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p28, A first in class peptide inhibitor of cop1 binding to p53
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“p28 inhibits the interaction between the E3 ligase COP1 and p53,517 improves the posttranslational stability of p53, and increases p53 protein expression in various p53 wild-type or mutated tumor cell lines.518,519”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [517]
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Citations
Cites
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 1×
“HDM2 or MDM2 is the major E3 ligase promoting p53 degradation (Haupt et al, 1997; Kubbutat et al, 1997), but TOPORS, Pirh2 and particularly COP1 also bind to and negatively regulate p53 (Leng et al, 2003; Dornan et al, 2004b; Rajendra et al, 2004).”
BackgroundThe IARC TP53 database: new online mutation analysis and recommendations to users
Olivier, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C., & Hainaut, P. (2002) · Human Mutation · doi:10.1002/humu.10081 · Cited by 1,248
Translating p53 into the clinic
Cheok, C. F., Verma, C. S., Baselga, J., & Lane, D. P. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.174 · Cited by 381
Kojima, K., Burks, J. K., Arts, J., & Andreeff, M. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0337 · Cited by 78
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Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Cell-Penetrating Peptides: Design, Synthesis, and Applications
Copolovici, D. M., Langel, K., Eriste, E., & Langel, Ü. (2014) · ACS Nano · doi:10.1021/nn4057269 · Cited by 963
Bacteriocins: Perspective for the development of novel anticancer drugs
Baindara, P., Korpole, S., & Grover, V. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9420-8 · Cited by 139
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Metadata
- Authors
- Yamada, T., Christov, K., Shilkaitis, A., Bratescu, L., Green, A., Santini, S., Bizzarri, A. R., Cannistraro, S., Gupta, T. K. D., & Beattie, C. W.
- Venue
- British Journal of Cancer
- Published
- 2013-06
- Volume
- 108
- Issue
- 12
- Pages
- 2495-2504
- ISSN
- 0007-0920
- 1532-1827
- Cited by
- 78
- References
- 4
- Language
- en
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