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Cited by 346

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

Open access
Stanimirovic, Danica B, Friedman, Alon·2012·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.2012.25
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Abstract

Pathophysiology of the neurovascular unit (NVU) is commonly seen in neurological diseases. The typical features of NVU pathophysiology include tissue hypoxia, inflammatory and angiogenic activation, as well as initiation of complex molecular interactions between cellular (brain endothelial cells, astroctyes, pericytes, inflammatory cells, and neurons) and acellular (basal lamina) components of the NVU, jointly resulting in increased blood–brain barrier permeability, brain edema, neurovascular uncoupling, and neuronal dysfunction and damage. The evidence of important role of the brain vascular compartment in disease pathogenesis has elicited the debate whether the primary vascular events may be a cause of the neurological disease, as opposed to a mere participant recruited by a primary neuronal origin of pathology? Whereas some hereditary and acquired cerebral angiopathies could be considered a primary cause of neurological symptoms of the disease, the epidemiological studies showing a high degree of comorbidity among vascular disease and dementias, including Alzheimer's disease, as well as migraine and epilepsy, suggested that primary vascular pathology may be etiological factor causing neuronal dysfunction or degeneration in these diseases. This review focuses on recent hypotheses and evidence, suggesting that pathophysiology of the NVU may be initiating trigger for neuronal pathology and subsequent neurological manifestations of the disease.

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Show all 22 references

Research works printed but not linked: 78

  1. 10.1016/j.nbd.2009.07.030 · DOI · Paper page
  2. 10.1111/j.1742-4658.2009.07176.x · DOI · Paper page
  3. 10.1016/0165-3806(87)90075-7 · DOI · Paper page
  4. 10.1160/TH05-07-0488 · DOI
  5. 10.1038/89490 · DOI · Paper page
  6. 10.1016/j.neuroscience.2008.06.025 · DOI · Paper page
  7. 10.1111/j.1468-2982.2009.01983.x · DOI · Paper page
  8. 10.1016/S1474-4422(09)70358-8 · DOI
  9. 10.1073/pnas.0805165106 · DOI · Paper page
  10. 10.1523/JNEUROSCI.2323-09.2009 · DOI · Paper page
  11. 10.2174/187152709787601867 · DOI · Paper page
  12. 10.1523/JNEUROSCI.3697-05.2005 · DOI
  13. 10.1111/j.1749-6632.2010.05760.x · DOI
  14. 10.1161/01.ATV.0000232525.65682.a2 · DOI
  15. 10.1038/nm.2333 · DOI · Paper page
  16. 10.1212/01.WNL.0000176298.63840.99 · doi:10.1212/01.wnl.0000176298.63840.99
  17. 10.1093/brain/awf007 · DOI · Paper page
  18. 10.1097/00004647-199809000-00007 · DOI · Paper page
  19. 10.1111/j.1469-7793.2001.0515i.x · DOI
  20. 10.1093/brain/awp102 · DOI · Paper page
  21. 10.1002/eji.200425327 · DOI · Paper page
  22. 10.1016/j.exger.2009.09.005 · DOI
  23. 10.1038/nm.1878 · DOI · Paper page
  24. 10.1016/j.eplepsyres.2009.03.005 · DOI · Paper page
  25. 10.1002/glia.20543 · DOI · Paper page
  26. 10.1038/jcbfm.1991.116 · DOI
  27. 10.1111/j.1365-2990.2010.01140.x · DOI · Paper page
  28. 10.1111/j.1471-4159.2008.05858.x · DOI
  29. 10.1152/japplphysiol.00954.2005 · DOI · Paper page
  30. 10.1186/1756-6606-4-32 · DOI
  31. 10.1007/978-1-60761-938-3_16 · DOI
  32. 10.1124/mol.109.061754 · DOI · Paper page
  33. 10.1177/0891988710383570 · DOI · Paper page
  34. 10.2174/156720205774322610 · DOI
  35. 10.1161/STROKEAHA.110.595488 · DOI
  36. 10.1038/sj.bjc.6605937 · DOI
  37. 10.1007/s00415-009-5384-z · DOI
  38. 10.1093/brain/awl317 · DOI · Paper page
  39. 10.3233/JAD-2009-1074 · DOI
  40. 10.2174/156720508783884675 · DOI
  41. 10.3233/JAD-2008-14110 · DOI
  42. 10.1093/brain/awn129 · DOI · Paper page
  43. 10.1042/BJ20110301 · DOI · Paper page
  44. 10.1186/2040-2384-2-1 · DOI
  45. 10.1161/01.STR.0000258100.04923.84 · DOI
  46. 10.1523/JNEUROSCI.3665-07.2008 · DOI
  47. 10.1111/j.1528-1167.2007.00988.x · DOI · Paper page
  48. 10.2174/138161211795164112 · DOI
  49. 10.1093/brain/awp049 · DOI
  50. 10.1073/pnas.92.5.1426 · DOI
  51. 10.1111/j.1469-7793.1998.711bm.x · DOI
  52. 10.1016/0006-8993(88)91062-1 · DOI · Paper page
  53. 10.1161/01.STR.0000014619.59851.65 · DOI
  54. 10.1038/nrn2995 · DOI · Paper page
  55. 10.1038/jcbfm.2010.78 · DOI
  56. 10.1038/jcbfm.2011.43 · DOI · Paper page
  57. 10.1111/j.1528-1167.2010.02909.x · DOI · Paper page
  58. 10.1111/j.1460-9568.2011.07688.x · DOI
  59. 10.1002/glia.20481 · DOI
  60. 10.1038/nature05193 · DOI · Paper page
  61. 10.1161/01.STR.32.1.17 · DOI
  62. 10.1523/JNEUROSCI.1751-04.2004 · DOI · Paper page
  63. 10.1056/NEJMra1011165 · DOI · Paper page
  64. 10.1001/jama.2010.574 · DOI · Paper page
  65. 10.1155/2009/278531 · DOI
  66. 10.1038/sj.jcbfm.9600252 · DOI · Paper page
  67. 10.1111/j.1468-2982.2009.01940.x · DOI
  68. 10.1007/978-3-0348-8297-2_9 · DOI
  69. 10.1111/j.1750-3639.2000.tb00248.x · DOI · Paper page
  70. 10.1038/nn1623 · DOI · Paper page
  71. 10.1016/j.nbd.2006.10.006 · DOI
  72. 10.1111/j.1471-4159.2011.07208.x · DOI · Paper page
  73. 10.1523/JNEUROSCI.23-25-08692.2003 · DOI · Paper page
  74. 10.2174/187152708784936635 · DOI
  75. 10.2741/3395 · DOI
  76. 10.1523/JNEUROSCI.5103-08.2009 · DOI
  77. 10.1038/nm1210-1370 · DOI · Paper page
  78. 10.1073/pnas.93.9.4229 · DOI · Paper page

Cited by

Metadata

Authors
Stanimirovic, D. B., & Friedman, A.
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
2012-03-07
Volume
32
Issue
7
Pages
1207-1221
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1038/jcbfm.2012.25
OpenAlex
W1981984722
Cited by
346
References
22
FWCI
14.78
Type
journal article
Language
en
Open access
green
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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