PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

Mullighan, C. G., Goorha, S., Radtke, I., Miller, C. B., Coustan‐Smith, E., Dalton, J., Girtman, K., Mathew, S., Ma, J., Pounds, S. B., et al. (2007) · Nature · doi:10.1038/nature05690 · Cited by 1,798 · see citing works

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532 · see citing works

Deletion of <i>IKZF1</i> and Prognosis in Acute Lymphoblastic Leukemia

Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808253 · Cited by 1,422 · see citing works

Regulation of B lymphocyte and macrophage development by graded expression of PU.1

DeKoter, R. P., & Singh, H. (2000) · Science · doi:10.1126/science.288.5470.1439 · Cited by 749 · see citing works

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works

CREBBP mutations in relapsed acute lymphoblastic leukaemia

Mullighan, C. G., Zhang, J., Kasper, L. H., Lerach, S., Payne-Turner, D., Phillips, L. A., Heatley, S. L., Holmfeldt, L., Collins-Underwood, J. R., Ma, J., et al. (2011) · Nature · doi:10.1038/nature09727 · Cited by 628 · see citing works

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

Wang, J., Nichogiannopoulou, A., Wu, L. J., Sun, L., Sharpe, A. H., Bigby, M. E., & Georgopoulos, K. (1996) · Immunity · doi:10.1016/s1074-7613(00)80269-1 · Cited by 614 · see citing works

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W. (1997) · Science · doi:10.1126/science.275.5299.540 · Cited by 583 · see citing works

Testing gene function early in the B cell lineage in mb1-cre mice

Hobeika, E., Thiemann, S., Storch, B., Jumaa, H., Nielsen, P. J., Pelanda, R., & Reth, M. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605944103 · Cited by 581 · see citing works

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Rosenbauer, F., Wagner, K., Kutok, J. L., Iwasaki, H., Le Beau, M. M., Okuno, Y., Akashi, K., Fiering, S., & Tenen, D. G. (2004) · Nature Genetics · doi:10.1038/ng1361 · Cited by 506 · see citing works

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

Cobaleda, C., Jochum, W., & Busslinger, M. (2007) · Nature · doi:10.1038/nature06159 · Cited by 502 · see citing works

Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

Ochiai, K., Maienschein‐Cline, M., Simonetti, G., Chen, J., Rosenthal, R. L., Brink, R. A., Chong, A. S., Klein, U., Dinner, A. R., Singh, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.009 · Cited by 469 · see citing works

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes &amp; Development · doi:10.1101/gad.9.11.1377 · Cited by 447 · see citing works

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

Pongubala, J. M., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Atchison, M. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.368 · Cited by 354 · see citing works

An Essential Role for BLNK in Human B Cell Development

Minegishi, Y., Rohrer, J., Coustan‐Smith, E., Lederman, H. M., Pappu, R., Campana, D., Chan, A. C., & Conley, M. E. (1999) · Science · doi:10.1126/science.286.5446.1954 · Cited by 346 · see citing works

Abnormal Development and Function of B Lymphocytes in Mice Deficient for the Signaling Adaptor Protein SLP-65

Jumaa, H., Wollscheid, B., Mitterer, M., Wienands, J., Reth, M. G., & Nielsen, P. J. (1999) · Immunity · doi:10.1016/s1074-7613(00)80130-2 · Cited by 321 · see citing works

PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors

DeKoter, R. P., Lee, H.-J., & Singh, H. (2002) · Immunity · doi:10.1016/s1074-7613(02)00269-8 · Cited by 319 · see citing works

Transcription Factor Pax5 Activates the Chromatin of Key Genes Involved in B Cell Signaling, Adhesion, Migration, and Immune Function

Schebesta, A., McManus, S., Salvagiotto, G., Delogu, A., Busslinger, G. A., & Busslinger, M. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.019 · Cited by 306 · see citing works

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

Pappu, R., Cheng, A. M., Li, B., Gong, Q., Chiu, C. W., Griffin, N., White, J. M., Sleckman, B. P., & Chan, A. C. (1999) · Science · doi:10.1126/science.286.5446.1949 · Cited by 305 · see citing works

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

Dakic, A., Metcalf, D., Di Rago, L., Mifsud, S., Wu, L., & Nutt, S. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050075 · Cited by 297 · see citing works

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

Schlissel, M. S., Corcoran, L. M., & Baltimore, D. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.711 · Cited by 284 · see citing works

IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte developmentPreprint

Lu, R., Medina, K. L., Lancki, D. W., & Singh, H. (2003) · Genes & Development · doi:10.1101/gad.1104803 · Cited by 275 · see citing works

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

Zhang, J., Mullighan, C. G., Harvey, R. C., Wu, G., Chen, X. '., Edmonson, M. N., Buetow, K. H., Carroll, W. L., Chen, I., Devidas, M., et al. (2011) · Blood · doi:10.1182/blood-2011-03-341412 · Cited by 273 · see citing works

PU.1 Functions in a Cell‐autonomous Manner to Control the Differentiation of Multipotential Lymphoid‐myeloid Progenitors

Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., & Singh, H. (1997) · Immunity · doi:10.1016/s1074-7613(00)80287-3 · Cited by 270 · see citing works

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

Brass, A. L., Kehrli, E., Eisenbeis, C. F., Storb, U., & Singh, H. (1996) · Genes &amp; Development · doi:10.1101/gad.10.18.2335 · Cited by 242 · see citing works

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1679 · Cited by 237 · see citing works

Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers

Brass, A. L., Zhu, A. Q., & Singh, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.977 · Cited by 207 · see citing works

Stage-specific control of early B cell development by the transcription factor Ikaros

Schwickert, T. A., Tagoh, H., Gültekin, S., Dakic, A., Axelsson, E., Minnich, M., Ebert, A., Werner, B., Roth, M., Cimmino, L., et al. (2014) · Nature Immunology · doi:10.1038/ni.2828 · Cited by 201 · see citing works

Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

Decker, T., di Magliano, M. P., McManus, S., Sun, Q., Bonifer, C., Tagoh, H., & Busslinger, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.012 · Cited by 194 · see citing works

Regulation of Immunoglobulin Light-Chain Recombination by the Transcription Factor IRF-4 and the Attenuation of Interleukin-7 Signaling

Johnson, K., Hashimshony, T., Sawai, C. M., Pongubala, J. M. R., Skok, J. A., Aifantis, I., & Singh, H. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.019 · Cited by 190 · see citing works

IRF4: Immunity. Malignancy! Therapy?

Shaffer, A. L., Emre, N. C. T., Romesser, P. B., & Staudt, L. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1845 · Cited by 189 · see citing works

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.

Eisenbeis, C. F., Singh, H., & Storb, U. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6452 · Cited by 182 · see citing works

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

Joshi, I., Yoshida, T., Jena, N., Qi, X., Zhang, J., Etten, R. A. V., & Georgopoulos, K. (2014) · Nature Immunology · doi:10.1038/ni.2821 · Cited by 158 · see citing works

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

Carotta, S., Willis, S. N., Hasbold, J., Inouye, M., Pang, S. H. M., Emslie, D., Light, A., Chopin, M., Shi, W., Wang, H., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140425 · Cited by 153 · see citing works

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

Cook, W. D., McCaw, B. J., Herring, C., John, D. L., Foote, S. J., Nutt, S. L., & Adams, J. M. (2004) · Blood · doi:10.1182/blood-2004-06-2234 · Cited by 140 · see citing works

Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia

Jumaa, H., Bossaller, L., Portugal, K., Storch, B., Lotz, M., Flemming, A., Schrappe, M., Postila, V., Riikonen, P. V., Pelkonen, J., et al. (2003) · Nature · doi:10.1038/nature01608 · Cited by 139 · see citing works

Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression

Ma, S., Pathak, S., Mandal, M., Trinh, L., Clark, M. R., & Lu, R. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00224-10 · Cited by 138 · see citing works

Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU. 1 complex

Kanno, Y., Levi, B.-Z., Tamura, T., & Ozato, K. (2005) · Journal of Interferon &amp; Cytokine Research · doi:10.1089/jir.2005.25.770 · Cited by 128 · see citing works

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B–cell differentiation

Ferreirós-Vidal, I., Carroll, T., Taylor, B., Terry, A. V., Liang, Z., Bruno, L., Dharmalingam, G., Khadayate, S. P., Cobb, B. S., Smale, S. T., et al. (2013) · Blood · doi:10.1182/blood-2012-08-450114 · Cited by 121 · see citing works

Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre–B-cell receptor and promote cell-cycle withdrawal in pre–B-cell development

