Nutrition and other lifestyle influences on arterial aging

LaRocca, Thomas J.; Martens, Christopher R.; Seals, Douglas R.

doi:10.1016/j.arr.2016.09.002

Cited by 83Cardiovascular Health and Disease PreventionNutritional Studies and DietNitric Oxide and Endothelin Effects

Nutrition and other lifestyle influences on arterial aging

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LaRocca, Thomas J., Martens, Christopher R., Seals, Douglas R.·2017·Ageing Research Reviews

DOI 10.1016/j.arr.2016.09.002PMC PMC5373983

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Abstract

As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial function. Accumulating evidence demonstrates that diet and nutrition may favorably modulate these arterial functions with aging, but many important questions remain. In this review, we will summarize the available information on dietary patterns and nutritional factors that have been studied for their potential to reduce arterial stiffness and improve endothelial function with age, with an emphasis on: 1) underlying physiological mechanisms, and 2) emerging areas of research on nutrition and arterial aging that may hold promise for preventing age-related CVD.

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Dietary restriction significantly reduces the risk of CVD in humans and is associated with beneficial changes in arterial walls in animal models.
“dietary restriction significantly reduces the risk of CVD in humans, and in animal models, dietary restriction is associated with numerous beneficial changes in arterial walls”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [264]

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RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity
Carmona-Ramírez, I., Santamarı́a, A., Tobón-Velasco, J. C., Orozco‐Ibarra, M., González-Herrera, I. G., Pedraza‐Chaverrí, J., & Maldonado, P. D. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.12.010 · Cited by 63 · see citing works
Retracted
Intravenous Fluids and Acute Kidney Injury
Ding, X., Cheng, Z., & Qian, Q. (2017) · Blood Purification · doi:10.1159/000452702 · Cited by 6,866 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · cited 1× · see citing works
“Although these factors certainly play a role in determining CVD risk, the major risk factor for CVD is advancing age itself (Mozaffarian et al., 2016).”
Background
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works
Forecasting the Future of Cardiovascular Disease in the United States: A Policy Statement From the American Heart Association
Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208 · see citing works
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., et al. (1998) · PubMed · doi:10.1182/blood.v91.10.3527 · Cited by 2,244 · see citing works
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study
Mitchell, G. F., Hwang, S.-J., Vasan, R. S., Larson, M. G., Pencina, M. J., Hamburg, N. M., Vita, J. A., Levy, D., & Benjamin, E. J. (2010) · Circulation · doi:10.1161/circulationaha.109.886655 · Cited by 2,225 · see citing works
Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works
Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness
Zieman, S. J., Melenovsky, V., & Kass, D. A. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000160548.78317.29 · Cited by 1,854 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
Enhanced cellular proliferation in intact stenotic lesions derived from human arteriovenous fistulas and peripheral bypass grafts. Does it correlate with flow parameters?
Hofstra, L., Tordoir, J. H. M., Kitslaar, P. J. E. H. M., Hoeks, A. P. G., & Daemen, M. J. A. P. (1996) · PubMed · doi:10.1161/01.cir.94.6.1283 · Cited by 1,603 · see citing works
The impact of diet and lifestyle on gut microbiota and human health
Conlon, M., & Bird, A. (2014) · Nutrients · doi:10.3390/nu7010017 · Cited by 1,567 · see citing works
Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,334 · see citing works
Hormesis defined
Mattson, M. P. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.08.007 · Cited by 1,253 · see citing works
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges
Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956 · see citing works
Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults
Yeboah, J., Crouse, J. R., Hsu, F., Burke, G. L., & Herrington, D. M. (2007) · Circulation · doi:10.1161/circulationaha.106.678276 · Cited by 890 · see citing works
Aortic Stiffness
Cavalcante, J. L., Lima, J. A. C., Redheuil, A. B., & Al-Mallah, M. H. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.017 · Cited by 845 · see citing works
Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China.
Avolio, A. P., Deng, F. Q., Li, W. Q., Luo, Y., Huang, Z., Xing, L. F., & O’Rourke, M. F. (1985) · Circulation · doi:10.1161/01.cir.71.2.202 · Cited by 838 · see citing works
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women
Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.171 · Cited by 804 · see citing works
Economic and social implications of aging societies
Harper, S. E. (2014) · Science · doi:10.1126/science.1254405 · Cited by 783 · cited 1× · see citing works
“In fact, the number of adults over age 65 is projected to more than double by the year 2050 (Harper, 2014).”
Background
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works
Self-citation
Arterial Aging: Is It an Immutable Cardiovascular Risk Factor?
Najjar, S. S., Scuteri, A., & Lakatta, E. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000177474.06749.98 · Cited by 640 · cited 1× · see citing works
“This is largely a result of age-related declines in arterial function that make us more susceptible to clinical CVD as we grow older (Najjar et al., 2005; Seals et al., 2014).”
Background
Exercise, oxidative stress and hormesis
Radak, Z., Chung, H. Y., Koltai, E., Taylor, A. W., & Goto, S. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.04.004 · Cited by 638 · see citing works
Effects of the DASH Diet Alone and in Combination With Exercise and Weight Loss on Blood Pressure and Cardiovascular Biomarkers in Men and Women With High Blood Pressure
Blumenthal, J. A. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.470 · Cited by 592 · see citing works
Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials
Schwingshackl, L., & HOFFMANN, G. E. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.03.003 · Cited by 590 · see citing works
Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women
Modena, M. G., Bonetti, L., Coppi, F., Bursi, F., & Rossi, R. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01976-9 · Cited by 573 · see citing works
Components of a Cardioprotective Diet: New Insights
Mozaffarian, D., Appel, L. J., & Van Horn, L. (2011) · Circulation · doi:10.1161/circulationaha.110.968735 · Cited by 571 · cited 1× · see citing works
“Healthy lifestyle and diet clearly have the potential to reduce CVD risk (Mozaffarian et al., 2011).”
Background
Cellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works
Meal frequency and timing in health and disease
Mattson, M. P., Allison, D. B., Fontana, L., Harvie, M., Longo, V. D., Malaisse, W. J., Mosley, M., Notterpek, L. M., Ravussin, É., Scheer, F. A. J. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413965111 · Cited by 533 · see citing works
Nutraceutical Antioxidants as Novel Neuroprotective Agents
Kelsey, N. A., Wilkins, H., & Linseman, D. A. (2010) · Molecules · doi:10.3390/molecules15117792 · Cited by 481 · see citing works
Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
Mattson, M. P., & Wan, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.007 · Cited by 464 · see citing works
Autophagy is required for exercise training‐induced skeletal muscle adaptation and improvement of physical performance
Lira, V. A., Okutsu, M., Zhang, M., Greene, N. P., Laker, R. C., Breen, D. S., Hoehn, K. L., & Yan, Z. (2013) · The FASEB Journal · doi:10.1096/fj.13-228486 · Cited by 432 · see citing works
Cocoa and Cardiovascular Health
Corti, R., Flammer, A. J., Hollenberg, N. K., & Lüscher, T. F. (2009) · Circulation · doi:10.1161/circulationaha.108.827022 · Cited by 424 · see citing works
Calorie restriction mimetics: an emerging research field
Ingram, D. K., Zhu, M., Mamczarz, J., Zou, S., Lane, M. A., Roth, G. S., & de Cabo, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00202.x · Cited by 415 · see citing works
Antioxidant Vitamin Supplements and Cardiovascular Disease
Kris‐Etherton, P. M., Lichtenstein, A. H., Howard, B. V., Steinberg, D. H., & Witztum, J. L. (2004) · Circulation · doi:10.1161/01.cir.0000137822.39831.f1 · Cited by 408 · see citing works
Long‐term effects of calorie or protein restriction on serum IGF‐1 and IGFBP‐3 concentration in humans
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396 · see citing works
Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial
Varady, K. A., Bhutani, S., Klempel, M. C., Kroeger, C. M., Trepanowski, J. F., Haus, J. M., Hoddy, K. K., & Calvo, Y. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-146 · Cited by 396 · see citing works
Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice
Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works
Self-citation
The danger of weight loss in the elderly
Miller, S. L., & Wolfe, R. R. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982710 · Cited by 384 · see citing works
Long-term caloric restriction ameliorates the decline in diastolic function in humans
Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.069 · Cited by 383 · see citing works
Role of Dietary Salt and Potassium Intake in Cardiovascular Health and Disease: A Review of the Evidence
Aaron, K. J., & Sanders, P. W. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.005 · Cited by 365 · see citing works
