Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment
Open accessAbstract
Background Prefrontal global brain connectivity with global signal regression (GBCr) was proposed as a robust biomarker of depression, and was associated with ketamine's mechanism of action. Here, we investigated prefrontal GBCr in treatment-resistant depression (TRD) at baseline and following treatment. Then, we conducted a set of pharmacological challenges in healthy subjects to investigate the glutamate neurotransmission correlates of GBCr.Methods In study A, we used functional magnetic resonance imaging (f MRI) to compare GBCr between 22 TRD and 29 healthy control. Then, we examined the effects of ketamine and midazolam on GBCr in TRD patients 24h post-treatment. In study B, we acquired repeated f MRI in 18 healthy subjects to determine the effects of lamotrigine (a glutamate release inhibitor), ketamine, and lamotrigine-by-ketamine interaction.Results In study A, TRD patients showed significant reduction in dorsomedial and dorsolateral prefrontal GBCr compared to healthy control. In TRD patients, GBCr in the altered clusters significantly increased 24h following ketamine (effect size = 1.0 [0.3 1.8]), but not midazolam (effect size = 0.5 [-0.6 1.3]). In study B, oral lamotrigine reduced GBCr 2h post-administration, while ketamine increased medial prefrontal GBCr during infusion. Lamotrigine significantly reduced the ketamine-induced GBCr surge. Exploratory analyses showed elevated ventral prefrontal GBCr in TRD and significant reduction of ventral prefrontal GBCr during ketamine infusion in healthy subjects.Conclusions This study provides first replication of the ability of ketamine to normalize depression-related prefrontal dysconnectivity. It also provides indirect evidence that these effects may be triggered by the capacity of ketamine to enhance glutamate neurotransmission.
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Treatment-resistant depression was characterized by decreased global connectivity within the right dorsolateral prefrontal cortex and bilateral dorsomedial prefrontal cortex, including the dorsal anterior cingulate cortex.
“Treatment-resistant depression (TRD) was characterized by decreased global connectivity within the right dlPFC and bilateral dmPFC (including the dACC) [76].”
From Prefrontal cortex and depression (2022) · cites this paper as [76]
The Results section (“GBCr in TRD & Post-ketamine”; page unavailable) reports significantly lower global brain connectivity in bilateral dorsomedial and right dorsolateral prefrontal clusters in TRD patients than in healthy controls. It does not identify the dorsal anterior cingulate cortex as part of those clusters, so the parenthetical detail is not established by our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredKetamine infusion increased global connectivity in the right dorsolateral prefrontal cortex and bilateral dorsomedial prefrontal cortex, including the dorsal anterior cingulate cortex.
“Notably, ketamine infusion increased global connectivity in all three regions.”
From Prefrontal cortex and depression (2022) · cites this paper as [76]
The Results section, “GBCr in TRD & Post-ketamine” (page unavailable), identifies three clusters in the bilateral dorsomedial and right dorsolateral prefrontal cortex, but reports a significant increase in their average connectivity 24 hours after treatment—not an increase in each cluster during infusion. The Results section, “GBCr & Glutamate Modulators” (page unavailable), reports increases during infusion in two clusters, in the bilateral dorsomedial and left frontolateral prefrontal cortex. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn healthy subjects, a direct link between prefrontal connectivity and glutamate neurotransmission was demonstrated, while showing an acute ketamine-induced surge in prefrontal connectivity, which is attenuated by a glutamate inhibitor.
“In healthy subjects, a direct link between prefrontal connectivity and glutamate neurotransmission was demonstrated, while showing an acute ketamine-induced surge in prefrontal connectivity, which is attenuated by a glutamate inhibitor [37].”
From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [37]
The Results (GBCr & Glutamate Modulators; page unavailable) report that ketamine increased prefrontal connectivity in healthy subjects and that lamotrigine pretreatment significantly reduced those increases. But the Abstract Conclusions call the link to glutamate neurotransmission indirect, and the Discussion notes that the study did not directly show lamotrigine blocking ketamine-induced glutamate transmission in humans. Thus, the claim overstates the evidence by saying a direct link was demonstrated. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThis dysconnectivity is normalized 24 h post-ketamine treatment.
“a dysconnectivity that is normalized 24 h post-ketamine treatment [37,57].”
From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [37]
Reduced PFC global connectivity is implicated in MDD.
“Using resting state fMRI, researchers have shown reduced PFC global connectivity to be implicated in MDD.209,210”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [210]
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Cites
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
Permutation inference for the general linear model
Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M., & Nichols, T. E. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.060 · Cited by 3,563 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609 · see citing works
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393 · see citing works
Mechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386 · see citing works
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
Murrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., Iqbal, S., Pillemer, S., Foulkes, A., Shah, A., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030392 · Cited by 1,205 · see citing works
Self-citationLi, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
Self-citationLiang, X., Zou, Q., He, Y., & Yang, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214900110 · Cited by 677 · see citing works
Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence
Cole, M. W., Yarkoni, T., Repovs, G., Anticevic, A., & Braver, T. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0536-12.2012 · Cited by 613 · see citing works
Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression.
