Cited by 1,245Circadian rhythm and melatoninRetinal Development and DisordersPhotoreceptor and optogenetics research

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice

Open access

Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., Yau, K.-W.·2003·Nature

DOI 10.1038/nature01761PMC PMC2885907

Open this paper in CoChat — free account

Abstract

In the mammalian retina, besides the conventional rod-cone system, a melanopsin-associated photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment. On ablation of the melanopsin gene, retinal ganglion cells that normally express melanopsin are no longer intrinsically photosensitive. Furthermore, pupil reflex, light-induced phase delays of the circadian clock and period lengthening of the circadian rhythm in constant light are all partially impaired. Here, we investigated whether additional photoreceptive systems participate in these responses. Using mice lacking rods and cones, we measured the action spectrum for phase-shifting the circadian rhythm of locomotor behaviour. This spectrum matches that for the pupillary light reflex in mice of the same genotype, and that for the intrinsic photosensitivity of the melanopsin-expressing retinal ganglion cells. We have also generated mice lacking melanopsin coupled with disabled rod and cone phototransduction mechanisms. These animals have an intact retina but fail to show any significant pupil reflex, to entrain to light/dark cycles, and to show any masking response to light. Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature01761

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citation
A Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting
Panda, S., Sato, T. K., Castrucci, A. M., Rollag, M. D., DeGrip, W. J., Hogenesch, J. B., Provencio, I., & Kay, S. A. (2002) · Science · doi:10.1126/science.1076848 · Cited by 861
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
Lucas, R. J., Hattar, S. S., Takao, M., Berson, D. M., Foster, F., & Yau, K. (2003) · Science · doi:10.1126/science.1077293 · Cited by 835
Self-citation
Role of Melanopsin in Circadian Responses to Light
Ruby, N. F., Brennan, T. J., Xie, X., Cao, V. H., Franken, P., Heller, H. C., & O’Hara, B. F. (2002) · Science · doi:10.1126/science.1076701 · Cited by 647
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646
Characterization of an ocular photopigment capable of driving pupillary constriction in mice
Lucas, R. J., Douglas, R. H., & Foster, R. G. (2001) · Nature Neuroscience · doi:10.1038/88443 · Cited by 614
Self-citation

Flagged first, then by citations

Show all 31 references

Research works printed but not linked: 1

Aschoff, J. in Trends in Chronobiology. Advances in the Biosciences Vol. 73 (eds Hekkens, W. T. J. M., Kerkhof, G. A. & Rietveld, W. J.) 149–161 (Pergamon, Oxford, 1988)