25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults
Jablonski, K., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160929 · Cited by 360 · see citing works
Self-citation
Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?
Stanimirovic, D. B., & Friedman, A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.25 · Cited by 352 · see citing works
Exercise Modalities and Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials
Ashor, A. W., Lara, J., Siervo, M., Celis-Morales, C. A., Oggioni, C., Jakovljević, D. G., & Mathers, J. C. (2014) · Sports Medicine · doi:10.1007/s40279-014-0272-9 · Cited by 347 · see citing works
Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.057042 · Cited by 341 · see citing works
Self-citation
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334 · see citing works
Persistent Impairment of Endothelial Vasomotor Function Has a Negative Impact on Outcome in Patients With Coronary Artery Disease
Kitta, Y., Obata, J., Nakamura, T., Hirano, M., Kodama, Y., Fujioka, D., Saitō, Y., Kawabata, K., Sano, K., Kobayashi, T., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.074 · Cited by 330 · see citing works
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
Seals, D. R., Justice, J. N., & LaRocca, T. J. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282665 · Cited by 312 · see citing works
Self-citation
Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277 · see citing works
SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans
Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works
Self-citation
Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
Gioscia‐Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.268680 · Cited by 263 · see citing works
Self-citation
Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans
Pierce, G. L., Lesniewski, L. A., Lawson, B. R., Beske, S. D., & Seals, D. R. (2009) · Circulation · doi:10.1161/circulationaha.108.804294 · Cited by 262 · see citing works
Self-citation
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
Fuentes, F. J., López‐Miranda, J., Sánchez, E., Sánchez, F., Paez, J., Paz-Rojas, E., Marı́n, C., Gómez, P., Jiménez-Perepérez, J., Ordovás, J. M., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00011 · Cited by 260 · see citing works
Folate, homocysteine, endothelial function and cardiovascular disease
Moat, S. J., Lang, D., McDowell, I., Clarke, Z., Madhavan, A. K., LEWIS, M. J., & Goodfellow, J. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.08.010 · Cited by 259 · see citing works
Translational evidence that impaired autophagy contributes to arterial ageing
LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 255 · see citing works
Self-citation
Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men
Gliemann, L., Schmidt, J. F., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., Mortensen, S. P., Nyberg, M., Bangsbo, J., Pilegaard, H., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.258061 · Cited by 244 · see citing works
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase
Durrant, J., Seals, D. R., Connell, M. L., Russell, M. J., Lawson, B. R., Folian, B. J., Donato, A. J., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169771 · Cited by 244 · see citing works
Self-citation
Time-restricted feeding and risk of metabolic disease: A review of human and animal studies
Rothschild, J., Hoddy, K. K., Jambazian, P., & Varady, K. A. (2014) · Nutrition Reviews · doi:10.1111/nure.12104 · Cited by 241 · see citing works
Mechanisms Underlying Caloric Restriction and Lifespan Regulation
Ungvari, Z. I., Parrado‐Fernández, C., Csiszár, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 239 · see citing works
Exercise Training Promotes SIRT1 Activity in Aged Rats
Ferrara, N., Rinaldi, B., Corbi, G., Conti, V., Stiuso, P., Boccuti, S., Rengo, G., Rossi, F., & Filippelli, A. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0576 · Cited by 238 · see citing works
Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors
Hill, A. M., Buckley, J. D., Murphy, K. J., & Howe, P. R. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1267 · Cited by 237 · see citing works
Dietary Sodium Restriction Rapidly Improves Large Elastic Artery Compliance in Older Adults With Systolic Hypertension
Gates, P. E., Tanaka, H., Hiatt, W. R., & Seals, D. R. (2004) · Hypertension · doi:10.1161/01.hyp.0000132767.74476.64 · Cited by 236 · see citing works
Self-citation
Effect of omega-3 fatty acids supplementation on endothelial function: A meta-analysis of randomized controlled trials
Wang, Q., Liang, X., Wang, L., Lu, X., Huang, J., Cao, J., Li, H., & Gu, D. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.01.006 · Cited by 233 · see citing works
Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging
Ferrari, C. K. B. (2004) · Biogerontology · doi:10.1007/s10522-004-2566-z · Cited by 227 · see citing works
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging
Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works
Self-citation
Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise
Fleenor, B. S., Marshall, K. D., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194753 · Cited by 212 · see citing works
Self-citation
The autophagy enhancer spermidine reverses arterial aging
LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 207 · see citing works
Self-citation
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics
Marzetti, E., Csiszár, A., Dutta, D., Balagopal, G., Calvani, R., & Leeuwenburgh, C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00936.2012 · Cited by 197 · see citing works
Proinflammation: the key to arterial aging
Wang, M., Jiang, L., Monticone, R. E., & Lakatta, E. G. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.10.002 · Cited by 195 · see citing works
Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial ,
Dower, J. I., Geleijnse, J. M., Gijsbers, L., Schalkwijk, C. G., Kromhout, D., & Hollman, P. C. H. (2015) · Journal of Nutrition · doi:10.3945/jn.115.211888 · Cited by 182 · see citing works
Arterial Destiffening With Weight Loss in Overweight and Obese Middle-Aged and Older Adults
Dengo, A. L., Dennis, E. A., Orr, J. S., Marinik, E. L., Ehrlich, E., Davy, B. M., & Davy, K. P. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.147850 · Cited by 179 · see citing works
Aging in America in the Twenty‐first Century: Demographic Forecasts from the MacArthur Foundation Research Network on an Aging Society
Olshansky, S. J., Goldman, D. P., Zheng, Y., & Rowe, J. W. (2009) · Milbank Quarterly · doi:10.1111/j.1468-0009.2009.00581.x · Cited by 178 · see citing works
Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates
Opländer, C., Volkmar, C. M., Paunel‐Görgülü, A., van Faassen, E. E., Heiß, C., Kelm, M., Halmer, D., Mürtz, M., Pallua, N., & Suschek, C. V. (2009) · Circulation Research · doi:10.1161/circresaha.109.207019 · Cited by 172 · see citing works
The effects of dietary and nutrient interventions on arterial stiffness: a systematic review
Pase, M. P., Grima, N., & Sarris, J. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002725 · Cited by 171 · see citing works
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice
Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 169 · see citing works
Self-citation
Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-Aged/Older Adults With Moderately Elevated Systolic Blood Pressure
Jablonski, K., Racine, M. L., Geolfos, C. J., Gates, P. E., Chonchol, M., McQueen, M. B., & Seals, D. R. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.010 · Cited by 169 · see citing works
Self-citation
Dietary saturated and unsaturated fats as determinants of blood pressure and vascular function
Hall, W. L. (2009) · Nutrition Research Reviews · doi:10.1017/s095442240925846x · Cited by 168 · see citing works
Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/Obese Adults
Pierce, G. L., Beske, S. D., Lawson, B. R., Southall, K. L., Benay, F. J., Donato, A. J., & Seals, D. R. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111427 · Cited by 167 · see citing works
Self-citation
Dietary Nitrate Reverses Vascular Dysfunction in Older Adults With Moderately Increased Cardiovascular Risk
Rammos, C., Hendgen-Cotta, U. B., Sobierajski, J., Bernard, A., Kelm, M., & Rassaf, T. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.691 · Cited by 165 · see citing works
Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
Wong, R. H. X., Berry, N. M., Coates, A. M., Buckley, J. D., Bryan, J., Kunz, I., & Howe, P. R. C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328362b9d6 · Cited by 162 · see citing works
Dietary Intake of Fruits and Vegetables Improves Microvascular Function in Hypertensive Subjects in a Dose-Dependent Manner
McCall, D. O., McGartland, C. P., McKinley, M. C., Patterson, C. C., Sharpe, P., McCance, D. R., Young, I. S., & Woodside, J. V. (2009) · Circulation · doi:10.1161/circulationaha.108.831297 · Cited by 161 · see citing works
Flow-Mediated Dilatation Is Impaired by a High–Saturated Fat Diet but Not by a High-Carbohydrate Diet
Keogh, J. B., Grieger, J. A., Noakes, M., & Clifton, P. M. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000163185.28245.a1 · Cited by 160 · see citing works
Aortic stiffness, pressure and flow pulsatility, and target organ damage
Mitchell, G. F. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00108.2018 · Cited by 159 · see citing works
Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works
Self-citation
Acute Effects of Chlorogenic Acid on Nitric Oxide Status, Endothelial Function, and Blood Pressure in Healthy Volunteers: A Randomized Trial
Mubarak, A., Bondonno, C. P., Liu, A. H., Considine, M. J., Rich, L., Mas, E., Croft, K. D., & Hodgson, J. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303440j · Cited by 157 · see citing works