Newport, D. J., Carpenter, L. L., McDonald, W. M., Potash, J. B., Tohen, M., Nemeroff, C. B., & The APA Council of Research Task Force on Novel Biomarkers and Treatments (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15040465 · Cited by 598 · see citing works
Identifying the brain's most globally connected regions
Cole, M. W., Pathak, S., & Schneider, W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.001 · Cited by 557 · see citing works
Targeting glutamate signalling in depression: progress and prospects
Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.16 · Cited by 482 · see citing works
Self-citationAnand, A., Charney, D. S., Oren, D. A., Berman, R. M., Hu, X. S., Cappiello, A., & Krystal, J. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.270 · Cited by 426 · see citing works
Self-citationAbdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-053013-062946 · Cited by 422 · see citing works
Self-citationA Double-Blind, Placebo-Controlled Study of Memantine in the Treatment of Major Depression
Zarate, C. A., Singh, J. B., Quiroz, J. A., De Jesus, G., Denicoff, K. K., Luckenbaugh, D. A., Manji, H. K., & Charney, D. S. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.153 · Cited by 387 · see citing works
Deakin, J. F. W., Lees, J., McKie, S., Hallak, J. E. C., Williams, S. R., & Dursun, S. M. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.37 · Cited by 311 · see citing works
Rowland, L. M., Bustillo, J. R., Mullins, P. G., Jung, R. E., Lenroot, R., Landgraf, E., Barrow, R., Yeo, R., Lauriello, J., & Brooks, W. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.394 · Cited by 304 · see citing works
Ketamine Treatment and Global Brain Connectivity in Major Depression
Abdallah, C. G., Averill, L. A., Collins, K. A., Geha, P., Schwartz, J., Averill, C., DeWilde, K. E., Wong, E., Anticevic, A., Tang, C. Y., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.186 · Cited by 300 · see citing works
Self-citationMathew, S. J., Murrough, J. W., Rot, M. A. H., Collins, K. A., Reich, D. L., & Charney, D. S. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000169 · Cited by 296 · see citing works
Self-citationStone, J. M., Dietrich, C., Edden, R., Mehta, M. A., De Simoni, S., Reed, L. J., Krystal, J. H., Nutt, D., & Barker, G. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.171 · Cited by 295 · see citing works
Self-citationAnticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M. W., Bednarski, S., Krystal, J. H., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.021 · Cited by 268 · see citing works
Self-citationGlobal Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History
Anticevic, A., Brumbaugh, M. S., Winkler, A. M., Lombardo, L. E., Barrett, J., Corlett, P. R., Kober, H., Gruber, J., Repovs, G., Cole, M. W., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.031 · Cited by 263 · see citing works
Self-citationEvidence of Cortical Inhibitory Deficits in Major Depressive Disorder
Levinson, A. J., Fitzgerald, P. B., Favalli, G., Blumberger, D. M., Daigle, M., & Daskalakis, Z. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.025 · Cited by 261 · see citing works
Wang, L., Dai, Z., Peng, H., Tan, L., Ding, Y., He, Z., Zhang, Y., Xia, M., Li, Z., Li, W., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22241 · Cited by 236 · see citing works
Variable Global Dysconnectivity and Individual Differences in Schizophrenia
Cole, M. W., Anticevic, A., Repovš, G., & Barch, D. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.010 · Cited by 227 · see citing works
Pharmacological approaches to the challenge of treatment-resistant depression
Ionescu, D. F., Rosenbaum, J. F., & Alpert, J. E. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.2/dionescu · Cited by 216 · see citing works
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22501 · Cited by 206 · see citing works
Self-citationValentine, G. W., Mason, G. F., Gomez, R., Fasula, M. K., Watzl, J., Pittman, B. P., Krystal, J. H., & Sanacora, G. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.10.009 · Cited by 205 · see citing works
Self-citationAnterior Cingulate Cortexγ-Aminobutyric Acid in Depressed Adolescents: Relationship to Anhedonia
