Cited by 339Immune Response and InflammationCardiac Fibrosis and RemodelingInflammasome and immune disorders

The emerging role of Toll-like receptor 4 in myocardial inflammation

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Yang, Y, Lv, J, Jiang, S, Ma, Z, Wang, D, Hu, W, Deng, C, Fan, C +3 more·2016·Cell Death & Disease

Abstract

Toll-like receptors (TLRs) are a family of pattern recognition receptors involved in cardiovascular diseases. Notably, numerous studies have demonstrated that TLR4 activates the expression of several of pro-inflammatory cytokine genes that play pivotal roles in myocardial inflammation, particularly myocarditis, myocardial infarction, ischemia-reperfusion injury, and heart failure. In addition, TLR4 is an emerging target for anti-inflammatory therapies. Given the significance of TLR4, it would be useful to summarize the current literature on the molecular mechanisms and roles of TLR4 in myocardial inflammation. Thus, in this review, we first introduce the basic knowledge of the TLR4 gene and describe the activation and signaling pathways of TLR4 in myocardial inflammation. Moreover, we highlight the recent progress of research on the involvement of TLR4 in myocardial inflammation. The information reviewed here may be useful to further experimental research and to increase the potential of TLR4 as a therapeutic target.

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Authors
Yang, Y., Lv, J., Jiang, S., Ma, Z., Wang, D., Hu, W., Deng, C., Fan, C., Di, S., Sun, Y., & Yi, W.
Affiliations
  • Nanjing Drum Tower Hospital (CN)
  • Air Force Medical University (CN)
  • Tang Du Hospital (CN)
  • Xijing Hospital (CN)
Corresponding author
Sun, Y
Venue
Cell Death & Disease
Published
2016-05-26
Volume
7
Issue
5
Pages
e2234-e2234
ISSN
2041-4889 (ISSN-L)
OpenAlex
W2403031333
Cited by
337
References
89
Citations by year
2026: 25 · 2025: 39 · 2024: 34 · 2023: 34 · 2022: 38 · 2021: 50 · 2020: 32 · 2019: 37 · 2018: 31 · 2017: 13 · 2016: 3 · 2013: 1
FWCI
2.70
Type
journal article
Language
en
Open access
Locations
  • Cell Death and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81500263, 81100081, 81422004, 2015M572681, 81470477, 81100137, 81470480)
  • China Postdoctoral Science Foundation (2015M572681, 81500263)
  • National Institute on Alcohol Abuse and Alcoholism (R00AA020514, K99AA020514, R01AA020919)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords
TLR4, myocarditis, myocardial infarction, ischemia-reperfusion injury, heart failure, inflammatory cytokines, TLR4 signaling, anti-inflammatory therapy, pattern recognition receptors
MeSH terms
Animals, Cardiotonic Agents, Clinical Trials as Topic, Disaccharides, Gene Expression Regulation, Heart Failure, Humans, Metformin, Myocardial Infarction, Myocarditis, Myocardium, Sugar Phosphates, Signal Transduction, Reperfusion Injury, NF-kappa B, Follistatin, Toll-Like Receptor 4, Myeloid Differentiation Factor 88

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