Dopaminergic effects on in vitro osteogenesis
Open accessAbstract
Multiple growth factors (e.g., BMP2, TGF-β1, FGF2) and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine (PDA) and dopamine (DA) monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA’s role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. mRNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression (ALP, BSP, OC, OSX, RUNX2, and Collagen1a2) with or without receptor antagonists (SCH233390 and GR103691). Two-way ANOVA was used for statistical analysis. All five DA receptors (D1, D2, D3, D4, and D5) mRNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days (P < 0.05). Osteogenic mineralization was significantly greater in the DA-treated group than control group (P < 0.05). Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair. Brain chemicals called neurotransmitters may play an important role in bone formation, new research from the US suggests. The role of the neurotransmitter dopamine in bone is largely unknown but recent research has suggested that bone cells may respond to neurotransmitters. Dr Ching-Chang Ko from the University of North Carolina and colleagues discovered adding dopamine to bone cells from mice stimulated cell division for up to seven days. Mineralization of the cells, an indication of bone formation, was also greater in the cells treated with dopamine than in untreated cells. The researchers suggest that dopamine can enhance bone regeneration. Using dopamine, potentially in conjunction with bone scaffolds in tissue engineering, could lead to a novel way of growing bone for use in orthopedic applications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Quantification of Alizarin Red S staining was performed according to a previous study.
“Quantification of Alizarin Red S staining was performed according to previous study [28].”
From A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties (2022) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965 · see citing works
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633 · see citing works
Single-molecule mechanics of mussel adhesion
Lee, H., Scherer, N. F., & Messersmith, P. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605552103 · Cited by 2,112 · see citing works
Jiang, J., Zhu, L., Zhu, L., Zhu, B., & Xu, Y. (2011) · Langmuir · doi:10.1021/la202877k · Cited by 750 · see citing works
General functionalization route for cell adhesion on non-wetting surfaces
Ku, S. H., Ryu, J., Hong, S. K., Lee, H., & Park, C. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.020 · Cited by 687 · see citing works
Wang, D., Christensen, K., Chawla, K., Xiao, G., Krebsbach, P. H., & Franceschi, R. T. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.6.893 · Cited by 666 · see citing works
Ashammakhi, N. A., & Ferretti, P. (2004) · UCL Discovery (University College London) · Cited by 382 · see citing works
Serre, C., Farlay, D., Delmas, P. D., & Chenu, C. (1999) · Bone · doi:10.1016/s8756-3282(99)00215-x · Cited by 259 · see citing works
Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering
Tsai, W., Chen, W.-T., Chien, H., Kuo, W., & Wang, M. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.07.024 · Cited by 221 · see citing works
Togari, A. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10121 · Cited by 211 · see citing works
Expression of Serotonin Receptors in Bone
Westbroek, I., van der Plas, A., de Rooij, K. E., Klein‐Nulend, J., & Nijweide, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101824200 · Cited by 206 · see citing works
Rim, N. G., Kim, S. J., Shin, Y. M., Jun, I., Lim, D. W., Park, J. H., & Shin, H. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.10.057 · Cited by 201 · see citing works
Lai, C., & Yu, P. H. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00731-9 · Cited by 198 · see citing works
The cytotoxicity of dopamine may be an artefact of cell culture
Clement, M., Long, L. H., Ramalingam, J. K., & Halliwell, B. B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00802.x · Cited by 140 · see citing works
Dopaminergic Signaling in the Cochlea: Receptor Expression Patterns and Deletion Phenotypes
Maison, S. F., Liu, X.-P., Eatock, R. A., Sibley, D. R., Grandy, D. K., & Liberman, M. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4720-11.2012 · Cited by 107 · see citing works
Sun, Y., Deng, Y., Ye, Z., Liang, S., Tang, Z., & Wei, S. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.05.037 · Cited by 95 · see citing works
Bliziotes, M. M., McLoughlin, S. W., Gunness, M. E., Fumagalli, F., Jones, S. R., & Caron, M. G. (2000) · Bone · doi:10.1016/s8756-3282(99)00232-x · Cited by 78 · see citing works
Dopamine D2-like receptor signaling suppresses human osteoclastogenesis
Hanami, K., Nakano, K., Saito, K., Okada, Y., Yamaoka, K., Kubo, S., Kondo, M., & Tanaka, Y. (2013) · Bone · doi:10.1016/j.bone.2013.04.019 · Cited by 65 · see citing works
Sympathetic nervous system and bone remodeling
Chenu, C., & Marenzana, M. (2005) · Joint Bone Spine · doi:10.1016/j.jbspin.2005.10.007 · Cited by 39 · see citing works
Functional GABAB receptors expressed in cultured calvarial osteoblasts
Fujimori, S., Hinoi, E., & Yoneda, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00405-9 · Cited by 39 · see citing works
Adrenaline, Noradrenaline and Dopamine Level Estimation in Depression : Does it Help?
