Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices
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Network activation triggers a significant energy metabolism increase in both neurons and astrocytes. Questions of the primary neuronal energy substrate (e.g., glucose vs. lactate) as well as the relative contributions of glycolysis and oxidative phosphorylation and their cellular origin (neurons vs. astrocytes) are still a matter of debates. Using simultaneous measurements of electrophysiological and metabolic parameters during synaptic stimulation in hippocampal slices from mature mice, we show that neurons and astrocytes use both glycolysis and oxidative phosphorylation to meet their energy demands. Supplementation or replacement of glucose in artificial cerebrospinal fluid (ACSF) with pyruvate or lactate strongly modifies parameters related to network activity-triggered energy metabolism. These effects are not induced by changes in ATP content, pH(i), [Ca(2+)](i) or accumulation of reactive oxygen species. Our results suggest that during network activation, a significant fraction of NAD(P)H response (its overshoot phase) corresponds to glycolysis and the changes in cytosolic NAD(P)H and mitochondrial FAD are coupled. Our data do not support the hypothesis of a preferential utilization of astrocyte-released lactate by neurons during network activation in slices--instead, we show that during such activity glucose is an effective energy substrate for both neurons and astrocytes.
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Neurons and astrocytes significantly used glucose as an energy substrate for ATP production via glycolysis and mitochondrial oxidative phosphorylation during periods of network activation in brain slices.
“Conversely, neurons and astrocytes significantly used glucose as an energy substrate for ATP production via glycolysis and mitochondrial oxidative phosphorylation during periods of network activation in brain slices [19].”
From Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation (2023) · cites this paper as [19]
In brain slices, [O2] shows a pronounced dip with stimulation, corresponding with increased O2 consumption.
“in brain slices, [O2] shows a pronounced dip with stimulation, corresponding with increased O2 consumption (Hall et al., 2012; Liotta et al., 2012; Ivanov et al., 2014).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Ivanov et al., 2014
Oxygen consumption increases promptly in response to stimulation in brain slices.
“Measurements of oxygen levels in brain slices indicate that oxygen consumption does increase promptly in response to stimulation (Hall et al., 2012; Ivanov et al., 2014)”
From Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake (2017) · cites this paper as Ivanov et al., 2014
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- Authors
- Ivanov, A. I., Malkov, A. E., Waseem, T., Mukhtarov, M., Buldakova, S., Gubkina, O., Zilberter, M., & Zilberter, Y.
- Affiliations
- Inserm (FR)
- INSERM UMR1106, Institut de Neurosciences des Systèmes, Aix-Marseille University, Marseille, France
- Corresponding author
- Zilberter, Yuri
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2013-12-11
- Volume
- 34
- Issue
- 3
- Pages
- 397-407
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC3948126
- OpenAlex
- W1999435933
- Cited by
- 113
- References
- 40
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 4 · 2021: 15 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 16 · 2016: 11 · 2015: 10 · 2014: 8
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- zvestiya of the National Academy of Sciences of Belarus (National Academy of Sciences of Belarus) (submittedVersion)
- Funders
- Alzheimer's Association (NESAD-12-242486)
- Agence Nationale de la Recherche (ANR-10-BLAN-1443)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- glycolysis, oxidative phosphorylation, neuronal energy metabolism, astrocytes, hippocampal slices, network activity, glucose utilization, lactate, pyruvate, NAD(P)H, synaptic stimulation, astrocyte-neuron lactate shuttle
- MeSH terms
- Adenosine Triphosphate, Animals, Astrocytes, Calcium, Electric Stimulation, Flavin-Adenine Dinucleotide, Female, Glucose, Glycolysis, Hippocampus, Male, NADP, Nerve Net, Neurons, Oxidative Phosphorylation, Oxygen Consumption, Lactic Acid, Tissue Culture Techniques, Mice, Synaptic Potentials
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