The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
T-Cell Activation in Patients With Irritable Bowel Syndrome
Abstract
OBJECTIVES: Irritable bowel syndrome (IBS) has been found to be associated with low-grade immune activation in a subset of patients. We therefore investigated blood and colonic T-cell activity in IBS patients. METHODS: Blood samples were initially obtained from 74 IBS patients and 30 controls. Supplementary blood samples, to confirm data, were taken from another cohort (26 patients and 14 controls). In addition, colonic biopsies were taken from a third cohort (11 patients and 10 controls). Peripheral blood and colonic mononuclear cells were stimulated with anti-CD3/CD28 antibodies. Proliferation, cytokine secretion, and T-cell phenotype were investigated. IBS symptom severity was assessed. RESULTS: IBS patients displayed an activated phenotype with increased frequencies of blood T cells expressing CD69 and integrin beta7/HLA-DR. Anti-CD3/CD28-stimulated blood and colonic T cells from IBS patients proliferated less than T cells from controls. IBS patients had an increased polyclonally stimulated T-cell secretion of IL-1beta, which also weakly correlated with increased bowel habit dissatisfaction. Furthermore, despite normal frequencies of CD25high T cells in the blood of IBS patients, lower blood CD25high T-cell frequencies were modestly correlated with more bowel habit dissatisfaction and increased total IBS symptom severity. CONCLUSIONS: IBS patients have an increased frequency of activated T cells, demonstrated by the expression of activation markers and reduced proliferation in response to restimulation in vitro. The increased level of T-cell activation is consistent with the hypothesis of low-grade immune activation in IBS and may also be involved in symptom generation in IBS.
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“In addition to elevated concentrations of T cells, patients with IBS may also have an increased numbers of activated T cells in the colon (36) and peripheral blood (122) compared with controls.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [122]
In the citing paper
“Furthermore, increases in the secretion of TNF-α following LPS stimulation of PBMCs and of IL-1β following T-cell anti-CD3/CD28 antibodies stimulation were significantly associated with anxiety (98) and bowel habit dissatisfaction and overall IBS symptoms (122), respectively.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [122]
In the citing paper
“Peripheral blood T cells from patients with IBS express elevated levels of integrin β7 (122, 123), which is important for homing of cells to the intestines.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [122]
In the citing paper
“Cytokine secretion following in vitro stimulation of peripheral blood lymphocytes/monocytes may also be altered in patients with IBS (90, 98, 122).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [122]
In the citing paper
“Overall, it seems that alterations in cytokine secretion by stimulated peripheral blood cells appear to favor an activated immune state (98, 122), and an altered immune response shifted toward a T-helper 2 phenotype(90) in IBS patients.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [122]
Citations
Cites
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
FRANCIS, C. Y., MORRIS, J., & WHORWELL, P. J. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.142318000.x · Cited by 1,708
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
Immune Activation in Patients With Irritable Bowel Syndrome
Liebregts, T., Adam, B., Bredack, C., Röth, A., Heinzel, S., Lester, S., Downie–Doyle, S., Smith, E., Drew, P., Talley, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.046 · Cited by 660
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636
Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583
Gwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387 · cited 1×
“Furthermore, individuals who develop IBS after an infectious gastroenteritis have increased expression of the proinflammatory cytokine IL-1β mRNA in rectal biopsies (”
BackgroundDunlop, S. P., Jenkins, D., & Spiller, R. C. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07542.x · Cited by 359 · cited 1×
“Accordingly, one of the most frequently reported phenomena in IBS patients is increased numbers of intraepithelial T lymphocytes and lamina propria T lymphocytes, which has been found in the colonic mucosa of both non-post-infectious IBS patients (”
BackgroundT lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats
Moalem‐Taylor, G., Xu, K., & Yu, L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.035 · Cited by 311
Long term benefits of hypnotherapy for irritable bowel syndrome
Gonsalkorale, W. M., Miller, V, Afzal, A., & Whorwell, P. J. (2003) · Gut · doi:10.1136/gut.52.11.1623 · Cited by 283
Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273
Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity
Posserud, I., Syrous, A., Lindström, L., Tack, J., Abrahamsson, H., & Simrén, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.024 · Cited by 248