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women
Akazawa, N., Choi, Y., Miyaki, A., Tanabe, Y., Sugawara, J., Ajisaka, R., & Maeda, S. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.09.002 · Cited by 153 · see citing works
Endothelial Dysfunction Induced by Post-Prandial Lipemia
Tyldum, G. A., Schjerve, I. E., Tjønna, A. E., Kirkeby‐Garstad, I., Stølen, T., Richardson, R. S., & Wisløff, U. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.033 · Cited by 152 · see citing works
Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female Mice
DeMarco, V. G., Habibi, J., Jia, G., Aroor, A. R., Ramirez‐Perez, F. I., Martinez‐Lemus, L. A., Bender, S. B., Garro, M., Hayden, M. R., Sun, Z., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05674 · Cited by 150 · see citing works
Curcumin ameliorates arterial dysfunction and oxidative stress with aging
Fleenor, B. S., Sindler, A. L., Marvi, N. K., Howell, K. L., Zigler, M. L., Yoshizawa, M., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.008 · Cited by 145 · see citing works
Self-citation
Consumption of Plant Seeds and Cardiovascular Health
Ros, E., & Hu, F. B. (2013) · Circulation · doi:10.1161/circulationaha.112.001119 · Cited by 145 · see citing works
Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism
Carrizzo, A., Puca, A. A., Damato, A., Marino, M., Franco, E., Pompeo, F., Traficante, A., Civitillo, F., Santini, L., Trimarco, V., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.01009 · Cited by 144 · see citing works
Capsaicin may have important potential for promoting vascular and metabolic health
McCarty, M. F., DiNicolantonio, J. J., & O’Keefe, J. H. (2015) · Open Heart · doi:10.1136/openhrt-2015-000262 · Cited by 144 · see citing works
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial
Heiß, C., Sansone, R., Karimi, H., Krabbe, M., Schuler, D., Rodriguez‐Mateos, A., Kræmer, T., Cortese-Krott, M. M., Kuhnle, G., Spencer, J. P. E., et al. (2015) · AGE · doi:10.1007/s11357-015-9794-9 · Cited by 142 · see citing works
Aerobic exercise and other healthy lifestyle factors that influence vascular aging
Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 141 · see citing works
Self-citation
You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging
Seals, D. R., Kaplon, R. E., Gioscia‐Ryan, R. A., & LaRocca, T. J. (2014) · Physiology · doi:10.1152/physiol.00059.2013 · Cited by 138 · cited 1× · see citing works
“This is largely a result of age-related declines in arterial function that make us more susceptible to clinical CVD as we grow older (Najjar et al., 2005; Seals et al., 2014).”
BackgroundSelf-citation
Whole Food versus Supplement: Comparing the Clinical Evidence of Tomato Intake and Lycopene Supplementation on Cardiovascular Risk Factors
Burton‐Freeman, B. M., & Sesso, H. D. (2014) · Advances in Nutrition · doi:10.3945/an.114.005231 · Cited by 134 · see citing works
NRF2, cancer and calorie restriction
Martín‐Montalvo, A., Villalba, J. M., Navas, P., & de Cabo, R. (2010) · Oncogene · doi:10.1038/onc.2010.492 · Cited by 128 · see citing works
Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects
Jauhiainen, T., Rönnback, M., Vapaatalo, H., Wuolle, K., Kautiainen, H., Groop, P., & Korpela, R. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.3 · Cited by 127 · see citing works
Habitually exercising older men do not demonstrate age‐associated vascular endothelial oxidative stress
Pierce, G. L., Donato, A. J., LaRocca, T. J., Eskurza, I., Silver, A., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00748.x · Cited by 122 · see citing works
Self-citation
Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries
Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00362.2014 · Cited by 118 · see citing works
Self-citation
Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study
Sugawara, J., Akazawa, N., Miyaki, A., Choi, Y., Tanabe, Y., Imai, T., & Maeda, S. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.24 · Cited by 117 · see citing works
Oral Vitamin C Reduces Arterial Stiffness and Platelet Aggregation in Humans
Wilkinson, I. B., Megson, I. L., MacCallum, H., Sogo, N., Cockcroft, J. R., & Webb, D. J. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199911000-00010 · Cited by 117 · see citing works
The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies
Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works
Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with α-linolenic acid on postprandial endothelial function in healthy men
Fuentes, F. J., López‐Miranda, J., Pérez‐Martínez, P., Jiménez, Y., Marı́n, C., Gómez, P., Fernández, J. M., Caballero‐Villarraso, J., Delgado‐Lista, J., & Pérez‐Jiménez, F. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508888708 · Cited by 113 · see citing works
Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials
Ashor, A. W., Siervo, M., Lara, J., Oggioni, C., Afshar, S., & Mathers, J. C. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000227 · Cited by 112 · see citing works
Nutraceuticals and Prevention of Atherosclerosis: Focus on ω‐3 Polyunsaturated Fatty Acids and Mediterranean Diet Polyphenols
Massaro, M., Scoditti, E., Carluccio, M. A., & Caterina, R. D. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00211.x · Cited by 106 · see citing works
Low-sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans
Al-Solaiman, Y., Jesri, A., Zhao, Y., Morrow, J. D., & Egan, B. M. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.32 · Cited by 102 · see citing works
Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial
Joris, P. J., Plat, J., Bakker, S. J. L., & Mensink, R. P. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131466 · Cited by 98 · see citing works
Pharmacological Strategies to Retard Cardiovascular Aging
Alfaras, I., Germanio, C. D., Bernier, M., Csiszár, A., Ungvari, Z. I., Lakatta, E. G., & de Cabo, R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307475 · Cited by 87 · see citing works
Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults
Kaplon, R. E., Hill, S. D., Bispham, N. Z., Santos‐Parker, J. R., Nowlan, M. J., Snyder, L. L., Chonchol, M., LaRocca, T. J., McQueen, M. B., & Seals, D. R. (2016) · Aging · doi:10.18632/aging.100962 · Cited by 84 · see citing works
Self-citation
Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women
Yoshizawa, M., Maeda, S., Miyaki, A., Misono, M., Choi, Y., Shimojo, N., Ajisaka, R., & Tanaka, H. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00433.2009 · Cited by 83 · see citing works
Relations Between Dairy Food Intake and Arterial Stiffness
Crichton, G. E., Elias, M. F., Dore, G. A., Abhayaratna, W. P., & Robbins, M. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.190017 · Cited by 82 · see citing works
Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
DeVan, A. E., Johnson, L. C., Brooks, F. A., Evans, T. D., Justice, J. N., Cruickshank-Quinn, C. I., Reisdorph, N. A., Bryan, N. S., McQueen, M. B., Santos‐Parker, J. R., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00879.2015 · Cited by 82 · see citing works
Self-citation
Healthy lifestyle-based approaches for successful vascular aging
Rossman, M. J., LaRocca, T. J., Martens, C. R., & Seals, D. R. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2018 · Cited by 82 · see citing works
Self-citation
Acute exercise activates AMPK and eNOS in the mouse aorta
Cacicedo, J. M., Gauthier, M., LeBrasseur, N. K., Jasuja, R., Ruderman, N. B., & Ido, Y. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01279.2010 · Cited by 81 · see citing works
Mitochondrial quality control and age-associated arterial stiffening
LaRocca, T. J., Hearon, C. M., Henson, G. D., & Seals, D. R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.07.008 · Cited by 81 · see citing works
Self-citation
Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB
Walker, A. E., Kaplon, R. E., Pierce, G. L., Nowlan, M. J., & Seals, D. R. (2014) · Clinical Science · doi:10.1042/cs20140030 · Cited by 81 · see citing works
Self-citation
Endothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Diet
Marı́n, C., Yubero‐Serrano, E. M., López‐Miranda, J., & Pérez‐Jiménez, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14058869 · Cited by 80 · see citing works
Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
da Luz, P. L., Tanaka, L. Y., Brum, P. C., Dourado, P. M. M., Favarato, D., Krieger, J. E., & Laurindo, F. R. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.007 · Cited by 77 · see citing works
Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity
Klonizakis, M., AlKhatib, A. H., Middleton, G., & Smith, M. F. (2012) · Clinical Science · doi:10.1042/cs20120412 · Cited by 76 · see citing works
Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations
Kroeger, C. M., Klempel, M. C., Bhutani, S., Trepanowski, J. F., Tangney, C., & Varady, K. A. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-98 · Cited by 74 · see citing works
Additive Beneficial Effects of Lactotripeptides Intake With Regular Exercise on Endothelium-Dependent Dilatation in Postmenopausal Women
Yoshizawa, M., Maeda, S., Miyaki, A., Misono, M., Choi, Y., Shimojo, N., Ajisaka, R., & Tanaka, H. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2009.270 · Cited by 73 · see citing works
Therapeutic modification of arterial stiffness: An update and comprehensive review
Wu, C.-F. (2015) · World Journal of Cardiology · doi:10.4330/wjc.v7.i11.742 · Cited by 72 · see citing works
Adherence to a Mediterranean dietary pattern in early life is associated with lower arterial stiffness in adulthood: the A msterdam G rowth and H ealth L ongitudinal S tudy
van de Laar, R. J. J., Stehouwer, C. D. A., van Bussel, B. C. T., Prins, M. H., Twisk, J. W. R., & Ferreira, I. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02577.x · Cited by 69 · see citing works
