The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Abstract
Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses. The levels of miRNAs in serum are stable, reproducible, and consistent among individuals of the same species. Employing Solexa, we sequenced all serum miRNAs of healthy Chinese subjects and found over 100 and 91 serum miRNAs in male and female subjects, respectively. We also identified specific expression patterns of serum miRNAs for lung cancer, colorectal cancer, and diabetes, providing evidence that serum miRNAs contain fingerprints for various diseases. Two non-small cell lung cancer-specific serum miRNAs obtained by Solexa were further validated in an independent trial of 75 healthy donors and 152 cancer patients, using quantitative reverse transcription polymerase chain reaction assays. Through these analyses, we conclude that serum miRNAs can serve as potential biomarkers for the detection of various cancers and other diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [117]
In the citing paper
“Contrary to cellular RNA species, extracellular miRNAs are highly stable, resisting degradation at room temperature for up to 4 days and in deleterious conditions such as boiling, multiple freeze-thaw cycles, and high or low pH (117, 124).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [117]
Citations
Cites
1 retracted
Leman, E. S., Schoen, R. E., Weissfeld, J. L., Cannon, G. W., Sokoll, L. J., Chan, D. W., & Getzenberg, R. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0649 · Cited by 50
RetractedCirculating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,989
Lawrie, C. H., Gal, S., Dunlop, H. M., Pushkaran, B., Liggins, A. P., Pulford, K. A. F., Banham, A. H., Pezzella, F., Boultwood, J., Wainscoat, J. S., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07077.x · Cited by 1,755
The role of microRNA genes in papillary thyroid carcinoma
He, H., Jażdżewski, K., Li, W., Liyanarachchi, S., Nagy, R. S., Volinia, S., Calin, G. A., Liu, C., Franssila, K., Suster, S. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509603102 · Cited by 1,218
Detection and Characterization of Placental MicroRNAs in Maternal Plasma
Chim, S. S. C., Shing, T. K. F., Hung, E. C. W., Leung, T.-Y., Lau, T. K., Chiu, R. W. K., & Lo, Y. M. D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097972 · Cited by 856
Micro-RNA profiling in kidney and bladder cancers
Gottardo, F., Liu, C. G., Ferracin, M., Calin, G. A., Fassan, M., Bassi, P., Sevignani, C., Byrne, D., Negrini, M., Pagano, F. C., et al. (2007) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2007.01.019 · Cited by 601
Cited by
Sorted by citations
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294
Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,513
Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,979
Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,934
miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database
Chou, C., Chang, N.-W., Shrestha, S., Hsu, S., Lin, Y., Lee, W.-H., Yang, C.-D., Hong, H.-C., Wei, T., Tu, S.-J., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1258 · Cited by 1,850
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765
Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,705
Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
Ling, H. Y., Fabbri, M., & Călin, G. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4140 · Cited by 1,487
MicroRNAs in body fluids—the mix of hormones and biomarkers
Cortez, M. A., Bueso-Ramos, C., Ferdin, J., Lopez‐Berestein, G., Sood, A. K., & Călin, G. A. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.76 · Cited by 1,497
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Hunter, M. P., Ismail, N., Zhang, X., Aguda, B. D., Lee, E. J., Yu, L., Xiao, T., Schafer, J., Lee, M. T., Schmittgen, T. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003694 · Cited by 1,476
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
Kosaka, N., Iguchi, H., & Ochiya, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01650.x · Cited by 1,147
miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
Huang, H., Lin, Y.-C.-D., Li, J., Huang, K., Shrestha, S., Hong, H.-C., Tang, Y., Chen, Y.-G., Jin, C.-N., Yu, Y., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz896 · Cited by 1,275
Self-citationMicroRNA: Function, Detection, and Bioanalysis
Dong, H., Lei, J., Ding, L., Wen, Y., Ju, H., & Zhang, X. (2013) · Chemical Reviews · doi:10.1021/cr300362f · Cited by 1,236
Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., et al. (2012) · Cell Research · doi:10.1038/cr.2011.158 · Cited by 1,216
Self-citationSecreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration
Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., Sun, F., Lu, J., Yin, Y., Cai, X. F., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.010 · Cited by 1,219
Self-citationKroh, E. M., Parkin, R. K., Mitchell, P. S., & Tewari, M. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.032 · Cited by 1,184
Wang, G., Zhu, J., Zhang, J., Li, Q., Li, Y., He, J., Qin, Y., & Jing, Q. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq013 · Cited by 1,184
Self-citationCirculating microRNAs, potential biomarkers for drug-induced liver injury
Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L. E., & Galas, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813371106 · Cited by 1,149
Self-citationJansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,150
Mohr, A. M., & Mott, J. L. (2015) · Seminars in Liver Disease · doi:10.1055/s-0034-1397344 · Cited by 1,092
Valsesia, A., Wang, Q., Gheldof, N., Carayol, J., Ruffieux, H., Clark, T., Shenton, V., Oyston, L. J., Lefebvre, G. C., Métairon, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08492-8 · Cited by 1,084
Characterization of human plasma-derived exosomal RNAs by deep sequencing.