Ma, S., Pathak, S., Trinh, L. X., & Lu, R. (2007) · Blood · doi:10.1182/blood-2007-08-110106 · Cited by 117 · see citing works

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia

Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.-J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30525 · Cited by 114 · see citing works

PU.1 Recruits a Second Nuclear Factor to a Site Important for Immunoglobulin κ 3' Enhancer Activity

Pongubala, J. M. R., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Atchison, M. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.368-378.1992 · Cited by 105 · see citing works

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals

Heizmann, B., Kastner, P., & Chan, S. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20131735 · Cited by 101 · see citing works

Effect of transcription-factor concentrations on leukemic stem cells

Rosenbauer, F., Koschmieder, S., Steidl, U. G., & Tenen, D. G. (2005) · Blood · doi:10.1182/blood-2005-02-0717 · Cited by 98 · see citing works

Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia

Metcalf, D., Dakic, A., Mifsud, S., Di Rago, L., Wu, L., & Nutt, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510616103 · Cited by 95 · see citing works

IFN Regulatory Factor 4 and 8 Promote Ig Light Chain κ Locus Activation in Pre-B Cell Development

Ma, S., Turetsky, A., Trinh, L. X., & Lu, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7898 · Cited by 95 · see citing works

PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch

Ye, M., Ermakova, O. V., & Graf, T. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051089 · Cited by 90 · see citing works

The development of functional B lymphocytes in conditional PU.1 knock-out mice

Polli, M., Dakic, A., Light, A., Wu, L., Tarlinton, D. M., & Nutt, S. L. (2005) · Blood · doi:10.1182/blood-2005-01-0283 · Cited by 89 · see citing works

Critical roles for c-Myb in lymphoid priming and early B-cell development

Greig, K. T., de Graaf, C. A., Murphy, J. M., Carpinelli, M. R., Pang, S. H. M., Frampton, J., Kile, B. T., Hilton, D. J., & Nutt, S. L. (2010) · Blood · doi:10.1182/blood-2009-08-239210 · Cited by 76 · see citing works

Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia

Sokalski, K. M., Li, S. K. H., Welch, I. D., Cadieux-Pitre, H.-A. T., Gruca, M. R., & DeKoter, R. P. (2011) · Blood · doi:10.1182/blood-2011-02-335539 · Cited by 74 · see citing works

Runx1 is essential at two stages of early murine B-cell development

Niebuhr, B., Kriebitzsch, N., Fischer, M., Behrens, K., Günther, T., Alawi, M., Bergholz, U., Müller, U., Roscher, S., Ziegler, M., et al. (2013) · Blood · doi:10.1182/blood-2013-01-480244 · Cited by 61 · see citing works

IRF-4 functions as a tumor suppressor in early B-cell development

Acquaviva, J., Chen, X., & Ren, R. (2008) · Blood · doi:10.1182/blood-2007-10-117838 · Cited by 59 · see citing works

A role for IRF4 in the development of CLL

Shukla, V., Ma, S., Hardy, R. R., Joshi, S. S., & Lu, R. (2013) · Blood · doi:10.1182/blood-2013-03-492769 · Cited by 55 · see citing works

IRF4 Is a Suppressor of c-Myc Induced B Cell Leukemia

Pathak, S., Ma, S., Trinh, L., Eudy, J. D., Wagner, K., Joshi, S. S., & Lu, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022628 · Cited by 54 · see citing works

A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma

Bouamar, H., Abbas, S., Lin, A., Wang, L., Jiang, D., Holder, K. N., Kinney, M. C., Hunicke‐Smith, S., & Aguiar, R. C. T. (2013) · Blood · doi:10.1182/blood-2013-04-495804 · Cited by 51 · see citing works

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance

Scheller, M., Schönheit, J., Zimmermann, K., Leser, U., Rosenbauer, F., & Leutz, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130706 · Cited by 48 · see citing works

Increased Incidence of Chronic Graft-Versus-Host Disease (GVHD) and No Survival Advantage with Filgrastim-Mobilized Peripheral Blood Stem Cells (PBSC) Compared to Bone Marrow (BM) Transplants From Unrelated Donors: Results of Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Protocol 0201, a Phase III, Prospective, Randomized Trial

Anasetti, C., Logan, B. R., Lee, S. J., Waller, E. K., Weisdorf, D. J., Wingard, J. R., Cutler, C. S., Westervelt, P., Woolfrey, A. E., Couban, S., et al. (2011) · Blood · doi:10.1182/blood.v118.21.1.1 · Cited by 46 · see citing works