Self-citationvan der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217
Simrén, M. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(01)04037-0 · Cited by 186
Self-citationHolmén, N., Lundgren, A., Lundin, S. B., Bergin, A.-M. H., Rudin, A., Sjövall, H., & Öhman, L. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200606000-00003 · Cited by 182
Self-citationDunlop, S., Jenkins, D., Neal, K. R., Næsdal, J., Borgaonker, M., Collins, S. M., & Spiller, R. E. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01640.x · Cited by 178
Parry, S. D., Stansfield, R., Jelley, D., Gregory, W., Phillips, E., Barton, J. R., & Welfare, M. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07664.x · Cited by 160
New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
Öhman, L., & Simrén, M. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.10.014 · Cited by 155
Self-citationNew Insights into the Pathogenesis and Pathophysiology of Irritable Bowel Syndrome
Collins, S. M. (1992) · Springer eBooks · doi:10.1007/978-1-4615-3314-6_9 · Cited by 115
Öhman, L., Isaksson, S., Lundgren, A., Simrén, M., & Sjövall, H. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00410-6 · Cited by 98
Self-citationRenno, T., Attinger, A., Locatelli, S., Bakker, T. R., Vacheron, S., & MacDonald, H. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6312 · Cited by 98
Collagenous, microscopic and lymphocytic colitis. An evolving concept
Bogomoletz, W. V. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00195769 · Cited by 83
A case for an immunological basis for irritable bowel syndrome
Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.34097 · Cited by 79
Parry, S. D., Stansfield, R., Jelley, D., Gregory, W., Phillips, E., Barton, J. R., & Welfare, M. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07242.x · Cited by 68
CD4+CD25+ regulatory T cells in irritable bowel syndrome patients
Holmén, N., Isaksson, S., Simrén, M., Sjövall, H., & Öhman, L. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00878.x · Cited by 38
Self-citation130 Activated Innate Immune System in Irritable Bowel Syndrome?
Langhorst, J., Junge, A., Rueffer, A., Wehkamp, J., Foell, D., Michalsen, A., Musial, F., & Dobos, G. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)60112-2 · Cited by 32
Collagenous, microscopic and lymphocytic colitis. An evolving concept
Bogomoletz, W. V. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01069735 · Cited by 28
Activated innate immune system in irritable bowel syndrome?
Langhorst, J., Wieder, A., Michalsen, A., Musial, F., Dobos, G., & Rueffer, A. (2007) · Gut · doi:10.1136/gut.2007.125005 · Cited by 26
Akiho, H., Murao, H., Ogino, H., Kanayama, K., Sumida, Y., Yoshinaga, S., Itaba, S., Nakamura, K., Takayanagi, R., Khan, W. I., et al. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)60053-0 · Cited by 2
Kindt, S., Berghe, P. V., & Tack, J. F. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)60682-4 · Cited by 1
Research works printed but not linked: 4
- Simrén M, 2002, Am J Gastroenterol, 97, 389, 10.1111/j.1572-0241.2002.05475.x · DOI · Paper page
- Parry SD, 2003, Am J Gastroenterol, 98, 1970
- Thompson WG, 1999, Gut, 45, 43
- Kindt S, 2008, Gastroenterology, 134, A147
Cited by
Sorted by citations
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
Öhman, L., & Simrén, M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.4 · Cited by 617
Self-citationAn overview of the last advances in probiotic and prebiotic field
Saad, N., Delattre, C., Urdaci, M. C., Schmitter, J., & Bressollier, P. (2012) · LWT · doi:10.1016/j.lwt.2012.05.014 · Cited by 540
Camilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 412
The role of inflammation in irritable bowel syndrome (IBS)
Ng, Q. X., Soh, A. Y. S., Loke, W., Lim, D. Y., & Yeo, W. S. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s174982 · Cited by 373
Gardner, A., & Boles, R. G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.030 · Cited by 333
Metadata
- Authors
- Öhman, L., Isaksson, S., Lindmark, A.-C., Posserud, I., Stotzer, P.-O., Strid, H., Sjövall, H., & Simrén, M.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Öhman, Lena
- Venue
- The American Journal of Gastroenterology
- Published
- 2009-04-14
- Volume
- 104
- Issue
- 5
- Pages
- 1205-1212
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2069870942
- Cited by
- 165
- References
- 32
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 13 · 2017: 10 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 12 · 2012: 21
- FWCI
- 20.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, T cell activation, CD69, beta7 integrin, HLA-DR, T cell proliferation, IL-1β, IBS symptom severity
- MeSH terms
- Adult, Biopsy, Needle, Cells, Cultured, Female, Flow Cytometry, Humans, Intestinal Mucosa, Lymphocyte Activation, Male, Middle Aged, Probability, Reference Values, Sensitivity and Specificity, Severity of Illness Index, T-Lymphocytes, Case-Control Studies, Cytokines, Statistics, Nonparametric, Irritable Bowel Syndrome, Cell Proliferation, Interleukin-1beta, Young Adult
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