Gabbay, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.131 · Cited by 201 · see citing works
Chowdhury, G. M. I., Zhang, J., Thomas, M., Banasr, M., Ma, X., Pittman, B., Bristow, L., Schaeffer, E., Duman, R. S., Rothman, D. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.34 · Cited by 197 · see citing works
Anticevic, A., Corlett, P. R., Cole, M. W., Savic, A., Gancsos, M., Tang, Y., Repovs, G., Murray, J. D., Driesen, N. R., Morgan, P. T., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.022 · Cited by 181 · see citing works
Self-citationCunningham, M. O., & Jones, R. S. G. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00051-4 · Cited by 163 · see citing works
Niciu, M. J., Henter, I. D., Luckenbaugh, D. A., Zarate, C. A., & Charney, D. S. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135950 · Cited by 161 · see citing works
Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder
Niciu, M. J., Ionescu, D. F., Richards, E. M., & Zarate, C. A. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1130-x · Cited by 157 · see citing works
Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder
Murrough, J. W., Abdallah, C. G., Anticevic, A., Collins, K. A., Geha, P., Averill, L. A., Schwartz, J., DeWilde, K. E., Averill, C., Jia‐Wei Yang, G., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23235 · Cited by 153 · see citing works
Self-citationMilak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.83 · Cited by 144 · see citing works
Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus
Neymotin, S. A., Lazarewicz, M. T., Sherif, M., Contreras, D., Finkel, L. H., & Lytton, W. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0501-11.2011 · Cited by 139 · see citing works
Neuroimaging-based biomarkers for treatment selection in major depressive disorder
Dunlop, B. W., & Mayberg, H. S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.4/bdunlop · Cited by 127 · see citing works
Portella, M. J., de Diego-Adeliño, J., Gómez-Ansón, B., Morgan-Ferrando, R., Vives, Y., Puigdemont, D., Pérez-Egea, R., Ruscalleda, J., Álvarez, E., & Pérez, V. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.08.010 · Cited by 127 · see citing works
The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder
Abdallah, C. G., Jackowski, A., Salas, R., Gupta, S., Sato, J. R., Mao, X., Coplan, J. D., Shungu, D. C., & Mathew, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.49 · Cited by 123 · see citing works
Self-citationBobo, W. V., Voort, J. L. V., Croarkin, P. E., Leung, J. G., Tye, S. J., & Frye, M. A. (2016) · Depression and Anxiety · doi:10.1002/da.22505 · Cited by 122 · see citing works
Ketamine as a promising prototype for a new generation of rapid‐acting antidepressants
Abdallah, C. G., Averill, L. A., & Krystal, J. H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12718 · Cited by 121 · see citing works
Self-citationSanacora, G., Johnson, M. R., Khan, A., Atkinson, S. D., Riesenberg, R. R., Schronen, J. P., Burke, M. A., Zajecka, J. M., Barra, L., Su, H.-L., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.224 · Cited by 120 · see citing works
Self-citationPotential Mechanisms of Action of Lamotrigine in the Treatment of Bipolar Disorders
Ketter, T. A., Manji, H. K., & Post, R. M. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000088915.02635.e8 · Cited by 116 · see citing works
Merkl, A., Schubert, F., Quante, A., Luborzewski, A., Brakemeier, E., Grimm, S., Heuser, I., & Bajbouj, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.009 · Cited by 106 · see citing works
Low plasma γ-aminobutyric acid levels in male patients with depression
Petty, F., Kramer, G. L., Gullion, C. M., & Rush, A. J. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90039-3 · Cited by 103 · see citing works
Zhang, C., Li, Z., Wu, Z., Chen, J., Wang, Z., Peng, D., Hong, W., Yuan, C., Wang, Z., Yu, S., et al. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3297-0 · Cited by 93 · see citing works
Coplan, J. D., Gopinath, S., Abdallah, C. G., & Berry, B. R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00189 · Cited by 90 · cited 1× · see citing works
“Major depressive disorder (MDD) is a disabling mental illness with poorly understood pathophysiology and high rates of inadequate treatment response (1, 2).”