PU.1 is a Component of a Multiprotein Complex Which Binds an Essential Site in the Murine Immunoglobulin λ2-4 Enhancer

Eisenbeis, C. F., Singh, H., & Storb, U. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6452-6461.1993 · Cited by 38 · see citing works

Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis

Jo, S., Schatz, J. H., Acquaviva, J., Singh, H., & Ren, R. (2010) · Blood · doi:10.1182/blood-2009-07-234559 · Cited by 37 · see citing works

Ikaros and acute leukemia

Mullighan, C. G., & Downing, J. R. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190801947500 · Cited by 33 · see citing works

PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45

Anderson, K. L., Nelson, S. L., Perkin, H. B., Smith, K. A., Klemsz, M. J., & Torbett, B. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009133200 · Cited by 32 · see citing works

Regulation of B Cell Linker Protein Transcription by PU.1 and Spi-B in Murine B Cell Acute Lymphoblastic Leukemia

Xu, L., Sokalski, K. M., Hotke, K., Christie, D. A., Zarnett, O. J., Piskorz, J., Thillainadesan, G., Torchia, J., & DeKoter, R. P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201267 · Cited by 31 · see citing works

PU.1 Opposes IL-7–Dependent Proliferation of Developing B Cells with Involvement of the Direct Target Gene Bruton Tyrosine Kinase

Christie, D. A., Xu, L., Turkistany, S. A., Solomon, L. A., Li, S. K. H., Yim, E., Welch, I. D., Bell, G. I., Hess, D. A., & DeKoter, R. P. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401569 · Cited by 22 · see citing works

Implication of IRF4 Aberrant Gene Expression in the Acute Leukemias of Childhood

Adamaki, M., Lambrou, G., Athanasiadou, A., Tzanoudaki, M., Vlahopoulos, S., & Moschovi, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072326 · Cited by 22 · see citing works

Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

Rubin, A. J., Parker, K. R., Satpathy, A. T., Qi, Y., Wu, B., Ong, A. J., Mumbach, M. R., Ji, A. L., Kim, D. S., Cho, S. W., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.022 · Cited by 314 · see citing works

The Multiple Roles of Interferon Regulatory Factor family in Health and Disease

Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178 · see citing works

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Willis, S. N., Tellier, J., Liao, Y., Trezise, S., Light, A., O’Donnell, K., Garrett‐Sinha, L. A., Shi, W., Tarlinton, D. M., & Nutt, S. L. (2017) · Nature Communications · doi:10.1038/s41467-017-01605-1 · Cited by 102 · see citing works

Transcription factor PU.1 and immune cell differentiation (Review)

Li, G., Hao, W., & Hu, W. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4763 · Cited by 98 · see citing works

Transcription Factors IRF8 and PU.1 Are Required for Follicular B Cell Development and BCL6‐driven Germinal Center Responses

Wang, H., Jain, S., Li, P., Lin, J.-X., Oh, J., Qi, C., Gao, Y., Sun, J., Sakai, T., Naghashfar, Z., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901258116 · Cited by 81 · see citing works

Batf-mediated Epigenetic Control of Effector CD8+ T Cell Differentiation

Tsao, H.-W., Kaminski, J., Kurachi, M., Barnitz, R. A., Iorio, M. D. D., LaFleur, M., Ise, W., Kurosaki, T., Wherry, E., Haining, W., et al. (2021) · bioRxiv · doi:10.1126/sciimmunol.abi4919 · Cited by 54 · see citing works

IRF8: Mechanism of Action and Health Implications

Moorman, H. R., Reategui-Almonacid, Y., Poschel, D. B., & Liu, K. (2022) · Cells · doi:10.3390/cells11172630 · Cited by 63 · see citing works

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

Pang, S. H. M., de Graaf, C. A., Hilton, D. J., Huntington, N. D., Carotta, S., Wu, L., & Nutt, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01264 · Cited by 60 · see citing works

Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2

Studd, J. B., Vijayakrishnan, J., Yang, M., Migliorini, G., Paulsson, K. M., & Houlston, R. S. (2017) · Nature Communications · doi:10.1038/ncomms14616 · Cited by 54 · see citing works

PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development

Batista, C. R., Li, S. K. H., Xu, L., Solomon, L. A., & DeKoter, R. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601709 · Cited by 46 · see citing works