Sorted by citations

Items 901–998 of 998

Violet Light Modulates the Central Nervous System to Regulate Memory and Mood
Sasaki, N., Gusain, P., Hayano, M., Sugaya, T., Tonegawa, N., Hatanaka, Y., Tamura, R., Okuyama, K., Osada, H., Ban, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.02.466604 · Cited by 5
Insomnia in Women Surviving Breast and Gynecological Cancers—A Narrative Review to Address the Hormonal Factor
Martella, S., Proserpio, P., Guerrieri, M. E., Galbiati, A., Ferini‐Strambi, L., Cucinella, L., Iacobone, A. D., Franchi, D., & Nappi, R. E. (2025) · Cancers · doi:10.3390/cancers17244022 · Cited by 6
Is white the right light for the clinical electrooculogram?
Constable, P. A., & Kapoor, G. (2021) · Documenta Ophthalmologica · doi:10.1007/s10633-021-09845-9 · Cited by 5
Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions
Bohl, J. M., Hassan, A. R., Sharpe, Z. J., Kola, M., Shehu, A., Beaudoin, D. L., & Ichinose, T. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1547066 · Cited by 5
Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas
Díaz, N. M., Sun, X., Gelder, R. N. V., Lang, R. A., & Buhr, E. D. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116045 · Cited by 6
Tangled up in blue: Contribution of short-wavelength sensitive cones in human circadian photoentrainment
Buhr, E. D. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219617120 · Cited by 5
A new role for photoresponsive neurons called simple photoreceptors in the sea slug Onchidium verruculatum: Potentiation of synaptic transmission and motor response
Shimotsu, K., Nishi, T., Nakagawa, S., & Gotow, T. (2010) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2010.01.026 · Cited by 5
Das Auge der Inneren Uhr – Pupillenforschung in neuem Licht
Wilhelm, B. (2010) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/s-0029-1245658 · Cited by 5
Color Pupillography in Dorsal Midbrain Syndrome
Kelbsch, C., Maeda, F., Straßer, T., Peters, T. M., Wilhelm, B., & Wilhelm, H. M. (2017) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000527 · Cited by 5
Circadian Rhythms and Addiction
Barko, K., Shelton, M. A., Seggio, J. A., & Logan, R. W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00013-0 · Cited by 7
Chronobiology in the wild: toolkit to study daily rhythms in free-living animals
Silvério, J. T., & Tachinardi, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200020 · Cited by 5
Altered Light Sensitivity of Circadian Clock in Shank3+/– Mouse
Alamilla, J., Ramiro‐Cortés, Y., Mejía-López, A., Chavez, J.-L., Rivera, D. O., Felipe, V., & Aguilar‐Roblero, R. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.604165 · Cited by 7
Evaluation of electrophysiological changes in migraine with visual aura
Hamurcu, M., & Bilen, N. B. (2022) · Taiwan Journal of Ophthalmology · doi:10.4103/2211-5056.354281 · Cited by 5
The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study
Petrowski, K., Schmalbach, B., Linhardt, M., Mekschrat, L., & Rohleder, N. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100504 · Cited by 6
Quantitative Analysis of Full Spectrum LEDs for High Quality Lighting
Liu, J. G., Tang, W., Qin, Y., Sun, G., & Shen, C. (2018) · China International Forum on Solid State Lighting & International Forum on Wide Bandgap Semiconductors China (SSLChina: IFWS) · doi:10.1109/ifws.2018.8587355 · Cited by 5
Fetal programming of adipose tissue function by gestational chronodisruption
Halabí, D., Ehrenfeld, P., Méndez, N., Hans, G. H. R., & Torres‐Farfan, C. (2020) · Sleep Science · doi:10.5935/1984-0063.20200014 · Cited by 8
Electroconvulsive shock alters the rat overt rhythms of motor activity and temperature without altering the circadian pacemaker
Anglès‐Pujolràs, M., Dı́ez-Noguera, A., Soria, V., Urretavizcaya, M., Menchón, J. M., & Cambras, T. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.021 · Cited by 5
Selective attention and Pavlovian conditioning
Russell, I. S., Russell, M. I., Castiglioni, J. A., Reuter, J. A., & Hof, M. W. V. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0404-z · Cited by 5
The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration
Álvarez-López, C., Cernuda‐Cernuda, R., & García-Fernández, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.022 · Cited by 6