Ambade, V. N., Arora, M., Singh, P., Somani, B. L., & Basannar, D. R. (2009) · Medical Journal Armed Forces India · doi:10.1016/s0377-1237(09)80006-3 · Cited by 35 · see citing works
Kinins and Neuro-osteogenic Factors
Lerner, U. H., Persson, E., & Lundberg, P. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00063-x · Cited by 30 · see citing works
Ko, C., Wang, Z., Tseng, H. C., Lee, D. J., & Guez, C. (2014) · Ceramic transactions /Ceramic transactions · doi:10.1002/9781118771587.ch13 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Barclay, T. G., Hegab, H. M., Clarke, S., & Ginić‐Marković, M. (2017) · Advanced Materials Interfaces · doi:10.1002/admi.201601192 · Cited by 386 · see citing works
Dopamine, Immunity, and Disease
Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J. R., & Gaskill, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 319 · see citing works
Matt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 286 · see citing works
Ajdary, R., Tardy, B. L., Mattos, B. D., Bai, L., & Rojas, O. J. (2020) · Advanced Materials · doi:10.1002/adma.202001085 · Cited by 242 · see citing works
Polydopamine-assisted surface modification for orthopaedic implants
Jia, L., Han, F., Wang, H., Zhu, C., Guo, Q., Li, J., Zhao, Z., Zhang, Q., Zhu, X., & Li, B. (2019) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2019.04.001 · Cited by 168 · see citing works
Ko, E., Lee, J. S., Kim, H., Yang, S. Y., Yang, D., Yang, K., Lee, J., Shin, J., Yang, H. S., Ryu, W., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03328 · Cited by 150 · see citing works
Effects of common environmental endocrine-disrupting chemicals on zebrafish behavior
Tao, Y., Li, Z., Yang, Y., Jiao, Y., Qu, J., Wang, Y., & Zhang, Y. (2021) · Water Research · doi:10.1016/j.watres.2021.117826 · Cited by 115 · see citing works
Lengthening primary cilia enhances cellular mechanosensitivity
Spasić, M. R., & Jacobs, C. R. (2017) · European Cells and Materials · doi:10.22203/ecm.v033a12 · Cited by 95 · see citing works
Hu, J., Ding, Y., Tao, B., Zhang, Y., Yang, Y., Xu, K., Li, X., Liu, P., & Cai, K. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.011 · Cited by 94 · see citing works
Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases
Otto, E., Knapstein, P., Jahn, D., Appelt, J., Frosch, K., Tsitsilonis, S., & Keller, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144946 · Cited by 87 · see citing works
Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion
Guo, J., Tian, X., Xie, D., Rahn, K., Gerhard, E. M., Kuzma, M. L., Zhou, D., Dong, C., Bai, X., Lu, Z., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002438 · Cited by 78 · see citing works
Bone-to-Brain: A Round Trip in the Adaptation to Mechanical Stimuli
Gerosa, L., & Lombardi, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.623893 · Cited by 77 · see citing works
A dual-functional PEEK implant coating for anti-bacterial and accelerated osseointegration
Yang, X., Wang, Q., Zhang, Y., He, H., Xiong, S., Chen, P., Li, C., Wang, L., Lu, G., & Xu, Y. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113196 · Cited by 74 · see citing works
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation
Dubiel, W., Dubiel, D., Wolf, D. A., & Naumann, M. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.11.010 · Cited by 73 · see citing works
Crosstalk Between the Neuroendocrine System and Bone Homeostasis
Zhao, Y., Peng, X., Wang, Q., Zhang, Z., Wang, L., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad025 · Cited by 71 · see citing works
Gao, C., Wang, Y., Han, F., Yuan, Z., Li, Q., Shi, C., Cao, W., Zhou, P., Xing, X., & Li, B. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02436c · Cited by 68 · see citing works
Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System
Hayashi, K., Yanagisawa, T., Kishida, R., & Ishikawa, K. (2022) · ACS Nano · doi:10.1021/acsnano.2c03776 · Cited by 67 · see citing works
Emerging roles of nerve‐bone axis in modulating skeletal system
Li, J., Zhang, Z., Tang, J., Hou, Z., Li, L., & Li, B. (2024) · Medicinal Research Reviews · doi:10.1002/med.22031 · Cited by 67 · see citing works
Bone-organ axes: bidirectional crosstalk
Deng, A.-F., Wang, F., Wang, S., Zhang, Y., Bai, L., & Su, J. (2024) · Military Medical Research · doi:10.1186/s40779-024-00540-9 · Cited by 60 · see citing works
Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway
Wang, L., Han, L., Xue, P., Hu, X., Wong, S., Deng, M., Tseng, H. C., Huang, B., & Ko, C. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109847 · Cited by 58 · see citing works
Self-citationPolydopamine-Modified functional materials promote bone regeneration
Wang, J., Cui, Y., Zhang, B., Sun, S., Xu, H., Yao, M., Wu, D., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112655 · Cited by 56 · see citing works
Yao, M., Zou, Q., Zou, W., Xie, Z., Li, Z., Zhao, X., & Du, C. (2021) · Biomaterials Science · doi:10.1039/d0bm01785j · Cited by 56 · see citing works
Amino acid metabolism and autophagy in skeletal development and homeostasis
Suzuki, A., & Iwata, J. (2021) · Bone · doi:10.1016/j.bone.2021.115881 · Cited by 54 · see citing works
Wang, C., Ge, X., Wang, M., Ma, T., Zhang, Y., & Lin, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1529-x · Cited by 51 · see citing works
Bioactivity and Delivery Strategies of Phytochemical Compounds in Bone Tissue Regeneration
Valentino, A., Cristo, F. D., Bosetti, M., Amaghnouje, A., Bousta, D., Conte, R., & Calarco, A. (2021) · Applied Sciences · doi:10.3390/app11115122 · Cited by 49 · see citing works
Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells
Liu, S., Fan, Y., Chen, A. B., Jalali, A., Minami, K., Ogawa, K., Nakshatri, H., Li, B., & Yokota, H. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0056 · Cited by 48 · see citing works
Motyl, K. J., Beauchemin, M., Barlow, D. J., Le, P. T., Nagano, K., Treyball, A., Contractor, A., Baron, R., Rosen, C. J., & Houseknecht, K. L. (2017) · Bone · doi:10.1016/j.bone.2017.07.008 · Cited by 47 · see citing works
Bimetallic ions regulated PEEK of bone implantation for antibacterial and osteogenic activities
Wang, L., He, H., Yang, X., Zhang, Y., Xiong, S., Wang, C., Yang, X., Chen, B., & Wang, Q. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100162 · Cited by 46 · see citing works
Zhang, Y., Huo, M., Wang, Y., Xiao, L., Wu, J., Ma, Y., Zhang, D., Lang, X., & Wang, X. (2022) · Journal of Biological Engineering · doi:10.1186/s13036-022-00301-z · Cited by 43 · see citing works
Wong, S.-W., Huang, B.-W., Hu, X., Ho Kim, E., Kolb, J. P., Padilla, R. J., Xue, P., Wang, L., Oguin, T. H., Miguez, P. A., et al. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-019-0341-6 · Cited by 42 · see citing works
Self-citationFabrication of 3D Bioprinted Bi-Phasic Scaffold for Bone–Cartilage Interface Regeneration
Chen, H., Gonnella, G., Huang, J., & Silvio, L. D. (2023) · Biomimetics · doi:10.3390/biomimetics8010087 · Cited by 41 · see citing works
Zhu, J., Feng, C., Zhang, W., Wang, Z., Zhong, M., Wang, Z., Wang, Z., Shi, H., Yin, Z., Shi, J., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00453-0 · Cited by 40 · see citing works
Self-citationROS-scavenging bioactive scaffold orchestrates bone regeneration for osteoporotic bone defect repair
Xiao, L., Yang, X., Liu, J., Tu, L., Wei, W., Wang, H., Wu, M., Cai, L., Zheng, Y., & Chen, Y. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111528 · Cited by 37 · see citing works