BackgroundSelf-citationde Diego-Adeliño, J., Portella, M. J., Gómez-Ansón, B., López-Moruelo, O., Serra-Blasco, M., Vives, Y., Puigdemont, D., Pérez-Egea, R., Álvarez, E., & Pérez, V. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110185 · Cited by 86 · see citing works
Multimodal Approaches to Define Network Oscillations in Depression
Smart, O. L., Tiruvadi, V., & Mayberg, H. S. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.002 · Cited by 85 · see citing works
Hippocampal volume and the rapid antidepressant effect of ketamine
Abdallah, C. G., Salas, R., Jackowski, A., Baldwin, P., Sato, J. R., & Mathew, S. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114544776 · Cited by 78 · see citing works
Self-citationInsel, T. R., Sahakian, B. J., Voon, V., Nye, J. S., Brown, V. J., Altevogt, B. M., Bullmore, E. T., Goodwin, G. M., Howard, R. J., Kupfer, D. J., et al. (2012) · Nature · doi:10.1038/483269a · Cited by 70 · see citing works
Glutamate normalization with ECT treatment response in major depression
Zhang, J., Narr, K. L., Woods, R. P., Phillips, O. R., Alger, J. R., & Espinoza, R. T. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.46 · Cited by 70 · see citing works
Abdallah, C. G., Wrocklage, K. M., Averill, C. L., Akiki, T. J., Schweinsburg, B. C., Roy, A. M., Martini, B. A., Southwick, S. M., Krystal, J. H., & Scott, J. C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.12 · Cited by 69 · see citing works
Self-citationAbdallah, C. G., Jackowski, A., Sato, J. R., Mao, X., Kang, G., Cheema, R., Coplan, J. D., Mathew, S. J., & Shungu, D. C. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.025 · Cited by 67 · see citing works
Self-citationAbdallah, C. G., Coplan, J. D., Jackowski, A. P., Sato, J. R., Mao, X., Shungu, D. C., & Mathew, S. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.009 · Cited by 66 · see citing works
Self-citationCSF GABA in depressed patients and normal controls
Roy, A., DeJong, J., & Ferraro, T. N. (1991) · Psychological Medicine · doi:10.1017/s0033291700022248 · Cited by 66 · see citing works
Taylor, M. J., Tiangga, E. R., Mhuircheartaigh, R. N., & Cowen, P. J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111405359 · Cited by 66 · see citing works
Region-specific glutamate changes in patients with unipolar depression
Grimm, S., Luborzewski, A., Schubert, F., Merkl, A., Kronenberg, G., Colla, M., Heuser, I., & Bajbouj, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.04.018 · Cited by 52 · see citing works
Liang, X., Connelly, A., & Calamante, F. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.11.013 · Cited by 48 · cited 1× · see citing works
“functional connectivity strength, have been used to identify major brain networks (30), were found to predict cognitive functioning and intelligence (31), and were shown to significantly correlate with regional cerebral blood flow (32, 33).”
BackgroundWhat’s the Buzz About Hydroxynorketamine? Is It the History, the Story, the Debate, or the Promise?
Abdallah, C. G. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.002 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
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Sorted by citations
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Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 644 · see citing works
Lower synaptic density is associated with depression severity and network alterations
Holmes, S. E., Scheinost, D., Finnema, S. J., Naganawa, M., Davis, M. T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G. A., Pietrzak, R. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09562-7 · Cited by 484 · see citing works
Self-citationKetamine and rapid antidepressant action: New treatments and novel synaptic signaling mechanisms
Krystal, J. H., Kavalali, E. T., & Monteggia, L. M. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01629-w · Cited by 262 · see citing works
Self-citationThe effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects
Abdallah, C. G., De Feyter, H. M., Averill, L. A., Jiang, L., Averill, C. L., Chowdhury, G. M. I., Purohit, P., de Graaf, R. A., Esterlis, I., Juchem, C., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0136-3 · Cited by 229 · see citing works
Self-citationAbdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.010 · Cited by 219 · see citing works
Self-citationMatveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · see citing works
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works
The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder
Abdallah, C. G., Averill, L. A., Akiki, T. J., Raza, M., Averill, C. L., Gomaa, H., Adikey, A., & Krystal, J. H. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021701 · Cited by 171 · see citing works
Self-citationGlutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments
Kadriu, B., Musazzi, L., Henter, I. D., Graves, M., Popoli, M., & Zarate, C. A. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy094 · Cited by 165 · see citing works
Bell, R. F., & Kalso, E. A. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000674 · Cited by 164 · see citing works
Kohtala, S. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00232-4 · Cited by 146 · see citing works
Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review
Jones, J. L., Mateus, C. F., Malcolm, R. J., Brady, K. T., & Back, S. E. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00277 · Cited by 136 · see citing works
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.007 · Cited by 114 · see citing works
Lüscher, B., & Möhler, H. (2019) · F1000Research · doi:10.12688/f1000research.18758.1 · Cited by 105 · see citing works
Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., Treccani, G., Seguini, M., Ieraci, A., Mingardi, J., et al. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100160 · Cited by 101 · see citing works
Allostasis, action and affect in depression: Insights from the theory of constructed emotion
Shaffer, C., Westlin, C., Quigley, K. S., Whitfield-Gabrieli, S., & Barrett, L. F. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-115627 · Cited by 94 · see citing works
Amidfar, M., Woelfer, M., Réus, G. Z., Quevedo, J., Walter, M., & Kim, Y.-K. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109668 · Cited by 86 · see citing works
Brain Changes Associated With Long-Term Ketamine Abuse, A Systematic Review
Strous, J. F. M., Weeland, C. J., van der Draai, F. A., Daams, J. G., Denys, D. A. J. P., Lok, A., Schoevers, R. A., & Figee, M. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.795231 · Cited by 85 · see citing works
“Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function
Candow, D. G., Forbes, S. C., Ostojić, S. M., Prokopidis, K., Stock, M. S., Harmon, K. K., & Faulkner, P. (2023) · Sports Medicine · doi:10.1007/s40279-023-01870-9 · Cited by 95 · see citing works
Is depression the missing link between inflammatory mediators and cancer?