Fish Consumption in Healthy Adults Is Associated with Decreased Circulating Biomarkers of Endothelial Dysfunction and Inflammation during a 6-Year Follow-Up
van Bussel, B. C. T., Henry, R. M. A., Schalkwijk, C. G., Ferreira, I., Feskens, E. J. M., Streppel, M. T., Smulders, Y. M., Twisk, J. W. R., & Stehouwer, C. D. A. (2011) · Journal of Nutrition · doi:10.3945/jn.111.139733 · Cited by 67 · see citing works
Epicatechin: Endothelial Function and Blood Pressure
Jiménez, R., Duarte, J., & Pérez‐Vizcaíno, F. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205370q · Cited by 66 · see citing works
Acute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and women
Ballard, K. D., Kupchak, B. R., Volk, B. M., Mah, E., Shkreta, A., Liptak, C., Ptolemy, A. S., Kellogg, M. D., Bruno, R. S., Seip, R. L., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002061 · Cited by 66 · see citing works
Switching to a 10-day Mediterranean-style diet improves mood and cardiovascular function in a controlled crossover study
Lee, J., Pase, M. P., Pipingas, A., Raubenheimer, J., Thurgood, M., Villalon, L., Macpherson, H., Gibbs, A., & Scholey, A. B. (2014) · Nutrition · doi:10.1016/j.nut.2014.10.008 · Cited by 66 · see citing works
Nutraceuticals in Cardiovascular Prevention: Lessons from Studies on Endothelial Function
Zuchi, C., Ambrosio, G., Lüscher, T. F., & Landmesser, U. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00165.x · Cited by 65 · see citing works
Vascular Endothelium: Functioning in Norm, Changes in Atherosclerosis and Current Dietary Approaches to Improve Endothelial Function
Chistiakov, D. A., Ревин, В. В., Sobenin, I. A., Orekhov, A. N., & Bobryshev, Y. V. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150226114031 · Cited by 64 · see citing works
Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics
S. Rocha, B., Gago, B., Pereira, C., M. Barbosa, R., Bartesaghi, S., O. Lundberg, J., Radi, R., & Laranjinha, J. (2011) · Current Drug Targets · doi:10.2174/138945011796150334 · Cited by 64 · see citing works
A Healthy Diet Is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease1–3
van Bussel, B. C. T., Henry, R. M. A., Ferreira, I., van Greevenbroek, M. M. J., Kallen, C., Twisk, J. W. R., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2015) · Journal of Nutrition · doi:10.3945/jn.114.201236 · Cited by 62 · see citing works
Coenzyme Q10 for the treatment of heart failure: a review of the literature
DiNicolantonio, J. J., Bhutani, J., McCarty, M. F., & O’Keefe, J. H. (2015) · Open Heart · doi:10.1136/openhrt-2015-000326 · Cited by 61 · see citing works
Antioxidant Vitamin Supplementation Reduces Arterial Stiffness in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Ashor, A. W., Siervo, M., Lara, J., Oggioni, C., & Mathers, J. C. (2014) · Journal of Nutrition · doi:10.3945/jn.114.195826 · Cited by 59 · see citing works
Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism
Lesniewski, L. A., Zigler, M. C., Durrant, J., Donato, A. J., & Seals, D. R. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.03.011 · Cited by 58 · see citing works
Self-citation
Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults
Justice, J. N., Johnson, L. C., DeVan, A. E., Cruickshank-Quinn, C. I., Reisdorph, N. A., Bassett, C. J., Evans, T. D., Brooks, F. A., Bryan, N. S., Chonchol, M. B., et al. (2015) · Aging · doi:10.18632/aging.100842 · Cited by 53 · see citing works
Self-citation
Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure
Jablonski, K., Gates, P. E., Pierce, G. L., & Seals, D. R. (2009) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944709345790 · Cited by 52 · see citing works
Self-citation
Diet and endothelial function
Landberg, R., Naidoo, N., & van Dam, R. M. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328351123a · Cited by 50 · see citing works
Aging compounds western diet-associated large artery endothelial dysfunction in mice: Prevention by voluntary aerobic exercise
Lesniewski, L. A., Zigler, M. L., Durrant, J., Nowlan, M. J., Folian, B. J., Donato, A. J., & Seals, D. R. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.001 · Cited by 50 · see citing works
Self-citation
Modulation of Vascular Endothelial Function by Low-Density Lipoprotein Cholesterol With Aging: Influence of Habitual Exercise
Walker, A. E., Eskurza, I., Pierce, G. L., Gates, P. E., & Seals, D. R. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.353 · Cited by 48 · see citing works
Self-citation
Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
DeVan, A. E., Eskurza, I., Pierce, G. L., Walker, A. E., Jablonski, K., Kaplon, R. E., & Seals, D. R. (2012) · Clinical Science · doi:10.1042/cs20120291 · Cited by 47 · see citing works
Self-citation
SFAs do not impair endothelial function and arterial stiffness
Sanders, T. A. B., Lewis, F. J., Goff, L. M., & Chowienczyk, P. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.063644 · Cited by 47 · see citing works
Weight loss in individuals with metabolic syndrome given DASH diet counseling when provided a low sodium vegetable juice: a randomized controlled trial
Shenoy, S. F., Poston, W. S. C., Reeves, R. S., Kazaks, A., Holt, R. R., Keen, C. L., Chen, H. J., Haddock, C. K., Winters, B., Khoo, C. S., et al. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-8 · Cited by 46 · see citing works
A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake
Blanch, N., Clifton, P. M., & Keogh, J. B. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.10.001 · Cited by 45 · see citing works
Vascular dilatory functions of ovo-lactovegetarians compared with omnivores
Lin, C.-L., Fang, T., & Gueng, M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00429-4 · Cited by 45 · see citing works
Systemic Vascular Function Is Associated with Muscular Power in Older Adults
Heffernan, K. S., Chalé, A., Hau, C., Cloutier, G. J., Phillips, E. M., Warner, P. J., Nickerson, H., Reid, K. F., Kuvin, J. T., & Fielding, R. A. (2012) · Journal of Aging Research · doi:10.1155/2012/386387 · Cited by 44 · see citing works
The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease
Evans, P. C. (2011) · The EPMA Journal · doi:10.1007/s13167-011-0064-3 · Cited by 42 · see citing works
Prognostic value of changes in arterial stiffness in men with coronary artery disease
Orlova, Y. A. (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s13591 · Cited by 40 · see citing works
The Role of Vitamin D in Blood Pressure, Endothelial and Renal Function in Postmenopausal Women
Liu, Z., Woo, J., Wu, S., & Ho, S. C. (2013) · Nutrients · doi:10.3390/nu5072590 · Cited by 39 · see citing works
Endothelial function and weight loss: Comparison of low‐carbohydrate and low‐fat diets
Mohler, E. R., Sibley, A. A., Stein, R. I., Dávila‐Román, V. G., Wyatt, H. R., Badellino, K. O., Rader, D. J., Klein, S., & Foster, G. D. (2013) · Obesity · doi:10.1002/oby.20055 · Cited by 31 · see citing works
Lifestyle Modification Decreases Arterial Stiffness in Overweight and Obese Men: Dietary Modification vs. Exercise Training
Maeda, S., Zempo‐Miyaki, A., Sasai, H., Tsujimoto, T., So, R., & Tanaka, K. (2014) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2013-0107 · Cited by 30 · see citing works
Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice
Henson, G. D., Walker, A. E., Reihl, K. D., Donato, A. J., & Lesniewski, L. A. (2014) · Physiological Reports · doi:10.1002/phy2.268 · Cited by 29 · see citing works
Effect of high potassium diet on endothelial function
Blanch, N., Clifton, P. M., Petersen, K. S., Willoughby, S. R., & Keogh, J. B. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.04.009 · Cited by 28 · see citing works
A Cross-sectional Study of the Relationship Between Habitual Tea Consumption and Arterial Stiffness
Lin, Q., Qiu, C., Wang, S.-L., Huang, L., Chen, Z.-Y., Chen, Y., & Chen, G. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1058197 · Cited by 25 · see citing works
Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial
Blumenthal, J. A., Smith, P. J., Welsh-Bohmer, K. A., Babyak, M. A., Browndyke, J. N., Lin, P., Doraiswamy, P. M., Burke, J. R., Kraus, W. E., Hinderliter, A. L., et al. (2012) · Contemporary Clinical Trials · doi:10.1016/j.cct.2012.09.004 · Cited by 23 · see citing works
Temocapril, an Angiotensin Converting Enzyme Inhibitor, Ameliorates Age-Related Increase in Carotid Arterial Stiffness in Normotensive Subjects
Hayashi, K., Miyagawa, K., Sato, K., Ueda, R., & Dohi, Y. (2006) · Cardiology · doi:10.1159/000093024 · Cited by 22 · see citing works
Consumption of coffee, not green tea, is inversely associated with arterial stiffness in Japanese men
Uemura, H., Katsuura‐Kamano, S., Yamaguchi, M., Nakamoto, M., Hiyoshi, M., & Arisawa, K. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.132 · Cited by 21 · see citing works
Effect of black tea consumption on brachial artery flow-mediated dilation and ischaemia–reperfusion in humans
Schreuder, T. H. A., Eijsvogels, T. M. H., Greyling, A., Draijer, R., Hopman, M. T. E., & Thijssen, D. H. J. (2013) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2012-0450 · Cited by 18 · see citing works
Assessment of enhanced endothelium-dependent vasodilation by intermittent fasting in Wistar albino rats.
Razzak, R. L. A., Abou-Hozaifa, B., Bamosa, A. O., & Ali, N. M. (2011) · PubMed · Cited by 16 · see citing works
Regulation of functional foods and nutraceuticals
Saad, S. M. I. (2006) · Revista Brasileira De Ciencias Farmaceuticas · doi:10.1590/s1516-93322006000300017 · Cited by 13 · see citing works
The Impact of Regulations on the Business of Nutraceuticals in the United States: Yesterday, Today, and Tomorrow
Wrick, K. L. (2005) · doi:10.1002/9780470277676.ch1 · Cited by 11 · see citing works