Lee, D. J., Lee, Y.-T., Zou, R. X., Daniel, R., & Ko, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-13326-y · Cited by 36 · see citing works
Self-citationWang, L., Hu, H., & Ko, C. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15080211 · Cited by 35 · see citing works
Self-citationWang, M., Wang, C., Zhang, Y., & Lin, Y. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112376 · Cited by 35 · see citing works
Small-molecule amines: a big role in the regulation of bone homeostasis
Zhang, Q., Yang, J., Hu, N., Liu, J., Yu, H., Pan, H., Chen, D., & Ruan, C. (2023) · Bone Research · doi:10.1038/s41413-023-00262-z · Cited by 34 · see citing works
Zhang, M., Mi, M., Hu, Z., Li, L., Chen, Z., Gao, X., Liu, D., Xu, B., & Liu, Y. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s473007 · Cited by 31 · see citing works
Intrinsic osteoinductivity of PCL‐DA / PLLA semi‐IPN shape memory polymer scaffolds
Arabiyat, A. S., Pfau, M. R., Grunlan, M. A., & Hahn, M. S. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37216 · Cited by 28 · see citing works
Current state of the treatment landscape of phenylketonuria
Nulmans, I., Lequeue, S., Desmet, L., Neuckermans, J., & Kock, J. D. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03840-y · Cited by 27 · see citing works
The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode
Chang, B., Qiu, H., Zhao, H., Yang, X., Wang, Y., Ji, T., Zhang, Y., Quan, Q., Li, Y., Zeng, J., et al. (2019) · Medical Science Monitor · doi:10.12659/msm.920396 · Cited by 27 · see citing works
Antipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling
Weerasinghe, D. K., Hodge, J. M., Pasco, J. A., Samarasinghe, R. M., Manavi, B. A., & Williams, L. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1184550 · Cited by 26 · see citing works
Wong, S., Huang, B., Hu, X., Kim, E. H., Kolb, J. P., Padilla, R. J., Xue, P., Wang, L., Oguin, T. H., Miguez, P. A., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0586-0 · Cited by 26 · see citing works
Self-citationApplications of Polydopamine in Implant Surface Modification
Ma, T., Wang, C., Ge, X., & Zhang, Y. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300067 · Cited by 25 · see citing works
Wang, L., Yang, X., Cao, W., Shi, C., Zhou, P., Li, Q., Han, F., Sun, J., Xing, X., & Li, B. (2017) · RSC Advances · doi:10.1039/c7ra10203h · Cited by 25 · see citing works
Wang, S., Ko, C., & Chung, M. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1365194 · Cited by 24 · see citing works
Self-citationSchwendich, E., Tejedor, L. S., Schmitz, G., Rickert, M., Steinmeyer, J., Rehart, S., Tsiami, S., Braun, J., Baraliakos, X., Reinders, J., et al. (2022) · Cells · doi:10.3390/cells11101609 · Cited by 20 · see citing works
Ifegwu, O. C., Awale, G. M., Kan, H., Rajpura, K., O’Neill, E. N., Kuo, C., & Lo, K. W. ‐. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0063-1 · Cited by 19 · see citing works
Zhang, M., Zhang, J., Ban, L., Qiu, L., Chen, J., Zhu, Z., & Wan, Y. (2020) · Biofabrication · doi:10.1088/1758-5090/ab8f20 · Cited by 19 · see citing works
Dopaminergic Enhancement of Cellular Adhesion in Bone Marrow Derived Mesenchymal Stem Cells (MSCs)
Ko, C., Wang, Z., Chen, S., Bai, B., Lee, D. J., Diachina, S., Li, Y., Wong, S., & Tseng, H. (2017) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000395 · Cited by 18 · see citing works
Self-citationBioactive PEEK: Surface Enrichment of Vitronectin-Derived Adhesive Peptides
Cassari, L., Zamuner, A., Messina, G. M. L., Marsotto, M., Chen, H., Gonnella, G., Coward, T. J., Battocchio, C., Huang, J., Iucci, G., et al. (2023) · Biomolecules · doi:10.3390/biom13020246 · Cited by 17 · see citing works
