Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
Abstract
Processing of neuronal information depends on interactions between the anatomical connectivity and cellular properties of single cells. We examined how these computational building blocks work together in the intact rat hippocampus. Single spikes in dentate granule cells, controlled intracellularly, generally failed to discharge either interneurons or CA3 pyramidal cells. In contrast, trains of spikes effectively discharged both CA3 cell types. Increasing the discharge rate of the granule cell increased the discharge probability of its target neuron and decreased the delay between the onset of a granule cell train and evoked firing in postsynaptic targets. Thus, we conclude that the granule cell to CA3 synapses are 'conditional detonators,' dependent on granule cell firing pattern. In addition, we suggest that information in single granule cells is converted into a temporal delay code in target CA3 pyramidal cells and interneurons. These data demonstrate how a neural circuit of the CNS may process information.
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Chemical potentiation markedly regulates the conditional detonation properties of the synapse.
“Thus, chemical potentiation markedly regulates the conditional detonation properties of the synapse [25,50,51].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [50]
Chemical potentiation can switch the hippocampal mossy fiber synapse from a subdetonation into a detonation mode.
“The unitary EPSP recordings (Fig 2) provide direct evidence for this hypothesis, demonstrating that chemical potentiation can switch the hippocampal mossy fiber synapse from a subdetonation into a detonation mode [50,51].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [50]
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- Authors
- Henze, D. A., Wittner, L., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Buzsáki, György
- Venue
- Nature Neuroscience
- Published
- 2002-07-15
- Volume
- 5
- Issue
- 8
- Pages
- 790-795
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1983628429
- Cited by
- 480
- References
- 4
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 20 · 2023: 16 · 2022: 15 · 2021: 25 · 2020: 18 · 2019: 33 · 2018: 24 · 2017: 22 · 2016: 17 · 2015: 20 · 2014: 23 · 2013: 29 · 2012: 18
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p41rr009754-09, 5f32mh012403-02)
- National Institute of Mental Health (R01MH054671, MH12403, MH54671)
- National Institute of Neurological Disorders and Stroke (NS 43157, R01NS043157, R01NS034994, NS-34994)
- National Center for Research Resources (5P41RR009754)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dentate gyrus granule cells, hippocampal CA3, CA3 pyramidal cells, interneurons, spike trains, synaptic transmission, hippocampal circuitry, rat hippocampus
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Hippocampus, Interneurons, Microelectrodes, Nerve Net, Synaptic Transmission, Neurons, Reaction Time, Rats, Sprague-Dawley, Pyramidal Cells, Rats
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