Neurophysiology of Sleep and Wakefulness
Chellappa, S. L., Schmidt, C., & Cajochen, C. (2014) · Springer eBooks · doi:10.1007/978-88-470-5388-5_3 · Cited by 5
Dynamic endocannabinoid-mediated neuromodulation of retinal circadian circuitry
Kumar, D., Khan, B., Okcay, Y., SİS, Ç. Ö., Abdallah, A., Murray, F., Sharma, A., Uemura, M. T., Taliyan, R., Heinbockel, T., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102401 · Cited by 5
Lateral habenula astroglia modulate the potentiating antidepressant-like effects of bright light stimulation in intractable depression
Delcourte, S., Bouloufa, A., Rovera, R., Brunet, E., Le, H. D., Williams, A. E., Panda, S., Azmani, R., Raineteau, O., Dkhissi‐Benyahya, O., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1592909 · Cited by 4
Pupillary responses to light are not affected by narrow irido-corneal angles
Rukmini, A. V., Najjar, R. P., Atalay, E., Sharma, S., Lock, J. Z., Baskaran, M., Nongpiur, M. E., Gooley, J. J., Aung, T., & Miléa, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-10303-3 · Cited by 4
PupilMetrics: a support system for preprocessing of pupillometric data and extraction of outcome measures
Amiot, V., Tomasoni, M., Minier, A., Gisselbaek, S., Kawasaki, A., & Kostic, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-79920-z · Cited by 4
A review of symptom, pathogenesis and treatment characteristics of the elderly with chronic insomnia
Xia, L., Liu, H., & Ren, J. (2025) · Medicine · doi:10.1097/md.0000000000041346 · Cited by 6
Optimizing the Potential Utility of Blue-Blocking Glasses for Sleep and Circadian Health
Glickman, G. L., Harrison, E. M., Herf, M., Herf, L., & Brown, T. M. (2025) · Translational Vision Science & Technology · doi:10.1167/tvst.14.7.25 · Cited by 5
A tablet that shifts the clock
Gelder, R. N. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423498112 · Cited by 4
Régulation circadienne et homéostatique du sommeil et de la veille
Taillard, J., & Gronfier, C. (2012) · Elsevier eBooks · doi:10.1016/b978-2-294-71025-4.00003-8 · Cited by 4
An Investigation of the Role of Macular Pigment in Attenuating Photostress through Comparison between Blue and Green Photostress Recovery Times
Tavazzi, S., Perego, F., Ferraro, L., Acciarri, M. F., & Zeri, F. (2018) · Current Eye Research · doi:10.1080/02713683.2018.1554151 · Cited by 4
Evaluation of Artificial Light with Respect to Human Health
Rossi, M. (2019) · Research for development · doi:10.1007/978-3-030-11087-1_3 · Cited by 8
Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
Volf, C., Aggestrup, A. S., Petersen, P. M., Dam‐Hansen, C., Knorr, U. B., Petersen, E. E., Engstrøm, J., Jakobsen, J. C., Hansen, T. S., Madsen, H. Ø., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-032233 · Cited by 4
Inhibitor of DNA binding 2 (Id2) Regulates Photic Entrainment Responses in Mice: Differential Responses of the Id2-/- Mouse Circadian System Are Dependent on Circadian Phase and on Duration and Intensity of Light
Duffield, G. E., Han, S., Hou, T. Y., de la Iglesia, H. O., McDonald, K. A., Mecklenburg, K. L., & Robles‐Murguia, M. (2020) · Journal of Biological Rhythms · doi:10.1177/0748730420957504 · Cited by 4
Targeted Disruption of the Inhibitor of DNA Binding 4 (Id4) Gene Alters Photic Entrainment of the Circadian Clock
Duffield, G. E., Robles‐Murguia, M., Hou, T. Y., & McDonald, K. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179632 · Cited by 4
Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells
Sheng, Y., Chen, L., Ren, X., Jiang, Z., & Yau, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-02832-9 · Cited by 4
Self-citation
Electrocortical temporal complexity during wakefulness and sleep: an updated account
González, J., Cavelli, M., Mondino, A., Pascovich, C., Castro‐Zaballa, S., Rubido, N., & Torterolo, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200013 · Cited by 6
Methods to Assess Melatonin Receptor-Mediated Phase-Shift and Re-entrainment of Rhythmic Behaviors in Mouse Models
Glatfelter, G. C., Sosa, J., Hudson, R. L., & Dubocovich, M. L. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2593-4_39 · Cited by 4
Circadian and Light Modulation of Behavior
Altimus, C. M., LeGates, T. A., & Hattar, S. S. (2009) · Neuromethods · doi:10.1007/978-1-60761-303-9_4 · Cited by 3