Luo, P. F., Zhang, Y., Huang, M., Luo, G., Ma, Y., & Wang, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s443413 · Cited by 17 · see citing works
Osteo-mucosal engineered construct: In situ adhesion of hard-soft tissues
Tabatabaei, F. S., Rasoulianboroujeni, M., Yadegari, A., Tajik, S., Moharamzadeh, K., & Tayebi, L. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112255 · Cited by 16 · see citing works
Chen, W., Nichols, L., Teer, L. B., Clinton, K., & Priddy, L. B. (2022) · Journal of Materials Science · doi:10.1007/s10853-022-07442-y · Cited by 16 · see citing works
Daley, E. J., Pajevic, P. D., Roy, S., & Trackman, P. C. (2019) · JBMR Plus · doi:10.1002/jbm4.10212 · Cited by 16 · see citing works
Sun, H., Feng, Y., Tu, S., Zhou, J., Wang, Y., Wei, J., Zhang, S., Hou, Y., Shao, Y., Ai, H., et al. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.03.025 · Cited by 15 · see citing works
Graphene Oxide Induced Osteogenesis Quantification by In-Situ 2D-Fluorescence Spectroscopy
Palmieri, V., Barba, M., Pietro, L. D., Conti, C., Spirito, M. D., Lattanzi, W., & Papi, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113336 · Cited by 15 · see citing works
Corrigan, M., Ferradaes, T. M., Riffault, M., & Hoey, D. A. (2018) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-018-00561-0 · Cited by 15 · see citing works
Repertoire of Structure–Activity-Based Novel Modified Peptides Elicits Enhanced Osteogenic Potential
Upadhyay, D., Kaur, T., Kapila, R., & Kapila, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03385 · Cited by 14 · see citing works
Mendoza‐Torreblanca, J. G., Cárdenas‐Rodríguez, N., Carro-Rodríguez, J., Contreras‐García, I. J., Garciadiego-Cázares, D., Ortega-Cuéllar, D., Martínez-López, V., Alfaro-Rodríguez, A., Evia-Ramírez, A. N., Ignacio‐Mejía, I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210199 · Cited by 13 · see citing works
Kuang, Z., Chen, Z., Tu, S., Mai, Z., Chen, L., Kang, X., Chen, X., Wei, J., Wang, Y., Peng, Y. W., et al. (2022) · Stem Cells International · doi:10.1155/2022/4154440 · Cited by 13 · see citing works
Elucidating the Mechanism(s) Underlying Antipsychotic- and Antidepressant-Mediated Fractures
Houseknecht, K. L. (2017) · JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY · doi:10.29245/2578-2959/2018/1.1106 · Cited by 13 · see citing works
Xia, R., Peng, H., Zhu, X., Suolang, W., Pambayi, S. T. L., Yang, X., Zeng, Y., & Shen, B. (2025) · Orthopaedic Surgery · doi:10.1111/os.70010 · Cited by 12 · see citing works
Park, S., & Jung, T. (2024) · Bioengineering · doi:10.3390/bioengineering11040343 · Cited by 12 · see citing works
Yang, D. H., Moon, S. W., Jang, G., Park, K., Yoo, Y.-B., & Lee, D. (2017) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.01.023 · Cited by 12 · see citing works
Self-citationBanaeyan, R., Nourany, M., Hosseini, S., Galefi, A., Alipour, A., Jahanfar, M., Wang, P. Y., Homaeigohar, S., & Shahsavarani, H. (2023) · Cellulose · doi:10.1007/s10570-023-05611-z · Cited by 11 · see citing works
Proteomic and genomic analysis of acid dentin lysate with focus on TGF-β signaling
Nasirzade, J., Kargarpour, Z., Mitulović, G., Strauß, F. J., Panahipour, L., Schwarz, F., & Gruber, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-89996-6 · Cited by 11 · see citing works
Expression and function of dopamine in odontoblasts
Fujino, S., Hamano, S., Tomokiyo, A., Itoyama, T., Hasegawa, D., Sugii, H., Yoshida, S., Washio, A., Nozu, A., Ono, T., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29314 · Cited by 10 · see citing works