Polityńska, B., Pokorska, O., Wojtukiewicz, A. M., Sawicka, M., Mysliwiec, M., Honn, K. V., Tucker, S. C., & Wojtukiewicz, M. Z. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108293 · Cited by 80 · see citing works
Chen, M.-H., Lin, W.-C., Tu, P.-C., Li, C.-T., Bai, Y.-M., Tsai, S.-J., & Su, T.-P. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.022 · Cited by 78 · see citing works
Promising Neuroimaging Biomarkers in Depression
Lai, C. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.07.25.2 · Cited by 75 · see citing works
Lai, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110234 · Cited by 71 · see citing works
Abdallah, C. G., Dutta, A., Averill, C. L., McKie, S., Akiki, T. J., Averill, L. A., & William Deakin, J. F. (2018) · Chronic Stress · doi:10.1177/2470547018796102 · Cited by 70 · see citing works
Self-citationSystematic Review of the Use of Intravenous Ketamine for Fibromyalgia
Pastrak, M., Abd-Elsayed, A. A., Ma, F., Vrooman, B., & Visnjevac, O. (2021) · Ochsner Journal · doi:10.31486/toj.21.0038 · Cited by 68 · see citing works
Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57 · see citing works
Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders
Jaudon, F., Thalhammer, A., & Cingolani, L. A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14859 · Cited by 57 · see citing works
Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities
Shinohara, R., Aghajanian, G. K., & Abdallah, C. G. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.006 · Cited by 54 · see citing works
Self-citationKraus, C., Mkrtchian, A., Kadriu, B., Nugent, A. C., Zarate, C. A., & Evans, J. W. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0624-0 · Cited by 54 · see citing works
Muscat, S.-A., Hartelius, G., Crouch, C., & Morin, K. W. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.710338 · Cited by 53 · see citing works
Beyond noise to function: reframing the global brain activity and its dynamic topography
Zhang, J., & Northoff, G. (2022) · Communications Biology · doi:10.1038/s42003-022-04297-6 · Cited by 50 · see citing works
Zhou, Z., Gao, Y., Bao, W., Liang, K., Cao, L., Tang, M., Li, H., Hu, X., Zhang, L., Sun, H., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105583 · Cited by 52 · see citing works
Abram, S. V., Roach, B. J., Fryer, S. L., Calhoun, V. D., Preda, A., van Erp, T. G. M., Bustillo, J., Lim, K. O., Loewy, R. L., Stuart, B. K., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01502-0 · Cited by 49 · see citing works
Self-citationPharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression
Vecera, C. M., C. Courtes, A., Jones, G., Soares, J. C., & Machado-Vieira, R. (2023) · Pharmaceuticals · doi:10.3390/ph16111572 · Cited by 48 · see citing works
Ding, Y., Yang, R., Yan, C., Chen, X., Bai, T., Bo, Q., Chen, G., Chen, N.-X., Chen, T.-L., Chen, W., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.030 · Cited by 45 · see citing works
Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45 · see citing works
Medeiros, G. C., Matheson, M., Demo, I., Reid, M. J., Matheson, S., Twose, C., Smith, G. S., Gould, T. D., Zarate, C. A., Barrett, F. S., et al. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00183-9 · Cited by 49 · see citing works
Veraart, J. K. E., Smith-Apeldoorn, S. Y., Bakker, I. M., Visser, B. A. E., Kamphuis, J., Schoevers, R. A., & Touw, D. J. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab039 · Cited by 46 · see citing works
Neural plasticity and depression treatment
Wang, Y., Song, N., Ding, Y., & Zhang, L. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.09.001 · Cited by 44 · see citing works
Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment
Abdallah, C. G., Averill, C. L., Ramage, A. E., Averill, L. A., Alkin, E., Nemati, S., Krystal, J. H., Roache, J. D., Resick, P. A., Young‐McCaughan, S., et al. (2019) · Chronic Stress · doi:10.1177/2470547019838971 · Cited by 40 · see citing works
Self-citationAntidepressant mechanisms of ketamine: Focus on GABAergic inhibition
Lüscher, B., Feng, M., & Jefferson, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.03.002 · Cited by 41 · see citing works
Imaging synaptic density in depression
Holmes, S. E., Abdallah, C., & Esterlis, I. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01368-4 · Cited by 39 · see citing works
Self-citationDifferences between ketamine’s short-term and long-term effects on brain circuitry in depression