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

Ponnusamy, K., Tzioni, M., Begum, M., Robinson, M. E., Caputo, V. S., Katsarou, A., Trasanidis, N., Xiao, X., Kostopoulos, I. V., Iskander, D., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.274480 · Cited by 47 · see citing works

Transcriptional Control of Mature B Cell Fates

Wang, H., Morse, H. C., & Bolland, S. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.04.011 · Cited by 48 · see citing works

The dynamic functions of IRF4 in B cell malignancies

Maffei, R., Fiorcari, S., Atene, C. G., Martinelli, S., Mesini, N., Pilato, F., Lagreca, I., Barozzi, P., Riva, G., Nasillo, V., et al. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00968-0 · Cited by 37 · see citing works

Cathepsin S: molecular mechanisms in inflammatory and immunological processes

Gao, H., Zhang, Z., Deng, J., & Song, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1600206 · Cited by 32 · see citing works

ETS Transcription Factors in Immune Cells and Immune-Related Diseases

Yang, Y., Han, X., Sun, L., Shao, F., Yin, Y., & Zhang, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810004 · Cited by 34 · see citing works

EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolismPreprint

Ramamoorthy, S., Kometani, K., Herman, J. S., Bayer, M., Boller, S., Edwards-Hicks, J., Ramachandran, H., Li, R., Geltink, R. I. K., Pearce, E. L., et al. (2020) · Genes & Development · doi:10.1101/gad.340216.120 · Cited by 31 · see citing works

The role of CD180 in hematological malignancies and inflammatory disorders

Edwards, K., Lydyard, P. M., Kulikova, N., Tsertsvadze, T., Volpi, E. V., Chiorazzi, N., & Porakishvili, N. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00682-x · Cited by 29 · see citing works

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Su, A. H., Ling, F. W., Vaganay, C., Sodaro, G., Benaksas, C., Bello, R. D., Forget, A., Pardieu, B., Lin, K., Rutter, J. C., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0970 · Cited by 29 · see citing works

Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B

Batista, C. R., Lim, M., Laramée, A.-S., Abu-Sardanah, F., Xu, L., Hossain, R., Bell, G. I., Hess, D. A., & DeKoter, R. P. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018019950 · Cited by 28 · see citing works

The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia

Tian, W., Guo, R., Wang, F., Jiang, Z., Tang, P., Huang, Y., & Sun, L. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.02.036 · Cited by 27 · see citing works

Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia

Chagas, P. S., de Sousa, G. R., Kodama, M. H., de Biagi, C. A. O., Yunes, J. A., Brandalise, S. R., Calin, G. A., Tone, L. G., Scrideli, C. A., & de Oliveira, J. C. (2020) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2019.12.003 · Cited by 26 · see citing works

RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells Through Activation of a SPIC-BCLAF1 Complex

Soodgupta, D., White, L. S., Yang, W., Johnston, R., Andrews, J. M., Kohyama, M., MURPHY, K. M. M., Mosammaparast, N., Payton, J. E., & Bednarski, J. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.026 · Cited by 24 · see citing works

Expression of ELF 1, a lymphoid ETS domain‐containing transcription factor, is recurrently lost in classical Hodgkin lymphoma

Paczkowska, J., Soloch, N., Bodnar, M., Kiwerska, K., Janiszewska, J., Vogt, J. A., Domanowska, E., Martín-Subero, J. I., Ammerpohl, O., Klapper, W., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.15757 · Cited by 23 · see citing works

Interferon regulatory factor 8 governs myeloid cell development

Xia, X., Wang, W., Yin, K., & Wang, S. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.03.003 · Cited by 23 · see citing works

The Landscape of Secondary Genetic Rearrangements in Pediatric Patients with B-Cell Acute Lymphoblastic Leukemia with t(12;21)

Kaczmarska, A., Derebas, J., Pinkosz, M., Niedźwiecki, M., & Lejman, M. (2023) · Cells · doi:10.3390/cells12030357 · Cited by 21 · see citing works

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Gerber, J. P., Russ, J., Chandrasekar, V., Offermann, N., Lee, H., Spear, S., Guzzi, N., Maida, S., Pattabiraman, S., Zhang, R., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00774-y · Cited by 19 · see citing works