Self-citation
Non-visual Biological Mechanism
van Bommel, W. (2019) · Springer eBooks · doi:10.1007/978-3-030-17195-7_5 · Cited by 5
Sleep and maternal behavior in the postpartum rat after haloperidol and midazolam treatments
Peña, F., Rivas, M., González, J., Schwarzkopf, N., Torterolo, P., Ferreira, A., & Benedetto, L. (2020) · Sleep Science · doi:10.5935/1984-0063.20200019 · Cited by 4
Social modulation on daily variability in electric behavior
Gascue, V., da Silva, A. C. R., & Migliaro, A. (2020) · Sleep Science · doi:10.5935/1984-0063.20200012 · Cited by 6
A Mathematical Model for the Action Spectrum of Steady-State Pupil Size in Photopic Vision with Insight into Healthful Lighting
Wang, S., Zhao, J., Wang, L., Hu, W., & Yan, F. (2023) · Buildings · doi:10.3390/buildings13030781 · Cited by 4
Transient Pupillary Light Reflex in Relation to Fundus Autofluorescence and Dark-Adapted Perimetry in Typical Retinitis Pigmentosa
Liu, Y., Liu, D. N., Meng, X. H., & Yin, Z. Q. (2011) · Ophthalmic Research · doi:10.1159/000330049 · Cited by 5
PHASE AND PERIOD RESPONSES OF THE JERBOAJACULUS ORIENTALISTO SHORT LIGHT PULSES
Moussaouiti, R. E., Bouhaddou, N., Sabbar, M., Cooper, H. M., & Lakhdar‐Ghazal, N. (2010) · Chronobiology International · doi:10.3109/07420528.2010.504315 · Cited by 4
How the clock sees the light
Gelder, R. N. V. (2008) · Nature Neuroscience · doi:10.1038/nn0608-628 · Cited by 4
Nonimage Forming Photoreceptors
Peirson, S. N., & Foster, F. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1262-6_4 · Cited by 4
Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse
Nobrega, A. K. D., & Lyons, L. C. (2017) · Neural Plasticity · doi:10.1155/2017/4723836 · Cited by 4
Evaluation of Light-Emitting Diodes’ Effects on the Expression Level of P53 and EGFR in the Gingival Tissues of Albino Rats
Ahmed, A. G., & Raziq, A. H. (2019) · Medicina · doi:10.3390/medicina55090605 · Cited by 4
Melanopsin Cells
Provencio, I. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00276-0 · Cited by 4
Circadian Timekeeping in the Suprachiasmatic Nucleus: Genes, Neurotransmitters, Neurons, and Astrocytes
Hastings, M. H., & Brancaccio, M. (2020) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-55643-3_11 · Cited by 4
Regulation of Prokineticin 2 Expression by Light and the Circadian Clock
Cheng, M., Bittman, E. L., Hattar, S. S., & Zhou, Q. (2014) · Apple Academic Press eBooks · doi:10.1201/b17253-3 · Cited by 4
Self-citation
Photoreceptors and Circadian Clocks
Peirson, S. N., & Foster, F. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01602-8 · Cited by 4
Neural-circuit architecture underlying non-image-forming visual functions
Shen, J., & Xue, T. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103052 · Cited by 3
Melanopsin-mediated image statistics from natural and human-made environments
Barrionuevo, P. A., & Díaz‐Barrancas, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-15981-y · Cited by 5
Partial blue light blocking glasses at night advanced sleep phase and reduced daytime irritability, disruptive behavior and improved morning mood, but did not alter salivary melatonin secretion in Japanese male schoolchildren
Nishino, N., Yoshimoto, R., Ono, T., Chiba, S., & Nishino, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0332877 · Cited by 6
Violet Chip Excited White LEDs for Sun-Like Lighting and Horticulture Lighting
Zhuo, Y., Zhu, H., Shen, C., Sun, G., & Liu, J. G. (2019) · China International Forum on Solid State Lighting & International Forum on Wide Bandgap Semiconductors China (SSLChina: IFWS) · doi:10.1109/sslchinaifws49075.2019.9019777 · Cited by 3
Introduction and reflections on the comparative physiology of sleep and circadian rhythms
Foster, F. (2024) · Journal of Comparative Physiology B · doi:10.1007/s00360-024-01567-z · Cited by 5
Multifaceted Roles of Melatonin in Sleep Disorders
Mahdi, D. T., & Rana (2024) · Wasit Journal of Pure sciences · doi:10.31185/wjps.366 · Cited by 3
Far-red LED light alters circadian rhythms and elicits dark-adapted ERG responses in rodents
Xian, C. H. E. N., Kreuser, S. C., & Hirenallur-Shanthappa, D. K. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326710 · Cited by 3
