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Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
Open accessAbstract
In the mammalian retina, besides the conventional rod-cone system, a melanopsin-associated photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment. On ablation of the melanopsin gene, retinal ganglion cells that normally express melanopsin are no longer intrinsically photosensitive. Furthermore, pupil reflex, light-induced phase delays of the circadian clock and period lengthening of the circadian rhythm in constant light are all partially impaired. Here, we investigated whether additional photoreceptive systems participate in these responses. Using mice lacking rods and cones, we measured the action spectrum for phase-shifting the circadian rhythm of locomotor behaviour. This spectrum matches that for the pupillary light reflex in mice of the same genotype, and that for the intrinsic photosensitivity of the melanopsin-expressing retinal ganglion cells. We have also generated mice lacking melanopsin coupled with disabled rod and cone phototransduction mechanisms. These animals have an intact retina but fail to show any significant pupil reflex, to entrain to light/dark cycles, and to show any masking response to light. Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions.
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“Additionally, melanopsin (λmax ~480 nm) is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) that mediate circadian entrainment, the pupillary light reflex, and light-regulated changes in mood (Panda et al., 2003; Hattar et al., 2003; Fernandez et al., 2018).”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Hattar et al., 2003
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Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Self-citationA Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting
Panda, S., Sato, T. K., Castrucci, A. M., Rollag, M. D., DeGrip, W. J., Hogenesch, J. B., Provencio, I., & Kay, S. A. (2002) · Science · doi:10.1126/science.1076848 · Cited by 861
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
Lucas, R. J., Hattar, S. S., Takao, M., Berson, D. M., Foster, F., & Yau, K. (2003) · Science · doi:10.1126/science.1077293 · Cited by 835
Self-citationRole of Melanopsin in Circadian Responses to Light
Ruby, N. F., Brennan, T. J., Xie, X., Cao, V. H., Franken, P., Heller, H. C., & O’Hara, B. F. (2002) · Science · doi:10.1126/science.1076701 · Cited by 647
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646
Characterization of an ocular photopigment capable of driving pupillary constriction in mice
Lucas, R. J., Douglas, R. H., & Foster, R. G. (2001) · Nature Neuroscience · doi:10.1038/88443 · Cited by 614
Self-citation
Research works printed but not linked: 1
- Aschoff, J. in Trends in Chronobiology. Advances in the Biosciences Vol. 73 (eds Hekkens, W. T. J. M., Kerkhof, G. A. & Rietveld, W. J.) 149–161 (Pergamon, Oxford, 1988)
Cited by
Sorted by citations
Dacey, D. M., Liao, H.-W., Peterson, B. B., Robinson, F. R., Smith, V. C., Pokorny, J., Yau, K.-W., & Gamlin, P. D. (2005) · Nature · doi:10.1038/nature03387 · Cited by 1,333
Self-citationMeasuring and using light in the melanopsin age
Lucas, R. J., Peirson, S. N., Berson, D. M., Brown, T. M., Cooper, H. M., Czeisler, C. A., Figueiro, M. G., Gamlin, P. D., Lockley, S. W., O’Hagan, J. B., et al. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.004 · Cited by 1,278
Self-citationPhysiology of Circadian Entrainment
Golombek, D. A., & Rosenstein, R. E. (2010) · Physiological Reviews · doi:10.1152/physrev.00009.2009 · Cited by 1,169
Light as a central modulator of circadian rhythms, sleep and affect
LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001
Self-citationCentral projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
Self-citationMammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
Neural Circuitry of Wakefulness and Sleep
Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966
Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision
Güler, A. D., Ecker, J. L., Lall, G. S., Haq, S., Altimus, C. M., Liao, H., Barnard, A. R., Cahill, H. B., Badea, T. C., Zhao, H., et al. (2008) · Nature · doi:10.1038/nature06829 · Cited by 903
Self-citationThe Types of Retinal Ganglion Cells: Current Status and Implications for Neuronal Classification
Sanes, J. R., & Masland, R. H. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034120 · Cited by 789
The circadian visual system, 2005
Morin, L. P., & Allen, C. N. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.08.003 · Cited by 796
Ecker, J. L., Dumitrescu, O. N., Wong, K. Y., Alam, N. M., Chen, S., LeGates, T. A., Renna, J. M., Prusky, G. T., Berson, D. M., & Hattar, S. S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.023 · Cited by 697
Self-citationCajochen, C. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.009 · Cited by 652
Terakita, A. (2005) · Genome biology · doi:10.1186/gb-2005-6-3-213 · Cited by 633
Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells
Gamlin, P. D. R., McDougal, D. H., Pokorny, J., Smith, V. C., Yau, K.-W., & Dacey, D. M. (2007) · Vision Research · doi:10.1016/j.visres.2006.12.015 · Cited by 617
Self-citationCircadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 635
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
Genetics of Circadian Rhythms in Mammalian Model Organisms
Lowrey, P. L., & Takahashi, J. S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00006-4 · Cited by 601
A neural mechanism for exacerbation of headache by light
Noseda, R., Kainz, V., Jakubowski, M., Gooley, J. J., Saper, C. B., Digre, K., & Burstein, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2475 · Cited by 565
Modulation of locomotor activity in larval zebrafish during light adaptation
Burgess, H. A., & Granato, M. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.003939 · Cited by 525
Effects of blue light on the circadian system and eye physiology
Tosini, G., Ferguson, I., & Tsubota, K. (2016) · Molecular Vision · doi:10.63500/mv_v22_61 · Cited by 517
McDougal, D. H., & Gamlin, P. D. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140014 · Cited by 645
Light Affects Mood and Learning through Distinct Retina-Brain Pathways
Fernandez, D. C., Fogerson, P. M., Lazzerini Ospri, L., Thomsen, M. B., Layne, R. M., Severin, D., Zhan, J., Singer, J. H., Kirkwood, A., Zhao, H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.004 · Cited by 505
Self-citationIllumination of the Melanopsin Signaling Pathway
Panda, S., Nayak, S. K., Campo, B., Walker, J. R., Hogenesch, J. B., & Jegla, T. J. (2005) · Science · doi:10.1126/science.1105121 · Cited by 477
Effect of Light on Human Circadian Physiology
Duffy, J. F., & Czeisler, C. A. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.004 · Cited by 477
Intrinsically Photosensitive Retinal Ganglion Cells
Do, M. T. H., & Yau, K. (2010) · Physiological Reviews · doi:10.1152/physrev.00013.2010 · Cited by 503
Self-citationEvolution of opsins and phototransduction
Shichida, Y., & Matsuyama, T. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0051 · Cited by 492
Ye, X., Wang, Y., Cahill, H. B., Yu, M., Badea, T. C., Smallwood, P. M., Peachey, N. S., & Nathans, J. (2009) · Cell · doi:10.1016/j.cell.2009.07.047 · Cited by 473
A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice
Ye, H., Baba, M. D., Peng, R., & Fussenegger, M. (2011) · Science · doi:10.1126/science.1203535 · Cited by 473
The Effects of Light at Night on Circadian Clocks and Metabolism
Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 494
Storch, K.-F., Paz, C., Signorovitch, J., Raviola, E., Pawlyk, B., Li, T., & Weitz, C. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.045 · Cited by 460
Gooley, J. J., Rajaratnam, S. M. W., Brainard, G. C., Kronauer, R. E., Czeisler, C. A., & Lockley, S. W. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000741 · Cited by 447
Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs
Chen, S., Badea, T. C., & Hattar, S. S. (2011) · Nature · doi:10.1038/nature10206 · Cited by 436
Self-citationClocks not winding down: unravelling circadian networks
Zhang, E. E., & Kay, S. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2995 · Cited by 446
Induction of photosensitivity by heterologous expression of melanopsin
Qiu, X., Kumbalasiri, T., Carlson, S. M., Wong, K. Y., Krishna, V., Provencio, I., & Berson, D. M. (2005) · Nature · doi:10.1038/nature03345 · Cited by 429
Phillips, A. J. K., Vidafar, P., Burns, A. C., McGlashan, E. M., Anderson, C., Rajaratnam, S. M. W., Lockley, S. W., & Cain, S. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901824116 · Cited by 430
Circadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426
Melanopsin: an exciting photopigment
Hankins, M. W., Peirson, S. N., & Foster, R. G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.002 · Cited by 426
Self-citationSleep and Circadian Rhythms in Humans
Czeisler, C. A., & Gooley, J. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.064 · Cited by 425
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403
Photochemical Damage of the Retina
Wu, J., Seregard, S., & Algvere, P. V. (2006) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2006.06.009 · Cited by 398
Pauley, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.020 · Cited by 394
Addition of human melanopsin renders mammalian cells photoresponsive
Melyan, Z., Tarttelin, E. E., Bellingham, J., Lucas, R. J., & Hankins, M. W. (2005) · Nature · doi:10.1038/nature03344 · Cited by 390
Self-citationThe mammalian circadian timing system: from gene expression to physiology
Gachon, F., Nagoshi, E., Brown, S., Ripperger, J. A., & Schibler, U. (2004) · Chromosoma · doi:10.1007/s00412-004-0296-2 · Cited by 398
A model of phototransduction by the human circadian system
Rea, M. S., Figueiro, M. G., Bullough, J. D., & Bierman, A. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.07.002 · Cited by 393
Genome of the Chinese tree shrew