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

Brown, L. M., Hediyeh-zadeh, S., Sadras, T., Huckstep, H., Sandow, J. J., Bartolo, R. C., Kosasih, H. J., Davidson, N., Schmidt, B., Bjelosevic, S., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021006076 · Cited by 14 · see citing works

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

Amanda, S., Tan, T. K., Ong, J. Z. L., Theardy, M. S., Wong, R. W. J., Huang, X. Z., Ali, M. Z., Li, Y., Gong, Z., Inagaki, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30053-9 · Cited by 16 · see citing works

Transcriptional regulation of the proto‐oncogene Zfp521 by SPI1 (PU.1) and HOXC13

Yu, M., Aldallal, S., Al‐Haj, L., Panjwani, S., McCartney, A. S., Edwards, S. M., Manjunath, P., Walker, C., Awgulewitsch, A., & Hentges, K. E. (2016) · genesis · doi:10.1002/dvg.22963 · Cited by 14 · see citing works

ETV6-RUNX1 interacts with a region in SPIB intron 1 to regulate gene expression in pre-B-cell acute lymphoblastic leukemia

Xu, L., Francis, A., Turkistany, S. A., Shukla, D., Wong, A., Batista, C. R., & DeKoter, R. P. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.03.004 · Cited by 12 · see citing works

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors

Smith, A. M., Zhang, C. R., Cristino, A. S., Grady, J. P., Fink, J. L., & Moore, A. S. (2019) · Oncotarget · doi:10.18632/oncotarget.27206 · Cited by 12 · see citing works

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Gupta, D. D., Paul, C., Samel, N., Bieringer, M., Staudenraus, D., Marini, F., Raifer, H., Menke, L., Hansal, L., Camara, B., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01005-z · Cited by 12 · see citing works

Lineage- and Stage-Specific Oncogenicity of IRF4

Amanda, S., Tan, T. K., Iida, S., & Sanda, T. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.07.300 · Cited by 11 · see citing works

ANP32B suppresses B‐cell acute lymphoblastic leukemia through activation of PU .1 in mice

Yang, Q., Liu, H., Yang, S., Wei, Y., Zhu, X., Zhi, Z., Zhu, D., Chen, G., & Yu, Y. (2023) · Cancer Science · doi:10.1111/cas.15822 · Cited by 11 · see citing works

Restoring PU.1 induces apoptosis and modulates viral transactivation via interferon-stimulated genes in primary effusion lymphoma

Goto, H., Kariya, R., Kudo, E., Okuno, Y., Ueda, K., Katano, H., & Okada, S. (2017) · Oncogene · doi:10.1038/onc.2017.138 · Cited by 10 · see citing works

Janus Kinase Mutations in Mice Lacking PU.1 and Spi-B Drive B Cell Leukemia through Reactive Oxygen Species-Induced DNA Damage

Lim, M., Batista, C. R., Oliveira, B. R., Creighton, R. L., Ferguson, J., Clemmer, K., Knight, D., Iansavitchous, J., Mahmood, D., Avino, M., et al. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00189-20 · Cited by 11 · see citing works

Identification of a novel IRF8 homozygous mutation causing neutrophilia, monocytopenia and fatal infection in a female neonate

Dang, D., Liu, Y., Zhou, Q., Li, H., Wang, Y., & Wu, H. M. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.105121 · Cited by 11 · see citing works

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia

Pingul, B. Y., Huang, H., Chen, Q., Alikarami‬, F., Zhang, Z., Qi, J., Bernt, K. M., Berger, S. L., Cao, Z., & Shi, J. (2022) · iScience · doi:10.1016/j.isci.2022.105139 · Cited by 10 · see citing works

DFF-ChIP: a method to detect and quantify complex interactions between RNA polymerase II, transcription factors, and chromatin

Spector, B. M., Santana, J. F., Pufall, M. A., & Price, D. H. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae760 · Cited by 10 · see citing works

Protein inhibitor of activated STAT1 (PIAS1) inhibits IRF8 activation of Epstein-Barr virus lytic gene expression

Zhang, K., Lv, D., & Li, R. (2019) · Virology · doi:10.1016/j.virol.2019.11.011 · Cited by 9 · see citing works

Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers

Andrews, J. M., Pyfrom, S., Schmidt, J. A., Koues, O. I., Kowalewski, R., Grams, N., Sun, J. J., Berman, L. R., Duncavage, E. J., Lee, Y.-S., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103559 · Cited by 7 · see citing works

Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/–Bcl-xLTg mice

Ramírez, J. A., Delaney, M. A., Straign, D. M., Lukin, K., Tsang, M., Iritani, B. M., & Hagman, J. R. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.55 · Cited by 7 · see citing works

Deletion of HO-1 blocks development of B lymphocytes in mice

Zhou, Z., Ma, D., Liu, P., Wang, P., Wei, D., Yu, K., Li, P., Fang, Q., & Wang, J. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109378 · Cited by 7 · see citing works

Transcriptional Regulation of Emergency Granulopoiesis in Leukemia

Hasan, S., Naqvi, A. R., & Rizvi, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00481 · Cited by 6 · see citing works

Antisense oligonucleotides targeting IRF4 alleviate psoriasis

Yu, Y., Wang, Y., Chen, W., Zhang, C., li, Z., Yu, J., Wang, M., Song, C., Yan, S., Lu, J., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.004 · Cited by 5 · see citing works

CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation

Zuo, Z., Kania, A. K., Patterson, D. G., Hicks, S. L., Maurer, J., Gupta, M., Boss, J. M., & Scharer, C. D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17527 · Cited by 5 · see citing works

Numbat-multiome: inferring copy number variations by combining RNA and chromatin accessibility information from single-cell data

Li, R., Alberge, J.-B., Keshavarzian, T., Tsuji, J., Gustafsson, J., Rahmat, M., Lightbody, E. D., Deng, S., Riviero, S., Miller, M. L., et al. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf516 · Cited by 4 · see citing works

Decreased PU.1 expression in mature B cells induces lymphomagenesis

Endo, S., Nishimura, N., Toyoda, K., Komohara, Y., Carreras, J., Yuki, H., Shichijo, T., Ueno, S., Ueno, N., Hirata, S., et al. (2024) · Cancer Science · doi:10.1111/cas.16344 · Cited by 3 · see citing works

Emerging roles of IL-9 and Th9 cells in respiratory viral illnesses

Dandotiya, J., Sadhu, S., Chandwaskar, R. R., & Awasthi, A. (2026) · Seminars in Immunology · doi:10.1016/j.smim.2026.102017 · Cited by 2 · see citing works

Puppet masters of B‐cell progenitor acute lymphoblastic leukemia: The preB cell receptor and the interleukin 7 receptor α

Gupta, D. D., & Lohoff, M. D. (2023) · European Journal of Immunology · doi:10.1002/eji.202250093 · Cited by 2 · see citing works

Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia

Daddali, R., Kettunen, K., Turunen, T., Knox, A. V. C., Laine, P., Chowdhury, I. M., Vänttinen, M., Mamia, N., Stiegler, A. L., Boggon, T. J., et al. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110503 · Cited by 2 · see citing works

Transcriptional Regulation of Early B-Cell Development

Ng, A. P., Morris, R., & Nutt, S. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95895-0.00014-3 · Cited by 2 · see citing works

Transcription Factor PU.1

Batista, C. R., & DeKoter, R. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101960 · Cited by 2 · see citing works

Overexpression of IRF8 and Pu.1 in B cells of systemic lupus erythematosus patients

Azizan, A., Farhadi, E., Faezi, S. T., Alikhani, M., Jamshidi, A., Vodjgani, M., & Mahmoudi, M. (2025) · Lupus · doi:10.1177/09612033251366400 · Cited by 1 · see citing works

Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia SubtypesPreprint

Chagas, P. S., de Sousa, G. R., Kodama, M. H., de Biagi, C. A. O., Andres, J. Y., Brandalise, S. R., Calin, G. A., Tone, L. G., Scrideli, C. A., & de Oliveira, J. C. (2018) · Preprints.org · doi:10.20944/preprints201810.0163.v1

Leukemogenesis in Acute Lymphoblastic Leukemia through the Lens of Developmental Dynamics of Lymphoid Progenitor Cells: a systematic reviewPreprint

Shafi, O., Rajpar, R., Kanwal, F., Waqas, M., Khan, O. J., Raveena, Kumar, A., Jabbar, A., & Madhwani, M. (2024) · medRxiv · doi:10.1101/2024.07.14.24310322 · Cited by 1 · see citing works

Deletion of genes encoding PU.1 and Spi-B leads to B cell acute lymphoblastic leukemia associated with driver mutations in Janus KinasesPreprint

Batista, C. R., Lim, M., Laramée, A.-S., Abu-Sardanah, F., Xu, L., Hossain, R., & DeKoter, R. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/291054

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivityPreprint

Gupta, D. D., Paul, C., Samel, N., Bieringer, M., Staudenraus, D., Marini, F., Raifer, H., Menke, L., Hansal, L., Camara, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.16.480573

Transcription Factor PU.1

Batista, C. R., & DeKoter, R. P. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101960-1

Faculty Opinions recommendation of Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks.