Flagged first, then by citations

Sorted by citations

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Biological Versus Chronological Aging
Hamczyk, M. R., Nevado, R. M., Barettino, A., Fuster, V., & Andrés, V. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.062 · Cited by 503 · see citing works
“function and CVD risk is diet, with healthy aging linked to unprocessed, plant-based nutrition with moderate consumption of lean meat and fish, features of the Mediterranean and Dietary Approaches to Stop Hypertension diets (62,63).”
BackgroundInfluential
Heart in space: effect of the extraterrestrial environment on the cardiovascular system
Hughson, R. L., Helm, A., & Durante, M. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.157 · Cited by 257 · see citing works
Aerobic exercise training and vascular function with ageing in healthy men and women
Seals, D. R., Nagy, E., & Moreau, K. L. (2019) · The Journal of Physiology · doi:10.1113/jp277764 · Cited by 231 · see citing works
“(7) If aerobic exercise training is determined to be less effective for enhancing vascular function in postmenopausal women than in middle-aged and older men, it will be essential to establish alternative evidence-based lifestyle and pharmacological prevention and treatment strategies to optimize cardiovascular health…”
BackgroundSelf-citation
Aortic stiffness, pressure and flow pulsatility, and target organ damage
Mitchell, G. F. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00108.2018 · Cited by 159 · see citing works
“The components of Life’s Simple 7 most closely associated with HVA were obesity and diabetes, which are also associated with longitudinal change in aortic stiffness (103), suggesting that relatively straightforward lifestyle interventions may prevent stiffening (53), promote HVA, and reduce CVD risk.”
Background
Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance
Jones, A. M., Vanhatalo, A., Seals, D. R., Rossman, M. J., Piknova, B., & Jonvik, K. L. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002470 · Cited by 156 · see citing works
Self-citation
Strategies for Achieving Healthy Vascular Aging
Nowak, K. L., Rossman, M. J., Chonchol, M., & Seals, D. R. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10439 · Cited by 152 · see citing works
“However, specific evidence on the effect of other dietary patterns, such as the Mediterranean or vegetarian diet on CFPWV, is currently lacking although alternate measurements of arterial stiffness suggest that such patterns may lead to improvements.(76) In trials implementing dietary patterns, including DASH, the Med…”
Self-citation
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Fontana, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0026-8 · Cited by 94 · see citing works
Healthy lifestyle-based approaches for successful vascular aging
Rossman, M. J., LaRocca, T. J., Martens, C. R., & Seals, D. R. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00521.2018 · Cited by 82 · see citing works
Self-citation
Perspective: Improving Nutritional Guidelines for Sustainable Health Policies: Current Status and Perspectives
Magni, P., Bier, D. M., Pecorelli, S., Agostoni, C. V., Astrup, A. V., Brighenti, F., Cook, R., Folco, E., Fontana, L., Gibson, R. A., et al. (2017) · Advances in Nutrition · doi:10.3945/an.116.014738 · Cited by 76 · see citing works
“This evidence also includes information from population-based epidemiologic studies that have identified food patterns, nutrient intakes, and lifestyles associated with health promotion or with increased risk or progression of NCDs (4, 16).”
Nutrigenetics—personalized nutrition in obesity and cardiovascular diseases
Barrea, L., Annunziata, G., Bordoni, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0014-4 · Cited by 69 · see citing works
Extracellular Matrix in Aging Aorta
Mammoto, A., Matus, K., & Mammoto, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.822561 · Cited by 68 · see citing works
“These changes in the intima layer contribute to aortic aging and pathogenesis of CVDs (inside-out theory: inner layer triggers remodeling of aortic wall) (Donato et al., 2015; Yin and Pickering, 2016).”
BackgroundInfluential
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism
Bruyne, T. D., Steenput, B., Roth, L., Meyer, G. R. Y. D., dos Santos, C. N., Valentová, K., Dambrova, M., & Hermans, N. (2019) · Nutrients · doi:10.3390/nu11030578 · Cited by 68 · see citing works
“Energy intake restriction and aerobic exercise also protect against arterial aging [9,17,19].”
Background
Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG‐Derived Physiological Aging
Toya, T., Ahmad, A., Attia, Z. I., Cohen, M. S., Ӧzcan, I., Noseworthy, P. A., López-Jiménez, F. A., Kapa, S., Lerman, L. O., Friedman, P. A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.018656 · Cited by 57 · see citing works
“Data were collected on the following parameters: (1) sex, age, and smoking status; (2) dyslipidemia, defined by a documented history of hyperlipidemia, treatment with lipid-lowering therapy, a low-density lipoprotein cholesterol level above the target (<130 mg/dL for low-risk patients, <100 mg/ dL for moderatehigh-ris…”
Background
Effects of Montmorency Tart Cherry Juice Consumption on Cardiometabolic Biomarkers in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Trial
Johnson, S. A., Navaei, N., Pourafshar, S., Jaime, S. J., Akhavan, N. S., Alvarez‐Alvarado, S., Proaño, G. V., Litwin, N. S., Clark, E. A., Foley, E., et al. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2019.0240 · Cited by 56 · see citing works
“This includes vascular endothelial dysfunction and arterial stiffness, which are largely driven by oxidative stress and inflammation in the vasculature.(7,8) These processes not only impair blood flow and lead to increases in systolic blood pressure but also promote the formation of atherosclerotic plaque within the a…”
Background
Keynote lecture: strategies for optimal cardiovascular aging
Seals, D. R., Brunt, V. E., & Rossman, M. J. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00734.2017 · Cited by 53 · see citing works
“One investigative approach to identifying promising compounds has been to establish the molecular and cellular mechanisms underlying positive effects of exercise and/or healthy diet and then to view these pathways as putative targets for primary and secondary prevention of cardiovascular aging (24, 28).”
BackgroundInfluentialSelf-citation
Photoplethysmography for the Assessment of Arterial Stiffness
Karimpour, P., May, J. M., & Kyriacou, P. A. (2023) · Sensors · doi:10.3390/s23249882 · Cited by 52 · see citing works
Association of lifestyle with mortality and the mediating role of aging among older adults in China
Jin, S., Li, C., Cao, X., Chen, C., Ye, Z., & Liu, Z. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104559 · Cited by 50 · see citing works
Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclinical models
Reeve, E. H., Barnes, J. N., Moir, M. E., & Walker, A. E. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00592.2023 · Cited by 51 · see citing works
The Landscape of Circular RNAs in Cardiovascular Diseases
Long, Q., Lv, B., Jiang, S., & Lin, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054571 · Cited by 31 · see citing works
“The incidence of cardiovascular disease (CVD) has been increasing rapidly in recent years, which is the leading cause of death worldwide [1,2].”
Background
Habitual coffee and caffeinated beverages consumption is inversely associated with arterial stiffness and central and peripheral blood pressure
Giorno, R. D., Scanzio, S., Napoli, E. D., Stefanelli, K., Gabutti, S., Troiani, C., & Gabutti, L. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1926935 · Cited by 29 · see citing works
“Physical activity, being overweight, excessive salt consumption, and low potassium intake represent the most investigated and the best understood factors among them (LaRocca et al. 2017; Greer et al. 2020).”
Background
Promoting healthy cardiovascular aging: emerging topics
Clayton, Z. S., Craighead, D. H., Darvish, S., Coppock, M. E., Ludwig, K. R., Brunt, V. E., Seals, D. R., & Rossman, M. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.27 · Cited by 29 · see citing works
“Moreover, we have published previous reviews focused on therapeutic strategies for promoting healthy vascular aging[9,19,20]; thus, the present review will focus on emerging interventions being studied in our laboratory.”
MethodSelf-citation
Association between diet and measures of arterial stiffness in type 1 diabetes – Focus on dietary patterns and macronutrient substitutions
Ahola, A. J., Gordin, D., Forsblom, C. M., & Groop, P. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.07.003 · Cited by 27 · see citing works
Protein-Added Healthy Lunch-Boxes Combined with Exercise for Improving Physical Fitness and Vascular Function in Pre-Frail Older Women: A Community-Based Randomized Controlled Trial
Park, W., Lee, J., Hong, K., Park, H., Park, S., Kim, N.-H., & Park, J. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s391700 · Cited by 26 · see citing works
“In middle-aged or older adults, whey protein reduces arterial stiffness and improves endothelial function.(25) Although dietary interventions may prevent CVD in older adults, data elucidating the effect of protein-added healthy dietary interventions on physical fitness and vascular function are limited.”
Background
Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine
Wu, Z., Zhang, H., Li, Z., Li, H., Miao, X., Pan, H., Wang, J., Liu, X., Kang, X., Li, X., et al. (2022) · The EPMA Journal · doi:10.1007/s13167-022-00298-x · Cited by 25 · see citing works
Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease
Hendrickx, J. O., Martinet, W., Dam, D. V., & Meyer, G. R. Y. D. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.651215 · Cited by 25 · see citing works
Utility of Home-Based Cardiac Rehabilitation for Older Adults
Beckie, T. M. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.07.003 · Cited by 20 · see citing works