Huang, X., Yuan, T., Tschannen, M., Sun, Z., Jacob, H., Du, M., Liang, M., Dittmar, R. L., Liu, Y., Liang, M., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-319 · Cited by 932
Hsu, S., Tseng, Y., Shrestha, S., Lin, Y., Khaleel, A., Chou, C., Chu, C.-F., Huang, H., Lin, C.-M., Ho, S.-Y., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1266 · Cited by 1,044
Creemers, E. E., Tijsen, A. J., & Pinto, Y. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.247452 · Cited by 1,035
Huang, H., Lin, Y.-C.-D., Cui, S., Tang, Y., Tang, Y., Xu, J., Bao, J., Li, Y., Wen, J., Zuo, H., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1079 · Cited by 997
Self-citationPlasma microRNAs are promising novel biomarkers for early detection of colorectal cancer
Huang, Z., Huang, D., Ni, S., Peng, Z., Sheng, W., & Du, X. (2009) · International Journal of Cancer · doi:10.1002/ijc.25007 · Cited by 975
Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies
Pritchard, C. C., Kroh, E., Wood, B., Arroyo, J. D., Dougherty, K. J., Miyaji, M. M., Tait, J. F., & Tewari, M. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0370 · Cited by 879
The Mammalian Ovary from Genesis to Revelation
Edson, M. A., Nagaraja, A. K., & Matzuk, M. M. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0012 · Cited by 869
Hu, Z., Chen, X., Zhao, Y., Tian, T., Jin, G., Shu, Y., Chen, Y., Xu, L., Zen, K., Zhang, C., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.9342 · Cited by 798
Self-citationCirculating microRNAs are new and sensitive biomarkers of myocardial infarction
D’Alessandra, Y., Devanna, P., Limana, F., Straino, S., Carlo, A. D., Brambilla, P., Rubino, M., Carena, M. C., Spazzafumo, L., Simone, M. C. D., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq167 · Cited by 800
MicroRNA as Biomarkers and Diagnostics
Wang, J., Chen, J., & Sen, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25056 · Cited by 793
Self-citationExosomes Derived from Mesenchymal Stem Cells
Yu, B., Zhang, X., & Li, X. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15034142 · Cited by 788
Self-citationCirculating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease
Corsten, M. F., Dennert, R., Jochems, S., Kuznetsova, T., Devaux, Y., Hofstra, L., Wagner, D. R., Staessen, J. A., Heymans, S., & Schroen, B. (2010) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.110.957415 · Cited by 794
An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration
Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3113 · Cited by 786
Secreted microRNAs: a new form of intercellular communication
Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 690
Self-citationBiomarkers of Acute Kidney Injury
Vaidya, V. S., Ferguson, M. A., & Bonventre, J. V. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094615 · Cited by 741
Boeri, M., Verri, C., Conte, D., Roz, L., Modena, P., Facchinetti, F., Calabrò, E., Croce, C. M., Pastorino, U., & Sozzi, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100048108 · Cited by 722
Aptamer-Based Detection of Circulating Targets for Precision Medicine
Wu, L., Wang, Y., Xu, X., Liu, Y., Lin, B., Zhang, M., Zhang, J., Wan, S., Yang, C. J., & Tan, W. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01140 · Cited by 706
Self-citationCirculating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer
Heneghan, H., Miller, N., Lowery, A., Sweeney, K., Newell, J., & Kerin, M. J. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181cc939f · Cited by 685
Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges
McDonald, J. S., Milosevic, D., Reddi, H. V., Grebe, S. K., & Algeciras‐Schimnich, A. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.157198 · Cited by 697
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Zhou, S., Jin, J.-P., Wang, J., Zhang, Z., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 690
Self-citationIn vivo delivery of miRNAs for cancer therapy: Challenges and strategies
Chen, Y., Gao, D.-Y., & Huang, L. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.009 · Cited by 693
The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva
Bahn, J. H., Zhang, Q., Li, F., Chan, T.-M., Lin, X., Kim, Y. D., Wong, D. T., & Xiao, X. G. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.230433 · Cited by 653
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
Schetter, A. J., Heegaard, N. H. H., & Harris, C. C. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp272 · Cited by 671
Plasma MicroRNA Panel to Diagnose Hepatitis B Virus–Related Hepatocellular Carcinoma
Zhou, J., Yu, L., Gao, X. J., Hu, J., Wang, J., Dai, Z., Wang, J.-F., Zhang, Z., Lu, S., Huang, X., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.2697 · Cited by 636
Self-citationBala, S., Petrášek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J. A., Alao, H., Kodys, K., & Szabó, G. (2012) · Hepatology · doi:10.1002/hep.25873 · Cited by 637
Circulating microRNAs in plasma of patients with gastric cancers
Tsujiura, M., Ichikawa, D., Komatsu, S., Shiozaki, A., Takeshita, H., Kosuga, T., Konishi, H., Morimura, R., Deguchi, K., Fujiwara, H., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605608 · Cited by 627
Bhaskaran, M., & Mohan, M. (2013) · Veterinary Pathology · doi:10.1177/0300985813502820 · Cited by 642
Immune-related MicroRNAs are Abundant in Breast Milk Exosomes
Zhou, Q. G., Li, M., Wang, X., Li, Q., Wang, T., Zhu, Q., Zhou, X., Wang, X., Gao, X., & Li, X. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.8.118 · Cited by 615
Self-citationTrends in the development of miRNA bioinformatics tools
Chen, L., Heikkinen, L., Wang, C., Yang, Y., Sun, H., & Wong, G. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby054 · Cited by 612
Circulating miRNAs are correlated with tumor progression in prostate cancer
Brase, J. C., Johannes, M., Schlomm, T., Fälth, M., Haese, A., Steuber, T. P., Beißbarth, T., Kuner, R., & Sültmann, H. (2010) · International Journal of Cancer · doi:10.1002/ijc.25376 · Cited by 594
Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells
Pigati, L., Yaddanapudi, S. C., Iyengar, R., Kim, D.-J., Hearn, S., Danforth, D. N., Hastings, M. L., & Duelli, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013515 · Cited by 601
Ohshima, K., Inoue, K., Fujiwara, A., Hatakeyama, K., Kanto, K., Watanabe, Y., Muramatsu, K., Fukuda, Y., Ogura, S., Yamaguchi, K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013247 · Cited by 593
Circulating microRNAs as novel biomarkers for diabetes mellitus
Guay, C., & Regazzi, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.86 · Cited by 563
microRNA as a new immune-regulatory agent in breast milk
Kosaka, N., Izumi, H., Sekine, K., & Ochiya, T. (2010) · Silence · doi:10.1186/1758-907x-1-7 · Cited by 572
The role of microRNAs in human diseases
Tüfekci, K. U., Öner, M. G., Meuwissen, R. L. J., & Genç, Ş. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-748-8_3 · Cited by 566
Xu, J., Wu, C., Che, X., Wang, L., Yu, D., Zhang, T., Huang, L., Li, H., Tan, W., Wang, C., et al. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20712 · Cited by 567
Guduric‐Fuchs, J., O’Connor, A., Camp, B., O’Neill, C. L., Medina, R. J., & Simpson, D. A. C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-357 · Cited by 574
Haemolysis during sample preparation alters microRNA content of plasma
Kirschner, M. B., Kao, S. C., Edelman, J. J., Armstrong, N. J., Vallely, M. P., van Zandwijk, N., & Reid, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024145 · Cited by 569
Murata, K., Yoshitomi, H., Tanida, S., Ishikawa, M., Nishitani, K., Ito, H., & Nakamura, T. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3013 · Cited by 541
Kong, L., Zhu, J., Han, W., Jiang, X., Xu, M., Zhao, Y., Dong, Q., Pang, Z., Guan, Q., Gao, L., et al. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0226-0 · Cited by 540
Self-citationCirculating microRNA-1 as a potential novel biomarker for acute myocardial infarction
Ai, J., Zhang, R., Li, Y., Pu, J., Lu, Y., Jiao, J., Li, K., Yu, B., Li, Z., Wang, R., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.005 · Cited by 526
Self-citationExtracellular miRNAs: the mystery of their origin and function
Turchinovich, A. A., Weiz, L., & Burwinkel, B. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.08.003 · Cited by 534
Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers
Zen, K., & Zhang, C. (2010) · Medicinal Research Reviews · doi:10.1002/med.20215 · Cited by 509
Self-citationNoncoding RNAs, cytokines, and inflammation-related diseases
Marques-Rocha, J. L., Samblas, M., Milagro, F. I., Bressan, J., Martínez, J. A., & Martí, A. (2015) · The FASEB Journal · doi:10.1096/fj.14-260323 · Cited by 485
Plasma miR-208 as a Biomarker of Myocardial Injury
Ji, X., Takahashi, R., Hiura, Y., Hirokawa, G., Fukushima, Y., & Iwai, N. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.125310 · Cited by 478
Circulating microRNAs: Association with disease and potential use as biomarkers
Reid, G., Kirschner, M. B., & van Zandwijk, N. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.11.004 · Cited by 472
Cazzoli, R., Buttitta, F., Nicola, M. D., Malatesta, S., Marchetti, A., Rom, W. N., & Pass, H. I. (2013) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318299ac32 · Cited by 465
Li, L., Hu, Z., Zhou, Z., Chen, X., Liu, F.-Y., Zhang, J., Shen, H., Zhang, C., & Zen, K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1001 · Cited by 456
Self-citationDirect Serum Assay for MicroRNA-21 Concentrations in Early and Advanced Breast Cancer
Asaga, S., Kuo, C. T., Nguyen, T. T., Terpenning, M., Giuliano, A. E., & Hoon, D. S. �. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.151845 · Cited by 455
MicroRNAs: Novel regulators in the hallmarks of human cancer
Ruan, K., Fang, X., & Ouyang, G. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.031 · Cited by 454
Circulating MicroRNA biomarker studies: pitfalls and potential solutions
Witwer, K. W. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.221341 · Cited by 447
Tanaka, Y., Kamohara, H., Kinoshita, K., Kurashige, J., Ishimoto, T., Iwatsuki, M., Watanabe, M., & Baba, H. (2013) · Cancer · doi:10.1002/cncr.27895 · Cited by 446
Laffont, B., Corduan, A., Plé, H., Duchez, A., Cloutier, N., Boilard, É., & Provost, P. (2013) · Blood · doi:10.1182/blood-2013-03-492801 · Cited by 452
Marrugo-Ramírez, J., Mir, M., & Samitier, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102877 · Cited by 456
da Silveira, J. C., Veeramachaneni, D. N. R., Winger, Q. A., Carnevale, E. M., & Bouma, G. J. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.093252 · Cited by 450
MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases
Cortez, M. A., & Calin, G. A. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590902932889 · Cited by 445
Methodological challenges in utilizing mi RNA s as circulating biomarkers
Moldovan, L., Batte, K. E., Trgovcich, J., Wisler, J., Marsh, C. B., & Piper, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12236 · Cited by 436
Sozzi, G., Boeri, M., Rossi, M., Verri, C., Suatoni, P., Bravi, F., Roz, L., Conte, D., Grassi, M., Sverzellati, N., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.50.4357 · Cited by 433
Karolina, D. S., Armugam, A., Subramaniam, T., Wong, M. T. K., Lim, S. C., Sum, C. F., & Jeyaseelan, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022839 · Cited by 445
Di Leva, G., & Croce, C. M. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.01.004 · Cited by 356
Serum microRNAs as non-invasive biomarkers for cancer
Brase, J. C., Wuttig, D., Kuner, R., & Sültmann, H. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-306 · Cited by 423
Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice
Castaño, C., Kalko, S. G., Novials, A., & Párrizas, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808855115 · Cited by 429
Interplay between miRNAs and human diseases
Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420
Circulating miRNA Profiles in Patients with Metabolic Syndrome
Karolina, D. S., Subramaniam, T., Armugam, A., Sepramaniam, S., Pek, S. L. T., Wong, M. T. K., Lim, S. C., Sum, C. F., & Jeyaseelan, K. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1996 · Cited by 409