Nihashi, Y., Miyoshi, M., Umezawa, K., Shimosato, T., & Takaya, T. (2022) · Nanomaterials · doi:10.3390/nano12101680 · Cited by 10 · see citing works
Zhou, R., Yang, H., Zhou, D., Yang, S., Shi, Z., Jin, Q., & Ding, Z. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.1099984 · Cited by 9 · see citing works
Endowing osseointegration ability to bioinert alumina by carbonate apatite coating
Hayashi, K., & Ishikawa, K. (2022) · Surfaces and Interfaces · doi:10.1016/j.surfin.2022.102617 · Cited by 9 · see citing works
Xin, M., Li, L., Wang, C., Shao, H., Liu, J., & Zhang, C. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1153779 · Cited by 9 · see citing works
Cassari, L., Zamuner, A., Messina, G. M. L., Marsotto, M., Chang, H.-C., Coward, T. J., Battocchio, C., Iucci, G., Marletta, G., Silvio, L. D., et al. (2023) · Materials · doi:10.3390/ma16103869 · Cited by 9 · see citing works
Fujino, S., Hamano, S., Tomokiyo, A., Sugiura, R., Yamashita, D., Hasegawa, D., Sugii, H., Fujii, S., Itoyama, T., Miyaji, H., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32126-1 · Cited by 8 · see citing works
The Effects of Chronic Psychostimulant Administration on Bone Health: A Review
Nowak, J., Aronin, J., Beg, F., O'Malley, N. T., Ferrick, M. R., Quattrin, T., Pavlesen, S., Hadjiargyrou, M., Komatsu, D. E., & Thanos, P. K. (2024) · Biomedicines · doi:10.3390/biomedicines12081914 · Cited by 8 · see citing works
Martiniaková, M., Kováčová, V., Bíro, R., Mondočková, V., Šarocká, A., Pénzes, N., Folwarczna, J., & Omelka, R. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118063 · Cited by 8 · see citing works
Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury
Zhang, W., Zou, J., & Zhang, L. (2025) · Advanced Science · doi:10.1002/advs.202503149 · Cited by 8 · see citing works
Knani, L., Venditti, M., Rouis, H., Minucci, S., & Messaoudi, I. (2024) · Bone · doi:10.1016/j.bone.2024.117271 · Cited by 8 · see citing works
Baek, S., Park, H., Igci, F. D., & Lee, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012490 · Cited by 8 · see citing works
Self-citationDeciphering the skeletal interoceptive circuitry to control bone homeostasis
Wu, Y., Guo, J., Chen, Z., Zhang, F., Chow, B., Chen, Z., Yeung, K., & Qiao, W. (2025) · BMEMat · doi:10.1002/bmm2.12138 · Cited by 6 · see citing works
Chen, H., Cheng, R., Chung, S. H., Marghoub, A., Zhong, H., Fang, G., Balabani, S., Silvio, L. D., & Huang, J. (2025) · Biomedical Technology · doi:10.1016/j.bmt.2025.100101 · Cited by 6 · see citing works
Wadhwa, R., Kumar, M., Paudel, Y. N., Iqbal, R., Kothari, P., Trivedi, R., & Vohora, D. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0908-1 · Cited by 5 · see citing works
Research Progress on the Molecular Mechanism by Which Depression Affects Bone Metabolism
Gao, H., Huang, C., Zhao, K., Chen, X., Zhang, X., Deng, Y., Liu, Z., & Duan, D. D. (2020) · DNA and Cell Biology · doi:10.1089/dna.2019.5284 · Cited by 5 · see citing works
Silver Nanoparticle—A Promising Anti-Mosquito's Agent: A Review
Sohail, S., Mashwani, Z., Raja, N. I., Ghaffar, A., Shah, M. A., Yameen, M., Umar, S., & Sohail, M. L. (2017) · Nanoscience and Nanotechnology Letters · doi:10.1166/nnl.2017.2586 · Cited by 4 · see citing works
Regulation of Stem Cells by Cullin-RING Ligase
Fu, L., Cui, C., & Zhang, L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_6 · Cited by 4 · see citing works
Emelyanov, A., Олеговна, Л. А., Litusova, E. M., Knyazev, N. A., Kulabukhova, D. G., Garaeva, L. A., Milyukhina, I. V., Беркович, О. А., & Пчелина, С. Н. (2018) · Cell and Tissue Biology · doi:10.1134/s1990519x18050024 · Cited by 3 · see citing works
Aghili, H. A. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/26217.10169 · Cited by 3 · see citing works