Healthy Vascular Aging Is Associated With Higher Cardiorespiratory Fitness
Fleenor, B. S., Carlini, N. A., Kaminsky, L. A., Whaley, M. H., Peterman, J. E., & Harber, M. P. (2021) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000530 · Cited by 20 · see citing works
The Association of Dietary Intake with Arterial Stiffness and Vascular Ageing in a Population with Intermediate Cardiovascular Risk—A MARK Study
Gómez‐Sánchez, L., Rodríguez‐Sánchez, E., Ramos, R., Martí‐Lluch, R., Gómez‐Sánchez, M., Lugones‐Sánchez, C., Tamayo‐Morales, O., Llamas‐Ramos, I., Rigo, F., García‐Ortiz, L., et al. (2022) · Nutrients · doi:10.3390/nu14020244 · Cited by 19 · see citing works
“arterial ageing and the underlying mechanisms is limited [16].”
Background
Effects of Aging and Diet on Cardioprotection and Cardiometabolic Risk Markers
Corina, A., Abrudan, M. B., Nikolic, D., Cătoi, A. F., Chianetta, R., Castellino, G., Citarrella, R., Stoian, A. P., Pérez‐Martínez, P., & Rizzo, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105111232 · Cited by 17 · see citing works
Hyperglycemia and arterial stiffness across two generations
Taimour, S., Gottsäter, A., Jujić, A., & Nilsson, P. M. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002677 · Cited by 15 · see citing works
“This suggests that diet and lifestyle [37] as well as genetic mechanisms [38,39] might be of relevance.”
Background
Nutraceuticals as a potential adjunct therapy toward improving vascular health in CKD
Kruse, N. T. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00152.2019 · Cited by 14 · see citing works
“These selective mitochondria targeting therapies may combat oxidative stress by correcting the redox imbalance in diseases and thus may be good candidates for targeting endothelial mitochondria of CKD (89, 146, 184).”
Background
Chronic snus use in healthy males alters endothelial function and increases arterial stiffness
Antoniewicz, L., Kabele, M., Nilsson, U., Pourazar, J., Rankin, G., Bosson, J. A., & Lundbäck, M. (2022) · PLOS ONE · doi:10.1371/journal.pone.0268746 · Cited by 13 · see citing works
“We did not evaluate additional factor that furthermore may influence endothelial function: level of education, monthly income and diet [42, 43].”
Background
Chrono‐nutrition for hypertension
Bohmke, N. J., Dixon, D. L., & Kirkman, D. L. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3760 · Cited by 15 · see citing works
“11 Vascular endothelial dysfunction and arterial stiffness are hallmark characteristics of impaired vascular function that result in vessels being less adept at responding to changing physiological needs.”
Background
Development and Validation of a Questionnaire to Assess Adherence to the Healthy Food Pyramid in Spanish Adults
Gila-Díaz, A., Arribas, S. M., de Pablo, Á. L. L., López-Giménez, M. R., Phuthong, S., & Ramiro‐Cortijo, D. (2020) · Nutrients · doi:10.3390/nu12061656 · Cited by 12 · see citing works
“These categories are important to evaluate health status and the influence of diet patterns [34,35].”
Background
Age-Related Vascular Dysfunction: What Registered Dietitian Nutritionists Need to Know
Johnson, S. A., Litwin, N. S., & Seals, D. R. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.03.016 · Cited by 11 · see citing works
Self-citation
Early Vascular Aging in Obese Individuals with Low Cardiovascular Health
Cunha, M. R., Mattos, S. S., Klein, M. R. S. T., & Neves, M. F. (2022) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-022-00555-0 · Cited by 12 · see citing works
“Importantly, healthy lifestyle behaviors favorably modulate these processes and reduce the risks [38, 39].”
Background
The Effect of Diet on Vascular Aging: A Narrative Review of the Available Literature
Theodoridis, X., Chourdakis, M., Papaemmanouil, A., Chaloulakou, S., Georgakou, A. V., Chatzis, G. V., & Triantafyllou, Α. (2024) · Life · doi:10.3390/life14020267 · Cited by 11 · see citing works
“These mechanisms seem to be associated with reduced AS and improved endothelium-dependent dilation [43].”
Background
Arterial ageing: Major nutritional and life-style effects
Papaioannou, T. G., Karatzi, K., Ψαλτοπούλου, Θ., & Tousoulis, D. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.004 · Cited by 11 · see citing works
“…of the available methods and devices for the estimation of arterial stiffness and endothelial function was out of the scope of this review (LaRocca et al., 2016), it should be emphasized that specific guidelines and recommendations exist for the proper application of these methods/devices…”
BackgroundMethodInfluential
Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease
Lefferts, W. K., Davis, M. M., & Valentine, R. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.866792 · Cited by 12 · see citing works
“Age-related increases in large artery stiffness may be due, in part, to endothelial dysfunction wrought by oxidative stress and subsequent reductions in nitric oxide bioavailability (Donato et al., 2015; LaRocca et al., 2017).”
Background
Association of time‐restricted feeding, arterial age, and arterial stiffness in adults with metabolic syndrome
Alinezhad‐Namaghi, M., Eslami, S., Nematy, M., Rezvani, R., Khoshnasab, A., Bonakdaran, S., Philippou, E., & Norouzy, A. (2023) · Health Science Reports · doi:10.1002/hsr2.1385 · Cited by 9 · see citing works
Dietary macronutrients do not differently affect postprandial vascular endothelial function in apparently healthy overweight and slightly obese men
Smeets, E. T. H. C., Mensink, R. P., & Joris, P. J. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02340-y · Cited by 9 · see citing works
Association between Different Types of Exercise and Intake of Nutrients including Carbohydrate, Fat, Protein, and B Vitamins in Young Adults
Zhang, J., Chen, J., Sui, X., Drenowatz, C. J., & Wang, Q. (2023) · Nutrients · doi:10.3390/nu15040806 · Cited by 9 · see citing works
“A healthy lifestyle can provide many benefits; for example, reducing the risk of chronic disease [1], promoting mental health [2], improving the quality of life for people with cancer [3], and reducing the incidence of age-related diseases [4,5].”
Background
Advancing PPG-based cf-PWV estimation with an integrated CNN-BiLSTM-Attention model
Abrisham, K. P., Alipour, K., Tarvirdizadeh, B., & Ghamari, M. (2024) · Signal Image and Video Processing · doi:10.1007/s11760-024-03496-4 · Cited by 8 · see citing works
The effect of smoking on quantification of aortic stiffness by ultrasound time-harmonic elastography
Elgeti, T., Fröhlich, M., Wismayer, K. K., Tzschätzsch, H., Hamm, B., Sack, I., & Schaafs, L.-A. (2022) · Scientific Reports · doi:10.1038/s41598-022-22638-7 · Cited by 8 · see citing works
“In sum, the following postprocessing steps were undertaken: (1) for every frame, maps of tissue displacement in axial direction were generated from radiofrequency data, (2) a temporal band-pass filter and Hilbert transformation were used to decompose vibration frequencies for calculation of time- and frequency-resolve…”
Method
The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study
Tang, Z., Lu, Y., Hao, Y., Morris, R., Kang, D., Wang, F., Fan, L., Wang, W., Wang, Y., & Cheng, F. (2021) · Journal of Diabetes Research · doi:10.1155/2021/3243135 · Cited by 8 · see citing works
“However, some studies such as the IKARIA study, of which assessed aortic stiffness and PWV in a small population known for longevity and great health, showed that the age-related increase in arterial stiffness may be remediated by an increase in physical activity and modifications to lifestyle choices [25, 26].”
Result
A questionnaire to assess eating behavior: Structure, validity and responsiveness of a new German eating behavior scale (SEV)
Wurst, R., Brame, J., Ramsenthaler, C., König, D., & Fuchs, R. (2021) · Appetite · doi:10.1016/j.appet.2021.105668 · Cited by 8 · see citing works
Effect of Intensive Lifestyle Intervention on Cardiovascular Risk Factors: Analysis From the Perspective of Long‐Term Variability
He, L., Liu, M., Zhuang, X., Guo, Y., Wang, P., Zhou, Z., Chen, Z., Peng, L., & Liao, X. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.030132 · Cited by 7 · see citing works
“31 In general, these functional improvements associated with physical exercise are a result of its powerful inhibitory effects on inflammation and oxidative stress.”
Association between psychosocial work-related factors at midlife and arterial stiffness at older age in a prospective cohort of 1736 white-collar workers
Massamba, V. K., Talbot, D. C., Milot, A., Trudel, X., Dionne, C. E., Vézina, M., Mâsse, B. R., Gilbert‐Ouimet, M., Dagenais, G. R., Pearce, N. E., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-073649 · Cited by 7 · see citing works
Longitudinal Associations of Dietary Fructose, Sodium, and Potassium and Psychological Stress with Vascular Aging Index and Incident Cardiovascular Disease in the CARDIA Cohort
Osborne, M., Bernard, A., Falkowski, E., Peterson, D., Vavilikolanu, A., & Komnenov, D. (2023) · Nutrients · doi:10.3390/nu16010127 · Cited by 6 · see citing works
“In addition, it is well known that hypertension leads to early vascular aging [6], as well as certain lifestyle factors including psychological stress and diet [7–9].”
BackgroundMethod
Coconut sugar derived from coconut inflorescence sap lowers systolic blood pressure and arterial stiffness in middle-aged and older adults: a pilot study
Carlini, N. A., Romanowski, S. M., Rabalais, E. N., Kistler, B. M., Campbell, M. S., Krishnakumar, I. M., Harber, M. P., & Fleenor, B. S. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00394.2022 · Cited by 6 · see citing works
The Association between Food Groups, Nutraceuticals, and Food Supplements Consumption on Vascular Health Outcomes: A Literature Review
Theodoridis, X., Chourdakis, M., Papaemmanouil, A., Chaloulakou, S., Papageorgiou, N., Georgakou, A. V., Chatzis, G. V., & Triantafyllou, Α. (2024) · Life · doi:10.3390/life14091210 · Cited by 6 · see citing works
Diagnostic value of circRNAs as effective biomarkers in human cardiovascular disease: an updated meta-analysis