Photic stimulation of the suprachiasmatic nucleus via the non-visual optic system. A gene expression study in the blind Crx −/− mouse
Rovsing, L., & Møller, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1910-0 · Cited by 3
An insight into light as a chronobiological therapy in affective disorders
Lall, G. S., Walsh, J., Atkinson, L., & Corlett, S. A. (2014) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s56589 · Cited by 3
Color-Enrichment Semiconductor Nanocrystals for Biorhythm-Friendly Backlighting
Erdem, T., & Demir, H. V. (2018) · Zeitschrift für Physikalische Chemie · doi:10.1515/zpch-2018-1134 · Cited by 3
Energy Effıcıent Human Centered Offıce Lıghtıng: A Case Study on Open Plan Offıce wıth Absent Access to Daylıght
Aliparast, S., & Onaygıl, S. (2023) · Light & Engineering · doi:10.33383/2023-052 · Cited by 3
Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock
Nakazawa, K., Matsuo, M., Kikuchi, Y., Nakajima, Y., & Numano, R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1186677 · Cited by 3
A Thalamic Circuit Lights up Mood
Yanar, J., & Halassa, M. M. (2018) · Cell · doi:10.1016/j.cell.2018.08.054 · Cited by 3
Células ganglionares fotosensibles: una población diminuta pero esencial
Vidal‐Villegas, B., Gallego‐Ortega, A., de Imperial‐Ollero, J. A. M., Martínez-de-la-Casa, J. M., Feijoo, J. G., & Vidal‐Sanz, M. (2020) · Archivos de la Sociedad Española de Oftalmología · doi:10.1016/j.oftal.2020.06.032 · Cited by 4
Intrinsically Photosensitive Retinal Ganglion Cells: Assessment of Their Influence on Pupillary Responses in Primates
Gamlin, P. D. (2022) · Neuromethods · doi:10.1007/978-1-0716-2577-4_7 · Cited by 3
Differential effects of retinal degeneration on sleep and wakefulness responses to short light–dark cycles in albino mice
Hsiao, F., Liao, Y., & Tsai, L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.033 · Cited by 3
Behavioural Ecology: Promiscuous Fathers Sire Young that Recognize True Family
Hauber, M. E., & Safran, R. J. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.036 · Cited by 3
Studio per la valutazione degli effetti della luce sugli esseri umani
Barbalace, M., Gugliermetti, F., Lucchese, F. A., & Bisegna, F. (2012) · IRIS Research product catalog (Sapienza University of Rome) · Cited by 3
Overview of the Circadian Timekeeping System and Diagnostic Tools for Circadian Rhythm Sleep Disorders
Lockley, S. W. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1703-7.10028-3 · Cited by 3
Circadian Rhythm Disorders and Chronotherapy for Mood Disorders
Timtim, S., & Welsh, D. K. (2020) · Springer eBooks · doi:10.1007/978-3-030-44447-1_10 · Cited by 3
Spectroscopic Analysis of Wavelength Sensitivities of Opsin-Type Photoreceptor Proteins
Kojima, D., & Fukada, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2577-4_8 · Cited by 3
Evaluation of a Novel Ambient Light Survey Question in the Cancer Prevention Study-3
Diver, W. R., Figueiro, M. G., Rea, M. S., Hodge, J. M., Flanders, W. D., Zhong, C., Patel, A. V., & Gapstur, S. M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043658 · Cited by 3
Functional Assessment of Melanopsin-Driven Light Responses in the Mouse: Multielectrode Array Recordings
Weng, S.-J., Renna, J. M., Chen, W., & Yang, X. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7720-8_20 · Cited by 3
Cellular localization of melatonin receptor Mel1b in pigeon retina
Sheng, W., Jin, M., Pan, G., Weng, S.-J., Attila Gabor, S. I. K., Han, L., & Liu, K. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101974 · Cited by 3
Photic Retinopathy
Mainster, M. A., & Boulton, M. E. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-0016-7.50177-6 · Cited by 3
Assessment of optic neuropathy as a result of direct and indirect injury using non- invasive functional and structural analytical tools
Mohan, K. (2012) · doi:10.31274/etd-180810-108 · Cited by 3
Correction: Inducible Ablation of Melanopsin-Expressing Retinal Ganglion Cells Reveals Their Central Role in Non-Image Forming Visual Responses
Hatori, M., Le, H., Vollmers, C., Keding, S. R., Tanaka, N., Buch, T., Waisman, A., Schmedt, C., Jegla, T. J., & Panda, S. (2008) · PLoS ONE · doi:10.1371/annotation/c02106ba-b00b-4416-9834-cf0f3ba49a37 · Cited by 3
Multiple Parallel Expansions of Bilaterian-Like Phototransduction Gene Families in the Eyeless AnthozoaPreprint