Yip, K. Y.-L. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734659860.793556264

PU.1 interacts with KLF7 to suppress differentiation and promote proliferation in chicken preadipocytes

Tan, M., Xu, H., Li, J., Jia, Z., Zhang, X., Shao, S., Zhang, W., Wang, W., & Sun, Y. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022202

Table S6 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Su, A. H., Ling, F., Vaganay, C., Sodaro, G., Benaksas, C., Bello, R. D., Forget, A., Pardieu, B., Lin, K., Rutter, J. C., et al. (2023) · doi:10.1158/2159-8290.22535072

Selective alteration to CD4 T cell differentiation by heterozygous IRF4 L116R protects against neuroinflammationPreprint

Jaeger, R. A., Roberts, N. A., Turnbull, C. M., Seneviratne, S., Buckland, R. L., Spensberger, D., Pettitt, J. A., Ballard, F. D., Brüstle, A., & Enders, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.25.661400

Clustering of Direct and Indirect DNA Binding Motifs of Human and Mouse Transcription Factors: X-TFBS Compendium from ChIP-seqPreprint

Sharov, A. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.09.687492

IRF4 (MUM1) in B-cell malignancies: molecular mechanisms, biological functions, and clinical implications

Wang, H., Chen, S., Tang, D., Chen, M., Peng, H., Zhang, G., & Wang, Y. (2025) · Pathology · doi:10.1016/j.pathol.2025.10.002

Anomalies moléculaires dans la macroglobulinémie de Waldenström : identification d’une mutation somatique récurrente dans le gène codant pour le facteur de transcription SPI1/PU.1 et description de ses conséquences fonctionnelles

Roos‐Weil, D. (2018) · doi:10.70675/1030cb13z12b8z4f7cz8f8az165206a6209a

Impacts fonctionnels et conséquences sur la différenciation hématopoïétique d’une mutation somatique récurrente du gène PU.1/SPI1 identifiée dans la macroglobulinémie de Waldenström

Decaudin, C. (2020) · doi:10.70675/e84f591cz6a69z4d60z9d03z6267895b1a9e

Rôle du facteur de transcription ETS1 dans la différenciation des lymphocytes B

Gama, L. (2022) · doi:10.70675/ffaf98a1z4fa8z49a7zbe9fz83a1f3e26bf4

Aberrant splicing caused by a homozygous AK2 c.498 + 1G > A variant in a patient with reticular dysgenesis and concurrent B-cell acute lymphoblastic leukemia

何龙楷, Zhao, C., Lu, P., & Zhao, X. (2026) · Gene · doi:10.1016/j.gene.2026.150439

IRF4 Is a Suppressor of c-Myc Induced B Cell Leukemia

Pathak, S., Ma, S., Trinh, L., Eudy, J. D., Wagner, K., Joshi, S. S., & Lu, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022628 · Cited by 54 · see citing works

Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia

Sokalski, K. M., Li, S. K. H., Welch, I. D., Cadieux-Pitre, H.-A. T., Gruca, M. R., & DeKoter, R. P. (2011) · Blood · doi:10.1182/blood-2011-02-335539 · Cited by 74 · see citing works

IFN Regulatory Factor 4 and 8 Promote Ig Light Chain κ Locus Activation in Pre-B Cell Development

Ma, S., Turetsky, A., Trinh, L. X., & Lu, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7898 · Cited by 95 · see citing works

IRF8 regulates B-cell lineage specification, commitment, and differentiation

Wang, H., Lee, C. H., Qi, C., Tailor, P. B., Feng, J., Abbasi, S., Atsumi, T., & Morse, H. C. (2008) · Blood · doi:10.1182/blood-2008-01-129049 · Cited by 140 · see citing works

IRF-4 Functions as a Tumor Suppressor in Early Stages of B Cell Development.

Acquaviva, J., & Ren, R. (2007) · Blood · doi:10.1182/blood.v110.11.154.154