Fan, Y., Huang, Z., Cao, C., Chen, C., Chen, Y.-X., Fan, D., He, J., Hou, H., Hu, L., Hu, X., et al. (2013) · Nature Communications · doi:10.1038/ncomms2416 · Cited by 366
Batten, M. L., Imanishi, Y., Maeda, T., Tu, D. C., Moise, A. R., Bronson, D., Possin, D., Van Gelder, R. N., Baehr, W., & Palczewski, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312410200 · Cited by 368
Information Processing in the Primate Retina: Circuitry and Coding
Field, G. D., & Chichilnisky, E. J. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094252 · Cited by 378
Zaidi, F. H., Hull, J. T., Peirson, S. N., Wulff, K., Aeschbach, D., Gooley, J. J., Brainard, G. C., Gregory-Evans, K., Rizzo, J. F., Czeisler, C. A., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.034 · Cited by 385
Biological rhythm disturbances in mood disorders
Wirz‐Justice, A. (2006) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000195660.37267.cf · Cited by 359
Lin (2005) · Genome biology · doi:10.1186/gb-2005-6-5-220 · Cited by 351
Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina
Iuvone, P. M., Tosini, G., Pozdeyev, N. V., Haque, R., Klein, D. C., & Chaurasia, S. S. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2005.01.003 · Cited by 349
A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds
Nakane, Y., Ikegami, K., Ono, H., Yamamoto, N., Yoshida, S., Hirunagi, K., Ebihara, S., Kubo, Y., & Yoshimura, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006393107 · Cited by 343
Interplay of Circadian Clocks and Metabolic Rhythms
Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 341
Breast cancer and circadian disruption from electric lighting in the modern world
Stevens, R. G., Brainard, G. C., Blask, D. E., Lockley, S. W., & Motta, M. E. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21218 · Cited by 332
Klassen, H. J., Ng, T. F., Kurimoto, Y., Kirov, I. I., Shatos, M. A., Coffey, P. J., & Young, M. J. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0511 · Cited by 327
Bailes, H. J., & Lucas, R. J. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2012.2987 · Cited by 319
Self-citationMelanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Do, M. T. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.016 · Cited by 320
Daytime Light Exposure Dynamically Enhances Brain Responses
Vandewalle, G., Balteau, E., Phillips, C., Degueldre, C., Moreau, V., Sterpenich, V., Albouy, G., Darsaud, A., Desseilles, M., Dang-Vu, T. T., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.031 · Cited by 313
Phototransduction in mouse rods and cones
Fu, Y., & Yau, K. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0194-y · Cited by 310
Self-citationThe impact of daytime light exposures on sleep and mood in office workers
Figueiro, M. G., Steverson, B., Heerwagen, J., Kampschroer, K., Hunter, C. M., Gonzales, K., Plitnick, B., & Rea, M. S. (2017) · Sleep Health · doi:10.1016/j.sleh.2017.03.005 · Cited by 308
Photon capture and signalling by melanopsin retinal ganglion cells
Do, M. T. H., Kang, S. H., Xue, T., Zhong, H., Liao, H., Bergles, D. E., & Yau, K. (2008) · Nature · doi:10.1038/nature07682 · Cited by 320
Self-citationHatori, M., Le, H. D., Vollmers, C., Keding, S. R., Tanaka, N., Schmedt, C., Jegla, T. J., & Panda, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002451 · Cited by 316
Melanopsin signalling in mammalian iris and retina
Xue, T., Do, M. T. H., Riccio, A., Jiang, Z., Hsieh, J. T., Wang, H. C., Merbs, S. L., Welsbie, D. S., Yoshioka, T., Weißgerber, P., et al. (2011) · Nature · doi:10.1038/nature10567 · Cited by 301
Self-citationArchitecture, Function, and Assembly of the Mouse Visual System
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Datta, S., & MacLean, R. R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.004 · Cited by 307
Cashmore, A. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00647-0 · Cited by 315
Modelling the spectral sensitivity of the human circadian system
Rea, M. S., Figueiro, M. G., Bierman, A., & Hamner, R. (2011) · Lighting Research & Technology · doi:10.1177/1477153511430474 · Cited by 304
Distinct Contributions of Rod, Cone, and Melanopsin Photoreceptors to Encoding Irradiance
Lall, G. S., Revell, V. L., Momiji, H., al Enezi, J., Altimus, C. M., Güler, A. D., Aguilar, C., Cameron, M. A., Allender, S., Hankins, M. W., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.037 · Cited by 306
Self-citationRods-cones and melanopsin detect light and dark to modulate sleep independent of image formation
Altimus, C. M., Güler, A. D., Villa, K. L., McNeill, D. S., LeGates, T. A., & Hattar, S. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808312105 · Cited by 286
Self-citationIntraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons
Zhang, D.-Q., Wong, K. Y., Sollars, P. J., Berson, D. M., Pickard, G. E., & McMahon, D. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803893105 · Cited by 300
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Foster, R. G. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0098 · Cited by 286
