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Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
Open accessAbstract
In the mammalian retina, besides the conventional rod-cone system, a melanopsin-associated photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment. On ablation of the melanopsin gene, retinal ganglion cells that normally express melanopsin are no longer intrinsically photosensitive. Furthermore, pupil reflex, light-induced phase delays of the circadian clock and period lengthening of the circadian rhythm in constant light are all partially impaired. Here, we investigated whether additional photoreceptive systems participate in these responses. Using mice lacking rods and cones, we measured the action spectrum for phase-shifting the circadian rhythm of locomotor behaviour. This spectrum matches that for the pupillary light reflex in mice of the same genotype, and that for the intrinsic photosensitivity of the melanopsin-expressing retinal ganglion cells. We have also generated mice lacking melanopsin coupled with disabled rod and cone phototransduction mechanisms. These animals have an intact retina but fail to show any significant pupil reflex, to entrain to light/dark cycles, and to show any masking response to light. Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions.
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“Additionally, melanopsin (λmax ~480 nm) is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) that mediate circadian entrainment, the pupillary light reflex, and light-regulated changes in mood (Panda et al., 2003; Hattar et al., 2003; Fernandez et al., 2018).”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Hattar et al., 2003
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Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citationA Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting
Panda, S., Sato, T. K., Castrucci, A. M., Rollag, M. D., DeGrip, W. J., Hogenesch, J. B., Provencio, I., & Kay, S. A. (2002) · Science · doi:10.1126/science.1076848 · Cited by 861
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
Lucas, R. J., Hattar, S. S., Takao, M., Berson, D. M., Foster, F., & Yau, K. (2003) · Science · doi:10.1126/science.1077293 · Cited by 835
Self-citationRole of Melanopsin in Circadian Responses to Light
Ruby, N. F., Brennan, T. J., Xie, X., Cao, V. H., Franken, P., Heller, H. C., & O’Hara, B. F. (2002) · Science · doi:10.1126/science.1076701 · Cited by 647
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646
Characterization of an ocular photopigment capable of driving pupillary constriction in mice
Lucas, R. J., Douglas, R. H., & Foster, R. G. (2001) · Nature Neuroscience · doi:10.1038/88443 · Cited by 614
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Flagged first, then by citations
Research works printed but not linked: 1
- Aschoff, J. in Trends in Chronobiology. Advances in the Biosciences Vol. 73 (eds Hekkens, W. T. J. M., Kerkhof, G. A. & Rietveld, W. J.) 149–161 (Pergamon, Oxford, 1988)
Cited by
Sorted by citations
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Tsujimura, S., Ukai, K., Ohama, D., Nuruki, A., & Yunokuchi, K. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.0330 · Cited by 123
Steele, T. A., Louis, E. K. S., Videnović, A., & Auger, R. R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01031-8 · Cited by 128
Spitschan, M., Bock, A. S., Ryan, J., Frazzetta, G., Brainard, D. H., & Aguirre, G. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711522114 · Cited by 116
Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells
Langer, K. B., Ohlemacher, S. K., Phillips, M. J., Fligor, C. M., Jiang, P., Gamm, D. M., & Meyer, J. S. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.010 · Cited by 113
The impact of light from computer monitors on melatonin levels in college students.
Figueiro, M. G., Wood, B., Plitnick, B., & Rea, M. S. (2011) · PubMed · Cited by 115
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115
Opperhuizen, A., Stenvers, D. J., Jansen, R., Foppen, E., Fliers, E., & Kalsbeek, A. (2017) · Diabetologia · doi:10.1007/s00125-017-4262-y · Cited by 114
Non-image-forming ocular photoreception in vertebrates
Fu, Y., Liao, H., Do, M. T. H., & Yau, K. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.06.011 · Cited by 118
Self-citationMelanopsin and inner retinal photoreception
Bailes, H. J., & Lucas, R. J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0155-7 · Cited by 121
Self-citationThe role of retinal photoreceptors in the regulation of circadian rhythms
Paul, K. N., Saafir, T. B., & Tosini, G. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9120-x · Cited by 122
Light‐Induced Melatonin Suppression in Humans with Polychromatic and Monochromatic Light
Revell, V. L., & Skene, D. J. (2007) · Chronobiology International · doi:10.1080/07420520701800652 · Cited by 115
Classical Photoreceptors RegulateMelanopsinmRNA Levels in the Rat Retina
Sakamoto, K., Liu, C., & Tosini, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2556-04.2004 · Cited by 111
Helfrich‐Förster, C. (2019) · Journal of Comparative Physiology A · doi:10.1007/s00359-019-01379-5 · Cited by 113
The post illumination pupil response is reduced in seasonal affective disorder
Roecklein, K. A., Wong, P. M., Ernecoff, N. C., Miller, M., Donofry, S. D., Kamarck, M. L., Wood‐Vasey, W. M., & Franzen, P. L. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.05.023 · Cited by 110
Photochemistry of retinal chromophore in mouse melanopsin
Walker, M., Brown, R. L., Cronin, T. W., & Robinson, P. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711397105 · Cited by 109
microRNA expression in the eyes and their significance in relation to functions
Xu, S. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.11.003 · Cited by 110
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Robinson, G. A., & Madison, R. (2004) · Vision Research · doi:10.1016/j.visres.2004.06.010 · Cited by 107
A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction
Keenan, W. T., Rupp, A. C., Ross, R., Somasundaram, P., Hiriyanna, S., Wu, Z., Badea, T. C., Robinson, P. R., Lowell, B. B., & Hattar, S. S. (2016) · eLife · doi:10.7554/elife.15392 · Cited by 105
Self-citationShort‐wavelength enrichment of polychromatic light enhances human melatonin suppression potency
Brainard, G. C., Hanifin, J. P., Warfield, B., Stone, M. K., James, M. E., Ayers, M. A., Kubey, A. A., Byrne, B. G., & Rollag, M. D. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12221 · Cited by 110
Esquiva, G., Lax, P., Pérez-Santonja, J. J., García-Fernández, J. M., & Cuenca, N. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00079 · Cited by 110
Nighttime dim light exposure alters the responses of the circadian system
Shuboni‐Mulligan, D. D., & Yan, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.009 · Cited by 107
Photic Entrainment of the Circadian System
Ashton, A., Foster, R., & Jagannath, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020729 · Cited by 106
Walker, W. H., Bumgarner, J. R., Walton, J. C., Liu, J. A., Meléndez‐Fernández, O. H., Nelson, R. J., & DeVries, A. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249360 · Cited by 115
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Kölsch, Y., Hahn, J., Sappington, A., Stemmer, M., Fernandes, A. M., Helmbrecht, T. O., Lele, S., Butrus, S., Laurell, E., Arnold-Ammer, I., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.12.003 · Cited by 97
Münch, M. Y., Léon, L., Crippa, S. V., & Kawasaki, A. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9494 · Cited by 110
Light pollution: the possible consequences of excessive illumination on retina
Contin, M. A., Benedetto, M. M., Quinteros-Quintana, M. L., & Guido, M. E. (2015) · Eye · doi:10.1038/eye.2015.221 · Cited by 105
Circadian temperature variation and ageing
Weinert, D. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.003 · Cited by 107
Cao, D., Nicandro, N., & Barrionuevo, P. A. (2015) · Journal of Vision · doi:10.1167/15.1.27 · Cited by 104
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Howarth, M., Walmsley, L., & Brown, T. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.014 · Cited by 101
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Alemán, T. S., Jacobson, S. G., Chico, J. D., Scott, M. L., Cheung, A. Y., Windsor, E. A. M., Furushima, M., Redmond, T. M., Bennett, J., Palczewski, K., et al. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-1230 · Cited by 101
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Davies, W. L., Hankins, M. W., & Foster, R. G. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00203h · Cited by 100
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Nelson, R. J., & Chbeir, S. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000198 · Cited by 97
Coupled network of the circadian clocks: a driving force of rhythmic physiology
Finger, A., Dibner, C., & Kramer, A. (2020) · FEBS Letters · doi:10.1002/1873-3468.13898 · Cited by 101
Anatomy and Physiology of the Retina
Hildebrand, G. D., & Fielder, A. R. (2010) · Springer eBooks · doi:10.1007/978-3-642-12041-1_2 · Cited by 106
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Østergaard, J., Hannibal, J., & Fahrenkrug, J. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1322 · Cited by 104
Short-Wavelength Sensitivity of the Human Circadian System to Phase-Advancing Light
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Sekaran, S., Lall, G. S., Ralphs, K. L., Wolstenholme, A. J., Lucas, R. J., Foster, F., & Hankins, M. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4716-06.2007 · Cited by 94
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Tauber, E., Last, K. S., Olive, P. J. W., & Kyriacou, C. P. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404268775 · Cited by 98
Pires, S. S., Hughes, S., Turton, M., Melyan, Z., Peirson, S. N., Zheng, L., Kosmaoglou, M., Bellingham, J., Cheetham, M. E., Lucas, R. J., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2036-09.2009 · Cited by 100
Self-citationDim Light Adaptation Attenuates Acute Melatonin Suppression in Humans
Jasser, S. A., Hanifin, J. P., Rollag, M. D., & Brainard, G. C. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406292391 · Cited by 98
Diversity and functional properties of bistable pigments
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Terakita, A., Tsukamoto, H., Koyanagi, M., Sugahara, M., Yamashita, T., & Shichida, Y. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05184.x · Cited by 93
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Metadata
- Authors
- Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., & Yau, K.-W.
- Affiliations
- Howard Hughes Medical Institute (US)
- Imperial College London (GB)
- University of Toronto (CA)
- City, University of London (GB)
- Tufts University (US)
- Ludwig-Maximilians-Universität München (DE)
- Technical University of Munich (DE)
- Corresponding author
- Yau, K.-W.
- Venue
- Nature
- Published
- 2003-06-15
- Volume
- 424
- Issue
- 6944
- Pages
- 75-81
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2885907
- OpenAlex
- W2014028088
- Cited by
- 1,245
- References
- 31
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 49 · 2023: 44 · 2022: 50 · 2021: 43 · 2020: 65 · 2019: 76 · 2018: 58 · 2017: 64 · 2016: 64 · 2015: 50 · 2014: 67 · 2013: 61 · 2012: 53
- FWCI
- 20.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Wellcome Trust
- National Eye Institute (R37EY006837, R01EY014596, R01EY006837)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- melanopsin, pupillary light reflex, circadian phase shifting, action spectrum, retinal ganglion cells, mice, light entrainment
- MeSH terms
- Melanopsin, Animals, Circadian Rhythm, Darkness, Female, Ion Channels, Light, Male, Mice, Inbred C3H, Motor Activity, Reflex, Pupillary, Retinal Ganglion Cells, Vision, Ocular, Visual Perception, Rod Opsins, Gene Deletion, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Mice, Knockout, Mice, Cyclic Nucleotide-Gated Cation Channels
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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