebellar System
Rodriguez, C. I., & Dymecki, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00059-3 · Cited by 149
Self-citationBerry, D. C., Jacobs, H., Marwarha, G., Gely-Pernot, A., O'Byrne, S. M., DeSantis, D., Klopfenstein, M., Feret, B., Dennefeld, C., Blaner, W. S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.484014 · Cited by 148
Blaess, S., Bodea, G. O., Kabanova, A., Chanet, S., Mugniery, E., Derouiche, A., Stephen, D., & Joyner, A. L. (2011) · Neural Development · doi:10.1186/1749-8104-6-29 · Cited by 133
Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
Gopinathan, L., Tan, S. L. W., Padmakumar, V. C., Coppola, V., Tessarollo, L., & Kaldis, P. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3440 · Cited by 123
Functional Characterization of Genetically Labeled Gonadotropes
Wen, S., Schwarz, J. R., Niculescu, D., Dinu, C., Bauer, C. K., Hirdes, W., & Boehm, U. (2008) · Endocrinology · doi:10.1210/en.2007-1502 · Cited by 112
Site-Specific Recombinases for Manipulation of the Mouse Genome
Birling, M.-C., Gofflot, F., & Warot, X. (2009) · Methods in Molecular Biology · doi:10.1007/978-1-60327-019-9_16 · Cited by 106
Mapping cell fate and function using recombinase-based intersectional strategies
Dymecki, S. M., Ray, R. S., & Kim, J. C. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)77011-7 · Cited by 104
Self-citationChen, J., Chen, M. X., Fogo, A. B., Harris, R. C., & Chen, J.-K. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010101 · Cited by 82
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Bartolini, G., Sánchez-Alcañiz, J. A., Osório, C., Valiente, M., García-Frigola, C., & Marín, O. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.089 · Cited by 74
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer
Kalisz, M., Bernardo, E., Beucher, A., Maestro, M. A., del Pozo, N., Millán, I., Haeberle, L., Schlensog, M., Safi, S. A., Knoefel, W. T., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019102808 · Cited by 77
Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program
van Eif, V., Stefanovic, S., van Duijvenboden, K., Bakker, M., Wakker, V., de Gier-de Vries, C., Zaffran, S., Verkerk, A. O., Boukens, B. J., & Christoffels, V. (2019) · Development · doi:10.1242/dev.173161 · Cited by 76
The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
Zhu, P., Zhang, C., Gao, Y., Wu, F., Zhou, Y., & Wu, W.-S. (2019) · Nature Communications · doi:10.1038/s41467-019-10479-4 · Cited by 66
Essentials of Recombinase-Based Genetic Fate Mapping in Mice
Jensen, P., & Dymecki, S. M. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-60327-292-6_26 · Cited by 54
Self-citationVoisinne, G., García‐Blesa, A., Chaoui, K., Fiore, F., Bergot, E., Girard, L., Malissen, M., Burlet‐Schiltz, O., Gonzalez de Peredo, A., Malissen, B., et al. (2016) · Molecular Systems Biology · doi:10.15252/msb.20166837 · Cited by 50
Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization
Zigrino, P., Ayachi, O., Schild, A., Kaltenberg, J., Zamek, J., Nischt, R., Koch, M., & Mauch, C. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.05.003 · Cited by 38
Williams Avram, S. K., Lee, H.-J., Fastman, J., Cymerblit-Sabba, A., Smith, A., Vincent, M., Song, J., Granovetter, M. C., Lee, S.-H., Cilz, N. I., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00218 · Cited by 22
Tyrrell, B. J., Woodham, E. F., Spence, H. J., Strathdee, D., Insall, R. H., & Machesky, L. M. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12506 · Cited by 21
The RAC1 Target NCKAP1 Plays a Crucial Role in the Progression of Braf;Pten-Driven Melanoma in Mice
Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F., Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J., & Machesky, L. M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.06.029 · Cited by 18
RTF2 controls replication repriming and ribonucleotide excision at the replisome
Conti, B. A., Ruiz, P. D., Broton, C., Blobel, N. J., Kottemann, M. C., Sridhar, S., Lach, F. P., Wiley, T. F., Sasi, N. K., Carroll, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45947-z · Cited by 8
Metadata
- Authors
- Rodríguez, C. I., Buchholz, F., Galloway, J., Sequerra, R., Kasper, J., Ayala, R., Stewart, A. F., & Dymecki, S. M.
- Venue
- Nature Genetics
- Published
- 2000-06
- Volume
- 25
- Issue
- 2
- Pages
- 139-140
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2150013759
- Cited by
- 1,159
- References
- 0
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.