Zheng, K., Li, W., Wang, T., Ge, G., Zhang, W., Qin, Y., Li, W., Wu, Z., Wang, Z., Rui, G., et al. (2025) · Advanced Science · doi:10.1002/advs.202502276 · Cited by 2 · see citing works
Self-citationThe effect of peripheral dopamine on fracture healing: an experimental study in a rat model
Yücel, M. O., Dalaslan, R. E., Sağlam, S., Arıcan, M., Karaduman, Z. O., Turhan, B., & Demir, F. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-06136-w · Cited by 2 · see citing works
Hua, Y., Wang, C., Ge, X., & Lin, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12051046 · Cited by 2 · see citing works
Bone involvement in the early stages of Parkinson’s disease: a case–control study
Liguori, S., Moretti, A., Paoletta, M., Gargiulo, F., Barra, G., Gimigliano, F., & Iolascon, G. (2024) · Journal of International Medical Research · doi:10.1177/03000605241237880 · Cited by 2 · see citing works
Wang, Y., Wang, J., Su, Y., Gong, H., Han, X., Ma, S., Sun, D., Liu, Y., Chen, W., Zhang, M., et al. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.114484 · Cited by 1 · see citing works
Karkehabadi, H., Khoshbin, E., Najafi, R., & Moosavi, P. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11026-9 · Cited by 1 · see citing works
Exosome immobilization of 3D-printed polycaprolactone scaffolds for bone tissue engineering
Jun, I., Ahn, J., Ahn, G., Kim, H.-J., Ahn, J., Lim, H., Lee, J., & Park, S. A. (2026) · International Journal of Bioprinting · doi:10.36922/ijb026030021 · Cited by 1 · see citing works
Peripheral Neuronal Control of Bone Remodeling
Motyl, K. J., & Barbe, M. F. (2018) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9781119266594.ch132 · Cited by 1 · see citing works
Multimodality Imaging Techniques in PD and Atypical Parkinsonism
Wei, Z., Nie, B., & Bu, L. (2024) · Frontiers research topics · doi:10.3389/978-2-8325-4517-1
Dong, D., Huang, Y., Lai, Y., & Yin, G. (2024) · PubMed Central · doi:10.7518/hxkq.2024.2023451
Insights into the mechanism of neuro-osseus overlap in Parkinson’s disease
Ali, S. J., Kisan, B., & Pasha, S. (2025) · International Journal of Advanced Biochemistry Research · doi:10.33545/26174693.2025.v9.i6d.4548
Knani, L., Rouis, H., Kessabi, K., Venditti, M., & Messaoudi, I. (2025) · Calcified Tissue International · doi:10.1007/s00223-025-01444-z
Zhu, J., Feng, C., Zhang, W., 王志栋, Zhong, M., Tang, W., Wang, Z., Shi, H., Yin, Z., Shi, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211489
Self-citation
- Authors
- Lee, D. J., Tseng, H. C., Wong, S. W., Wang, Z., Deng, M., & Ko, C.-C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke Medical Center (US)
- Corresponding author
- Ko, Ching-Chang
- Venue
- Bone Research
- Published
- 2015-07-07
- Volume
- 3
- Issue
- 1
- Pages
- 15020-15020
- ISSN
- 2095-4700 (ISSN-L)
- 2095-6231
- PMC
- PMC4639997
- OpenAlex
- W2316245666
- Cited by
- 101
- References
- 23
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 15 · 2023: 12 · 2022: 13 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 13
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bone Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- National Eye Institute (K08EY021520)
- National Institute of Dental and Craniofacial Research (K08DE018695, R01DE022816)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- dopamine, dopamine receptors, osteogenic differentiation, osteoblasts, mineralization, cell proliferation, polydopamine, MC3T3-E1 cells, dopamine D1/D5 receptors, receptor antagonists, bone formation, bone remodeling, bone tissue engineering, Runx2, osteogenic gene expression, orthopedic applications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