Hansen, S., Payne, M., & McCulloch, K. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.14.557824 · Cited by 2
IL-6 after wake-up in human males: Exposure to red versus blue light and the interplay with cortisol
Mekschrat, L., Schmalbach, B., Rohleder, N., & Petrowski, K. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100833 · Cited by 3
Differential Effects of Light Spectra on Sleep Architecture and Melatonin in Rats
Chiu, Y.-C., Yi, P.-L., & Chang, F. (2025) · Brain Sciences · doi:10.3390/brainsci15050445 · Cited by 3
Full‐Length Cryptochrome 1 in the Outer Segments of the Retinal Blue Cone Photoreceptors in Humans and Great Apes Suggests a Role Beyond Transcriptional Repression
Bartölke, R., Nießner, C., Reinhard, K., Uwe Wolfrum, B., Meimann, S., Bolte, P., Feederle, R., Mouritsen, H., Dedek, K., Peichl, L., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402614r · Cited by 2
Impact of Studies of the Drosophila norpA Mutation on Understanding Phototransduction
Shortridge, R. D. (2012) · Journal of Neurogenetics · doi:10.3109/01677063.2011.647142 · Cited by 4
A longitudinal population study of the impact of cataract extraction on sleep quality
Chen, Y., Nondahl, D. M., Schubert, C. R., Dalton, D. S., Paulsen, A. J., Klein, R., Klein, R., & Cruickshanks, K. J. (2017) · Cogent Medicine · doi:10.1080/2331205x.2017.1314905 · Cited by 2
Performance Evaluation of Blue Light Meters in the Market
Seo, G. H., Jung, M.-H., Kim, C., & Choi, E. J. (2021) · Journal of Korean Ophthalmic Optics Society · doi:10.14479/jkoos.2021.26.4.281 · Cited by 2
Role of biological rhythms in the interpretation of clinical laboratory results. Basic concepts.
Lorenzo-Lozano, M. C., Manzanera, A. L. B., Sarasola, M. E. R., de Medio, E. P., Sánchez, R. B., Gómez, L. C., Luna, F. G., Tenor, D. P., Sánchez, A. C., & Menchero, S. P. (2020) · Revista de Medicina de Laboratorio · doi:10.20960/revmedlab.00022 · Cited by 4
Entrainment to gradual vs. immediate 8-hour phase advance shifts with and without short-wavelength enriched polychromatic green light
Chang, A., Anderson, C., Cain, S. W., Reichenberger, D., Ronda, J. M., Lockley, S. W., & Czeisler, C. A. (2023) · Sleep Health · doi:10.1016/j.sleh.2023.09.007 · Cited by 3
Looking for a Beam of Light to Heal Chronic Pain
Xu, J., Zhang, H., Chen, D. D., Xu, K., Li, Z., Wu, H., Geng, X., Wei, X., Wu, J., Cui, W., et al. (2024) · Journal of Pain Research · doi:10.2147/jpr.s455549 · Cited by 3
Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity
Nolan, R. B., Fan, J.-Y., & Price, J. L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1401721 · Cited by 2
Non-invasive neurostimulation to improve sleep quality and depressive symptoms in patients with major depressive disorder: A meta-analysis of randomized controlled trials
Qiao, M.-X., Yu, H., & Li, T. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.06.023 · Cited by 3
Relevance of the regulation of the brain-placental axis to the nocturnal bottleneck of mammals
Poudel, S. P., & Behura, S. K. (2024) · Placenta · doi:10.1016/j.placenta.2024.08.001 · Cited by 3
Non-Rod Non-Cone Photoreception☆
Wong, K. Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02834-0 · Cited by 2
Construction of a Multiwell Light-Induction Platform for Traceless Control of Gene Expression in Mammalian Cells
Mansouri, M., Lichtenstein, S., Strittmatter, T., Buchmann, P., & Fussenegger, M. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0755-8_13 · Cited by 2
Circadian Rhythm Disorders
Krahn, L. E. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-421-6_24 · Cited by 2
Ganglion-Cell Photoreceptors and Non-Image-Forming Vision
Wong, K. Y., & Berson, D. M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-05714-1.00026-1 · Cited by 2
The Mammalian Circadian System: from Genes to Behavior
Miller, B. H., McDearmon, E. L., & Takahashi, J. S. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_22 · Cited by 2
Vision: Melanopsin and the Pharmacology of Photons
Gelder, R. N. V. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.052 · Cited by 2
Circadian Regulation of Endocrine Functions
Butler, M. P., Karatsoreos, I. N., Kriegsfeld, L. J., & Silver, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00012-2 · Cited by 2

