Cited by 165Gastrointestinal motility and disordersInflammatory Bowel DiseaseGut microbiota and health

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T-Cell Activation in Patients With Irritable Bowel Syndrome

Öhman, Lena, Isaksson, Stefan, Lindmark, Ann-Charlotte, Posserud, Iris, Stotzer, P-O, Strid, Hans, Sjövall, Henrik, Simrén, Magnus·2009·The American Journal of Gastroenterology

DOI 10.1038/ajg.2009.116

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Abstract

OBJECTIVES: Irritable bowel syndrome (IBS) has been found to be associated with low-grade immune activation in a subset of patients. We therefore investigated blood and colonic T-cell activity in IBS patients. METHODS: Blood samples were initially obtained from 74 IBS patients and 30 controls. Supplementary blood samples, to confirm data, were taken from another cohort (26 patients and 14 controls). In addition, colonic biopsies were taken from a third cohort (11 patients and 10 controls). Peripheral blood and colonic mononuclear cells were stimulated with anti-CD3/CD28 antibodies. Proliferation, cytokine secretion, and T-cell phenotype were investigated. IBS symptom severity was assessed. RESULTS: IBS patients displayed an activated phenotype with increased frequencies of blood T cells expressing CD69 and integrin beta7/HLA-DR. Anti-CD3/CD28-stimulated blood and colonic T cells from IBS patients proliferated less than T cells from controls. IBS patients had an increased polyclonally stimulated T-cell secretion of IL-1beta, which also weakly correlated with increased bowel habit dissatisfaction. Furthermore, despite normal frequencies of CD25high T cells in the blood of IBS patients, lower blood CD25high T-cell frequencies were modestly correlated with more bowel habit dissatisfaction and increased total IBS symptom severity. CONCLUSIONS: IBS patients have an increased frequency of activated T cells, demonstrated by the expression of activation markers and reduced proliferation in response to restimulation in vitro. The increased level of T-cell activation is consistent with the hypothesis of low-grade immune activation in IBS and may also be involved in symptom generation in IBS.

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Authors: Öhman, L., Isaksson, S., Lindmark, A.-C., Posserud, I., Stotzer, P.-O., Strid, H., Sjövall, H., & Simrén, M.
Affiliations: University of Gothenburg (SE)
Corresponding author: Öhman, Lena
ORCID: Öhman, Lena
Strid, Hans
Simrén, Magnus
Venue: The American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-04-14
Volume: 104
Issue: 5
Pages: 1205-1212
ISSN: 0002-9270 (ISSN-L)
1572-0241
DOI: 10.1038/ajg.2009.116
OpenAlex: W2069870942
Cited by: 165
References: 32
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 12 · 2012: 21
FWCI: 20.18
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: The American Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: irritable bowel syndrome, T cell activation, CD69, beta7 integrin, HLA-DR, T cell proliferation, IL-1β, IBS symptom severity
MeSH terms: Adult, Biopsy, Needle, Cells, Cultured, Female, Flow Cytometry, Humans, Intestinal Mucosa, Lymphocyte Activation, Male, Middle Aged, Probability, Reference Values, Sensitivity and Specificity, Severity of Illness Index, T-Lymphocytes, Case-Control Studies, Cytokines, Statistics, Nonparametric, Irritable Bowel Syndrome, Cell Proliferation, Interleukin-1beta, Young Adult

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T-Cell Activation in Patients With Irritable Bowel Syndrome

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