Zhang, Z., Guo, R., Wang, Y., Huang, H., Liu, J., Wang, C., Wu, H., & Zou, T. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.67094 · Cited by 6 · see citing works
“Among noncommunicable diseases, cardiovascular disease (CVD) is the most severe public health problem, threatening the health of the general population [2].”
Background
Reception of Dietary and Other Health-Related Lifestyle Advice to Address Non-communicable Diseases in a Primary Care Context: A Mixed-Method Study in Central Argentina
Urbano, R. E. S., Paredes, A., Chambi, F. R. V., Ruela, P. G., Olivares, D. E. V., Pereira, B. T. S., Pacheco, S. O. S., & Pacheco, F. J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.622543 · Cited by 5 · see citing works
“Recent evidence is linking unhealthy dietary and other-lifestyle habits with low chronic grade inflammation (36), which ultimately may lead to the development of NCD.”
Background
Precision Measurements to Assess Baseline Status and Efficacy of Healthy Living Medicine
Hwang, C., Bishop, J., Ching, J., Elokda, A. S., da Silva, A. L. G., Laddu, D., & Phillips, S. A. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.12.011 · Cited by 5 · see citing works
The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure
Choi, Y. D., Kapadia, P., Spiegel, J., Cullen, A. E., LaFarga, J., & Walker, A. E. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2025 · Cited by 4 · see citing works
Two cosmoses, one universe: a narrative review exploring the gut microbiome's role in the effect of urban risk factors on vascular ageing
Bridge, L. A., Vargas, J. A. H., Trujillo-Cáceres, S. J., Beigrezaei, S., Chatelan, A., Salehi‐Abargouei, A., Muka, T., Uriza-Pinzón, J. P., Raeisi‐Dehkordi, H., Franco, O. H., et al. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.107951 · Cited by 4 · see citing works
EVA (Early Vascular Aging) – Übersetzung in den klinischen Alltag
Middeke, M. (2019) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-0657-1708 · Cited by 4 · see citing works
“Hier gibt es zahlreiche Ansatzmöglichkeiten [21] (s. „Info – Lebensstilfaktoren“).”
BackgroundInfluential
Heart Disease and Microgravity: The Dawn of a New Medical Era?: A Narrative Review
Giacinto, O., Garo, M. L., Pelliccia, F., Minati, A., Chello, M., & Lusini, M. (2023) · Cardiology in Review · doi:10.1097/crd.0000000000000581 · Cited by 3 · see citing works
“47,48 Other molecules, as nicotinamide riboside, found in milk and yeast foods, can contribute to the formation of oxidized nicotinamide adenine dinucleotide.”
Efficacy of γ‐linolenic acid, Vitis vinifera extract, and acetyl‐L‐carnitine combination therapy for improving arterial stiffness in Korean adults: Real‐world evidence
Ahn, H., Cho, E. Y., & Yum, K. (2023) · Journal of Clinical Hypertension · doi:10.1111/jch.14708 · Cited by 3 · see citing works
Improved nutrition in early life and pulse wave velocity and augmentation index in mid-adulthood: Follow-up of the INCAP Nutrition Supplementation Trial Longitudinal Study
Kroker-Lobos, M. F., Ford, N. D., González-Casanova, I., Martorell, R., Ramírez‐Zea, M., & Stein, A. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239921 · Cited by 2 · see citing works
Repeated exposure to psychosocial work-related factors and arterial stiffness among aging workers
Massamba, V. K., Milot, A., Talbot, D. C., Gilbert‐Ouimet, M., Brisson, C., & Trudel, X. (2025) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-025-02177-0 · Cited by 2 · see citing works
“On the other hand, chronic stress can act indirectly by promoting a high-risk lifestyle (LaRocca et al. 2017 ; Wang et al. 2018 ).”
Association between Arterial Stiffness and Obesity Indicators: A Comparative Study of Traditional and Novel Anthropometric Measures in Northern Chinese
Li, Z., Lin, X., Lin, J., Huang, Y., Jing, H., Chacha, S., Shen, Y., Kang, Y., Wang, D., Yan, H., et al. (2026) · Annals of Nutrition and Metabolism · doi:10.1159/000550364 · Cited by 2 · see citing works
Water-soluble tomato concentrate combats vascular aging through the regulation of endothelial cell senescence via DNA-sensing AIM2 inflammasome
Sun, Y., Wang, Y., Zheng, Q., Wang, Y., Fan, M., Qian, H., He, R., Li, Y., & Wang, L. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118559 · Cited by 2 · see citing works
Experimental model systems to study vascular aging
Tuna, B. G., Rey, A. B. A., Julve, J., Borrell-Pagés, M., Praet, M. V., Riches‐Suman, K., Roks, A. J. M., Rochfort, K. D., Keles, N. A., Tura-Ceide, O., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103256 · Cited by 2 · see citing works
Early Vascular Aging in Young Adults Is Instrumental as the Screening Tool to Combat CVD Epidemics in the Population
Evsevyeva, M. E., Сергеева, О. В., Владимирович, Е. М., Simches, E. V., Rostovceva, M. V., Kudriavceva, V. D., Martynov, M. Y., Koshel, I. V., & Golubnitschaja, O. (2024) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-3-031-46891-9_12 · Cited by 2 · see citing works
Nutrición y envejecimiento. Una revisión narrativa desde la geriatría
Altamar, G. (2023) · Medicina · doi:10.56050/01205498.2232 · Cited by 2 · see citing works
Nutrition for Elderly
Rath, P. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_19 · Cited by 2 · see citing works
The Effects of Berry Bioactive Compounds on Vascular Function
Rodriguez‐Mateos, A., Sayec, M. L., Istas, G., & Johnson, S. A. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165450-00120 · Cited by 2 · see citing works
Longitudinal Associations of Dietary Fructose and Psychological Stress with Vascular Aging Index and Incident Cardiovascular Disease in the CARDIA CohortPreprint
Osborne, M., Bernard, A., Falkowski, E., Peterson, D., Vavilikolanu, A., & Komnenov, D. (2023) · medRxiv · doi:10.1101/2023.10.03.23296515 · Cited by 2 · see citing works
Characteristics and Influencing Factors of Intra-Dialysis Blood Pressure Variability in Hemodialysis Patients: A Retrospective Study
Xu, H., Wang, X., Feng, M., & Chen, L. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s479035 · Cited by 1 · see citing works
“30 A reasonable diet could improve the nutritional status of patients, and correcting anemia and hypoproteinemia will help reduce blood pressure fluctuations during dialysis and improve patient prognosis.”
Background
Distinct Effects of Wheat and Black Bean Consumption on Postprandial Vascular Responses in People with Arterial Stiffness: A Pilot Randomized Cross-Over Study
Zahradka, P. C., Perera, D., Charney, J., & Taylor, C. G. (2025) · Nutrients · doi:10.3390/nu17071159 · Cited by 1 · see citing works
“A key precursor to CVD is age-related arterial dysfunction, characterized by increased stiffness of the arteries and impaired function of the arterial wall (endothelial function) [3].”
Exposure to organochlorine pesticides and polychlorinated biphenyls, adherence to an ideal cardiovascular health, and arterial stiffness among Chinese adults
Bi, J., Liu, Q., Fan, G., Fang, Q., Zhang, X., Qin, X., Wu, M., Wan, Z., Lv, Y., Wang, Y., et al. (2023) · Environmental Geochemistry and Health · doi:10.1007/s10653-023-01791-6 · Cited by 1 · see citing works
“The possible explanations might be that individuals with ideal CVH can promote inflammation repair and reduce the production of reactive oxygen species, which may partially offset the risk of arterial stiffness caused by OCPs and PCBs exposure (LaRocca et al., 2017; Madden et al., 2009).”
Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk
Huang, B., Lai, Z., Wang, X., Zhang, Q., Hu, T., Yu, F., Zhou, S., Zhang, T., & Meng, J. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1559798 · Cited by 1 · see citing works
The Relationship of Physical Activity and Fruit and Vegetable Intake on Pulse Wave Velocity
Nave, A. L. (2019) · SUNY Digital Repository Support (State University of New York System)
Diet and Nutrition in Alzheimer’s Disease and Healthy Aging
Bule, M. H., Shah, M. A., Abdurahman, A. A., Ullah, M. S., Shah, S., Amin, A., & Niaz, K. (2019) · Springer eBooks · doi:10.1007/978-981-13-9636-6_3
Nutritional strategies to improve endothelial function during the fasting and postprandial phase
Smeets, E. T. H. C. (2021) · doi:10.26481/dis.20220114es
Eating frequency has an inverse correlation with adiposity measures and non-invasive arterial stiffness parameters in healthy adult people
Arefinia, S., Jarahi, L., Khedmatgozar, H., Abadi, S. E. H., Moghadam, M. R. S. F., Tchernof, A., Soleimaninia, H., & Rezvani, R. (2022) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2022.06.004
Aging of the Vasculature
Leucker, T. M., Goldenberg, J., & Gerstenblith, G. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-16594-8_4
Eating frequency has an inverse correlation with adiposity measures and non-invasive arterial stiffness parameters in healthy adult people
Arefinia, S., Jarahi, L., Khedmatgozar, H., Abadi, S. E. H., Moghadam, M. R. S. F., Tchernof, A., Soleimaninia, H., & Rezvani, R. (2023) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2023.02.003
Prävention zum Erhalt der Nierengesundheit
Pommer, W. (2023) · Springer eBooks · doi:10.1007/978-3-662-65648-8_38
The association of biological age and its trajectory with incident heart failure: a cohort study from China
Hu, Y., Sun, H., Zhu, C., Hu, J., Tao, J., Li, B., Cai, Q., Wu, Y. L., Chen, S., wu, S., et al. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1651743
“Nevertheless, owing to variations in epigenetics (2), nutritional intake (3), environmental exposure (4), and access to healthcare (5, 6), individuals with identical CA may have exhibited disparate rates of biological aging.”
The Modulating Effects of Fruit and Fruit-Derived Interventions on Arterial Stiffness
Campbell, M. S. (2026) · Nutrients · doi:10.3390/nu18162627
“The current duration for dietary interventions to elicit a change in arterial stiffness is unknown, although more robust interventions that include caloric restriction leading to weight loss or a complete alteration of dietary patterns might produce a more profound change in less time [111,112].”