Authors: Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., & Yau, K.-W.
Affiliations: Howard Hughes Medical Institute (US)
Imperial College London (GB)
University of Toronto (CA)
City, University of London (GB)
Tufts University (US)
Ludwig-Maximilians-Universität München (DE)
Technical University of Munich (DE)
Corresponding author: Yau, K.-W.
ORCID: Hattar, S.
Lucas, R. J.
Thompson, S.
Douglas, R. H.
Hankins, M. W.
Biel, M.
Hofmann, F.
Yau, K.-W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-06-15
Volume: 424
Issue: 6944
Pages: 75-81
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01761
PMC: PMC2885907
OpenAlex: W2014028088
Cited by: 1,245
References: 31
Citations by year: 2026: 19 · 2025: 32 · 2024: 49 · 2023: 44 · 2022: 50 · 2021: 43 · 2020: 65 · 2019: 76 · 2018: 58 · 2017: 64 · 2016: 64 · 2015: 50 · 2014: 67 · 2013: 61 · 2012: 53
FWCI: 20.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: Wellcome Trust
National Eye Institute (R37EY006837, R01EY014596, R01EY006837)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
Keywords: melanopsin, pupillary light reflex, circadian phase shifting, action spectrum, retinal ganglion cells, mice, light entrainment
MeSH terms: Melanopsin, Animals, Circadian Rhythm, Darkness, Female, Ion Channels, Light, Male, Mice, Inbred C3H, Motor Activity, Reflex, Pupillary, Retinal Ganglion Cells, Vision, Ocular, Visual Perception, Rod Opsins, Gene Deletion, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Mice, Knockout, Mice, Cyclic Nucleotide-Gated Cation Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks