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Cited by 4,560MicroRNA in disease regulationExtracellular vesicles in diseaseCancer-related molecular mechanisms research

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

Chen, Xi, Ba, Yi, Ma, Lijia, Cai, Xing, Yin, Yuan, Wang, Kehui, Guo, Jigang, Zhang, Yujing, Chen, Jiangning, Guo, Xing, Li, Qibin, Li, Xiaoying, Wang, Wenjing, Zhang, Yan, Wang, Jin, Jiang, Xueyuan, Xiang, Yang, Xu, Chen, Zheng, Pingping, Zhang, Juanbin, Li, Ruiqiang, Zhang, Hongjie, Shang, Xiaobin, Gong, Ting, Ning, Guang, Wang, Jun, Zen, Ke, Zhang, Junfeng, Zhang, Chen-Yu·2008·Cell Research
DOI 10.1038/cr.2008.282
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Abstract

Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses. The levels of miRNAs in serum are stable, reproducible, and consistent among individuals of the same species. Employing Solexa, we sequenced all serum miRNAs of healthy Chinese subjects and found over 100 and 91 serum miRNAs in male and female subjects, respectively. We also identified specific expression patterns of serum miRNAs for lung cancer, colorectal cancer, and diabetes, providing evidence that serum miRNAs contain fingerprints for various diseases. Two non-small cell lung cancer-specific serum miRNAs obtained by Solexa were further validated in an independent trial of 75 healthy donors and 152 cancer patients, using quantitative reverse transcription polymerase chain reaction assays. Through these analyses, we conclude that serum miRNAs can serve as potential biomarkers for the detection of various cancers and other diseases.

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Crossref · 10.1038/cr.2008.282

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Metadata

Authors
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., Li, Q., Li, X., Wang, W., Zhang, Y., Wang, J., Jiang, X., Xiang, Y., Xu, C., Zheng, P., Zhang, J., Li, R., Zhang, H., Shang, X., Gong, T., Ning, G., Wang, J., Zen, K., Zhang, J., & Zhang, C.-Y.
Affiliations
  • State Key Laboratory of Pharmaceutical Biotechnology (CN)
  • Tianjin Medical University Cancer Institute and Hospital (CN)
  • BGI Group (China) (CN)
  • Shanghai Jiao Tong University (CN)
  • Shanghai Municipal Center For Disease Control Prevention (CN)
Corresponding author
  • Wang, Jin
  • Zhang, Juanbin
  • Zen, Ke
  • Zhang, Chen-Yu
ORCID
Venue
Cell Research
Publisher
Springer Science and Business Media LLC
Published
2008-09-02
Volume
18
Issue
10
Pages
997-1006
ISSN
  • 1001-0602 (ISSN-L)
  • 1748-7838
DOI
10.1038/cr.2008.282
OpenAlex
W2097233439
Cited by
4,560
References
21
Citations by year
2026: 77 · 2025: 146 · 2024: 144 · 2023: 212 · 2022: 240 · 2021: 302 · 2020: 301 · 2019: 284 · 2018: 346 · 2017: 324 · 2016: 365 · 2015: 405 · 2014: 394 · 2013: 356 · 2012: 272
FWCI
44.41
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Cell Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (30471991, 973 Program, 30570731, 30225037)
  • Government of Jiangsu Province
  • Natural Science Foundation of Jiangsu Province (BK2006714)
  • National Key Research and Development Program of China (2006CB503909)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
microRNA, serum microRNA, plasma microRNA, tumor markers, non-invasive cancer diagnosis, lung cancer, colorectal cancer, diabetes mellitus, miRNA expression profiling, miRNA stability
MeSH terms
Animals, Carcinoma, Non-Small-Cell Lung, Cattle, Diabetes Mellitus, Type 2, Female, Horses, Humans, Lung Neoplasms, Male, Neoplasms, Biomarkers, Tumor, Colorectal Neoplasms, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Rats

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