Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells
Abstract
According to the temporal coding hypothesis, neurons encode information by the exact timing of spikes. An example of temporal coding is the hippocampal phase precession phenomenon, in which the timing of pyramidal cell spikes relative to the theta rhythm shows a unidirectional forward precession during spatial behaviour. Here we show that phase precession occurs in both spatial and non-spatial behaviours. We found that spike phase correlated with instantaneous discharge rate, and processed unidirectionally at high rates, regardless of behaviour. The spatial phase precession phenomenon is therefore a manifestation of a more fundamental principle governing the timing of pyramidal cell discharge. We suggest that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes.
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LTP and LTD, respectively, can result from slight differences in the phase of theta oscillations between pre- and postsynaptic neurons.
“Likewise, LTP and LTD, respectively, can result from slight differences in the phase of theta oscillations between pre-and postsynaptic neurons (514).”
From About Sleep's Role in Memory (2013) · cites this paper as [514]
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Schmidt, R., Diba, K., Leibold, C., Schmitz, D., Buzsáki, G., & Kempter, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2270-09.2009 · Cited by 126 · see citing works
Self-citationSpike phase precession persists after transient intrahippocampal perturbation
Zugaro, M., Monconduit, L., & Buzsáki, G. (2004) · Nature Neuroscience · doi:10.1038/nn1369 · Cited by 125 · see citing works
Self-citationSegregation of cortical head direction cell assemblies on alternating theta cycles
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Human neocortical oscillations exhibit theta phase differences between encoding and retrieval
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Data Sharing for Computational Neuroscience
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Self-citationNetwork mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons
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From synaptic plasticity to spatial maps and sequence learning
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- Authors
- Harris, K. D., Henze, D. A., Hirase, H., Leinekugel, X., Dragoi, G., Czurkó, A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Buzsáki, György
- Venue
- Nature
- Published
- 2002-06
- Volume
- 417
- Issue
- 6890
- Pages
- 738-741
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1991417588
- Cited by
- 398
- References
- 26
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 18 · 2023: 31 · 2022: 12 · 2021: 10 · 2020: 13 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 11 · 2015: 21 · 2014: 21 · 2013: 22 · 2012: 17
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- phase precession, hippocampal pyramidal neurons, theta oscillations, temporal coding, spike timing, spatial behavior, somatic inhibition, hippocampus
- MeSH terms
- Action Potentials, Analysis of Variance, Animals, Computer Simulation, Dendrites, Kinetics, Male, Motor Activity, Sleep, REM, Theta Rhythm, Pyramidal Cells, Rats
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