Gass, N., Becker, R., Reinwald, J., Cosa‐Linan, A., Sack, M., Weber‐Fahr, W., Vollmayr, B., & Sartorius, A. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0506-6 · Cited by 41 · see citing works
Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder
Abdallah, C. G., Averill, C. L., Ramage, A. E., Averill, L. A., Goktas, S., Nemati, S., Krystal, J. H., Roache, J. D., Resick, P. A., Young‐McCaughan, S., et al. (2019) · Chronic Stress · doi:10.1177/2470547019850467 · Cited by 36 · see citing works
Self-citationValence processing in the PFC: Reconciling circuit-level and systems-level views
Coley, A. A., Padilla-Coreano, N., Patel, R. R., & Tye, K. M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.12.002 · Cited by 35 · see citing works
Antianhedonic effect of repeated ketamine infusions in patients with treatment resistant depression
Wilkowska, A., Wiglusz, M. S., Gałuszko-Wegielnik, M., Włodarczyk, A., & Cubała, W. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.704330 · Cited by 35 · see citing works
Zhang, Y., Huang, C., Zhao, J., Liu, Y., Xia, M., Wang, X., Wei, D., Chen, Y., Liu, B., Zheng, Y., et al. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00323-0 · Cited by 38 · see citing works
Crowley, N. A., Magee, S. N., Feng, M., Jefferson, S. J., Morris, C., Dao, N. C., Brockway, D. F., & Lüscher, B. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.003 · Cited by 34 · see citing works
Abdallah, C. G., Ahn, K.-H., Averill, L. A., Nemati, S., Averill, C. L., Fouda, S., Ranganathan, M., MORGAN, P. T., D’Souza, D. C., Mathalon, D. H., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00864-9 · Cited by 33 · see citing works
Self-citationFrontal Lobe Circuitry in Posttraumatic Stress Disorder
Selemon, L. D., Young, K. A., Cruz, D. A., & Williamson, D. E. (2019) · Chronic Stress · doi:10.1177/2470547019850166 · Cited by 31 · see citing works
Abdallah, C., Averill, L. A., Gueorguieva, R., Goktas, S., Purohit, P., Ranganathan, M., D'Souza, D. C., Formica, R., Southwick, S. M., Duman, R. S., et al. (2018) · doi:10.1101/500959 · Cited by 30 · see citing works
Self-citationThe Effect of Ketamine on Electrophysiological Connectivity in Major Depressive Disorder
Nugent, A. C., Ballard, E. D., Gilbert, J. R., Tewarie, P. K. B., Brookes, M. J., & Zarate, C. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00519 · Cited by 30 · see citing works
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review
Demchenko, I., Tassone, V. K., Kennedy, S. H., Dunlop, K., & Bhat, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864902 · Cited by 29 · see citing works
“VMPFC GBCr was also predictive of treatment response, even though ketamine did not have any significant effect on the VMPFC connectivity (132, 133).”
BackgroundInfluentialNeuroimaging-Derived Biomarkers of the Antidepressant Effects of Ketamine
Zavaliangos‐Petropulu, A., Al‐Sharif, N., Taraku, B., Leaver, A. M., Sahib, A. K., Espinoza, R. T., & Narr, K. L. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.11.005 · Cited by 28 · see citing works
Alario, A. A., & Niciu, M. J. (2021) · Chronic Stress · doi:10.1177/24705470211014210 · Cited by 26 · see citing works
A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants
Nemati, S., Akiki, T. J., Roscoe, J., Ju, Y., Averill, C. L., Fouda, S., Dutta, A., McKie, S., Krystal, J. H., Deakin, J. F. W., et al. (2019) · iScience · doi:10.1016/j.isci.2019.100800 · Cited by 26 · see citing works
Self-citationImpact of Tai Chi as an adjunct treatment on brain connectivity in geriatric depression
Kilpatrick, L., Siddarth, P., Milillo, M. M., Krause-Sorio, B., Ercoli, L., Narr, K., & Lavretsky, H. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.049 · Cited by 22 · see citing works
Ketamine and Lamotrigine Combination in Psychopharmacology: Systematic Review
Wilkowska, A., Wiglusz, M. S., Jakuszkowiak‐Wojten, K., & Cubała, W. J. (2022) · Cells · doi:10.3390/cells11040645 · Cited by 23 · see citing works
Averill, L. A., Jiang, L., Purohit, P., Coppoli, A., Averill, C. L., Roscoe, J., Kelmendi, B., Feyter, H. M. D., de Graaf, R. A., Gueorguieva, R. V., et al. (2022) · Chronic Stress · doi:10.1177/24705470221092734 · Cited by 22 · see citing works
Self-citationKetamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?
Abdallah, C. G., & Krystal, J. H. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112628 · Cited by 23 · see citing works
Self-citationKetamine and esketamine for crisis management in patients with depression: Why, whom, and how?
