Cited by 418DNA Repair MechanismsEffects of Radiation ExposurePARP inhibition in cancer therapy

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The endless tale of non-homologous end-joining

Weterings, Eric, Chen, David J·2008·Cell Research

DOI 10.1038/cr.2008.3

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Abstract

DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive oxygen species. In addition, they are commonly generated during V(D)J recombination, an essential aspect of the developing immune system. Failure to effectively repair these DSBs can result in chromosome breakage, cell death, onset of cancer, and defects in the immune system of higher vertebrates. Fortunately, all mammalian cells possess two enzymatic pathways that mediate the repair of DSBs: homologous recombination and non-homologous end-joining (NHEJ). The NHEJ process utilizes enzymes that capture both ends of the broken DNA molecule, bring them together in a synaptic DNA-protein complex, and finally repair the DNA break. In this review, all the known enzymes that play a role in the NHEJ process are discussed and a working model for the co-operation of these enzymes during DSB repair is presented.

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Authors: Weterings, E., & Chen, D. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Chen, David J
ORCID: Chen, David J
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2008-01
Volume: 18
Issue: 1
Pages: 114-124
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2008.3
OpenAlex: W2104191744
Cited by: 418
References: 74
Citations by year: 2026: 13 · 2025: 9 · 2024: 22 · 2023: 9 · 2022: 12 · 2021: 17 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 19 · 2016: 24 · 2015: 25 · 2014: 21 · 2013: 48 · 2012: 32
FWCI: 3.50
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Aeronautics and Space Administration (NNA05CM04G)
National Institutes of Health (CA92584)
National Cancer Institute (R37CA050519, P01CA092584)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: non-homologous end joining, DNA double-strand breaks, DNA repair, homologous recombination, V(D)J recombination, protein-DNA complex, ionizing radiation, reactive oxygen species, chromosome breakage, immune system development
MeSH terms: Animals, DNA Repair, Humans, Models, Biological, Recombination, Genetic, Gene Rearrangement, VDJ Exons, DNA Breaks, Double-Stranded

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The endless tale of non-homologous end-joining

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