Age-Related Vascular Dysfunction: What Registered Dietitian Nutritionists Need to Know
Johnson, S. A., Litwin, N. S., & Seals, D. R. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.03.016 · Cited by 11 · see citing works
Self-citation
Can aerobic exercise alleviate the compound detrimental effects of age and Western diet on vascular function?
Gomez, D. H., & Aldokhayyil, M. (2020) · The Journal of Physiology · doi:10.1113/jp281065
Modulatory influences on ageing of the vasculature in healthy humans
Seals, D. R., Moreau, K. L., Gates, P. E., & Eskurza, I. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.001 · Cited by 86 · see citing works
Self-citation
The Effect of Diet on Vascular Aging: A Narrative Review of the Available Literature
Theodoridis, X., Chourdakis, M., Papaemmanouil, A., Chaloulakou, S., Georgakou, A. V., Chatzis, G. V., & Triantafyllou, Α. (2024) · Life · doi:10.3390/life14020267 · Cited by 11 · see citing works
Association of Vascular Endothelial Cell with Aging: The Role of Dietary Pattern and Health Functional Food
Kwon, Y., & Park, H. (2022) · Food Engineering Progress · doi:10.13050/foodengprog.2022.26.4.217 · Cited by 1 · see citing works

Authors: LaRocca, T. J., Martens, C. R., & Seals, D. R.
Affiliations: University of Colorado Boulder (US)
Corresponding author: LaRocca, Thomas J.
ORCID: LaRocca, Thomas J.
Martens, Christopher R.
Seals, Douglas R.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2017-10
Volume: 39
Pages: 106-119
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2016.09.002
PMC: PMC5373983
OpenAlex: W2526372177
Cited by: 83
References: 165
Citations by year: 2026: 5 · 2025: 4 · 2024: 9 · 2023: 16 · 2022: 11 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 7 · 2017: 2 · 2016: 1
FWCI: 1.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. National Institutes of Health awards (AG013038, AG006537, AG000279, TR001082, NS063964)
Glenn Foundation and the American Federation for Aging Research
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: arterial aging, arterial stiffness, endothelial function, diet, nutrition, lifestyle factors, cardiovascular disease prevention, aging
MeSH terms: Healthy Aging, Aging, Arteries, Cardiovascular Diseases, Diet, Diet Therapy, Endothelium, Vascular, Humans, Life Style, Nutritional Status, Risk Factors, Vascular Stiffness

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