Lengvenytė, A., Strumila, R., Olié, É., & Courtet, P. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.02.004 · Cited by 21 · see citing works
Spies, M., Klöbl, M., Höflich, A. S., Hummer, A., Vanicek, T., Michenthaler, P., Kranz, G. S., Hahn, A., Winkler, D., Windischberger, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46702-x · Cited by 22 · see citing works
(2020) · Advances in Pharmacology · doi:10.1016/bs.apha.2020.04.003 · Cited by 18 · see citing works
Self-citationDepression patient-derived cortical neurons reveal potential biomarkers for antidepressant response
Avior, Y., Ron, S., Kroitorou, D., Albeldas, C., Lerner, V., Corneo, B., Nitzan, E., Laifenfeld, D., & Solal, T. C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01319-5 · Cited by 18 · see citing works
Ketamine: A Review for Clinicians
Sanacora, G., & Katz, R. R. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20180012 · Cited by 17 · see citing works
Spatiotemporal Psychopathology – A novel approach to brain and symptoms
Northoff, G. (2022) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.28146 · Cited by 19 · see citing works
Zhou, Y., Wang, C., Lan, X., Li, W., Chao, Z., Wu, K., McIntyre, R. S., & Ning, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.779326 · Cited by 15 · see citing works
Stress, mental disorder and ketamine as a novel, rapid acting treatment
Dutton, M., Can, A., Lagopoulos, J., & Hermens, D. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.09.006 · Cited by 15 · see citing works
New medications for treatment-resistant depression: a brief review of recent developments
Thase, M. E. (2017) · CNS Spectrums · doi:10.1017/s1092852917000876 · Cited by 15 · see citing works
Joseph, B., Núñez, N. A., Kung, S., Voort, J. L. V., Pazdernik, V., Schak, K. M., Boehm, S. M., Carpenter, B., Johnson, E. K., Malyshev, G., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16081164 · Cited by 14 · see citing works
Yang, C., Zhou, Z., Bao, W., Zhong, R., Tang, M., Wang, Y., Gao, Y., Hu, X., Zhang, L., Qiu, L., et al. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae225 · Cited by 14 · see citing works
Gonzalez, S., Vasavada, M. M., Njau, S. N., Sahib, A. K., Espinoza, R. T., Narr, K. L., & Leaver, A. M. (2020) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2020.08.006 · Cited by 14 · see citing works
Asch, R. H., Abdallah, C. G., Carson, R. E., & Esterlis, I. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01913-3 · Cited by 13 · see citing works
Self-citation(Es)Ketamine for Suicidal Ideation and Behavior: Clinical Efficacy
Alario, A. A., & Niciu, M. J. (2022) · Chronic Stress · doi:10.1177/24705470221128017 · Cited by 16 · see citing works
Is there a risk of esketamine misuse in clinical practice?
Roncero, C., Torres, M. M., Szerman, N., Torrens, M., Vega, P., Andrés-Olivera, P., & Alvarez, E. (2025) · Therapeutic Advances in Drug Safety · doi:10.1177/20420986241310685 · Cited by 12 · see citing works
Joffe, M. E., Santiago, C. I., Vermudez, S. A. D., Fisher, N. M., Dogra, S., Niswender, C. M., & Conn, P. J. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01041-2 · Cited by 12 · see citing works
Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality
Dutton, M., Boyes, A., Can, A., Mohamed, A. Z., Hajishafiee, M., Shan, Z., Lagopoulos, J., & Hermens, D. F. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.11.040 · Cited by 9 · see citing works
Collo, G., & Pich, E. M. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.270305 · Cited by 8 · see citing works
Meiering, M. S., Weigner, D., Gärtner, M., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., Weigand, A., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03120-6 · Cited by 7 · see citing works
Shinohara, R., & Furuyashiki, T. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.12.015 · Cited by 7 · see citing works
Toxicity patterns associated with chronic ketamine exposure
Hottat, A., & Hantson, P. E. (2023) · Annales de Toxicologie Analytique · doi:10.1016/j.toxac.2023.02.001 · Cited by 6 · see citing works
Neurobiological Mechanisms of Ketamine: Depression, Suicide, Trauma, and Chronic Stress Pathologies
Averill, L. A., Averill, C. L., & Abdallah, C. G. (2020) · Psychiatric Annals · doi:10.3928/00485713-20200109-02 · Cited by 6 · see citing works
Self-citationCollo, G., Cavalleri, L., & Pich, E. M. (2019) · Chronic Stress · doi:10.1177/2470547019842545 · Cited by 5 · see citing works
Functional connectome-based predictive modeling of suicidal ideation
Averill, L. A., Tamman, A. J. F., Fouda, S., Averill, C. L., Nemati, S., Ragnhildstveit, A., Gosnell, S. N., Akiki, T. J., Salas, R., & Abdallah, C. G. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119518 · Cited by 4 · see citing works