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Poller, W. C., Dimmeler, S., Heymans, S. R. B., Zeller, T., Haas, J., Karakas, M., Leistner, D. M., Jakob, P., Nakagawa, S., Blankenberg, S., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx165 · Cited by 417
Liu, R., Zhang, C., Hu, Z., Li, G., Wang, C., Yang, C., Huang, D., Chen, X., Zhang, H., Zhuang, R., et al. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.10.025 · Cited by 411
Self-citationDetection of Cancer with Serum miRNAs on an Oligonucleotide Microarray
Lodes, M. J., Caraballo, M., Suciu, D., Munro, S. B., Kumar, A., & Anderson, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006229 · Cited by 405
A Pilot Study of Circulating miRNAs as Potential Biomarkers of Early Stage Breast Cancer
Zhao, H., Shen, J., Medico, L., Wang, D., Ambrosone, C. B., & Liu, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013735 · Cited by 398
Caporali, A., Meloni, M., Völlenkle, C., Bonci, D., Sala-Newby, G. B., Addis, R., Spinetti, G., Losa, S., Masson, R., Baker, A. H., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.952325 · Cited by 397
Expression Profile of MicroRNAs in Young Stroke Patients
Tan, K. S., Armugam, A., Sepramaniam, S., Lim, K. Y., Karolina, D. S., Wang, C. W., & Jeyaseelan, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007689 · Cited by 397
RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
Bajan, S., & Hutvágner, G. (2020) · Cells · doi:10.3390/cells9010137 · Cited by 409
Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer
Liu, R., Chen, X., Du, Y., Yao, W., Shen, L., Wang, C., Hu, Z., Zhuang, R., Ning, G., Zhang, C., et al. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.172767 · Cited by 388
Self-citationIntercellular Transport of MicroRNAs
Boon, R. A., & Vickers, K. C. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300139 · Cited by 402
Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations
Glinge, C., Clauss, S., Boddum, K., Jabbari, R., Jabbari, J., Risgaard, B., Tomsits, P., Hildebrand, B., Kääb, S., Wakili, R., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0167969 · Cited by 351
Chen, X., Gao, C., Li, H., Huang, L., Sun, Q., Dong, Y., Tian, C., Gao, S., Dong, H., Guan, D., et al. (2010) · Cell Research · doi:10.1038/cr.2010.80 · Cited by 382
Self-citationPlasma MicroRNA 499 as a Biomarker of Acute Myocardial Infarction
Adachi, T., Nakanishi, M., Otsuka, Y., Nishimura, K., Hirokawa, G., Goto, Y., Nonogi, H., & Iwai, N. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.144121 · Cited by 384
Metadata
- Authors
- Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., Li, Q., Li, X., Wang, W., Zhang, Y., Wang, J., Jiang, X., Xiang, Y., Xu, C., Zheng, P., Zhang, J., Li, R., Zhang, H., Shang, X., Gong, T., Ning, G., Wang, J., Zen, K., Zhang, J., & Zhang, C.-Y.
- Affiliations
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- BGI Group (China) (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Municipal Center For Disease Control Prevention (CN)
- Corresponding author
- Wang, Jin
- Zhang, Juanbin
- Zen, Ke
- Zhang, Chen-Yu
- ORCID
- Venue
- Cell Research
- Published
- 2008-09-02
- Volume
- 18
- Issue
- 10
- Pages
- 997-1006
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2097233439
- Cited by
- 4,560
- References
- 21
- Citations by year
- 2026: 77 · 2025: 146 · 2024: 144 · 2023: 212 · 2022: 240 · 2021: 302 · 2020: 301 · 2019: 284 · 2018: 346 · 2017: 324 · 2016: 365 · 2015: 405 · 2014: 394 · 2013: 356 · 2012: 272
- FWCI
- 44.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30471991, 973 Program, 30570731, 30225037)
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK2006714)
- National Key Research and Development Program of China (2006CB503909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, serum microRNA, plasma microRNA, tumor markers, non-invasive cancer diagnosis, lung cancer, colorectal cancer, diabetes mellitus, miRNA expression profiling, miRNA stability
- MeSH terms
- Animals, Carcinoma, Non-Small-Cell Lung, Cattle, Diabetes Mellitus, Type 2, Female, Horses, Humans, Lung Neoplasms, Male, Neoplasms, Biomarkers, Tumor, Colorectal Neoplasms, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