Seasonal Regulation of Reproduction in Mammals
Hazlerigg, D. G., & Simonneaux, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00034-x · Cited by 288
Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal
Fisk, A. S., Tam, S. K. E., Brown, L. A., Vyazovskiy, V. V., Bannerman, D. M., & Peirson, S. N. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00056 · Cited by 295
Enezi, J. A., Revell, V., Brown, T., Wynne, J., Schlangen, L., & Lucas, R. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411409719 · Cited by 278
Self-citationVandewalle, G., Gais, S., Schabus, M., Balteau, E., Carrier, J., Darsaud, A., Sterpenich, V., Albouy, G., Dijk, D. J., & Maquet, P. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm007 · Cited by 277
Bright-Light Therapy in the Treatment of Mood Disorders
Pail, G., Huf, W., Pjrek, E., Winkler, D., Willeit, M., Praschak-Rieder, N., & Kasper, S. F. (2011) · Neuropsychobiology · doi:10.1159/000328950 · Cited by 291
Structure of cone photoreceptors
Mustafi, D., Engel, A. H., & Palczewski, K. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.05.003 · Cited by 275
McDougal, D. H., & Gamlin, P. D. (2009) · Vision Research · doi:10.1016/j.visres.2009.10.012 · Cited by 286
Vandewalle, G., Schmidt, C., Albouy, G., Virginie Sterpenich, A., Darsaud, A., Rauchs, G., Berken, P.-Y., Balteau, E., Degueldre, C., Luxen, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001247 · Cited by 280
Synaptic influences on rat ganglion‐cell photoreceptors
Wong, K. Y., Dunn, F. A., Graham, D. M., & Berson, D. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.133751 · Cited by 277
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Rea, M. S., & Figueiro, M. G. (2016) · Lighting Research & Technology · doi:10.1177/1477153516682368 · Cited by 279
Sensitivity of the Human Circadian System to Short-Wavelength (420-nm) Light
Brainard, G. C., Sliney, D., Hanifin, J. P., Glickman, G., Byrne, B., Greeson, J. M., Jasser, S., Gerner, E., & Rollag, M. D. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730408323089 · Cited by 260
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Hirota, T., & Fukada, Y. (2004) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.21.359 · Cited by 264
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Altimus, C. M., Güler, A. D., Alam, N. M., Arman, A. C., Prusky, G. T., Sampath, A. P., & Hattar, S. S. (2010) · Nature Neuroscience · doi:10.1038/nn.2617 · Cited by 267
Self-citationBechtel, W., & Abrahamsen, A. A. (2010) · Studies in History and Philosophy of Science Part A · doi:10.1016/j.shpsa.2010.07.003 · Cited by 257
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Peirson, S. N., Halford, S., & Foster, F. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0050 · Cited by 260
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Cideciyan, A. V. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.04.002 · Cited by 256
Adaptation of Human Pineal Melatonin Suppression by Recent Photic History
Smith, K. A., Schoen, M. W., & Czeisler, C. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032100 · Cited by 256
Spectral quality of light modulates emotional brain responses in humans.
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“Figures based on (Lucas et al., 2014) (A) and (Dacey et al., 2005) B). ere lost were all responses to light abolished (Hattar et al., 2003; anda et al., 2003).”
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Metadata
- Authors
- Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., & Yau, K.-W.
- Affiliations
- Howard Hughes Medical Institute (US)
- Imperial College London (GB)
- University of Toronto (CA)
- City, University of London (GB)
- Tufts University (US)
- Ludwig-Maximilians-Universität München (DE)
- Technical University of Munich (DE)
- Corresponding author
- Yau, K.-W.
- Venue
- Nature
- Published
- 2003-06-15
- Volume
- 424
- Issue
- 6944
- Pages
- 75-81
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2885907
- OpenAlex
- W2014028088
- Cited by
- 1,245
- References
- 31
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 49 · 2023: 44 · 2022: 50 · 2021: 43 · 2020: 65 · 2019: 76 · 2018: 58 · 2017: 64 · 2016: 64 · 2015: 50 · 2014: 67 · 2013: 61 · 2012: 53
- FWCI
- 20.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Wellcome Trust
- National Eye Institute (R37EY006837, R01EY014596, R01EY006837)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- melanopsin, pupillary light reflex, circadian phase shifting, action spectrum, retinal ganglion cells, mice, light entrainment
- MeSH terms
- Melanopsin, Animals, Circadian Rhythm, Darkness, Female, Ion Channels, Light, Male, Mice, Inbred C3H, Motor Activity, Reflex, Pupillary, Retinal Ganglion Cells, Vision, Ocular, Visual Perception, Rod Opsins, Gene Deletion, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Mice, Knockout, Mice, Cyclic Nucleotide-Gated Cation Channels
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