Self-citationBiomarkers in Psychiatric Drug Development: From Precision Medicine to Novel Therapeutics
Carreon, R. L., Rivas-Grajales, A. M., Murphy, N., Mathew, S. J., & Jha, M. K. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-21054-9_12 · Cited by 4 · see citing works
Self-citationGärtner, M., Weigand, A., Meiering, M. S., Weigner, D., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02977-x · Cited by 3 · see citing works
Damm‐Ganamet, K. L., Rives, M., Wickenden, A. D., McAllister, H., & Mirzadegan, T. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ac119.011190 · Cited by 3 · see citing works
Ketamin in der Schmerztherapie
Bell, R. F., & Kalso, E. A. (2019) · Der Schmerz · doi:10.1007/s00482-019-0364-4 · Cited by 2 · see citing works
Wang, K., Smolker, H. R., Brown, M. S., Snyder, H. R., Cheng, Y., Hankin, B. L., & Banich, M. T. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01408-1 · Cited by 2 · see citing works
Han, S., Tian, Y. Q., Yang, H., Zheng, R., Li, S., Fang, K., Wen, B., Liu, L., Wei, Y., Chen, Y., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.06.006 · Cited by 2 · see citing works
Fletcher, K., Ezard, N., Siefried, K. J., Macdonald, H., Acheson, L. S., Bedi, G., Guerin, A. A., Knock, E., Millard, M., May, R., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-092504 · Cited by 1 · see citing works
Weigner, D., Meiering, M. S., Weigand, A., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., Gärtner, M., et al. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251346705 · Cited by 1 · see citing works
Yonezawa, K., Nakajima, S., Hondo, N., Ohtani, Y., Nomoto‐Takahashi, K., Yatomi, T., Tomiyama, S., Nagai, N., Kusudo, K., Takahashi, K., et al. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.08.017 · Cited by 1 · see citing works
Dong, Y., Wu, Y., Zhao, Y.-L., Chen, Y.-M., Liu, T.-Y., Zhang, Y.-H., Xie, J.-Y., Zhang, J., Zhang, H., Chen, H., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01643-2 · Cited by 1 · see citing works
From Bench to Bedside: Understanding General Anesthetics' Impact on PTSD
Li, K., Meimei, G., Wei, W., Li, X., & Peng, M. (2026) · Current Neuropharmacology · doi:10.2174/011570159x402072251103071408 · Cited by 1 · see citing works
Harnessing Neuroimaging to Enhance Our Understanding of the Effects of Ketamine in Depression
Jaworska, N., & Phillips, J. L. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.005 · Cited by 1 · see citing works
Krystal, J. H., Southwick, S. M., & Girgenti, M. J. (2022) · Psychiatry · doi:10.1080/00332747.2022.2068931 · Cited by 1 · see citing works
Self-citationSar-El, R., Raz, G., Lubianiker, N., Sharon, H., & Hendler, T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/212480 · Cited by 1 · see citing works
Salience Network Disruption in US Army Soldiers with PTSDPreprint
Abdallah, C. G., Averill, C. L., Ramage, A. E., Averill, L. A., Goktas, S., Krystal, J. H., Roache, J. D., Resick, P. A., Young‐McCaughan, S., Peterson, A. L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/496505 · Cited by 1 · see citing works
Self-citationUsing Neuroimaging to Decipher the Mechanism of Action of Ketamine: A Pathway to Novel Therapeutics?
Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.08.006
- Authors
- Abdallah, C. G., Averill, C. L., Salas, R., Averill, L. A., Baldwin, P. R., Krystal, J. H., Mathew, S. J., & Mathalon, D. H.
- Affiliations
- United States Department of Veterans Affairs (US)
- Michael E. DeBakey VA Medical Center (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Abdallah, Chadi G.
- ORCID
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 2
- Issue
- 7
- Pages
- 566-574
- ISSN
- 2451-9022 (ISSN-L)
- PMC
- PMC5635826
- OpenAlex
- W2607285009
- Cited by
- 111
- References
- 67
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 10 · 2022: 20 · 2021: 13 · 2020: 15 · 2019: 18 · 2018: 10 · 2017: 3
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX000994)
- GlaxoSmithKline
- National Institutes of Health (5k23mh101498-05, UL1TR001863)
- Genentech
- National Institute of Mental Health (K23MH-101498(, R01MH081870)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- treatment-resistant depression, global brain connectivity, prefrontal connectivity, ketamine, glutamatergic neurotransmission, lamotrigine, midazolam, dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, ventral prefrontal cortex, depression biomarkers, pharmacological challenge
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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